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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Diabetic microangiopathy is a degenerative process specific to diabetes. Metabolic theory holds that the metabolic defect predisposes to vascular abnormalities, but other theory suggests that microangiopathy and metabolic disorders are of different origin. Metabolic and ultrastructural modifications in kidney and retina are reviewed. Human and animal studies suggest a specific organ response to fortuitous association of several factors leading to microvascular disease.
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PMID:Diabetic microangiopathy: renal and retinal aspects. 33 42

Examinations of the lung vessels in diabetes of various degrees of severity and duration revealed changes in the vessels similar to diabetic microangiopathy in other organs (kidneys, skin). Manifestations of diabetic microangiopathy in the lungs are most marked in arterioles and capillaries of the alveolar septae. Diabetic microangiopathy in the lungs is characterized by phenomena of plasmorrhagy and insudation, thickening of capillary basal membranes, sclerosis and hyalinosis of capillary and arteriola walls, and accumulation of alveolar macrophages resorbing metabolism products in alveolar lumen. Diabetic microangiopathy leads to the development of alveolar septae sclerosis and to centrilobular pulmonary emphysema. As compared with the involvement of the vessels in the kidneys and the skin, manifestations of diabetic microangiopathy in the lungs lag in their development and are less manifest.
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PMID:[Morphological changes in the lung blood vessels in diabetes mellitus]. 42 38

Diabetic microangiopathy, particularly as seen in the renal glomerulus, is characterized by morphological and biochemical alterations of the capillary basement membrane. Observations from a number of disciplines have indicated that the microvascular disease is not a separately inherited entity but a true consequence or "complication" of insulin deficiency. An evaluation of the biochemical events which could be responsible for the basement membrane lesions of diabetes indicates that the hyperglycemia or plasma somatotropin elevation of this disease alone, or in combination, may play an important role.
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PMID:Search for a biochemical basis of diabetic microangiopathy. 76 87

Diabetic microangiopathy is a slowly progressive condition that usually manifests itself years after the onset of the carbohydrate-metabolism disturbance. It is a far more striking problem in some diabetics than in others. Differences in the pattern of its effect in several body systems suggest that the local vascular disturbance is a mixture of a general microcirculatory change in diabetes and a specific vascular alteration in each tissue. Its manifestations in the individual diabetic appear to be influenced by both elements. Evidence is presented that plasma protein changes in diabetes and their effects on blood flow play a role in acclerating the rate of progression of diabetic microangiopathy by raising plasma viscosity and by increasing the affinity of erythrocytes for each other. The plasma protein change is dominated by a possibly hormonally mediated pattern of alpha-globulin elevation seen in many chronic disorders. This elevation of acute-phase proteins is not likely by itself to produce diabetic microangiopathy, but it may cause an additional stress on the metabolically disturbed diabetic microcirculation. The basic change is a disturbance in the average molecular shape of the plasma proteins that both directly increases plasma viscosity and enhances the aggregation of erythrocytes. Studies are now in progress to determine which of these two mechanisms is more likely to be important in accelerating the development of diabetic microangiopathy.
Diabetes 1976
PMID:Plasma protein changes, blood viscosity, and diabetic microangiopathy. 97 90

Skin biopsies from 40 patients 17 to 75 years old with type I and II diabetes mellitus were studied morphologically. The formation of diabetic microangiopathy starts with the damage of endotheliocytes, vascular permeability disturbance, activation of pericytes and smooth muscle elements with subsequent thickening of basal membranes and capillary and arteriole hyalinosis, these lesions being directly related to the duration of diabetes. Diabetic microangiopathy is a manifestation of the disease and its morphology is similar in both type I and II diabetes.
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PMID:[Morphogenesis of diabetic microangiopathy]. 174 70

