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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

An epidemiologic study designed to elucidate the possible roles of the artificial sweeteners saccharin and cyclamate in human urinary bladder cancer was recently completed. The previous intake of each of these substances among 519 patients with histopathologically confirmed bladder cancer and an equal number of matching controls in metropolitan Baltimore did not differ significantly in frequency, quantity, or duration. These normal findings persisted after simultaneous adjustment for the effects of smoking, occupation, age, diabetes mellitus, and a number of other potentially confounding factors. They are substantiated by the failure of the relative risk of bladder cancer to increase with increasing exposure to artificial sweeteners. It is concluded that neither saccharin nor cyclamate is likely to be carcinogenic in man, at least at the moderate dietary ingestion levels reported by the patient sample.
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PMID:Saccharin, cyclamate, and human bladder cancer. No evidence of an association. 66 Aug 69

The frequency with which diabetes mellitus was mentioned on the death certificates of 18,733 patients dying from bladder cancer has been compared with that of 19,709 patients dying from other cancers (excluding cancer of the lung and pancreas). The estimated relative risk of bladder cancer in diabetics was 0-98 with 95% confidence limits 0-70-1-38. There was no increase in risk of bladder cancer in patients with diabetes of long duration. Diabetics were shown by questionnaire to consume substantially more saccharin than non-diabetics, and the duration of regular saccharin use by diabetics was highly correlated with the duration of diabetes. There was therefore no evidence from this study that consumption of above average amounts of saccharin had led to bladder cancer in diabetics. The proporation of current smokers among diabetics was significantly less than among non-diabetics, and this may account for a low relative risk of lung cancer in the former (0-72).
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PMID:Bladder cancer mortality in diabetics in relation to saccharin consumption and smoking habits. 118 56

Between April, 1988 and August, 1990, the OmniPhase penile prosthesis, a non-inflatable self-contained penile prosthesis, was implanted in 34 patients, aged from 37 years to 79 years, averaging 54.2 years. The etiologies of the impotence were radical surgery for bladder cancer or rectal cancer in 17 patients, diabetes mellitus in 7 patients, vascular abnormality in 3 patients, spinal injury in 2 patients, penile disorders in 2 patients and others in 3 patients. Penile prosthesis was implanted by subcoronal incision under spinal or general anesthesia. Clinical results were evaluated 12 weeks after surgery. Thirty-two patients (94.1%) could have intercourse postoperatively. Eighteen patients (52.9%) were completely satisfied and 14 patients (41.2%) were satisfied, whereas one patient (2.9%) had no improvement and another patient (2.9%) deteriorated. There was no serious complication. However, prosthesis was explanted because of skin erosion in one patient. Pain, which lasted for more than 10 days, was seen in 3 patients (8.8%), penile edema in 11 patients (32.4%), and acute epididymitis in one patient. The obtained results showed that implantation of OmniPhase penile prosthesis is a safe and useful procedure for treatment of organic impotence.
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PMID:[Implantation of self-contained non-inflatable penile prosthesis in patients with organic impotence]. 150 23

The authors present an analysis of the results of therapy of 236 breast cancer patients, 212 patients with cancer of the uterine body, 269 patients with bladder cancer and 386 lung cancer patients. The frequency of diabetes mellitus is compared among cancer patients of different age groups. Cancer patients with diabetes mellitus were, on an average, more advanced in age than patients without it. A possible metabolic effect of glucose and acidification of tumors on the patients' cure is discussed.
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PMID:[Does diabetes affect the probability of cure and prolongation of life of oncological patients?]. 301 56

A case-control study of diet and bladder cancer was conducted during 1979-1982 in Edmonton, Calgary, Toronto, and Kingston, Canada. A total of 826 histologically verified cancer cases were individually matched by age, sex, and area of residence to 792 randomly selected population controls. Subjects were interviewed concerning their histories of exposure to a number of dietary factors, including table-top artificial sweeteners, low calorie foods and drinks, beverages containing caffeine or ethanol, and certain other food items. Also, subjects provided information on their past medical, occupational, and residential histories, in addition to their exposures to tobacco and other life-style factors. For the analysis, conditional logistic regression methods were used. Under adjustment for cumulative lifetime amount of cigarette smoking, the dietary factors, with little exception, were not associated with significant alteration of risk for bladder cancer. In particular, ever regular use of artificial sweeteners did not appear to be associated with increased risk, either among men (odds ratio = 0.95, p = 0.70) or among women (odds ratio = 1.15, p = 0.53). However, daily intake of cholesterol, calculated from reported frequencies of consumption of nine relevant food items, suggested a mild increase in risk; the odds ratio estimate of trend was 1.07/100 mg average daily intake (i.e., 1.07(5.5) = 1.45 for 550 mg cholesterol per day, as might be consumed in one egg; p = 0.009). A history of diabetes mellitus of onset after age 20 years also seemed to be associated with increased risk of bladder cancer (odds ratio = 1.65, p = 0.019), but this increase did not appear to be the result of use of insulin or other medications, or use of artificial sweeteners or low calorie foods. Thus, this study tends to confirm reports of a lack of association between use of artificial sweeteners and subsequent risk of bladder cancer.
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PMID:Dietary factors and the incidence of cancer of the urinary bladder. 336 17

