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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of this study was to investigate, using the CPITN system, the periodontal treatment needs in diabetic patients, and to shed additional light on the possible effects of the duration and control of diabetes on the periodontal status in these patients. A comparison was made between 222 diabetic patients (mean age, 46.9 years) and 189 control subjects (mean age, 43.9 years). Edentulous patients were not included in the study. The results indicated that diabetic patients demonstrated significantly more missing teeth (P less than 0.001). The mean number of missing sextants was also significantly higher in diabetics. Pathologic pockets of 6 mm or more were found in 1.3 and 0.3 sextants in the diabetic and control group subjects, respectively (P less than 0.001). Up to the age of 34, no differences were observed between the diabetic and control group subjects regarding pathologic pockets of 6 mm or more. Above this age, diabetics demonstrated significantly more sextants with deep pockets (P less than 0.001). Concerning the type of diabetes, no differences related to CPITN score were found between insulin dependent and non-insulin dependent diabetics. Neither were any differences found in the periodontal condition related to the duration and control of diabetes, whereas diabetics with advanced retinopathy demonstrated more sextants with deep pockets. Oral hygiene instructions and scaling were required in all patients from both study groups. On an average, 1.3 sextants in 50.9% of diabetics and 0.3 sextants in 17.9% of control subjects required complex treatment.
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PMID:CPITN assessment of periodontal disease in diabetic patients. 322 28

In order to evaluate general and local contraindications for implantation for 65-yr-old subjects from a medium-sized Finnish city, 431 such persons were examined anamnestically and by means of panoramic radiographs. The population represents 61% of the total age group in the city (born in 1923). It was shown that several degrees of cardiac problems and increased blood pressure followed by pulmonary diseases and diabetes were the most commonly encountered relative contraindications for implantation. Eleven percent of the patients said that they smoked regularly and the bone quality was estimated to be less suitable for implantation in 21% of the cases. Implantation was evaluated according to the Bonefit system (implant lengths between 6 and 16 mm) in 10 regions in the maxilla and 6 regions in the mandible and was shown to be possible in 38% of the regions in the partially edentulous maxillae and 50% of those in the partially edentulous mandibles, the corresponding figures for the edentulous jaws were 55% in the maxilla and 61% in the mandible.
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PMID:General and local contraindications for endosseal implants--an epidemiological panoramic radiograph study in 65-year-old subjects. 778 Dec 99

Examining 230 edentulous patients, a significant degree of atrophy in the maxilla and mandible relatively often has been found. Atrophy could be detected more often in the mandible of female patients. For these forms of manifestation, among others, systemic causes: osteoporosis, diabetes and periodontal disease could be found. The results and their classification may help to draw the attention in the course of treatment to strong dissimilarities or similarities of the edentulous mouth. The degree of atrophy observed on both jaw-bones--among other factors--is significant for the planning and prognosis when indicating total prosthetic treatment.
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PMID:[Study of the atrophy of the jaws]. 782 51

The NHANES I Epidemiologic Follow-up Study (NHEFS) of 1982-84 collected longitudinal data from 10,523 individuals initially seen during the first National Health and Nutrition Examination Survey (NHANES I) of 1971-75. Among this additional data was information on the incidence of total tooth loss during the 10 years between the surveys, which could then be added to NHANES I data to identify risk factors. In this analysis, a series of bivariate analyses were carried out, followed by logistic regression analysis to assess the simultaneous effect of major variables. Results showed that 7.4 percent of dentate Americans aged 25-74 at NHANES I became edentulous over the next 10 years. In bivariate analyses, the incidence of edentulism was correlated with baseline measures of lower income and education status, poorer oral health, self-perceptions of poor general health and oral health, absence of a regular dentist, and a lower number of remaining teeth at baseline. No correlation was found with gender and geographic region, nor with self-reported diabetes and arthritis, and age was not a factor when the number of remaining teeth at baseline were taken into account. In a logistic regression model assessing the effect of these variables simultaneously, none of the demographic variables retained significance; the only variable statistically significant in both age groups was the number of teeth remaining at baseline. Other significant variables in younger persons were higher periodontal disease scores, perceived poor dental health, perceived need for extractions, history of smoking, and low ascorbic acid intake. Some of these variables were reflections of negative health behavior and attitudes rather than direct correlates. Principal findings from this study were the importance of early tooth loss in eventual edentulism and the virtual disappearance of gender and age as determinants of total tooth loss.
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PMID:Risk factors for total tooth loss in the United States; longitudinal analysis of national data. 816 92

