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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The occurrence of oral leukoplakia and lichen planus in 1600 patients with diabetes mellitus (815 type 1: insulin-dependent, 761 type 2: non-insulin-dependent)-under care at the International Medicine Department-was studied. Precancerous lesions and conditions were diagnosed and grouped according to internationally accepted criteria. The prevalence of oral leukoplakia in diabetic patients was 6.2%, as compared to 2.2% in the healthy controls, that of oral lichen was 1.0% in the test-, and 0.0% in the control group. Leukoplakia and lichen both showed the highest occurrence in the second year of established diabetes, and their prevalence was higher among insulin-treated diabetics. Smokers were more often affected, by both kind of lesions, oral lichen showed a more frequent association with candidiasis. The prevalence of oral leukoplakia and lichen in diabetes mellitus patients was higher, than average ratios in population samples from the same country.
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PMID:Occurrence of oral leukoplakia and lichen planus in diabetes mellitus. 140 44

The authors describe a clinical case observed at the Inst of Oral & Maxillofacial Surgery characterized by three simultaneous symptoms: arterious hypertension, diabetes mellitus, oral erosive lichen planus. Grinspan & his co-workers observed this syndrome. The results of their research were exposed at the Congress on Dermatology in Buenos Aires, 1963. In 1965 in a repetitive study Grupper & Avul seemed confirm the existence of this symptomatological triad; therefore the authors defined this complex as "Grinspan's syndrome". Further researches conducted by other authors (Jolly, Powell. Howell e Rick) confirmed the association hypertension-diabetes-"erosive" lichen. However there were other worthwhile studies (Lozada-Nur, Christensen) which emphasized a not significant high frequency of patients with diabetes and high blood pressure and the oral sugar tolerance like random specimens of common people. Besides the authors notice that their clinical case is interesting not only because of their simultaneous presence of the three symptoms but also because of the bioptic appearance of a cancer likely appeared on a pre-existing inveterate lichenoid lesion.
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PMID:[A case of a carcinoma arising in lichen planus in a subject with diabetes mellitus and arterial hypertension (Grinspan's syndrome)]. 149 59

Patients with the following diagnoses were presented: pyoderma gangraenosum in a patient with myelodysplastic syndrome passing into an acute myelomonocytic leukemia and specific cutaneous infiltration, primary genital infection with herpes simplex virus, type 1 (HSV-1) in an adult patient, pellagroid, Sweet's syndrome with follicular involvement, Sweet's syndrome in a patient with cancer of the breast, lichen amyloidosus, angiolymphoid hyperplasia with eosinophilia, Darier's disease 1. associated with basal cell carcinoma 2. with specific cutaneous infiltrations in a patient with acute myeloid leukemia, body building, anabolic steroids and fertility, multiple trichodiscomas and perifollicular fibromas, Buschke's scleroedema adultorum, extensive necrobiosis lipoidica without diabetes mellitus, extramammary, multifocal type of Paget's disease.
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PMID:[52d Cologne Dermatology Meeting of the Cologne University Dermatology Clinic 24 January 1990]. 198 79

In this study the data on 200 patients affected by various features of lichen planus (LP) are reported. All subjects were in-patients of the Department of Dermatology, Bari, from 1973 to 1988. In 87% of cases the disease appeared as lichen tuber planus, and in 9% there was involvement of mucous membranes. Equal involvement of sex incidence has been found, and the patients were middle-aged (mean, 47 years). The lesion were not subsided in about 10% of cases. Associated fortuitous skin conditions were mainly alopecia areata and vitiligo. In addition, LP has been observed in association with diabetes (8%) and hepatic diseases (10%). These last values could appear relevant, but in our region, Apulia, both diabetes and hepatitis, and especially B-hepatitis, are very frequent diseases. Our clinical follow-up did not allow to consider LP as a symptom of other subsequent organic diseases.
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PMID:[A retrospective study of 200 cases of lichen]. 237 21

To investigate the role of systemic factors such as age, diabetes, and hypertension in the formation of subepithelial immune deposits in oral lichen planus (OLP) we performed circulating immune complex CIC determinations by polyethylene glycol precipitation in sera of patients with OLP, diabetes mellitus, and hypertension and in sera of healthy control subjects. We examined patients with leukoplakia as a control group with oral keratosis but no OLP. Forty percent of the OLP patients were suffering from diabetes, hypertension, or both. The occurrence of CIC positivity was higher in the OLP group with diabetes than in the group with OLP only. However, we could not find CIC positivity in our control patients with diabetes. The almost equal distribution of hypertension among, patients with OLP who tested positive for CIC and those who tested negative does not seem to support the hypothesis that this factor causes the CIC positivity in OLP. The same applies to other assumed factors such as age, medication, dental foci, or metal framework. In summary, we support the idea that CIC positivity may be the consequence of lichen itself, but diabetes and hypertension contribute to the development of erosive OLP lesions.
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PMID:Circulating immune complex studies on patients with oral lichen planus. 281 11

