Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The results of the study of 37 patients with gastric polyps are analysed. The different methods show as most frequent findings; solitary polyps, 73%; sessile, 60%; of antral localization, 70%; smaller than 2 cm., 78%; with chronic gastritis histology, 50%; and with hypochlorhydria, 77% (achlorhydria, 62%). The incidence of malignancy was of 10%. The fost frequent concomitant pathologies were cholecystopathy (33%) and diabetes mellitus (30%). Abdominal pain, anaemia and digestive tube bleeding were the most frequent findings, with an incidence of 40%. An attempt is made to establish diagnostic and therapeutics standards and follow up criteria are presented.
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PMID:[Gastric polyps: review and analysis of 37 cases]. 74 5

Surface electrogastrograms were recorded in 95 patients. There were 6 groups of patients: chronic superficial gastritis (20), chronic atrophic gastritis (20), duodenal ulcer (20), gastric ulcer (17), gastric cancer (8), and diabetes mellitus (10). Electrogastrographic examination was continuously carried out for 60 minutes both in fasting and postprandial state. (1) During the fasting state, in 72% of the cases, there was a 50% to 100% change in the mean of the amplitude among six 10-minute periods of recording. (2) In 23 cases (25%), there was no amplitude increase in the postprandial electrogastrogram. Feeding caused an increase in amplitude by 30-240 microV over the prefeeding state in 70 cases (75%). (3) The distribution of amplitude in various groups of disease overlapped each other. The difference in amplitude or frequency would not be used as a diagnostic parameter of gastric diseases. (4) Tachygastria of 5-7.3 cycles per minute was observed in 15 of the 95 patients. The longest episode was a wave with 7.3 cycles per minute lasting for 20 minutes. It is difficult to evaluate the clinical significance of the observed tachygastria.
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PMID:[Electrogastrography: the clinical significance of changes during fasting and postprandial state]. 191 65

The presence of Campylobacter pylori was investigated in gastric antral biopsy specimens. In 50 consecutive patients undergoing upper gastrointestinal tract endoscopy microbiological cultures, histological examination and rapid urease test were parallel performed, and a 92 per cent sensitivity and 100 per cent specificity of rapid and cheap urease test were determined. Afterwards--in a prospective study--311 patients were examined for C. p. by the rapid urease test only. C. p. was detected in 92 per cent of duodenal ulcer patients, in 52 per cent of patients with gastric ulcer, in 67 per cent of non-ulcer dyspepsia, in 62 per cent of mixed diabetic patient material, and in 21 per cent only of asymptomatic volunteers. It has been found by the authors, that the rate of C. p. infection increased parallel with the continuance of diabetes and did not follow the increasing with age as in the general population. This is the first observation in the world literature concerning the correlation between C. p. and diabetes mellitus. Very close, significant correlation has been found between C. p. infection and chronic active gastritis. C. p. may play an important role in the recurrences of duodenal ulcer and in the pathogenesis of non-ulcer and diabetic dyspepsia. Further studies are planned to the correct evaluation of pathogeneity of Campylobacter pylori.
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PMID:[The significance of Campylobacter pylori infection in gastroenterologic and diabetic practice]. 266 37

One hundred consecutive patients, 74 women and 26 men, aged between 18 and 83 years (mean = 54.8 years), referred with complaints related to oral galvanism were investigated and treated and the treatment results were evaluated after 2-3 years. Forty of the patients reported facial pain, pain from the teeth, temporomandibular joints (TMJ) and masticatory muscles and TMJ clicking and locking and 26 reported headache. Smarting in the oral mucosa, smarting of the tongue and xerostomia were reported by 26, 21 and 24 patients, respectively, and 30 patients reported an unpleasant taste, a metallic taste or a battery taste. The same patient often reported several symptoms. The patients also reported various general symptoms, above all joint symptoms, pain in the back, neck and shoulders and general muscular pain but also tiredness, weakness, difficulty in concentrating, depression and insomnia. After clinical and radiological examination, salivary tests, determination of the maximum galvanic current at metallic contacts and screening for contact allergy to dental materials, various oral diagnoses could be established. Most of the patients exhibited functional disturbances of the masticatory system, periodontitis, smarting of the oral mucosa, xerostomia, pulpitis and pulpal necrosis and mucosal lesions. The medical illnesses the patients reported themselves to be suffering from or had been treated for included cardiovascular disorders, high and low blood pressure, asthma, rheumatic disorders, diabetes, pernicious anaemia, gastritis and peptic ulcer. Seventy-six patients took drugs regularly. In most cases there were several oral, dental and medical explanations for the symptoms.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Results obtained from patients referred for the investigation of complaints related to oral galvanism. 345 16

In 40 patients with insulin-dependent diabetes mellitus, the number of gastrin cells in the mucous membrane of the antrum of the stomach was measured by immunohistochemistry according to the method of L. Sternberger. The number of the cells depended on the gravity of antral gastritis, namely their number decreased as the lesion was aggravated. The basal level of serum gastrin was determined by radioimmunoassay in 144 patients with insulin-dependent diabetes mellitus. The high basal level of gastrin was recorded in patients with achlorhydria. However, no correlation was established between the gravity of antral gastritis and the basal level of serum gastrin. If the basal gastrin level is too high, the possibility of asymptomatic paresis of the stomach should be taken into account together with the other factors.
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PMID:[Gastrin cells and the basal level of serum gastrin in patients with insulin-dependent diabetes mellitus]. 351 19

