Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The implantation of an artificial lens into the retropupillary space, be it the sulcus ciliaris or the capsular bag, has proved to be a safe procedure in the vast majority of cases. However, posterior chamber lens implantation invariable provokes some intraocular inflammatory reaction, though in general only a clinically insignificant one. Occasionally, serious reactions may occur, such as fibrinous exsudates, "toxic lens syndrome", UGH syndrome, and the "intermittent white-out" syndrome. Lens-induced, IOL-induced, or even microbe-induced uveitis or endophthalmitis have also been seen. The clinical pictures of such complications are described. Prophylaxis and appropriate therapeutic measures are outlined. With regard to postoperative inflammatory reactions whose etiology is unclear, the potential role of the following factors is discussed: lens material, lens manufacturing technology, sterilization, and sulcus fixation vs. capsule fixation. Presently, there is no evidence of any obvious relationship between these factors and major inflammatory responses. However, patients suffering from glaucoma, diabetes, or uveitis seem to be more prone to significant postoperative reactions than others. Generally, in cases of unusual intraocular inflammation following posterior chamber lens implantation, the various clinical pictures described here should be taken into consideration. The possibility of a slowly developing microbe-induced endophthalmitis should not be overlooked.
 ...
PMID:[Intraocular inflammatory reactions following implantation of a retropupillary lens]. 330 12

A 20-year-old woman with a 13-year history of insulin-dependent diabetes mellitus presented with a history of malaise, fever, a non-healing ulcer of the great toe, and an insect bite incurred during recent travel to a foreign country. Milky white infiltrates accompanied by inflammatory cells located within close proximity to neovascular fronds in both vitreous cavities led to the suspicion of bilateral metastatic endophthalmitis. Studies conducted during hospitalization failed to show evidence of systemic blood born infection. A diagnostic vitrectomy in one eye failed to grow organisms, though lipid laden macrophages were identified by electron microscopy. The clinical appearance improved in both eyes during her hospitalization coincident with improved diabetic control. It was later concluded that the milky white infiltrates were associated with hyperlipidemia as a consequence of poorly controlled diabetes and a familial tendency toward hyperlipidemia.
 ...
PMID:Pseudo-endophthalmitis caused by intravitreal lipid transudation in association with proliferative diabetic retinopathy and hyperlipidemia. 348 55

A 63-year-old male was admitted to our hospital because of high fever and delirium. He had been diagnosed as diabetes mellitus five years before but not treated at all. An abdominal CT scan showed gas-containing abscess in the right lobe of the liver. Klebsiella pneumoniae and Bacteroides distasonis were cultured both from the punctured specimen of the abscess and from arterial blood. Catheter drainage was carried out percutaneously under guidance with ultrasonography and antibiotics was administered intravenously. He was diagnosed as purulent meningitis by lumbar puncture on admission and as endophthalmitis because of swelling of the left eyeball on hospital day 4. CT scan also showed multiple metastatic lesions in the cerebrum and in the lung. After three months, he was discharged from the hospital in good condition, except for loss of vision of the left eye.
 ...
PMID:[A case of gas-containing liver abscess with multiple metastatic lesions]. 759 94

I present the only comprehensive review of hepatic abscess from Klebsiella pneumoniae. The world literature contains 46 individually reported cases and 3 large studies of K pneumoniae liver abscess. The source of the abscesses frequently was not found. Diabetes mellitus was a frequent underlying condition and may predispose patients to the development of liver abscess with this organism. The exact mechanism is unclear, and further investigation is necessary. In addition, extrahepatic metastases, such as septic endophthalmitis, often occurred with serious complications, particularly in patients with diabetes. The association between K pneumoniae liver abscess and diabetes is so close that a search for underlying diabetes mellitus is warranted in all patients with K pneumoniae liver abscess. Fortunately, earlier diagnoses and better treatment modalities have improved the outcome for these patients.
 ...
PMID:Review of hepatic abscess from Klebsiella pneumoniae. An association with diabetes mellitus and septic endophthalmitis. 772 4

Patients with diabetes mellitus exhibit particular susceptibility to three severe infections of the head and neck: rhinocerebral mucormycosis, postoperative endophthalmitis, and malignant otitis externa. Rhinocerebral mucormycosis is an extensive life-threatening infection beginning in the nasal passages and sinuses and extending often into the orbit and the cerebrum. Endophthalmitis, which is infection of the vitreal contents, can occur secondary to bacteremia, trauma, or postoperatively. Invasive external otitis or malignant otitis externa is an invasive infection beginning in the adjacent soft tissue and into bone. It is usually secondary to Pseudomonas aeruginosa and occurs almost exclusively in diabetics. These will all be discussed in this article.
 ...
PMID:Infections of the head and neck in diabetes mellitus. 776 18

