Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A healthy 10-year-old boy was admitted to the hospital in diabetic ketoacidosis within three days of onset of symptoms of a flu-like illness. He died seven days later and post-mortem examination showed lymphocytic infiltration of the islets of Langerhans and necrosis of beta cells. Inoculation of mouse, monkey and human cell cultures with homogenates from the patient's pancreas led to isolation of a virus. Serologic studies revealed a rise in the titer of neutralizing antibody to this virus from less than 4 on the second hospital day to 32 on the day of death. Neutralization data showed that the virus was related to a diabetogenic variant derived from Coxsackievirus B4. Inoculation of mice with the human isolate produced hyperglycemia, inflammatory cells in the islets of Langerhans and beta-cell necrosis. Staining of mouse pancreatic sections with fluorescein-labeled antiviral antibody revealed viral antigens in beta cells. Both the clinical picture and animal studies suggested that the patient's diabetes was virus induced.
 ...
PMID:Isolation of a virus from the pancreas of a child with diabetic ketoacidosis. 21 45

The bivalent influenza vaccines for the 1977-1978 immunization period will contain inactivated influenza A and B viruses representing currently prevalent strains and will be available in "split-virus" and "whole-virus" preparations, which differ in side-effects and immunogenicity. Annual vaccination is recommended for adults and children of all ages with chronic diseases, especially diabetes mellitus or cardiac, pulmonary, or renal disease. Vaccination is also recommended for persons over age 65 years and persons in vital community services. Age-related doses are specified in a table, and side-effects and use in pregnancy are discussed in the text.
 ...
PMID:Influenza vaccine: recommendations of the Public Health Service Advisory Committee on Immunization Practices, Center for Disease Control, U.S. Department of Health, Education, and Welfare; Atlanta, Georgia. 90 Jun 79

The use of the indicator "years of potential life lost" (YPLL) highlights the extent to which premature mortality in Puerto Rico is a predominantly male phenomenon. While men accounted for 58.6% of all deaths in 1987, they represented fully 71.8% of all YPLL attributed to the thirteen leading causes of death. The breakdown of YPLL by gender also underlines sex-specific differences in the causes of mortality. While accidents constitute the leading cause of premature death among men, malignant neoplasms take the lead among women. Similarly, homicides and cirrhosis are significant sources of years of life lost among males, while pneumonia/influenza and diabetes are higher priorities among females. These findings suggest that health promotion strategies need to be gender-specific in order to reach the right targets.
 ...
PMID:The death divide: differentials in premature mortality by gender in Puerto Rico. 150 82

The oral cavity is responsible for two essential functions: the production of speech and the initiation of alimentation. All of the specialized oral tissues and sensory systems that allow for the execution of these functions are susceptible to age-, disease-, and treatment-related changes, and alterations in any one or more function may result in deleterious consequences to the host and impact on the quality of life. Oral physiology is generally believed to be age-stable in healthy individuals; however, in the presence of single or multiple medical diseases and their treatment, these functions deteriorate. This article focuses on the influence of common geriatric diseases, disorders, and impairments on oral health and function. Data are presented to suggest that oral health is altered in the presence of heart, cerebrovascular, liver, and renal diseases, cancer, COPD, diabetes, pneumonia, and influenza. Arthritic, hearing, visual, orthopedic, and speech impairments multiple medical problems. Finally, adjustments in treatment and management strategies may be necessary for older patients with these diseases and impairments.
 ...
PMID:Oral sequelae of common geriatric diseases, disorders, and impairments. 150 40

Pregnancy is perceived as a miracle. Many women feel an inner glow and bond to the growing fetus as they change shape, behavior, and attitude. For the sake of the unborn child, women will abstain from alcohol, coffee, and medicine even when they are ravaged by headache and flu. This response to pregnancy is normal and is consistent with the maternal need to protect her young. Women with diabetes are no different from other women in their concern for their fetuses, but they need to work even harder. Even minor deviations from normal glucose values may have a major impact on fetal well-being. The extra work becomes worthwhile with the birth of a healthy infant.
 ...
PMID:Pregnancy in the diabetic woman. Guidelines for a successful outcome. 161 74

