Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In November 1990, we carried out a survey of chronic complications of diabetes in more than 2000 diabetic patients who were seen on one day in 35 medical institutions including university hospitals, other hospitals and small clinics. More than 60% were aged 55-74 years. About 7% of patients had IDDM. Hypertension was present in 38.5%. Proteinuria was positive in 20% and 1% of patients were on dialysis therapy. 28% had visual disturbance and 2.9% had blindness in one or both eyes. Retinopathy was observed in 38% and proliferative retinopathy in 10%. The prevalences of myocardial infarction, angina pectoris, cerebral infarction and foot ulcer and gangrene were 2.1%, 4.7%, 5.7% and 2%, respectively, including the histories of these complications. Amputation of lower extremities was seen in only 0.6%. Microangiopathies were generally more frequent and more severe in IDDM than NIDDM. The prevalence of microangiopathy was as common as, but macroangiopathy seems less frequent than, the figures given in 'Diabetes in America'.
Diabetes Res Clin Pract 1994 Oct
PMID:Prevalence of chronic complications in Japanese diabetic patients. 785

Non-fatal or small infarction, especially with multiple occurrence, is a feature of cerebrovascular disease complicating diabetes mellitus. The atherosclerosis of the cervical and cerebral arteries, especially in the posterior circulation, in diabetes is more severe than that in non-diabetics. We reviewed the incidence of vascular lesions, and clinical history in 25 male and 26 female diabetic autopsy subjects. In addition, the long-term effects of blood pressure and glucose values were evaluated in 267 stroke patients without cerebral embolism, 99 of whom had diabetes mellitus. Asymptomatic cerebral infarction is not rare in diabetic subjects, and can now be accurately pathologically and clinically evaluated using MRI. The results of our study indicate that high blood pressure and poor blood glucose control are associated with the higher incidence of cerebral infarction in the diabetic patients.
Diabetes Res Clin Pract 1994 Oct
PMID:Diabetes mellitus and cerebral vascular disease. 785 6

An extensive survey of stroke in Taiwan was carried out by members of the Neurological Society, R.O.C. (Taiwan). Of a total 7,355 acute stroke patients who were admitted to 26 teaching hospitals in Taiwan (January 1 through December 31, 1985), there were 3,949 (53.7%) patients of cerebral infarction (CI). There was little seasonal variation in CI occurrence. In 90.5% of CI patients, the age of onset was above 50 years. The male to female ratio was 1.51:1. Hypertension was noted in 2,648 patients (67.1%), diabetes in 1,030 (22.9%), and heart disease in 953 (17.4%). A previous history of one or more strokes was obtained in 24.6% of the CI patients, and transient ischemic attacks (TIAs) in 6.4%. The stroke onset during the ordinary activities was noted in 41.1% of the CI patients, during sleep in 12.8% and at rest in 9.9%. CI occurred most frequently in the morning hours (24.0%). The majority of patients (85.9%) underwent computed tomography which provided valuable information in making distinction between cerebral infarction and cerebral hemorrhage. Angiography was performed in 3.3% of the patients for visualizing the stenosis and/or occlusion of the intracranial and the extracranial vessels. The mortality rate for CI was 8.4%, and 49.4% of fatal cases died within the first week after onset. At the time of discharge, the stroke survivors were rated "recovered" in 10.8% of CI patients, "minimally disabled" in 26.3%, "moderately disabled" in 38.0% and "severely disabled" in 16.9%.
 ...
PMID:[Ischemic stroke in Taiwan]. 792 97

Regional cerebral blood flow (rCBF) was measured using N-isopropyl-123I-iodoamphetamine (123I-IMP) with single photon emission computed tomography (SPECT) in 27 patients with diabetes mellitus with an average age of 64.1 years and with an average fasting plasma glucose of 145 mg dl-1. Their data were compared with those of 12 non-diabetic subjects with an average age of 64.6 years. None had cerebral infarction on computed tomographic (CT) studies. There were no significant differences in the physiological or laboratory data between the diabetic and non-diabetic groups except for their fasting plasma glucose and HbA1c levels. A reference sampling method using continuous arterial blood sampling was employed to quantify the rCBF. The average rCBF in each region of the cerebrum and cerebellum was significantly lower in the diabetic group than in the non-diabetic group (P < 0.01). Although a definite cause was obscure, the rCBF of the diabetic patients was reduced even in the absence of findings indicative of cerebral infarction on a CT study.
 ...
PMID:Regional cerebral blood flow in diabetic patients: evaluation by N-isopropyl-123I-IMP with SPECT. 807 42

