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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A 46 year old woman who used oral contraceptives (OCs) for 10 years developed severe arteriosclerosis of the base of the brain and renally fixed hypertension. She subsequently died of cerebral hemorrhage. The relationship between o.c. use and hypertension is discussed. A thorough family and personal anamnesis must be taken for women who want to use o.c.s; hypertension, kidney ailments, obesity, or diabetes mellitus require particular attention. Blood pressure should be checked for the first 3 months of o.c. use and every 6 months thereafter. Weight gain during o.c. use may serve as a warning symptom. Hypertension or several other difficulties require discontinuation of o.c. use to determine whether they may be caused by o.c.s.
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PMID:[The problem of hypertension and ovulation inhibitors]. 47 16

Human clinical biomicroscopy is an aid to the assessment of the microcirculation in health and disease. It has only limited diagnostic value but in some important conditions gives helpful clues and in a few conditions pathognomonic information. Features which can be evaluated include intravascular red cell aggregation, small blood vessel patterns, diameter of vessels, stasis pools, microaneurysms, petechiae and vasomotion. Red cell aggregation correlates well with sedimentation rate. Some of these factors, or combinations of them, correlate well with arteriosclerosis, diabetes, and hypertension. The apparatus required is relatively simple, and the method is noninvasive.
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PMID:An evaluation of biomicroscopy of the conjunctival vessels. 49 55

The phenomenon called paradoxical undressing has been described from 33 cases of hypothermia collected from Swedish police reports. The cases were almost evenly distributed with regard to sex, age, and geographical distribution. The cases occurred more frequently in open land although cases from town areas were also found. Most incidents were recorded from November to February at low ambient temperatures, although cases were also reported at temperatures above 0 degree C. Arteriosclerosis and chronic alcoholism were important concomitant illnesses, the latter being frequent in middle-aged men. Epilepsy, diabetes, and pregnancy were present in single cases. Ethanol and other drugs were present in 67% of the males and in 78% of the females, ethanol predominating in men and various psychotropic agents in women. The mean blood ethanol concentration in males was 0.16% and in females, 0.18%. Most frequent findings at necropsy were purple spots or discoloration on the extremities, pulmonary edema, and gastric hemorrhages. It is concluded that paradoxical undressing might be explained by changes in peripheral vasoconstriction in the deeply hypothermic person. It represents the last effort of the victim and is followed almost immediately by unconsciousness and death.
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PMID:"Paradoxical undressing" in fatal hypothermia. 54 27

The prevalence of diabetes was investigated in 473 patients who had been fitted with pacemakers because of severe bradycardiac arrhythmia. Irrespective of the type of arrhythmia, 36.1% of the male and 45.5% of the female patients exhibited overt diabetes. The metabolic disorder was known in about half (55%) of the cases; average duration of known diabetes in these patients was 7.1 years (0.5-23 years). The more frequent occurence of diabetes in women was attributed to the frequency of overweight (twice as high) in this group. Only one fifth of the male and one tenth of the female patients had myocardial infarction as a sign of manifest coronary arteriosclerosis. The 6 to 10 times higher diabetes prevalence of pacemaker patients compared to the general population of corresponding age may indicate ischemic damage to the conduction system caused by diabetes-specific vascular changes.
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PMID:Diabetes prevalence in patients with bradycardiac arrhythmias. 61 87

The 10-year course of diabetes in 250 patients detected by glucosuria screening in 1963 was evaluated in an inter-individual pair comparison with patients from the same territory admitted during the same calendar year. Pairs were grouped according to age, sex, and weight. Judged by mortality, survival time, causes of death, and vascular complications, the medium-term prognosis was not improved by screening, although in the screening group a strict diet could be maintained to a greater extent. Problems of evaluation and effectiveness of mass examination in chronic diseases are discussed. Glucosuria and hyperglycemia do not suffice as screening criteria for the early recognition of the complex risk of arteriosclerosis in maturity onset diabetes. Multi-screening in groups with especially high diabetes risk is expected to yield higher effectiveness than the mass screening hitherto performed.
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PMID:[Prognosis of diabetes mellitus after an early diagnosis by means of glucosuria screening. Results of a 10 year course control]. 62 39

