Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors outline in two papers to what extent the interpretability of a radiograph is changed when converted by means of the Densitron. They confined themselves to the interpretation of dental films and panoramic radiographs. For reasons of clinical interest, particular attention was paid in dental films on localized processes (such as dental caries), and in panoramic radiographs on possible bone diseases as a sequel or concomitant affection in case of renal insufficiency, diabetes mellitus and hyperthyreosis.
 ...
PMID:[Studies on the uses of the electronic image evaluating device "Densitron" for the evaluation of dental radiographs. III. Standardisation in densitometry]. 26 3

Nutritional factors in the aetiology of coronary heart disease, maturity-onset diabetes, diverticular disease and dental caries are discussed. Four principles for a prudent diet are suggested, namely: avoid excess intake of energy, increase dietary fibre intake, reduce total fat intake to approximately 30 per cent of energy intake, take a high proportion of fat as the polyunsaturated form.
 ...
PMID:A prudent diet for the nation. 42 45

Of the 25,672 patients who visited this clinic between January 1964 and March 1973, 126 were diabetic. These were examined statistically and the following results were obtained. 1. Together with diabetes the following disorders pertaining to the realm of oral surgery were observed: Alveolar pyorrhea (49 cases), infection of oral tissues other than periodontal tissues (24 cases), simple periodontitis (15 cases), tumors (13 cases), dental caries (9 cases), neuralgia (6 cases) and several disorders. 2. Of these 126 cases, 85 needed tooth extraction, which was actually performed in 67 cases with the following results: (a) Of the 67 cases, 13 developed complications such as dry socket, postoperative infection, sequestrum around the extraction socket, etc. This was a significantly higher incidence than in an equal number of controls. (b) In the cases with complications convalescence was prolonged to an average of 54.2 days. (c) In the cases with complications, the preoperative fasting blood sugar level averaged 194.5 mg/dl, which was much higher than in the cases which did not develop complications (average 142.4 mg/dl).
 ...
PMID:Clinical studies on diabetes mellitus and diseases of the oral region. 106 91

Eighty-five 12-18-yr-old adolescents suffering from insulin-dependent diabetes mellitus (IDDM) and their healthy age- and sex-matched controls were investigated with respect to dental caries, salivary flow rate, pH and buffering capacity of saliva, counts for lactobacilli and mutans streptococci, and salivary glucose content. The diabetics had their disease well controlled according to the HbA1 levels. The results showed no statistically significant difference between diabetics and controls in DMF and DMFS indexes and the number of initial caries lesions. Mean number of initial caries lesions was 3.2 in diabetics, 2.3 in controls. Mean stimulated salivary flow rate was 1.2 ml/min in the patients, 1.4 ml/min in the controls. The pH and buffering capacity values were 7.3 and 4.8 in the patients, 7.4 and 5.1 in the controls, respectively. High counts of mutans streptococci (> 10(6) CFU/ml) and lactobacilli (> 10(5) CFU/ml) were observed more often, but not significantly so, among the patients than in the controls. The mean concentration of glucose in saliva was 10.3 micrograms/ml in the patients, 9.7 1 microgram/ml in the controls. Thus, if the patients' IDDM is well controlled, their salivary and caries data does not differ from that of healthy controls.
 ...
PMID:Caries and saliva in 12-18-year-old diabetics and controls. 146 62

Salivary status and caries incidence were studied in 28 young, Type 1 diabetics from the onset of the disease and during a two-year period. Flow rate, buffer capacity, glucose content, total protein concentration and levels of mutans streptococci and lactobacilli were determined in stimulated whole saliva every third month. Dental caries was recorded at onset and then once a year. Forty-six per cent of the children developed caries during the observation period. Caries incidence was significantly higher (P less than 0.05) during the first year of diabetes, compared with the second. Caries-active children displayed significantly higher HbA1c levels (P less than 0.001), compared with caries-inactive diabetics. The number of salivary lactobacilli dropped significantly (P less than 0.05) during the first six months of the disease, while mutans streptococci levels remained unchanged during the study period. Salivary glucose concentration showed a considerable individual variation, but tended to be lower during the second year. The results suggest a possible relationship between Type 1 diabetes treatment and caries.
 ...
PMID:Two-year longitudinal observations of salivary status and dental caries in children with insulin-dependent diabetes mellitus. 152 88