Twenty patients with vulvar dystrophy (19 Lichen sclerosus, 1 Lichen ruber planus) were treated for 3 months with etretinate (Tigason) with an initial dose 0.54 mg/kg/day, maintenance dosage 0.26 mg/kg/day. All the patients had been unsuccessfully treated previously with topical oestrogen and corticosteroids. The therapeutic effect of etretinate on the subjective and objective symptoms of the disease was excellent. In most of the patients the pruritus and burning symptoms diminished within 2 weeks of treatment, and after 3 months the grade of symptoms was lower in 95% of cases. Clinically, a decrease in severity was achieved in 93% of cases among the group with severe vulvar dystrophy. The therapeutic effect of etretinate is strongly anti-inflammatory and it has a powerful effect on the epidermal tissues. According to the latest studies, etretinate also has a strong immuno-modifying effect on the epidermal cells. The secondary inflammatory changes, such as excoriatia, fissures and superinfections disappeared. In the histopathological follow-up hyperkeratosis in the stroma diminished and the inflamed cells and connective tissue normalised after 3 months of treatment. Side effects included cheilitis, dryness of mucous membranes and slight loss of hair. It must be taken into account that etretinate may cause liquid metabolism disturbances, particularly among risk factor patients (diabetes, obesity etc.). In our experience the best results to date in the treatment of vulvar dystrophy can be achieved with etretinate. Due to the teratogenic effect of etretinate, a reliable method of contraception must be used by fertile women of childbearing age.
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PMID:[Oral treatment of vulvar dystrophy with an aromatic retinoid, etretinate]. 371 Jan 21

In 177 patients with lichen ruber planus of the oral mucosa and in 177 sex- and age-matched healthy control subjects, the data of 24 laboratory parameters were studied prospectively. Abnormal glucose tolerance was observed in 30.1% of cases and in 11.9% of the control group (P less than or equal to 0.01%). Elevated serum cholesterin levels were found in 35.5% of the lichen ruber patients compared with 17.5% of the control population (P less than or equal to 0.1%). The coexistence of hyperglycemia and hypercholesterolemia was revealed in 11.9% of our lichen ruber patients and in 1.7% of the control group. Similar statistically significant differences in the mentioned parameters were seen in patients with sole skin involvement, as compared to the controls. The possible pathogenetic relationship between lichen ruber and diabetes mellitus is discussed, based on the results of this study.
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PMID:[Lichen ruber and diabetes mellitus--pathogenetic relations?]. 646 33

Four cases of lichen with atrophy of the nail are reported. Three of them had erosive lesions on the sole of the feet. They all had lichen planus of the mouth and some slight lesions of typical lichen planus of the skin too. One of them also had lichen sclerosus of the scalp, and two women had non-atrophic alopecia of the axillary and pubic hair. There were other heterogeneous associated clinical features in all the cases: diabetes in one case; "esophageal diverticula", xerophthalmia, low figures of C.4 and antinuclear antibodies in serum in another case; hyperuricaemia and hypertriglyceridemia a in another case; hepatic cirrhosis and ferropenic anaemia in the other case.
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PMID:[Erosive plantar lichen planus with onycho-atrophy]. 675 6

Oral lichen ruber (OLR) is a chronic, recurrent disease with a worldwide prevalence of 0.9%-2.2%. In Croatia, the disease has been on a constant increase over the last 10 years, and its prevalence has reached the upper limit. The aim of the study was to identify OLR specificities in a Croatian population. The study included 100 subjects, 84 women and 16 men, mean age 53 +/- 13.88 years, with recurrent OLR. Results showed a four-fold prevalence of OLR in women as compared to men. In women, the disease was found to develop later than in men. Oral changes indicated the reticular form of the disease in 62% and erosive in 33%, whereas all other types were present in 5% of study subjects. Systemic disorders underlying OLR were found in 93% of study patients, predominantly isolated or in combination. Pathologic values of laboratory tests were recorded in 23% of study subjects. Significant differences were obtained in OLR associated with gastritis and diabetes mellitus (p < 0.05), and with gastritis and cholecystopathy (p < 0.001). Increased values of bilirubin (p < 0.01), triglycerides (p < 0.01) and blood glucose (p < 0.001) were recorded in men. The level of total lipids was significantly higher in OLR associated with cholecystopathy (p < 0.05). Accordingly, the occurrence of OLR in the Croatian population was found to be most commonly associated with the hepatobiliary system diseases, followed by gastric disorders and diabetes mellitus.
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PMID:Characteristics of oral lichen in the Croatian population. 995 Nov 44

Prurigo pigmentosa is rather frequently observed in Japan. By contrast, this skin disease has so far rarely been reported in German speaking countries or elsewhere in Europe. In order to make the European dermatologists familiar with this peculiar skin disease, the epidemiological features as well as the clinical and histopathological findings are reviewed. The disease can be discriminated from prurigo simplex subacuta by the typical reticular hyperpigmentation, by the sparing of arms and legs and by the response to treatment with dapsone or minocycline. Additional differential diagnostic possibilities include lichen amyloidosus and confluent and reticulate papillomatosis of Gougerot-Carteaud. Diabetes or malnutrition may represent etiological factors. Because this unusual skin disease may also occur in Europe, dermatologists here should include prurigo pigmentosa in the differential diagnosis of acquired pigmentary disorders.
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PMID:[Prurigo pigmentosa]. 1124 87


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