Prevalence of intraoperative contamination of the eyelids, conjunctival sac, and aqueous humor of 50 canine eyes that underwent elective cataract surgery was determined, and the short-term outcomes for contaminated and noncontaminated eyes were compared by scoring media clarity, pupil size and shape, and behavioral evidence of vision during the initial 30-day postoperative period. Results of bacteriologic culture of anterior chamber samples were positive for 12 of the 50 (24%) eyes, but anterior chamber contamination was unrelated to results of bacteriologic culture of eyelids or conjunctival sac swab samples. Eyes undergoing phacoemulsification were less likely to be contaminated than were eyes undergoing intra- or extracapsular extraction. Eyes undergoing intra- or extracapsular extraction and eyes with anterior chamber contamination had a greater likelihood of developing glaucoma postoperatively. We did not detect an association between intraocular contamination and the surgeon performing the operation, the need for postoperative administration of tissue plasminogen activator, or the presence or absence of diabetes mellitus. Also, we did not detect any differences in outcome between eyes with and without intraocular contamination. Despite intraoperative bacterial contamination of the anterior chamber, bacterial endophthalmitis did not develop in any of the eyes.
 ...
PMID:Intraocular bacterial contamination during cataract surgery in dogs. 778 43

A case of fungal endophthalmitis caused by Paecilomyces lilacinus after cataract surgery is reported. An 84-year-old woman had been suffering from diabetes mellitus and hypertension. She underwent an uncomplicated extracapsular cataract extraction with implantation of a posterior chamber intraocular lens in the right eye. Approximately one month after the surgery iritis was noted, and treated systemically and topically with corticosteroids and antibiotics. The inflammation was improved by these therapies at first, but worsened when the dose of oral corticosteroid was reduced. White fluffy exudates were present on the iris near the chamber angle with the hypopyon. Removal of the intraocular lens, vitrectomy and medicinal therapy were undertaken. The eye was salvaged but the final visual acuity was counting fingers. Paecilomyces lilacinus was identified from the intraocular specimen taken at the time of surgery. The clinical effects and the results of in-vitro sensitivity test showed that fluconazole and amphotericin B were ineffective, and that econazole, thimerosal and miconazole were effective.
 ...
PMID:[Endophthalmitis caused by Paecilomyces lilacinus after cataract surgery: a case report]. 810 39

Endophthalmitis is a rare complication of Escherichia coli-induced septicemia. Nine cases of endogenous endophthalmitis caused by E. coli have been reported previously, all except one in patients with diabetes. The most common primary site of infection is the urinary tract. The course of illness is rapidly progressive with a poor visual prognosis. Concurrent systemic morbidity, including body abscesses and endocarditis, is high. We report an additional case of endogenous endophthalmitis from E. coli in a diabetic woman. Enucleation was required despite aggressive topical and systemic treatment. The pertinent literature is reviewed.
 ...
PMID:Endogenous endophthalmitis caused by Escherichia coli. 846 Aug 86

A 3-year retrospective study on the risk factors of positive donor rim cultures in penetrating keratoplasty was performed. One thousand and ninety-seven consecutive donor rim cultures were reviewed from the period between June 1990 and October 1993 to determine the rate of culture positivity. The sex, age, diabetes status, use of respirator at time of death, cause of death, harvesting technique, storage time, and corneal storage medium utilized for the donors with positive donor rim culture were compared to those for 100 randomly selected culture negative donor controls. Logistic analysis was performed to eliminate confounding effects. Forty-six of the 1,097 (4.19%) donor rim cultures were positive. We found an association between the in situ technique for donor harvesting and culture negativity (p = 0.03). None of the other donor characteristics was associated with culture positivity. None of the 46 recipients who received the positive culture corneas developed endophthalmitis. In situ cornea harvesting promotes less contamination than enucleation and enriched gentamicin and streptomycin storage medium may further decrease donor rim culture positivity.
 ...
PMID:Positive donor rim culture in penetrating keratoplasty. 853 57

From June 1, 1990 to September 1, 1995 we have operated within our department o Ophthalmology 759 eyes at 714 patients using the method of Extra-Capsular Extraction (EEC). From these 759 eyes, 242 (31.88%) were subjects of an artificial lens implant, 239 eyes were subjects of posterior chamber implant and 4 of anterior chamber. The used technique was the classical EEC one. The patients' age was between 8 and 93 years, with the maximal frequencies at the groups of 60-70 years (43.83%) and 70-80 years (35.57%). Considering the type of cataract we have operated 12 (1.58%) traumatic cataracts, 81 (10.67%) pre-senile cataracts and 621 (81.81%) senile ones. The most frequent complications were: capsule breaking and zonular dialysis, 8 cases (1.05%). vitreous out going, 12 cases (1.57%), post-surgical oedema of cornea, 132 cases (17.5%). increase of intraocular pressure, 158 cases (20.81%), irido-ciliary inflammation. 45 cases (5.9%), endophthalmitis, 3 cases (0.39%), oedematous-bubbling keratopathy, 6 cases (0.79%), macular cystoid oedema, 2 cases (0.26%), posterior capsule opacification, 52 cases (6.8%). The results we have obtained are good: 530 patients (69.8%) have a visual acuity of 0.5 or better. The rest of the patients have a lower visual acuity because of intra- or post-surgical complications as well as exfoliation syndrome, diabetes, glaucoma, myopia, pigmentary retinopathy and Fuchs' heterochromia. The artificial lens implant has increased, reaching in 1995 a total of 78.61%.
 ...
PMID:[Extracapsular extraction of the crystalline lens]. 896 53


<< Previous 1 2 3 4 5 6 7 8 9 Next >>