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To define a strategy for coronary circulation assessment is a difficult task as most of the studies have been carried out in vascular surgery, as some of them are controversial, and as no test has a 100% sensitivity and specificity. However patients with high perioperative risk of cardiac events have to be identified, in order to intensify medical treatment or to consider myocardial revascularisation. A first evaluation is based on history, physical examination and simple tests, such as rest electrocardiogram and thorax X-Ray. Additional tests are not required when surgery does not elicit a major activity of the cardiocirculatory system. Postoperative cardiac risk is low when none of the nine risk factors defined by Goldman and/or coronary insufficiency (residual angina elicited by minor physical activity, unstable angina, myocardial infarction) are present. The problem remains in patients with Goldman risk factors and/or at risk of coronary artery disease because of diabetes mellitus, heavy smoking, hypercholesterolaemia, arterial hypertension, undergoing major abdominal, thoracic or vascular surgery. Preoperative electrocardiographic Holter monitoring is still of value, especially in patients with known or supposed ischaemic heart disease and unable to make a physical effort. A poor exercise capacity and changes in electrocardiographic stress testing are factors of poor prognosis. The dobutamine stress echocardiography has a good sensitivity and specificity when an effort test cannot be performed. The value of dipyridamole-thallium 201 scintigraphy could be improved by a quantitative analysis of the number of affected segments and territories. Patients with angina or ischaemic episodes on continuous electrocardiogram, or with dobutamine echocardiography kinetic disturbances and with stress myocardic scintigraphy or stress exercise testing abnormalities could undergo a coronarography, in order to consider myocardic revascularization prior to surgery.
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PMID:[Preoperative evaluation of coronary circulation]. 875 83

The introduction of coronary stents for the treatment of acute vessel closure has probably improved the safety of angioplasty, but little data are available regarding angioplasty complication rates when bailout stenting is available. Therefore baseline and patient outcome data for 2242 consecutive patients treated at a single tertiary referral center were compared before and after bailout coronary stenting was introduced. Patients treated after stents became available were more likely to have diabetes (16% prestent availability vs 19% poststent, p < 0.05), unstable angina (61% prestent vs 70% poststent, p < 0.01), and to have received intravenous nitroglycerin before the procedure (22% prestent vs 28% poststent, p < 0.01). Major complications occurred in 4.1% of patients before stent availability and 2.0% afterwards (p < 0.01). These complications included in-hospital death (1.1% prestent vs 0.7% poststent, p = not significant [NS]), Q wave myocardial infarction (0.5% prestent vs 0.3% poststent, p = NS), and emergency bypass surgery (2.9% prestent vs 1.1% poststent, p < 0.01). The introduction of coronary stents was associated with a > 50% reduction in major complications despite greater patient acuity. The traditionally reported complication rates for angioplasty appear not to apply when ballout stenting is available.
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PMID:Reduction in angioplasty complications after the introduction of coronary stents: results from a consecutive series of 2242 patients. 880 18

A comprehensive case-control study was conducted in an Italian region in order to compare the influence of family history of cardiovascular events, socioeconomic factors, social networks, and their joint associations with major risk factors, on the risk, of myocardial infarction (MI), unstable angina (UA) and ischemic stroke (IS). A total of 513 patients with MI, 178 with UA, 237 with IS, and 928 hospitalised controls were recruited. The odds ratio (OR) of MI for two or more relatives with a positive history of MI was 3.6 (95% CI: 1.8-7.3). Family history of MI was predictive for UA (OR = 5.8; 95% CI: 1.2-28.7), but not for IS. A family history of stroke was more associated with the risk of MI than of IS. After adjustment for known risk factors, the OR of MI for more educated people was 2.1 (1.3-3.6) compared with less-educated people. Large family size seemed to be protective for MI. The effect of major risk factors on MI ranged from additive (diabetes) to multiplicative jointly with high education and family history of MI. A family history of stroke increased IS risk threefold jointly with smoking and hyperlipidemia, and eightfold with diabetes. Besides a family history of MI and IS, in this community a higher educational status seems to better identify groups at increased risk of MI. The joint associations have important preventive implications since by identifying high-risk individuals (for MI and IS) a more careful assessment and control of risk factors amenable to intervention may be performed.
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PMID:Family history and socioeconomic factors as predictors of myocardial infarction, unstable angina and stroke in an Italian population. PROGETTO 3A Investigators. 881 97