A survey was done in a sample of 105 patients, 45 females and 60 males, from October 1989 to January 1990, in the Diabetes Clinic of Mekane Hiwet Hospital, Asmara, Ethiopia. The objective was to assess the incidence of dental and periodontal problems among diabetic patients. Dental caries was found in 79%, with no significant relation to age of patient or duration of illness. Gingival recession was found in 70.5%, gingival inflammation in 65.7% and loss of attachment in 73.3%; none of them related to age of the patient or duration of diabetes. However, 63.5% of the gingival recession and 78.3% of the gingival inflammation was moderate to advanced, indicating the seriousness of the problem. Females had a significantly higher loss of teeth. These findings show a high incidence of dental and periodontal problems among diabetic patients (in comparison to other observations in Ethiopian non-diabetics), and is suggestive of the adverse influence of diabetes on dental health. Considering the seriousness of the problem, education on oral hygiene and dental care need to be strengthened for diabetic patients.
 ...
PMID:A study of dental problems in diabetic patients. 160 49

The present study was undertaken to establish the dental disease and treatment levels in 101 young insulin dependent diabetic patients in Northern Ireland. There was a significantly greater proportion of children from the higher social classes in the diabetic group. Their dental caries experience was lower than that reported for the general population and the restorative indices were high. However, those whose diabetes was diagnosed at a late stage had a higher caries experience. There was significantly more gingivitis detected in older diabetic patients, but oral hygiene status did not significantly differ with age. There was a pattern of regular dental attendance in the majority of diabetic subjects.
 ...
PMID:Dental health of young insulin dependent diabetic subjects in Northern Ireland. 179 Apr 78

Human salivary proteins have been studied by electrophoresis in denaturing and non-denaturing polyacrylamide gel electrophoresis (PAGE) as well as by isoelectric focusing (IEF) and two-dimensional procedures, and the clinical applications of this have been reviewed. Whilst non-denaturing PAGE is useful in studying polymorphisms, sodium dodecylsulphate PAGE appears to be otherwise preferable. Immobilized pH gradients containing carrier ampholytes (CAs) give better resolution than CA-based IEF and overcome the problems of cathode drift and loss of basic material. Proline-rich proteins stain poorly with conventional procedures and special techniques are necessary. In clinical studies, findings must be viewed over and above the large number of polymorphisms which occur normally. Studies relating salivary protein and peptide profiles to dental caries susceptibility are encouraging. Specific protein abnormalities have been associated with connective tissue disorders and could form the basis of new non-invasive diagnostic procedures. Protein differences associated with cystic fibrosis and diabetes mellitus, however, merit reinvestigation with the new procedures now available. Detection of HIV antigens in saliva is a new area of research. In the light of new techniques available and new information which has arisen from DNA studies, future prospects for the clinical applications of electrophoresis of saliva look good.
 ...
PMID:Clinical applications of electrophoresis of human salivary proteins. 193 89

It has been reported that the natural defence mechanisms against bacterial infection decreases in diabetic patients. Saliva and salivary gland have an important role to keep healthy condition in oral cavity. Thus, it is possible that saliva from diabetic subject may influence to a development of dental caries. The purpose of this study is to examine the histopathological changes and excretory function of the salivary glands of hamsters with streptozotocin (SZ) induced diabetes. Male hamsters were provided in this experiment at 8 weeks after a single i.p. injection with a dose of SZ (65 mg/kg b. wt.). The flow rate of saliva was determined by stimulation with pilocarpine (8 mg/kg b. wt.). Three major salivary glands and pancreas were obtained from these animals. No difference between diabetic and non-diabetic animals in the flow rate of saliva and wet weight of submandibular and sublingual gland was observed. Pathological finding of salivary gland was not observed in both of the 2 groups of animals but the wet weight of the parotid gland of diabetic hamsters was heavier than that of the non-diabetic hamsters. Moreover, an enlargement of some acinus cells was observed only in the parotid gland of diabetic hamsters.
 ...
PMID:[The histopathological observation of the salivary gland in hamsters with streptozotocin induced diabetes]. 214 24

Carbohydrates are a major component of our food, they are important as body energy stores and they play an important role in cellular structures. In the present paper a classification of food carbohydrates, of dietary fibers and sweeteners is presented and the major physiological effects are discussed. Furthermore, the significance of carbohydrates for the etiology and the treatment of nutrition related diseases which are closely related to the development of arteriosclerosis is outlined. Carbohydrates are beside fat the major determinants of the daily caloric intake. This illustrates their impact on the development of obesity with its predominant role as a risk factor for the development of cardiovascular disease. Furthermore, the role of sugar consumption in the relation to dental caries is stressed. Also the central role of carbohydrate consumption for the treatment of diabetes mellitus is described. Problems of the diabetes diet, the role of the dietary fiber in the treatment of different diseases and the necessity of sweetness in nutrition are discussed in greater detail.
 ...
PMID:[Diet and civilization diseases--carbohydrate aspects]. 217 Dec 32


1 2 3 4 5 6 7 8 9 10 Next >>