Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In potential diabetics, environmental factors, especially overweight, appear to be more significant for the prognosis than genetic factors. The frequency of overt diabetes is higher in females than in males. Mean life expectancy amounts to about 70%, compared with the whole population. Mean survival after manifestation is more than 18 years. Diabetic coma has almost disappeared as cause of death. Today, approximately 75% of diabetics die from vascular complications, mainly from coronary heart disease. The coronaries are affected with same frequency in diabetic males and females. Renovascular complications are the leading cause of death only in young diabetics. Diabetic macro- and microangiopathy is correlated with the duration, not with the severity of diabetes. It should be imperative to physicians to control diabetes very strictly, especially during the first years following manifestation, in order to reduce frequency and/or severity of vascular complications.
 ...
PMID:[Course of disease and prognosis of diabetes mellitus]. 79 63

In order to study the relationship between the fatty acid composition of adipose tissue and coronary heart disease (CHD), 34 consecutive male patients with acute myocardial infarction and 33 hospitalized men free of CHD were compared. Patients with diabetes mellitus, endocrine disorders, liver and kidney diseases, recent changes in body weight and deviations from the "normal", customary diet were exlcuded. A statistically significant difference between the two groups was observed only in stearic acid, its proportion being lower in CHD patients (3.25% vs. 4.13%). Using multivariate discriminant analysis, age discriminated best between the groups, followed by stearic acid. The signs observed were positive for the former and negative for the latter. All other acids, relative body weight, and skinfold measurements did not significantly contribute to the discrimination. Age did not correlate with the proportion of stearic acid. Blood lipids from samples taken within 24 h of admission did not significantly differ between the groups. Three months later they had risen considerably in the infarct patients. The metabolic basis of the relationship between CHD and stearic acid is not clear at present. Additional studies are necessary to substantiate the importance of this acid as an indicator of CHD.
 ...
PMID:Fatty acid composition of adipose tissue in patients with coronary heart disease. 83 46

In 50 patients with coronary heart disease (CHD) and 38 controls, comparative data on age, sex, serum cholesterol level, hypertension, obesity, diabetes, smoking habits, and ear-lobe creases were analyzed statistically. After adjustment for age differences, the factors which chiefly distinguished the two groups were the incidences of smoking, obesity, diabetes, and ear-lobe creases. Of these, the ear-lobe crease seemed to be correlated best with CHD, and may prove to be a useful diagnostic sign.
 ...
PMID:Ear lobe creases and heart disease. 84 60

A retrospective analysis of a cohort of 5210 diabetic patients revealed a mortality rate 1.3 times higher than in the general population of Warsaw. The higher death rate in the cohort under study was mainly due to an excess mortality from coronary heart disease and cerebrovascular disease. The excess mortality was greater in men than in women. Th risk of death from cardiovascular diseases was higher among the patients with early onset diabetes. Mortality from cerebrovascular disease was highest in patients treated with insulin, intermediate in the group treated with oral drugs, and lowest in the group treated only with diet. The mortality ratio from coronary heart disease in men was not related to the method of hypoglycaemic therapy given at the onset or during the course of the diabetes. In women, the highest mortality was in the group treated with insulin, intermediate in the group treated with oral agents, and lowest in the group treated with diet only.
 ...
PMID:Mortality from cardiovascular diseases among diabetics. 91 25

A review of 132 consecutive patients 65 years of age and older who had a myocardial infarction showed that two-thirds of them experienced pain at onset. Pain was the only symptom leading to bedside diagnosis in one-fourth of the patients. Pain at onset combined with sudden or increased dyspnea was present in one-fifth of the patients and pain associated with other symptoms in one-sixth. Dyspnea unaccompanied by pain heralded onset of infarction in one-fifth of the patients, and in almost 7 percent, onset was marked only by other symptoms. Cerebral symptoms dominated onset in one-tenth of the patients. Preexisting coronary heart disease, hypertension, or diabetes was not predictive of painless infarction. To avoid pitfalls and facilitate bedside diagnosis of infarction, physicians should be aware of the different clinical presentations of painless infarction in the aged, which occurred in over one-third of the patients in this cohort. They also should suspect the possibility of myocardial infarction in any patient in whom symptoms are not clear, even when they are mild and unobtrusive. Questioning of the elderly patient, his family, or others around him as early as possible after the onset of an acute attack is likely to elicit a history of pain, which may lead to the correct diagnosis.
 ...
PMID:The initial manifestations of acute myocardinal infarction. 93 23