Arterial hypertension is though to be associated with reduced coronary vasodilator reserve in the coronary microcirculation. Increased ventricular mass and coronary arteriolar abnormalities are the dominant features in patients with severe hypertension, while large-vessel coronary disease is the predominant feature in patients with mild hypertension. In the present study we have evaluated how hypertension influences the outcome of coronary artery bypass grafting (CABG), with emphasis on patients with preoperative left-ventricular ejection fraction (LVEF) < or = 25%. Between January 1, 1990 and November 1, 1994, 77 consecutive patients with LVEF < or = 25% (Hypertensive, n = 38 [group I] and normotensive, n = 39 [group II] underwent CABG. During the same time period 2289 patients with LVEF > 25% underwent CABG (Hypertensive, n = 870 [group III] and normotensive, n = 1419 [group IV]) and were studied for comparison. Mean age (64 years), sex distribution (86% men), and other classical risk factors did not differ between the groups, except a higher incidence of insulin-dependent diabetes in patients with LVEF < or = 25%. There were 18% reoperative CABG, 91% of the patients were Canadian Cardiovascular Society's (CCS) angina class 3 and 4 preoperatively, 38% had unstable angina, and 35% underwent urgent surgery (within 24 hours of admission). Angiography and operation data did not differ significantly between the groups. Hospital mortality in group I was 5.3% and in group II 15.4%, p < 0.008. In group III it was 6.3% and in group IV 2.2%, p < 0.001. Postoperative low cardiac output occurred in 18% (group I) and 39% (group II), p < 0.05, and only in 5% in groups III and IV, p < 0.001. Non-fatal myocardial infarction and other postoperative complications revealed no group differences. LVEF and CCS class improved from 1 month postoperatively in groups I and II, however, significantly more in group I (hypertensives), p < 0.001. Hypertensive patients with poor left-ventricular function preoperative to were found to have a lower hospital mortality and incidence of postoperative low cardiac output than normotensiven with LVEF < or = 25%. Hypertensive patients also had a better improvement of their left-ventricular function and CCS class than normotensiven. Left-ventricular hypertrophy and previous myocardial infarction were predictors for mortality in patients with LVEF > 25%. Patients with LVEF < or = 25% showed the same tendency, though not statistically significant.
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PMID:The impact of arterial hypertension on the results of coronary artery bypass grafting. 885 94

Dipyridamole-sestamibi (PMIBI) is recommended prior to vascular surgery in patients with > or = 1 Eagle criteria (Q waves, history of ventricular ectopy, diabetes, advanced age, and/or angina). To review our cardiac morbidity and mortality and the need for preoperative PMIBI, we reviewed 109 consecutive patients with a mean age of 59 years who underwent 145 elective major vascular procedures over a 1-year period. Seventy patients (with a mean of 0.8 Eagle criteria) underwent 92 vascular procedures without preoperative PMIBI and without coronary revascularization. Thirty-one patients (with a mean of 1.1 Eagle criteria) underwent 39 procedures without coronary revascularization following PMIBI, which showed reversible ischemia in seven and a fixed defect in 10; findings were normal in 14. Preoperative coronary bypass or angioplasty was limited to eight patients (14 procedures, mean of 1.6 Eagle criteria) who had unstable angina with (2 patients) or without (6 patients) acute myocardial infarction. There were four perioperative myocardial infarctions (2.8%), seven cardiac events overall (4.8%), and one cardiac death (0.7%). Three (43%) of the seven cardiac events occurred in patients with a normal scan or fixed defect on PMIBI imaging. In the absence of unstable angina, PMIBI had a sensitivity of only 25% and a specificity of 80% for cardiac events. We conclude that among patients without severe cardiac symptoms (1) PMIBI has a very limited ability to identify patients at risk for cardiac complications, and (2) preoperative PMIBI is neither necessary nor cost-effective.
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PMID:Cardiac assessment prior to vascular surgery: is dipyridamole-sestamibi necessary? 887 86

To investigate whether circulating endothelin-1 (Et-1) may be related to the increased incidence and severity of ischaemic heart disease in type 2 diabetes mellitus, we compared the concentrations in type 2 diabetic patients and in non-diabetic patients with coronary artery disease (CAD) angiographically documented. Plasma levels of Et-1 were determined in 34 type 2 diabetic patients with CAD (16 with stable angina, 6 with unstable angina, 12 with previous myocardial infarction) and in 19 nondiabetic patients with CAD (4 with stable angina, 5 with unstable angina, 10 with previous myocardial infarction). Fifteen diabetic patients without CAD and 9 healthy volunteers served as control subjects. In the type 2 diabetic patients, the mean Et-1 levels were 3.19 +/- 1.61 pmol/l in those with stable angina, 3.58 +/- 1.92 pmol/l in those with unstable angina, 4.24 +/- 2.53 pmol/l in those with myocardial infarction. These values were not significantly different one another, nor from the values obtained from type 2 diabetic controls (3.64 +/- 2.13 pmol/l). In the non-diabetic patients, the mean Et-1 levels were 3.92 +/- 0.73 pmol/l in those with stable angina, 4.35 +/- 1.67 pmol/l in those with unstable angina, 4.33 +/- 1.66 pmol/l in those with myocardial infarction. These values were not significantly different one another, but significantly higher than those obtained from healthy controls (2.07 +/- 0.67 pmol/l; P < 0.001). No significant differences were found in Et-1 levels between diabetic and non-diabetic patients with stable, unstable angina and previous myocardial infarction. In contrast, a statistically significant difference was found in Et-1 levels between diabetic and non-diabetic control subjects (P < 0.05). In conclusion, similar raised concentrations of Et-1 in diabetic and non-diabetic patients with stable, unstable angina and previous myocardial infarction do not support the hypothesis that higher levels of Et-1 in diabetic patients are responsible for the increased incidence of CAD in diabetes mellitus. However, the raised Et-1 levels found in diabetic patients in the absence of CAD strongly suggest that a generalised endothelial dysfunction, documented in our study by increased levels of Et-1, most probably precedes subsequent cardiovascular diseases.
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PMID:Circulating endothelin-1 levels in type 2 diabetic patients with ischaemic heart disease. 890 34

