Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Abdominal aortic aneurysmectomy is being performed with progressively lower operative mortality and morbidity. Three hundred thirty seven patients have had elective aneurysm repair since 1954. Factors affecting mortality and morbidity in the last 108 cases are analyzed. Seventy-four per cent of patients had pre-existing disease, either cardiac, pulmonary, renal, cerebrovascular, diabetes mellitus, or hypertension. Six patients died following operation, a mortality rate of 5.5%. One died of pulmonary and 5 of cardiac causes. No patient died of renal failure or required dialysis. A signficant feature of management is the regimen of fluid therapy using dextrose in lactated Ringer's solution during and after operation to minimize hypotensive and renal complications. No patient developed a wound infection, graft infection, wound dehiscence, stroke, or intestinal ischemia. Serious postoperative complications were largely cardiac or pulmonary. Despite recent liberalization of indications for operation, comparative figures show continued reduction in operative mortality from 17% during 1954-1961, or 7.4% during 1962-1967, to 5.5% in the 1968-1974 era. This declining mortality is related to earlier diagnosis using non-invasive methods (sonogram), simplified operative techniques, improvement in fluid management, innovations in cardiopulmonary therapy, and recognition and proper handling of unusual manifestations of aortic aneurysms.
 ...
PMID:Surgical management of abdominal aortic aneurysms: factors influencing mortality and morbidity--a 20-year experience. 12 60

Diabetes was induced in pregnant rats by administration of streptozotocin and the changes of the feto-placental unit were investigated. Dead fetuses were found in 12% of the untreated diabetic animals. In comparison to the controls, the fetal weights were significantly smaller and placental weights greater in diabetic animals. The changes were clearly characterized by the ratio fetal placental weight. Edema and cystic degeneration were characteristic of insulin treated diabetic placentas while fibrosis and ischemia were observed mainly in untreated animals. Insulin treatment resulted in hemorrhages and necrosis in the placenta of normal pregnant rats; the change is ascribed to hypoglycaemia.
 ...
PMID:Clinical and morphological studies in streptozotocin diabetic pregnant rats. 13 71

The influence of warm ischemia on pancreatic islet viability was studied by means of 63 isologous transplantations in adult AGUS rats. The pancreases were harvested 0, 20 and 40 min after circulatory arrest. The islets were isolated with collagenase and transplanted intra-portally in known numbers into streptozotocin-diabetic recipients. The islet-dose-metabolic-response relationships in three groups of recipients were compared. No significant difference was found in the quantitative yield. The smallest number of islets which reversed diabetes increased by 25% after a period of warm ischemia regardless of its duration.
 ...
PMID:Viability of the islets of Langerhans after warm ischemia as judged by isologous transplantation. 41 67

In patients with severe lower extremity ischemia (ischemic necrosis or pain at rest associated with physical findings of peripheral arterial insufficiency), diabetes mellitus should not deter thorough arteriography and consideration of arterial reconstruction. Infrapopliteal bypass can produce prolonged limb salvage in diabetic patients in lieu of primary amputation.
 ...
PMID:Long-term results of femoroinfrapopliteal bypass in diabetic patients with severe ischemia of the lower extremity. 45 59

Sensory conduction along the median nerve was evaluated during 30 minutes of ischemia in patients with diabetes mellitus. There was abnormal persistence of the sensory evoked potential in 19 of 22 diabetic patients, but not in normal controls, patients with nonmetabolic neuropathies, or 5 of 6 patients with motor neuron diseases. There was an excellent correlation between ischemic resistance and effective control of glucose metabolism, as manifested by Hb A1C levels. These data suggest that abnormal ischemic resistance in diabetes may be the most sensitive indicator of peripheral neural dysfunction even when there are no other electrophysiologic or clinical abnormalities.
 ...
PMID:Ischemia and sensory nerve conduction in diabetes mellitus. 57 68

Ischemic cardiopathies in Eastern Africans at Djibouti are frequent: 2.9 % of the in patients and 73 % of the cardiac diseases. Male prevalence is marked. Coronary insufficiency is most often demonstrated by the usual symptomatology. Three groups of electrocardiopathic manifestations have been individualised: ischemia proving angor (288 cases), anginose syndromes revealing a myocardic infarct (81 cases), acute myocardic infarcts (62 cases). The patients come for the most part from Djibouti and belong to any social class. The part played by a food mainly constituted of complex glucids, refined sugar and lipids is pointed out. Arterial hypertension, diabetes, essential hypercholesterolemia and tobacco intoxication are the most frequent risk factors. This coronary pathology is closer the one met with in the Near East than ischemic cardiopathies observed in tropical Africa which begin to emerge.
 ...
PMID:[Ischemic cardiopathies in Africans in Djibouti. Study of 431 cases in 5 years]. 58 Sep 20