A series of 44 cases is presented of patients who received surgical treatment for unruptured aneurysms in the anterior circulation, and which were associated with ischemic cerebrovascular disease (CVD). The age of patients varied from 34 to 76 (mean 62.8) years old. The associated ischemic CVD was transient ischemic attack (TIA) in ten, minor completed stroke in 23, and major completed stroke in 11 cases. Thirty five patients recovered fully. However, there were three deaths due to new cerebral infarction or delayed intracranial hemorrhage within 30 days after surgery (mortality 6.8%). Transient morbidity occurred in four patients (9.1%), and permanent morbidity in two patients (4.5%). In six cases, new ischemic events occurred after the surgery. In contrast, all 40 patients whose unruptured aneurysms were not associated with CVD fully recovered from the surgery they underwent. The authors indicate three risk factors which might lead to complication; diabetes mellitus, aneurysms located in the middle cerebral artery, and those larger than 6mm in diameter. Another three life-threatening factors are; elderly patients (> 65 year-old), male, aneurysms larger than 7mm in diameter. Direct surgery for unruptured aneurysms in ischemic CVD patients should be considered in cases free of risk factors indicated above. Eight cases in this series had extracranial carotid artery stenosis on the same side as the aneurysm. Carotid endoarterectomy (CEA) was performed prior to aneurysmal clipping in six patients, and their postoperative courses were excellent. In two patients, clipping was performed prior to CEA, and transient morbidity occurred in one of them.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Surgical indication for unruptured cerebral aneurysm in patients with ischemic cerebrovascular disease]. 809 Feb 62

The annual incidence of strokes (all types) is estimated to be between two and four per thousand in the 55 to 64 year age-group and reaches about 15 per thousand over the age of 75 years. Population registries and hospital registries show that cerebral infarcts represent about 80% of all strokes and indicate the respective roles of the principal causes. A significant reduction in mortality related stroke in general and cerebral infarction in particular has been observed in many countries over recent decades. Hypertension constitutes the principal risk factor for ischaemic and haemorrhagic stroke. This risk varies by about 40% when the mean diastolic blood pressure varies from 5 to 10 mmHg, even in normotensive subjects. Several studies have demonstrated that treatment of moderate or severe hypertension lowers the incidence of stroke. Smoking, diabetes, chronic alcoholism (> 3 standard glasses per day), hypercholesterolaemia and raised plasma fibrinogen also constitute independent risk factors for cerebral infarction. Of the emboligenic heart diseases, non-valvular atrial fibrillation (80% of all cases of atrial fibrillation) is the most potent risk factor for cerebral infarction: subjects with this disease have a risk of cerebral infarction of approximately 5% per year. The presence of asymptomatic carotid artery stenosis is associated with an annual risk of cerebral infarction generally estimated to be between 1 and 2% which, in reality, increases with the degree of stenosis. Even in the case of tight stenosis, the risk of ipsilateral cerebral infarction remains low (< 3% per year for stenosis > 75%).(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Epidemiology of cerebral infarction]. 817 87

The authors report a rare case of intracranial aspergillosis presenting marked granulomatous pachymeningitis. A 58-year-old male who had a three-year history of diabetes and chronic bronchitis was referred to us because of progressive left hemiparesis and dysarthria. Postcontrast CT scan showed a ring-enhancing lesion with marked perifocal edema in the right parietal lobe, and right subdural enhancing mass. MR image revealed hypertrophic dura mater in the right convexity. On June 9, 1992, partial removal of the intra-axial cystic mass and granulomatous dura mater was performed. A number of characteristic aspergillus hyphae were recognized in the resected cyst and granulomatous dura mater. Postoperatively, the patient was treated with amphotericin-B and fluconazole. But granulomatous pachymeningitis became progressively enlarged and eventually created a large mass effect again. On January 23, 1993, the patient died of pneumonia. Cerebral aspergillosis is getting common but preoperative diagnosis is still difficult because of its causing several clinical features such as brain abscess, granuloma, intracerebral hemorrhage, cerebral infarction, meningitis, and encephalitis. Several comments were made about the pathogenesis of these features, and the necessity of early diagnosis and treatment was emphasized.
 ...
PMID:[A case of aspergillosis presenting marked granulomatous pachymeningitis]. 819 39