In this retrospective study on 226 patients with bladder cancer before radiotherapy following diagnostic or conservative surgery, bacterial infection of the urine was evaluated. The incidence of urine infection was 65.5%. 12.3% of the patients had sterile urine and in 22.1% of patients the investigation for urine infection was not performed. 77% of infections were caused by Gram-negative bacilli. No dependence of infection incidence on the tumor-T-stage, incidence of diabetes mellitus, prostatic gland size and tumor location near the internal ostium of the urethra was found. Thus, the cancer itself, transurethral diagnostic and/or transurethral or abdominal operation and the hospital stay appear to be of primary importance for the development of infection. To prevent serious late postradiation reactions it is important to manage infection before the start of radiotherapy. Some features of infection therapy in bladder cancer patients are discussed.
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PMID:Bacterial infection of urine in patients with bladder cancer. 337 12

A population-based, incident case-control study was conducted in Utah to assess the relationship between fluid intake and bladder cancer. Cancer cases (n = 419) were identified through the Utah Cancer Registry, and controls (n = 889) were obtained through random digit dialing and the Health Care Financing Administration. After adjustment for cigarette smoking, age, sex, history of diabetes, and history of bladder infections using multiple logistic regression analysis, total fluid intake was not found to be related to bladder cancer development. Specific fluids related to bladder cancer risk were milk intake (OR = 0.64) and caffeinated coffee intake (OR = 1.60). A linear trend for a dose-response protective effect was observed for milk, while coffee increased risk only when 40 or more cups were consumed per week. Alcohol increased risk only when consumed at high levels (over 3.64 ounces or 103 g per week) by people who never smoked cigarettes (OR = 2.37). Likewise, tea consumption in non-cigarette smokers increased bladder cancer risk (OR = 2.25). Results from this study suggest that types of fluids consumed may play a role in the development of bladder cancer. Furthermore, it is hypothesized that the dietary components of these beverages may be related to the development of bladder cancer.
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PMID:Fluid intake and bladder cancer in Utah. 339 5

A 41-year-old woman was diagnosed as having Werner's syndrome associated with bladder cancer. The patient noticed sudden, total gross hematuria in September, 1985. Cystoscopy revealed a papillary tumor with a stalk that was accompanied by a daughter tumor and concealed the left ureteral orifice. The tumors were 25 X 20 X 10 mm and 15 X 10 X 5 mm. Double contrast cystograms, computed tomography and transurethral echo showed no invasion of muscle layer. Intravesical instillation of mitomycin (10 mg), cylocide (300 mg) and adriacin (30 mg) was carried out 3 times per week for 4 weeks. Tumor size was reduced, and then TUR was performed. High power section of the removed bladder tumor showed pathologically PNT, TCC, grade II, INF alpha, pTla, lyo and v(-). The patient had such clinical manifestations as short stature with low body weight, thin limbs and stocky trunk, senile face, early graying hair, highpitched voice, bilateral cataracts, osteoporosis, sclerodermia-like signs, flat feet, tendency toward diabetes mellitus and parental consanguinity. Hyaluronic acid was not detected in the urine. To the best of our knowledge, this seems to be the 30th report describing the association of malignancy with Werner's syndrome in Japan; besides, only one other case of bladder cancer in Werner's syndrome has been reported to date in the world.
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PMID:[A case of Werner's syndrome associated with bladder cancer]. 359 91

Health economics research has shown pharmaceutical therapy to be a highly cost-effective modality of care in a variety of disease states. Specific examples include vaccines and products aimed at the treatment of infectious disease, mental illness, gastrointestinal disorders, diabetes, and cancer. A review of the characteristics of mitomycin (Mutamycin) for injection therapy and of patients with superficial bladder cancer facilitates examining mitomycin from the standpoint of cost effectiveness. Third-party payment programs, including Medicare and Medicaid, often provide coverage for intravesical chemotherapy for superficial bladder cancer. Methods for obtaining reimbursement for therapy associated with the management and treatment of superficial bladder cancer are suggested. Finally, the total cost of intravesical therapy is examined. Issues such as the cost of surgery and chemotherapy are discussed, as well as the importance of weighing intangible factors, such as lost work time, productivity, and social costs, into the sum of total cost of care.
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PMID:Economic aspects of treatment of superficial bladder cancer. 393 29

Potential risk factors for bladder cancer were studied in a series of 76 male and 76 female bladder cancer cases and 238 male and 254 female controls who reported never having smoked. Risk factors included usual occupation, smoking by the spouse, sidestream smoke exposure at home and at work and in transportation, coffee drinking (caffeinated and decaffeinated), artificial sweetener use, body mass index, and a history of diabetes and high blood pressure. No association was found with spouse's smoking or reported sidestream smoke exposure, coffee drinking, artificial sweetener use, or a number of other variables; however, there was some indication that several occupations were overrepresented in the cases. A positive association was found with snuff use in women, but the numbers were small (three cases and one control). Restriction of the study to lifetime nonsmokers permitted the assessment of potential risk factors in the absence of potential confounding and interactive effects of smoking. The study had adequate statistical power to detect moderately small elevated risks due to the main factors examined.
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PMID:Bladder cancer in nonsmokers. 394 69


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