Choosing appropriate antimicrobial therapy for patients with pneumonia requires knowledge of the etiologic agents seen in specific kinds of patients at specific times and places. For community-acquired pneumonia, there is an important difference in the agents seen in the normal and the compromised host. The normal host most often presents with viral, mycoplasmal, or pneumococcal pneumonia. The exact place of Chlamydia pneumoniae is still under study. A normal host who aspirates is at risk of anaerobic pneumonia. Normal hosts with influenza may acquire superinfection with Streptococcus pneumoniae, Haemophilus influenzae, or Staphylococcus aureus. Under specific epidemiologic conditions, community-acquired pneumonia may be due to Legionella species, Yersinia pestis, Francisella tularensis, Coxiella burnetii, Chlamydia psittaci, a mycotic agent, or tuberculosis. Patients with chronic bronchitis and emphysema are predisposed to H. influenzae, Moraxella catarrhalis, and S. pneumoniae infections. HIV-infected patients are likely to have Pneumocystis carinii pneumonia and pneumonia due to cytomegalovirus, S. pneumoniae, and H. influenzae. Patients with diabetes, nursing-home patients, hospitalized patients, immuno-compromised patients, and patients with recent antibiotic therapy are predisposed to pneumonia due to Gram-negative aerobic bacilli of enteric and environmental origin. Initial therapy should be directed at the likely organism or organisms based on hospital susceptibility surveillance. In the normal host with community-acquired pneumonia, the therapy will often be penicillin G or erythromycin. In the patient predisposed to Gram-negative pneumonia, a third-generation cephalosporin with or without an aminoglycoside is the usual choice.
 ...
PMID:Pneumonia. Patient profiles, choice of empiric therapy, and the place of third-generation cephalosporins. 173 Jan 86

The article presents an evaluation of an anti-influenza vaccination programme in a population at risk, with a special study of the general characteristics of the group of non-complying patients, and the possible relation of these characteristics with their conduct. Moreover, a study was made of the possible motives for not complying with the vaccination programme by means of a survey carried out by post and telephone in a representative sample of 108 individuals. A 34.77% of the registered population did not receive the anti-influenza vaccine, corresponding largely with the youngest age group (15 to 44 years) and there were no significant differences determined by sex or risk factor or doctor. A positive response was received from 75% of those surveyed, and the basic conclusions drawn were a low proportion of information error attributable to the programme (2.94%), and patient refusal as the principal cause of non-compliance (54.41%), followed by "other reasons" (hospitalisation, absence from home, etc.) (32.35%). The strategies that may be followed in the face of this problem require definition of the group of non-compliers, further understanding of the motives for their conduct, and educational measures to change their attitude. 95.9%). Incidence of hypertension and hyperlipemia was 56.2% and 47.3%. Late vascular events varied between 2.6% (nephropathy) and 19.5% (retinopathy). A total of 101 patients (44.6%) were unaware of the existence of diabetic health education programmes. Moreover, 68 (30.3%) declared that they had never received any previous information about their diabetes. Practical skills were evaluated on an individual basis.
 ...
PMID:[The evaluation of noncompliance in an anti-influenza vaccination program]. 175 43