A hospital-based case-control study was undertaken at Prasat Neurological Hospital and Institute, Bangkok, in 1990 to determine the association between blood lipid variables (i.e., total cholesterol and triglycerides) and cerebral infarction. To alleviate the unwanted effects of sample selection a number of inclusion and exclusion criteria were also made. A total of 193 newly diagnosed cerebral infarction patients together with an equal number of age-sex-matched controls, male and female 45 to 84 years of age, were studied. The association was assessed by logistic regression analysis. Other potential risk factors for cerebral infarction were entered in the logistic models as covariates to be adjusted. The results showed that, total cholesterol and triglycerides were statistically significant related to cerebral infarction (p < 0.0001) in univariated analysis. After adjusting for the covariates through multivariate logistic regression analyses, total cholesterol remained significantly related to cerebral infarction (p = 0.0430) but triglycerides was not significant (p = 0.3953). Other factors, namely, hypertension, cardiac impairment, diabetes mellitus and hemoglobin concentration were strongly related to cerebral infarction in both the univariate and multivariate analyses. The interaction between blood lipids variables and potential risk factors was also assessed. The finding showed significant multiplicative interaction between triglyceride levels and diabetes mellitus status (p = 0.0026). Other interaction terms did not approach statistical significance.
 ...
PMID:Blood lipids, the risk factor of cerebral infarction. 822 99

Autopsy cases from Annual Report of Autopsy Cases published by the Japan Society of Pathology showed an increase of myocardial infarction from 13.2% in the years 1958-65 to 26.6% in the years 1983-85. However, cerebral infarction and hemorrhage showed no definite increase during the period. Frequency of diabetes mellitus was extremely increased among the cases of myocardial infarction who were admitted to our hospital. Arteriographic characteristics of coronary atherosclerosis in diabetics consist of multiple tight stenoses in one major artery and two or three arterial obstructions. Carotid arterial blood flow and plaque formation and calcification of the arteries were examined by doppler imaging technology and B-mode (5 MHz) real time ultrasound using ultrasonographic equipment in diabetic patients. Both blood flow volume and blood flow velocity in the elderly patients with diabetes mellitus (over 65 years old) were significantly reduced compared with those in the younger patients with diabetes mellitus (7.4 +/- 0.4 vs. 8.5 +/- 0.2 in blood flow volumes. p < 0.01; 12.4 +/- 0.8 in blood flow velocities. p < 0.01). Plaque formation and calcification of carotid arteries were significantly more frequent in the elderly patients with diabetes mellitus than in the younger patients with diabetes mellitus (p < 0.05). Asymptomatic cerebral infarction was studied in 37 diabetic patients by brain magnetic resonance imaging (MRI) in the absence of prior stroke. T2 weighted MRI imaging showed 27 patients among 37 patients (73%) to suffer from lacunar infarction. Hyperintensities were seen in the brain stem (28.6%), white matter (62.9%), basal ganglia (60.0%), and paraventricular areas (PVH) (20.0%).(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Diabetic macroangiopathy in the elderly]. 831 44

The authors experienced two elderly patients of megacolon associated with cerebral infarction and diabetes mellitus. The first patient was a 66-year-old female who was admitted to our hospital for rehabilitation with a complaint of knee pain. She had suffered from diabetes mellitus since she was 30 years old and multiple cerebral infarction since age 62. Two months after admission, she had an episode of abdominal distension and obstructive symptoms. The roentgenograms of her abdomen showed diffuse dilatation of the colon. The second patient was a 78-year-old female admitted to our hospital with complaints of abdominal pain, distension of the abdomen and vomiting. Her abdomen was severely distended and plain roentgenograms of the abdomen, X-ray studies of the colon with the aid of contrast medium and CT scan of the abdomen showed striking dilatation of the colon. Megacolon may be congenital or acquired, and in acquired forms the conditions are secondary to organic diseases, smooth muscle atrophy, metabolic and neurological diseases, ulcerative colitis or psychogenic origin (idiopathic). The two patients in this series were suffered from cerebral infarction and diabetes mellitus. The mechanisms of megacolon seen in these two patients are not known, but involvement of the visceral autonomic innervation is presumed. Some elderly patients have chronic constipation, and dilatation of the colon may not be uncommon due to underlying diseases or drugs. Therefore, when examining elderly patients, careful attention should be paid to their bowel movement.
 ...
PMID:[Two elderly cases of megacolon associated with cerebral infarction and diabetes mellitus]. 836 Oct 82


<< Previous 1 2 3 4 5 6 7 8 9 10