A longitudinal study of circulating autoantibodies in the sera of 48 BB rats was performed by indirect immunofluorescence. No pancreatic islet cell, adrenocortical, or thyroid microsomal autoantibodies were found. However, autoantibodies reactive to gastric parietal cells (PCA), smooth muscle, and thyroid colloidal antigens were identified, PCA were not detected in Wistar-Furth or BB x Wistar-Furth F1 hybrid rats. The range of ages at the time of first appearance of PCA was the same as that of onset of insulin-dependent diabetes (IDD) in the BB rats, suggesting that the processes leading to PCA and IDD were occurring at the same time of life in these animals. The presence of PCA was associated with degrees of lymphocytic gastritis and with squamous metaplasia of the gastric mucosa in the oldest BB rats (9 mo of age). Levels of serum iron and vitamin B12 did not differ between PCA-positive and PCA-negative BB rats, nor was achiorhydria found in any rat studied. The identification of PCA (and chronic gastritis) and other autoantibodies in the BB rat suggests that these animals have an underlying autoimmune diathesis. These findings thus provide indirect support for an autoimmune pathogenesis for IDD in the BB rat.
Diabetes 1982 Apr
PMID:Gastric parietal cell and other autoantibodies in the BB rat. 675 47

A 2-year-old boy with familial extramembranous glomerulonephritis was unfortunately treated with corticosteroids (1 to 0.5 mg/kg/day) and Chlorambucil (cumulative dose: 2.5 g) over a period of 7 years. Three years later, after recovery from the renal affection, he developed fatty diarrhoea from exocrine pancreatic deficiency, followed 5 years later by the onset of diabetes with hypochlorhydric gastritis. The diagnosis of non-calcifying chronic pancreatitis was suggested by scintigraphic and ultrasonographic investigations and confirmed by the marked increase in lactoferrin levels and the lactoferrin/lipase ratio (greater 0.1 p. cent) in pancreatic juice. The etiology was more likely to be direct toxicity of corticoids and/or immunosuppressors on the pancreas than an immunologically-mediated disease.
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PMID:[Global pancreatic and gastric deficiency after a familial membranous glomerulonephritis in a child treated by corticoids and chlorambucil for a long time (author's transl)]. 681 Jul 39

After stating and evaluating the different ulcer theories in reference to the morphological, physiological and biochemical premises, the integrating components of vascular factors for the ulcer genesis were generally exposed. Apart from the magical 50th birthday after which the old age ulcer in terms of Spang should develop, the clinical appearance of the ulcer in old age can correspond with the following morphological equivalents: 1. with increasing age the reduction of the turnover rate of gastric mucosa epithelium 2. with increasing age a general reduction of the lymphatic reticulum tissue and consequently of the immunological defense reaction in the stomach 3. atrophic mucosa in old age with/without gastritis 4. increase of intestinal metaplasia with age 5. as a result of 1-4 increased qualitative and quantitative faulty composition of the mucus barrier 6. changes in the intramural stomach arteries a) secondary sclerosing proliferating arteries b) loss of elasticity of the elastic muscle accompanying apparatus of the stomach arteries c) primary sclerosis of the preterminal vascular system by diabetes mellitus as well as hypertension d) due to the vascular sclerosis as well as elastosis with obliteration of the perivascular shifting layer increased danger of bleeding and the impossibility of vessel invagination as a method of spontaneous blood clotting after erosion.
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PMID:[Is there a special ulcer of old age? A contribution on the significance of vascular factors as integrating components in the pathogenesis of stomach ulcer]. 710 31

In two large general populations of Yugoslav men from Tuzia, Bosnia, and Remetinec, Croatia, examined in 1964-1965, it was found that a greater alcohol consumption was accompanied by higher blood pressures, higher pulse rates, and higher concentrations of serum cholesterol and hematocrit. A greater consumption was also associated with an enlarged liver, as well as a higher prevalence rate of chronic bronchitis and thrombophlebitis. All these were statistically significant even after allowing for differences in cigarette smoking and demographic characteristics. Pulse rate, liver size, and varices appear to be specifically associated with a history of episodes of drunkenness. There were significant differences in drinking habits by place of residence, religious background, years of schooling, and kind of work. These were allowed for in evaluating the relationship of drinking to other characteristics. Two anomalous findings were low prevalence rates for diabetes and gastritis among those drinking most frequently.
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PMID:Drinking habits and other characteristics: the Yugoslavia Cardiovascular Disease Study. 711 39

It is reported on a 61-year-old patient in whom since 1959 has been existing a diabetes mellitus in need of insulin. 1973 in the endoscopic control of roentgenological findings of a stomach suspect to tumour by means of the Wolf-Schindler gastroscope the suspicion to a gastric carcinoma was expressed. In May 1975 he was again admitted to hospital on account of a hypoglycemic shock. Roentgenologically large filling defects in the stomach were found, gastroscopically macroscopically no clearly explained whitish yellow masses (Histology: remains of food, chronic superficial gastritis, extended settlement of fungi). Only after several days of food carency and daily gastric lavages gastroscopically normal findings could be made. Together with the roentgenological findings of the stomach the diagnosis gastroparesis diabeticorum was made. Therapeutically an optimum stopping of diabetes is recommended and the application of metoclopramide. A surgical intervention is not advisable.
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PMID:[Diabetic gastroparesis]. 744 11


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