The results obtained at entry in the subjects included in a pilot study (Institute of Internal Medicine, Bucharest) for the detection and prevention of coronary heart disease and hypertension, are presented. These data are the prevalences of the risk factors of coronary heart disease (high serum cholesterol, hypertension, smoking, overweight, diabetes, nonspecific minor ECG signs, family history), as well as the prevalences of the various forms of coronary heart disease. The study of the frequency distribution of biologic parameters likely to become risk factors showed that in middle aged subjects the upper limit of the normal should be lowered from the 95th percentile to the 76th one.
 ...
PMID:Coronary heart disease and its risk factors in a group of 5,000 middle aged men in urban environment. 94 93

The annual incidence of coronary heart disease (CHD) in a 8000 male professionnal group, aged 42-53, is computed from the model of LELLOUCH and al. described in the first part of this work. It is shown that each of five risk factors (cholesterol, blood pressure, cigarettes consumption, diabetes history and abnormal electrocardiogram) brings its own contribution to the CHD risk, which may be estimated by an exponential function of a linear combination of the levels of the five factors. "Risk tables" useful in current practice are described.
 ...
PMID:[Estimation of risk as a function of risk factors. II.--Application to the multivariate analysis of coronary heart disease in a middle aged male population (author's transl)]. 95 29

Cholesterol, triglyceride, and lipoprotein levels were determined in serum from 40 children with diabetes and from controls. Mean cholesterol levels in the children with diabetes (205 +/- 78 mg/dl) were statisically higher than for controls (155 +/- 27 mg/dl), as were mean triglyceride levels (120 +/- 63 vs 85 +/- 23 mg/dl). Eight of the children with diabetes had hypercholesterolemia, five had hypertriglyceridemia, and nine had combined hypercholesterolemia and hypertriglyceridemia. Low-density lipoprotein levels were statistically higher and high-density lipoprotein levels statistically lower for children with diabetes compared with control children. Increased urine glucose spillage was found to correlate with higher serum triglyceride levels, suggesting that the elevated triglyceride levels may have been related to diabetes control. With the known association between hyperlipidemia and coronary heart disease (CHD) and between diabetes and CHD, the results of the present study indicate that all children with juvenile diabetes mellitus should have a serum lipid analysis annually.
 ...
PMID:Juvenile diabetes mellitus and serum lipids and lipoprotein levels. 97 14

We now possess enough data concerning prognosis so that we can highlight the areas of concentration for the practicing physician. A history of congestive failure, hypertension,or diabetes is of greatest importance. Smoking is in a similar category, but cholesterol elevation is not. Electrocardiographic findings can be used as an immediate discriminator, depending on whether they are normal or abnormal. Further refinements are possible, depending on whether there are ST-segment depressions or elevations, ventricular conduction defects, repetitive ventricular dysrhythmias, left ventricular hypertrophy, or Q waves of prior infarctions. The exercise electrocardiogram provides additional important information and, if markedly abnormal, can detect with reasonable degree of accuracy the presence and degree of ischemic heart disease. The coronary arteriogram, which influences many of the preceding clinical criteria, permits an accurate prediction of five-year mortality and in a preliminary fashion can be integrated with electrocardiographic and ventriculographic abnormalities to derive a significant measure of prognosis. Finally, cardiac function, if assessed according to specific criteria, becomes an extremely important variable in predicting natural history in coronary heart disease.
 ...
PMID:Natural history of coronary heart disease. 97 44

The one year mortality of patients from the Perth Acute Myocardial Infarction Register surviving the acute episode (first 28 days) is presented. Of 1138 patients suffering definite or possible acute myocardial infarction in one year, 705 (62%) survived 28 days. There were 89 deaths (11-5%) in the subsequent 11 months. One year mortality was related to age but not sex, previous symptoms of coronary heart disease, but not hypertension or diabetes, to tachycardia and congestive cardiac failure at first examination, but not arrhythmias in the acute episode. These observations highlight the importance of protecting the myocardium in the acute phase of myocardial infarction.
 ...
PMID:Acute myocardial infarction: one year follow-up of 1138 cases from the Perth Community Coronary Register. 107 74


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>