As patients become edentulous, dental implants have been one treatment alternative. Although studies indicate that dental implants inserted in healthy patients have been successful, their placement in the diabetic patient remains controversial. The purpose of this study utilizing histometric parameters compares the course of osseous healing around endosseous implants in normal non-diabetic and insulin controlled diabetic rats. Diabetes was induced by a single intraperitoneal injection of streptozotocin. Blood glucose was monitored by the glucose-oxidase method and controlled with daily insulin injections. Sterile custom fabricated commercially pure solid cylinder titanium implants, with a titanium plasma-sprayed surface were placed in the femora of each animal. The results indicate that insulin therapy was able to upregulate the formation of bone around implants inserted in the streptozotocin-induced diabetic rat model. However, histometric parameters utilized indicated that although the total quantity of bone formation was greater in the insulin controlled group, there was significantly less bone-to-implant contact in the insulin controlled diabetic group as compared to normal non-diabetic controls.
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PMID:The effect of insulin therapy on osseointegration in a diabetic rat model. 1055 Oct 61

Moderate elevation of serum C-reactive protein (CRP) is a risk factor for cardiovascular disease among apparently healthy individuals, although factors that create this inflammatory response in the absence of systemic illness have not been clarified. This study aimed to: (1) evaluate associations among periodontal disease, established risk factors for elevated CRP, and CRP levels within the US population; and (2) determine whether total tooth loss is associated with reduced CRP. Data were obtained from the third National Health and Nutrition Examination Survey. A random sample of the US population was interviewed in their homes and examined at mobile examination centers. CRP was quantified from peripheral blood samples and analyzed as a continuous variable and as the prevalence of elevated CRP (> or = 10 mg/L). Some 12,949 people aged 18+ years who had periodontal examinations and an additional 1,817 edentulous people aged 18+ years were included in the analysis. Dentate people with extensive periodontal disease (> 10% of sites with periodontal pockets 4+ mm) had an increase of approximately one-third in mean CRP and a doubling in prevalence of elevated CRP compared with periodontally healthy people. Raised CRP levels among people with extensive periodontal disease persisted in multivariate analyses (P < 0.01), with established risk factors for elevated CRP (diabetes, arthritis, emphysema, smoking, and anti-inflammatory medications) and sociodemographic factors controlled for. However, CRP levels were similarly raised in edentulous people. Furthermore, the established risk factors for elevated CRP modified relationships between oral status and CRP levels. Periodontal disease and edentulism were associated with systemic inflammatory response in the US population, most notably among people who had no established risk factors for elevated CRP.
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PMID:Acute-phase inflammatory response to periodontal disease in the US population. 1069 Jun 60