A prospective study of 47 patients with 51 hands treated for carpal tunnel syndrome by surgical release of the deep transverse carpal ligament was performed using intraoperative motor nerve conduction latency measured over a standard distance across the carpal tunnel both before and after release of the ligament. The results of intraoperative conduction latencies indicated a dramatic and immediate reduction in the conduction latency across the carpal canal in all but seven patients, two of whom had diabetes. When the results were subjected to statistical analysis, they were significant (P is equal to 0.00001). Although further studies are indicated, these data suggest that a rapidly reversible mechanical or metabolic block, such as ischemia in the segment of the median nerve, may be responsible for the symptoms of carpal tunnel syndrome.
 ...
PMID:Intraoperative changes in motor nerve conduction latency in carpal tunnel syndrome. 62 69

The diagnosis of occlusion of the intradural vertebrobasilar artery (OIDVBA) was made by means of cerebral angiography in 22 patients. The clinical presentation, course and followup were studied in conjunction with the angiographic findings in each case and the following conclusions made. OIDVBA is not rare. It occurs one-fourth as often as occlusion of the carotid artery. The correct diagnosis is not made clinically before angiography in the majority of patients. Complete visualization of the neck and intracranial vasculature is necessary to document the occlusion. Atherosclerotic thrombosis is the most common type of occlusive lesion. The most common predisposing factors are atherosclerosis, hypertensive cardiovascular disease, diabetes mellitus, and developmental vertebrobasilar hypoplasia. Most patients with occlusion are in the 7th and 8th decades of life and transient attacks of vertebrobasilar ischemia precede the occlusion in one-half of the cases. Emboli usually lodge in the terminal portion of the basilar artery whereas thrombotic occlusions tend not to be located in a characteristic segment. A majority of patients diagnosed angiographically survive their OIDVBA, but most distal occlusions result in death, often following several weeks of coma. In the surviving majority, disturbance of gait, impairment of vision, and symptoms of transient vertebrobasilar ischemia are the most common sequelae.
 ...
PMID:Occlusion of the intradural vertebrobasilar artery. 63 67

Although many patients with coronary artery disease (CAD) have a positive exercise test without pain, the frequency and significance of this "silent" ischemia is unclear. Therefore, we studied 122 consecutive clinically stable patients with angiographically defined CAD (greater than 75 per cent luminal stenosis) and a positive exercise test. Seventy-eight patients had pain or anginal equivalent during or after a positive exercise test; 44 did not, including 32 (26 per cent) with no symptoms at all. Patients were evaluated as to age, sex, prior myocardial infarction, congestive failure, hypertension, diabetes mellitus, and digoxin or propranolol therapy--in addition to anginal symptoms before, during, or after the exercise itself. Extent of CAD, presence of collaterals, and left ventricular ejection fraction were also determined. All exercise tests were evaluated for evidence of ST-T abnormalities or prior infarction on the control ECG as well as peak heart rate during exercise and post-exercise degree of ST segment depression. There were no significant differences between patients with and without exercise-induced pain in regard to any of the clinical and angiographic features noted above, demonstrating that "silent" myocardial ischemia during or after exercise testing is not uncommon and is not readily attributable to any obvious clinical or catheterization findings. Further studies are necessary to determine if patients with evidence of "silent" myocardial ischemia are especially prone to sudden death.
 ...
PMID:"Silent" myocardial ischemia during and after exercise testing in patients with coronary artery disease. 63 80

One hundred consecutive patients with femoropopliteal autogenous vein grafts for limb salvage were reviewed five years later. In this group 40% died and 30% of the limbs had been lost at the end of five years. Limb survival correlated best with adequacy of distal run-off, but not with the presence or absence of diabetes. Forty-seven per cent of the grafts were still patent among surviving patients, and when combined with the limbs that were viable despite failure of the original graft, 70% of the limbs were salvaged among the survivors at five years. Temporary graft patency was effective in preserving ischemic tissue by facilitating healing of ulcers or limited amputations. Femoral-popliteal bypass grafting in the presence of advanced ischemia is capable of improving the quality of life for many of these patients.
 ...
PMID:Results of 100 consecutive femoropopliteal vein grafts for limb salvage. 68 81


1 2 3 4 5 6 7 8 9 10 Next >>