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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Anatomico-radiological study of a macerated skeleton in a 43-year-old diabetic woman. An important spondylosis with hyperostosis of the cervical, thoracic and lumbar vertebrae was seen. There were associated changes of insertional hyperostosis at various levels, particularly at the iliac crests. Paget's disease of the left iliac crest was also noted in the corresponding hyperostosis. This case presentation offers an opportunity to discuss local mechanical factors (observed at the tendinous insertions) as well as generalized considerations on the "terrain" of diabetes and perhaps malnutrition. It also demonstrates the interest that an anatomico-radiological comparison on macerated specimens can have for certain osteoarticular research, teaching and paleopathology.
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PMID:Diffuse enthesopathic hyperostosis--anatomical and radiological study on a macerated skeleton. 15 69

The rheumatologic disorders associated with diabetes mellitus have been reviewed. From the evidence presented, it can be concluded that neuroarthropathy and osteolysis are definitely assoicated with diabetes. Ankylosing hyperostosis and periarthritis probably represent valid associations, and possible, but still unproven associations exist for gout, pseudogout, the carpal tunnel syndrome, osteoarthritis, Dupuytren's contracture and joint contractures. Despite the lack of a proven pathophysiologic basis these interrelationships may be clinically relevant. The discovery of one of these disorders may provide a clue to underlying glucose intolerance, and idabetics should be followed with the knowledge that they are at risk for the development of certain musculoskeletal problems.
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PMID:The rheumatologic manifestations of diabetes mellitus. 30 42

Radiographs of 175 patients with diffuse idiopathic skeletal hyperostosis (DISH) of the spine or ankylosing spondylitis were reviewed. DISH most frequently began in the middle and lower portions of the thoracic spine; it was rare in the upper portion. A few vertebrae were first affected, and then involvement extended, sometimes throughout the thoracic spine. The anterior and lateral aspects of vertebral bodies were mainly affected. Hyperostosis vertically spanning the anterior aspects of the vertebrae varied in thickness up to 10 mm, and the rate at which the hyperostosis proliferated was not specific for any vertebra. Males were 12 times more frequently affected than females, especially in the older age groups. Diabetes mellitus and hypertension have reportedly been associated with DISH, but no such correlation was found in this study. Despite the existence of criteria for differential diagnosis, it is sometimes difficult to distinguish ankylosing spondylitis from DISH radiologically. The radiologic features helpful in the differential diagnosis are described, and a review of the pertinent literature is included.
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PMID:Radiologic aspects of diffuse idiopathic skeletal hyperostosis in the spine. 41 Feb 64

The changes seen in vertebral hyperostosis are due to a slow ossification of the perivertebral connective tissue causing osteophytic spurs and/or bridging of intervertebral ankylosis. The same changes seen in man are also seen in all land and aquatic mammals. This confrontation of comparative pathology emphasizes certain essential points in common. There is a relation between the vertebral hyperostosis and local anatomic and physiologic conditions linked to a ligament insertions. It occurs in bipodisis or tetrapodisis as well as in an aquatic environment. It must be distinguished from an osteoarthritic intervertebral remodeling and the evolution of its bone tissue is dissociated from that of the adjacent vertebral bone tissue. It is frequently observed in relation to general conditions (aging -- diabetes in man -- dietary imbalance in the animal). This example emphasizes the interest that comparative pathology can have for the rheumatologist.
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PMID:[Comparative pathology of vertebral hyperostosis]. 50 48

Morgagni's Syndrome is a polyglandular endocrine syndrome, occurring almost exclusively in the female sex. It is characterized of the classical triad: internal frontal hyperostosis, obesity, virillism, and often accompanied by an old-age type of diabetes. In itself the hyperostosis is of little significance, but sometimes it is a valuable sign of a disorder of the carbohydrate metabolism. In many cases the syndrome is almost symptomless, in other cases senile neuro-psychiatric symptoms and ailments of old age dominate the clinical picture. The internal frontal hyperostosis has no closer relation to other more or less diffuse thickenings of the skull.
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PMID:[Morgagni's syndrome]. 81 85

Anatomical and radiological features of two cases with hyperostosis of the iliac crest are related. They help to illustrate a brief discussion of the general prcal factors as well as general medical conditions (especially diabetes mellitus, for which careful clinical investigations should be performed when hyperostosis is discovered radiologically); 2) histological structure; 3) differentiation from osteophytes of osteoarthrosis.
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PMID:[Hyperostosis of the iliac crest. Anatomo-radiologic features]. 84 62

Heel pain is most commonly the result of mechanical abnormality in foot structure or function. Systemic disease, however, may also affect the heel, resulting in pain, deformity, or both of the rearfoot. This article discusses and reviews notable systemic conditions, exclusive of the seronegative spondyloarthropathies, which may produce subjective or objective heel findings. Specific conditions discussed are rheumatoid arthritis, crystal deposition arthropathies, osteoporosis, diffuse idiopathic skeletal hyperostosis, diabetes mellitus, hypertrophic osteoarthropathy, Paget's disease, hyperlipidemia, sarcoidosis, sickle cell anemia, and acromegaly and their effects on the heel.
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PMID:The heel in systemic disease. 218 35

The prevalence of diffuse idiopathic skeletal hyperostosis (DISH) was studied in a hospital based population of African Blacks over the age of 40 years. The study was based on an analysis of the lateral chest radiographs of 1000 patients in a retrospective study and 500 consecutive medical admissions in a prospective study. The overall prevalence of DISH was 3.9% (males 3.8% and females 4.2%). There was a rise in the prevalence of DISH with increasing age from 1% in the 40-49 year age group to 13.6% in those over 70 years. The prevalence of diabetes was 52.4% in the 21 patients with DISH who were seen in the prospective analysis. Ankylosing spondylitis, which is associated with HLA-B27, is rare in African Blacks. However, DISH is not uncommon but its prevalence is lower than in a similar hospital based study of Jews in Israel.
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PMID:The prevalence of diffuse idiopathic skeletal hyperostosis in African blacks. 232 69

Thirty-four patients of diffuse idiopathic skeletal hyperostosis (DISH) were presented. Twenty-four of them were associated with myelopathy or radiculopathy, mainly due to spinal stenosis. Plain X-ray films showed there was spinal flowing or laminated ossification on the anterior or right lateral side, forming continuous bony bridge at least of four vertebral bodies. Ossification occurred both on the spinal and extra-spinal region. Operative findings of 11 cases revealed significant encroachment of the ossified mass on the dural sac, especially at the level of the apophyseal joint. OPLL was found in ten cases. DISH and OPLL may be different manifestations of same entity. In this series, there was not enough evidence of diabetes mellitus related to DISH, and no specific antigen in HLA typing.
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PMID:[Myelopathy and radiculopathy in diffuse idiopathic skeletal hyperostosis]. 251 51

Although diffuse idiopathic skeletal hyperostosis generally affects the lumbar spine, any segment of the spine may be involved. When the cervical spine is affected, dysphagia may occur. Diabetes mellitus is commonly present. A history of previous cervical trauma is an indication to obtain cervical spine radiographs. Barium swallow and endoscopy provide confirmation of etiology. Surgery is curative.
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PMID:Dysphagia due to diffuse idiopathic skeletal hyperostosis. 265 Apr 99


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