An increasing number of studies point to the detrimental effect of plaque bacteria on periimplant tissue health. The purpose of this retrospective study was to explore a possible relationship between the clinical and microbiological periimplant conditions of osseointegrated oral implants after several years of service and the dental and medical history, as well as the conditions of the residual dentition. 45 partially edentulous patients (mean age: 51 years, range: 27-83 years), with a total of 64 implants participated in this retrospective analysis. The time between examination and the last dental visit ranged from 6 to 24 months (mean: 13 months) and the time since the last maintenance therapy appointment with a dental hygienist ranged between 3 and 24 months (mean 7 months). During 5 to 10 years between implant installation and examination, 9 implants experienced one episode and an additional 6 implants two episodes of periimplantitis. As a consequence of extensive bone loss associated with these infections, one of these implants, in a patient who had a history of diabetes, was lost. With this exception, the other episodes of periimplantitis were successfully treated employing the principles of the Cumulative Interceptive Supportive Therapy (CIST) protocol. At examination, 42 implants (66%) showed a probing pocket depth exceeding 4 mm. Of the periimplantitis sites, four implants showed cultural evidence for presence of Porphyromonas gingivalis, and 2 implants were positive for Actinobacillus actinomycetemcomitans. Statistical analysis revealed a significant relationship between periimplant probing depth and the total anaerobic cultivable microbiota as well as the frequency of detection of P. gingivalis.
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PMID:Retrospective assessment of clinical and microbiological factors affecting periimplant tissue conditions. 1135 74

A series of prospective studies started in the mid-1980s at the University of Toronto have provided evidence of the efficacy and effectiveness of implants in the treatment of the fully and partially edentulous patients. These studies have focused primarily on treatment outcomes at the surgical and prosthodontic levels, with an overall failure rate of 7.7% over a 20-year period. Because a considerable proportion of these failures (4.2%) occurred before insertion of the prosthesis, and because osseointegration is essentially a wound-healing process, factors that interfere with healing, including systemic conditions, may contribute to implant failure. This paper reviews studies on the impact of selected systemic conditions, including osteoporosis, cardiovascular diseases, diabetes mellitus, and hypothyroidism, as well as smoking behaviour, on the success or survival of oral implants in patients treated in the Implant Prosthodontic Unit at the University of Toronto.
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PMID:Implant prosthodontics in medically challenged patients: the University of Toronto experience. 1186

This study evaluated whether oral disorders were associated with chronic systemic diseases in 532 Canadian adults who are old and very old and living in institutions. A brief oral examination documented tooth retention, caries, and periodontal and gingival health. Medical records provided information about chronic systemic conditions. A history of stroke was associated with a higher experience of caries, a higher ratio of decayed-to-present teeth, and more gingival and periodontal problems. Participants with high blood pressure, osteoporosis, or diabetes were more likely to be edentulous or to have fewer teeth than participants who did not have these conditions. Participants who had arthritis retained more teeth with age. Participants who had more diseases also tended to have poorer gingival or periodontal conditions, fewer teeth, and higher risk of edentulousness. The associations between systemic diseases and more severe oral disorders may be direct or may be mediated by underlying factors such as health behaviors.
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PMID:Oral disorders and chronic systemic diseases in very old adults living in institutions. 1508 56

The aim of this study was to evaluate the prevalence of peri-implant diseases around Branemark system implants in Brazilians and the possible relationship with periodontal bone loss, systemic condition, and demographic profile. A total of 113 individuals were enrolled in this study, and they received 347 implants. The implants were clinically and radiographically examined and diagnosed as healthy implants, mucositis, or peri-implantitis. The demographic and systemic profiles of the individuals were assessed via questionnaires, and the time of loading was obtained from files. The presence of periodontal bone loss in partially edentulous patients was determined by standardized radiographic evaluation. With regard to implants, the prevalence was 60.5% (n = 210), 32% (n = 111), and 7.5% (n = 26) for healthy tissues, mucositis, and peri-implantitis, respectively. No correlation was found between peri-implant tissue conditions and socioeconomic status, body mass index, smoking status, gender, age, diabetes mellitus, osteopenia, and osteoporosis. Statistically significant positive correlations were found in implants with mucositis and peri-implantitis in relation to time of loading and with peri-implantitis in relation to periodontal bone loss in the 4 quadrants (P < .05). Presence of peri-implant diseases may be associated with the increasing time of loading and generalized periodontal bone loss.
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PMID:Peri-implant diseases may be associated with increased time loading and generalized periodontal bone loss: preliminary results. 1917 Feb 93


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