Results of histologic, immunohistochemical and ultrastructural examination of pulmonary vessels of 85 necropsy cases (65 patients had diabetes and 20 were controls with atherosclerosis). In the lung vessels in diabetes the changes in the arteries of the elastomuscular and muscular types were frequently found (73.8 and 81.5%, respectively) which were regarded as manifestations of diabetic macroangiopathy, as well as those of arterioles, capillaries (81.5 and 55.4%, respectively) which are the expression of diabetic macroangiopathy. Macroangiopathy is represented by thickening of the endothelial basal membrane, destruction of the internal elastic lamina, its mucoid edema. An extreme manifestation is lipogranulomatosis of the arteries of muscle type. These changes are frequently associated with arterial thrombosis. Diabetic microangiopathy is characterized by plasmorrhagy and hyalinosis of the wall (lipohyaline) with the development of the nodular arteriolo-hyalinosis, the thickening of the endothelial basal membrane and frequent necrosis of capillary pericytes. A specific feature of the diabetic angiopathy is lipidosis of all cells in the lung artery system and its extracellular structures combined with lipidosis of type II pneumocytes producing surfactant and phagocyting alveolar macrophages and polinuclear leukocytes.
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PMID:[Diabetic macro- and microangiopathy of the lungs]. 208 71

The incidence of erectile dysfunction in patients with long-term diabetes mellitus can be as high as 50%. Diabetic microangiopathy is regarded as the most important pathogenic factor. In this review of a group of 210 impotent patients evaluated and treated at our centre we report on the examination data (angiopathy, neuropathy, psychogenic factors) in 36 patients with diabetes in comparison with the corresponding findings in 169 non-diabetic patients. In 5 patients erectile dysfunction had actually preceded the clinical manifestations of diabetes mellitus. Autoinjection therapy was started in 62% of all the diabetic patients, since this is effective, minimally invasive and, therefore, applicable to a large group of patients. This form of therapy was accepted by 90% of our patients' partners, which is in accordance to the reports in the literature. However, treatment had to be interrupted in 2 out of the 22 patients, owing to lack of cooperation on the part of the sexual partner. No complications were attributable to autoinjection therapy.
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PMID:[Disorders of erectile potency in diabetes mellitus]. 304 17

Patients with diabetes mellitus are more prone to stroke than non-diabetic patients. Using Duplex ultrasound imaging of the carotid bifurcation, we have found it possible to classify atherosclerotic plaques into four groups which appear to reflect the plaque pathology. Using this classification we have found that diabetics and non-diabetics have similar ultrasound plaque type distributions in symptomatic patients. Further subdivision of the diabetic patients on the basis of their mode of diabetic control has shown that insulin treated diabetics tend to show little evidence of intraplaque haemorrhage and ulceration. These features suggest that factors other than atherosclerosis at the carotid bifurcation may be responsible for the increased stroke risk in diabetic patients. Diabetic microangiopathy and reduced vessel compliance due to medial calcification have been suggested as possible factors. Insulin treatment of diabetics may protect against the development of occlusive atherosclerosis.
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PMID:Carotid artery disease: the influence of diabetes mellitus. 306 9

The biopsies of the thigh skin from 85 patients with insulin-dependent (juvenile) diabetes mellitus are studied. Diabetic microangiopathy is detected histologically in 70 patients. The degree of microangiopathy was positively correlated with the duration of diabetes (p less than 0.01) and this allowed to calculate the probability of vascular alterations development at various periods of disease. The patient age and the gravity of insulin-dependent diabetes did not influence significantly the frequency and the degree of diabetic microangiopathy (p greater than 0.05).
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PMID:[Incidence of microangiopathy in insulin-dependent diabetes mellitus (data from the morphological examination of skin biopsy specimens)]. 370 90

Alteration in prostanoid and TXA2 production are involved in the development of diabetic microangiopathy underlying DR. Diabetic microangiopathy is characterized by abnormalities in platelet function and increased susceptibility to thrombus formation. The synthesis of excessive amounts of PGs and TXA2 by platelets obtained from diabetic patients is underlying alteration in platelet responsiveness seen in diabetes mellitus. An associated reduction in PGI2 by endothelial blood vessels results in further disruption of the homeostatic mechanism regulating the aggregatory process. However, PGI2 behaviour in different tissues, and in blood vessels of varied calibre is yet unclear. PGI2 synthesis is restored to normal on reduction of blood glucose levels. Restoration of the synthesis of both prostanoids and PGI2 to normal, might be achieved by using drugs that inhibit prostanoid and TXA2 formation as well as by controlling glucose blood levels. Affecting the imbalance of prostanoid and TXA2 seen in diabetes might be of clinical implication in prevention and treatment of DR.
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PMID:Prostanoids and thromboxane A2 involvement in diabetic retinopathy. 676 48


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