The influence of epidemic influenza on hospitalizations because of influenza, pneumonia and diabetic acidosis in patients with diabetes mellitus was investigated. Data on the weekly incidence of influenza-like illness were obtained from the Continuous Morbidity Registration and the cumulative data on hospitalizations in short-stay hospitals were obtained from the National Medical Registration. Patients with duodenal ulcer were used as a control population. Epidemic elevations of influenza infections were observed in 1976 and 1978. The estimated relative risk for hospitalization because of influenza infection was 1.1 and 1.0 for the two non-epidemic years 1977 and 1979, respectively. For the epidemic years 1976 and 1978 this risk was calculated to be 5.7 and 6.2, respectively. An increased relative risk was also noted for pneumonia; being 25.6 for both epidemic years. The estimated relative risk of dying during hospitalization rose from 30.9 in 1977 to 91.8 in 1978. The number of hospitalizations for ketoacidosis was 50% higher in 1978 than in the other three years. During the epidemic years, 25.7% of patients hospitalized for pneumonia died, while this percentage was 14.6% in the non-epidemic years (P less than 0.05). Differences in mortality due to diabetic acidosis were similar: 25.4% in epidemic and 14.7% in non-epidemic years (P less than 0.01). During the 1978 epidemic, one out of every 1300 patients with diabetes mellitus was hospitalized because of pneumonia. It is estimated that 1 of every 260 patients with IDDM was hospitalized for diabetic acidosis. It is concluded that patients with diabetes mellitus have indeed a very high influenza-associated morbidity.
Diabetes Res Clin Pract 1991 Apr
PMID:Effect of epidemic influenza on ketoacidosis, pneumonia and death in diabetes mellitus: a hospital register survey of 1976-1979 in The Netherlands. 190 98

Conditions other than underlying cause of death listed on death certificates may provide useful information for epidemiologic research. We explored this possibility for any mention of diabetes, renal diseases, and pneumonia-influenza-bronchitis on death certificates from the Chicago Western Electric Study. When we used any mention, sufficient numbers of deaths for analyses of risk factor associations with diabetes (N = 47), renal diseases (N = 25), and pneumonia-influenza-bronchitis (N = 59) were available; analyses for these risk factors were not possible using underlying cause of death alone (N = 3, 6, and 16, respectively). Using Cox regression, we observed positive associations of age, systolic blood pressure, serum cholesterol, body mass index, and cigarettes smoked per day with any mention of diabetes or renal disease. Age, systolic blood pressure, and cigarettes smoked per day were positively related to any mention of pneumonia-influenza-bronchitis; serum cholesterol and body mass index were inversely related to this endpoint. Whether we identified cardiovascular disease deaths using underlying cause, other mention, or any mention, the relations of established major risk factors with 25-year mortality were similar.
 ...
PMID:Conditions other than underlying cause of death listed on death certificates provide additional useful information for epidemiologic research. 191 42

Blacks, Hispanics, and whites were interviewed in a door-to-door survey assessing personal concern about AIDS relative to other health threats and willingness to attend in-home AIDS education programs. The survey consisted of three parts: (1) an open-ended inquiry regarding which health problems individuals wanted to learn more about, (2) ratings of concern about AIDS and nine other common health threats, and (3) assessment of willingness to participate in future neighborhood-based AIDS education programs. Usable data were obtained from 453 respondents. Sixty-seven health threats were mentioned in response to the open-ended inquiry; AIDS was mentioned by 50.7%, followed by cancer (19.9%). AIDS was mentioned more frequently by blacks (63.9%) than by Hispanics (42.5%) or whites (45.7%), X2(3) = 32.07, p less than .002. Participants also reported higher levels of concern about AIDS than any other health problem with the exception of cancer. Concern about AIDS was greater among blacks (M = 2.68) than among Hispanics (M = 2.33) or whites (M = 2.36), F(2,351) = 5.06, p less than .01. Differences as a function of ethnicity, gender, and/or age were observed with respect to concern about heart disease, high blood pressure, diabetes, drug abuse, colds and flu, and herpes. In general, blacks and Hispanics expressed more interest in participating in AIDS education programs than did whites. Concern about AIDS and other health threats was not consistently related to either disease prevalence or severity.
 ...
PMID:AIDS and competing health concerns of blacks, Hispanics, and whites. 201 May 68


1 2 3 4 5 6 7 8 9 10 Next >>