Reoperative (redo) coronary artery bypass grafting is an efficient treatment for patients with progressive coronary artery disease and those with conduit failure. Previous studies have demonstrated that a short time interval between primary and redo coronary artery bypass grafting is associated with a significantly higher mortality rate. In the present report this particular group have been specifically evaluated. Between 1 January 1990 and 1 October 1994, 383 consecutive patients underwent redo coronary artery bypass grafting. Thirty-three patients (8.6%) were operated on at < or = 1 year (group 1) and 350 patients at > 1 year after the primary bypass (group II). The main indications for redo in group I were graft failure (58%), incomplete revascularization (39%) and progress of disease (3%); respective values in group II were 26% 15%, and 23%. In addition, 36% of patients in group II had combinations of complications. Patient characteristics did not differ between groups, except a higher incidence of insulin-dependent diabetes in group I (P < 0.05). There was a higher incidence of left main stem stenosis of > 70% in group I (P < 0.05). Group I patients had a longer aortic cross-clamping time and needed thromboendarterectomy and patching of coronary vessels more often than did those in group II (P < 0.05). The internal mammary artery had been more frequently used at the primary coronary artery bypass grafting in group I (P < 0.01). The overall mortality rate was 8.9%; that in group I was 18% and in group II, 8% (P < 0.05). There was a higher incidence of non-fatal myocardial infarction and a need for prolonged ventilatory support (> 24 h) in group I. Other postoperative complications did not differ. Significant risk factors for mortality in group I were preoperative Canadian Cardiovascular Society class > or = 3, unstable angina, need for urgent operation and left ventricular ejection fraction < 40%, and > or = 70% left main stem stenosis. In group II, the risk factors were: unstable angina, urgent operation, left ventricular ejection fraction < 40%, internal mammary artery not used at primary coronary artery bypass grafting and the need for coronary thromboendarterectomy. The 3-year survival and cardiac event-free survival did not differ between the groups. This study has confirmed that early redo coronary artery bypass grafting (< or = 1 year from primary bypass) is associated with an increased operative risk.
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PMID:The impact of a short interval ( < or = 1 year) between primary and reoperative coronary artery bypass grafting procedures. 901 14

Of 450 consecutive patients with unstable angina admitted to a tertiary care, university-based medical center over a 24-month period, 334 were administered heparin and aspirin for some length of time. Two groups of 98 patients matched for acuity and gender at baseline were treated with either < or = 48 hours (group 1) or > 48 hours (group 2) of heparin. The acuity model used in this study incorporates 6 factors: age, recent myocardial infarction, treatment with intravenous nitroglycerin, previous therapy with beta blockers or calcium antagonists, baseline ST depression, and diabetes. Despite similar risks and overall clinical outcome, group 2 had significantly more myocardial infarction or death after 48 hours than group 1 (p = 0.01). In part, this was due to a delay in the performance of coronary angiography (2.8 +/- 1.4 vs 3.5 +/- 15 days, p = 0.01), coronary intervention (2.7 +/- 1.8 vs 5.1 +/- 2.3 days, p = 0.01), and bypass surgery (3.8 +/- 3.6 vs 7.0 +/- 5.6 days, p = 0.02). There was no difference between groups regarding the success of coronary intervention (90% vs 88%, p = NS). Heparin duration was influenced by the finding of intracoronary thrombus or ulceration on angiography before revascularization, as each finding was seen more often in group 2 (thrombus, 12% vs 24%; ulceration, 38% vs 60%). These results suggest that the optimal duration of heparin therapy is up to 48 hours after admission in unstable angina; a longer time period is associated with increased adverse consequences.
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PMID:Comparison of heparin therapy for < or = 48 hours to > 48 hours in unstable angina pectoris. 903 41