One hundred and eighty-three conservative amputations of some part of the foot in 161 patients with gangrene from diabetes or arteriosclerosis have been studied retrospectively. They constituted 48 per cent of all amputations in one orthopaedic service over a period of twelve years, during which the minimal feasible procedure was always chosen. Sixty per cent healed soundly, but in over a third of these cases at least one revision to a higher level on the foot had been required. Factors that significantly influenced the outcome of the initial operation were the level of amputation, the age of the patient, the interval between the onset of gangrene and operation, anaemia and pyrexia.
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PMID:Partial amputation of the foot for diabetic or arteriosclerotic gangrene. Results and factors of prognostic value. 62 72

Fibrinolytic therapy was started 90 min after central retinal occlusion in a 62-year-old male patient, but the retinal function did not recover. Another patient, aged 64 years, with occlusion of a retinal artery branch, had therapy started only 6 hours after the event and showed full recovery as was documented by angiography. General contraindications against fibrinolytic therapy are: hypertension over 200 mm Hg, arteriosclerosis, diabetes with retinal changes, previous cerebral insults, malignancy or ulcer, hepatocirrhosis, recent surgical or angiographic interventions, renal insufficiency, pregnancy, cogenital or acquired abnormal blood coagulation. If these contraindications do not apply, fibrinolytic therapy of central retinal arterial obstruction is recommended provided this therapy can be started not later than 6 hours after the event. Occlusions of the central retinal vein should have fibrinolytic therapy only if there are very few haemorrhages and if the occlusion is not older than 24 hours.
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PMID:[Indications and limitations of fibrinolytic therapy for central artery occlusion (author's transl)]. 62 82

Thirty-one growth-hormone-deficient dwarfs were re-examined after a period of 10 to 12 years. These subjects had initially shown glucose intolerance, insulinopenia and hyperlipidemia comparable to those of diabetic patients matched for age and sex, but vascular complications were not present in dwarfs. After 10 years glucose tolerance became progessively more abnormal in dwarfs than could be accounted for by expected deterioration with age, and hyperglycemia after mixed meals remained greater than in control subjects. Serum lipid and serum lipoprotein concentrations were abnormal in over one third of the dwarfs. Despite the metabolic similarity to the diabetic patients, clinical complications of diabetes were absent in dwarfs: retinopathy did not occur, and the prevalence of hypertension and arteriosclerosis was considerably lower in dwarfs than in the diabetic subjects in both study periods. The follow-up data support the hypothesis that growth hormone has at least a supportive role in the pathogenesis of vascular disease in the diabetic state.
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PMID:A follow-up study of vascular disease in growth-hormone-deficient dwarfs with diabetes. 65 62

A thorough search for the natural history of arteriosclerosis involving the cerebrum, aorta, and peripheral vessels has been made. The disease's rate of progress has been studied anatomically, clinically, radiologically, and plethysmographically. We conclude that arteriosclerosis is usually associated with other diseases such as diabetes, high blood cholesterol, and hypertension. Heart disease in particular is often the cause of the patient's death, rather than the peripheral arteriosclerotic disease itself. The usually slow development and course of arteriosclerosis indicate that its treatment is largely a medical problem. It seems important to control the various risk factors and to utilize surgical therapy to attack specific lesions which threaten the tissues. A thorough cardiovascular profile of the patient should be compiled and should include a glucose tolerance test and lipoprotein phenotyping.
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PMID:The natural course of arteriosclerosis in animals and man. 65 60

We studied serum zinc, copper, ceruloplasmin, insulin, basal glycemia and cholesterol in 49 diabetics on oral anti-diabetic agent and in 10 normal people. We found there is an elevation of serum zinc, copper and ceruloplasmin in the diabetic group that is statistically significant (p less than 0.001). There is a significant correlation between zinc and insulin (p less than 0.001), and between the quotient zinc/copper and cholesterol (p less than 0.001). The increase of plasma zinc can reflect a deficient storage or a chronic hypersecretion of insulin in hyperglucemic patients. We think that the quotient zinc/copper/might play a role in the pathogenesis of the arteriosclerosis in diabetes.
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PMID:Serum, zinc, copper and insulin in diabetes mellitus. 66 89


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