There is clear evidence of the negative influence of type I or II diabetes non-insulin-dependent diabetes mellitus (NIDDM) on the prevalence, severity, and prognosis of cardiovascular disease. Epidemiologic studies have confirmed the relationship between NIDDM and the occurrence of coronary artery disease (CAD) and cardiac heart failure (CHF). The clinical aspects of NIDDM cardiac complications include a high rate of silent events, which merit an improvement in their diagnosis and treatment. Besides pharmacological therapy, aggressive approaches including percutaneous transluminal coronary angioplasty (PTCA), and coronary surgery should be considered for the treatment of stable angina. IN some subgroups, the benefit of surgery has been proven. Available data indicate that diabetes (both type I and II) is a risk factor for an increase in morbidity and mortality following coronary bypass surgery. These data do not differentiate results between type I and type II diabetes. The indications for surgical revascularization are: three-vessel disease, left main artery stenosis, two-vessel disease including proximal left anterior descending artery stenosis, and two-vessel disease with left ventricular dysfunction. For PTCA, diabetes (type I more than type II) renders the technique more difficult and restenosis more frequent. From the results obtained in the general population and from a few specific studies, it is suspected that, in type II diabetes, PTCA and CABG are superior to conventional medical treatment. However, further specific studies on the beneficial effects of PTCA/CABG over optimal medical therapy are needed, at least in some angiographic conditions. Management of the diabetic patient with acute myocardial infarction is for the most part similar to the nondiabetic patient, with certain special considerations. Treatment includes thrombolytic therapy, invasive management, surgery, PTCA, beta blocker use, and aspirin use. Finally, diabetes mellitus is a cause of systolic and diastolic function, leading to clinical signs of CHF. Conventional medical therapy also applies to cardiac failure complicating diabetes. Medical therapy includes as the first line diuretics and angiotensin-converting enzyme inhibitors. We conclude that cardiac care can be improved in diabetic patients. For the time being, the first step is to improve the detection of coronary artery disease. As serious events are more likely to occur in the diabetic population, it would be easier (shorter studies and less patients) to demonstrate the benefit of a selected therapy. Further studies are therefore required. In the meantime, special efforts can be made: (1) prevent the development of coronary artery disease. Preventive measures aimed at the control of risk factors at the individual level must be optimal. What should be promoted is a more global approach to the patient, taking into account all parts of the risk factor profile, in order to amplify the reduction in risk and in cardiovascular morbidity and mortality. (2) When CAD is confirmed: the goal is to prevent all major cardiac events: unstable angina, myocardial infarction, sudden death, and CHF secondary to silent ischemic events. This can be achieved through the improvement of the accuracy of noninvasive diagnostic procedures, taking into account the cost of these procedures and the absence of pain perception in diabetic patients.
J Diabetes Complications
PMID:Cardiac complications in non-insulin-dependent diabetes mellitus. 910 98

The present study was designed to assess the prognostic value of clinical and angiographic factors, and especially restenosis or rapid progression in non-dilated sites, on major spontaneous coronary events at long-term follow-up after a first successful coronary angioplasty performed for angina pectoris. A second aim was to assess the prognostic factors and especially restenosis in asymptomatic patients after angioplasty. The first 352 consecutive patients undergoing a successful coronary angioplasty were selected and followed-up. The following variables: age, sex, unstable angina, previous myocardial infarction, diabetes, hypercholesterolemia, tobacco consumption, hypertension, fibrinogen, coronary extent, single or multiple dilatation, restenosis, new progression, clinical deterioration of anginal status just before angiographic restudy or asymptomatic status were subjected to a stepwise regression analysis. Restenosis (a loss of 30% in diameter and/or a return to a >50% stenosis) and progression in non-dilated segments (a 20% reduction in diameter) were assessed by a computer-assisted method. Cardiac death, new myocardial infarction or new unstable angina, at long-term follow-up after angiographic restudy, were regarded as spontaneous coronary events and pooled in a single dependent variable. Thus 41 patients had a coronary event. In the overall population, clinical deterioration of anginal status (p<0.001, relative risk: 3.65) and fibrinogen (p<0.05, relative risk: 1.03) were independent predictors of spontaneous coronary events. Restenosis or new progression were not predictors. In asymptomatic patients (n=187), fibrinogen (p<0.01, relative risk=1.06) was the only predictor and restenosis was not an independent predictor of spontaneous coronary events. The best predictor of spontaneous coronary events at long-term follow-up after a first successful coronary angioplasty is clinical deterioration in anginal status in the months following the procedure. Restenosis does not appear as an independent predictor. Rapid progression observed in non-dilated sites is not an important prognostic factor.
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PMID:Restenosis or rapid progression in non-dilated sites are not predictors of late spontaneous coronary events. 922 92


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