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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hyperosmolar diabetic coma revealed the presence of a pancreatic cancer in two patients. The first case was a 59-year-old man, without a history of diabetes, treated with prednisone for jaundice and marked weight loss over the last month, and admitted in hyperosmolar coma (346 m0sm/l). After recovery from the acute episode, a diagnosis of adenocarcinoma of the head of the pancreas was established following operation. The patient died six months later. The second case, a 71-year-old man also without a history of diabetes, was admitted in hyperosmolar coma (315 m0sm/l) during the course of a pulmonary infection. Rapidly fatal cholostatic jaundice appeared one year later. An adenocarcinoma of the head of the pancreas was demonstrated at autopsy. The diagnostic criteria in both cases were those of hyperosmolar diabetic coma. Though cases of combined diabetes and pancreatic cancer are well documented, only one case of hyperosmolar coma and cancer of the pancreas has been reported in the published literature. The pathogenesis of hyperosmolar diabetic coma is discussed. The fact that it developed during the course of a pancreatic affection could be explained by a functional reduction in insulin secretion, associated with a triggering factor such as dehydration, infection, hypoglycemic agent administration, etc... The onset of hyperosmolar diabetic coma in an elderly patient without a history of diabetes, especially with associated marked weight loss, should lead to investigation for a possible pancreatic cancer.
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PMID:[Pancreatic cancer revealed by hyperosmolar coma: report on two cases (author's transl)]. 701 54

A case-control study of the epidemiology of endometrial cancer in women aged 45-74 years was carried out in 7 hospitals in Connecticut from 1977-79. 167 cases of adenocarcinoma, adenocanthoma, and adenosquamous neoplasms of the endometrium were included. 903 women of the same age admitted to surgical services except gynecology served as controls. Response rates were 67% for cases and 72% for controls. Odds ratios for the association between selected variables and endometrial cancer, adjusted by linear logistic regression for the effect of all other variables in the table, indicated that elevated risks were associated with being white and being well-educated, among demographic variables, and with nulliparity, fewer pregnancies, later age at menopause, use of estrogen replacement therapy, and a history of ovarian or endometrial cancer in mother or a sister, among reproductive variables. The longer estrogen replacement therapy was used, the higher the risk, up to 10 years of use. Heavier women were found to be at higher risk, although the risk for women of medium weight was only slightly increased. Women who reported a history of diabetes had a somewhat increased risk, while a history of ever having blood clots in the veins or of having had tubes tied was associated with reduced risk. Use of oral contraceptives was associated with a decreased risk, although the decrease did not reach statistical significance.
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PMID:A case-control study of cancer of the endometrium. 711 42

Benign or malignant cystadenoma of the pancreas is a rare but not exceptional tumor. Up to present, 300 of the former and 100 of the latter have been reported in the world literature. Three personal observations are reported, comprising 2 benign cystadenomas, the first discovered on abdominal palpation and the second after massive bleeding of gastric varices and thrombosis of the splenic vein. After removal of the tumor both patients were alive 20 and 7 1/2 years later respectively. Total excision of a cystadenocarcinoma in a third case required 90% pancreatectomy with ensuing diabetes. A review of the literature shows that total excision of a cystadenocarcinoma is always justified since the survival rate approximates 70%. This contrasts singularly with the catastrophic prognosis of pancreatic adenocarcinoma.
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PMID:[Cystadenomas and cystadenocarcinomas of the pancreas]. 724 1

Thirty-five consecutive patients with adenocarcinoma of the endometrium and an equal number of control subjects matched to the cancer patients for age and percentage of ideal weight were studied prospectively. In the cancer patients, the mean +/- SE serum androstenedione, testosterone, estrone (E1) and estradiol (E2) levels were 503 +/- 34 pg/ml, 224 +/- 22 pg/ml, 38.7 +/- 3.6 pg/ml, and 14.5 +/- 0.9 pg/ml, respectively. Similar concentrations were found in the control subjects. Body weight and percentage of ideal weight showed highly significant correlations (P less than 0.001) with E1 and E2 but not with the androgen concentrations in either group. The heavier patients had higher E1 and E2 levels. Age and years since menopause did not correlate with any of the hormonal levels. The cancer patients with overt diabetes tended to be more obese and have higher estrogen levels than did the nondiabetic subjects. Those with a history of prior estrogen usage were more slender and had lower endogenous estrogens than the nonusers. Twenty-three of the cancer patients (66%) had a presumed risk factor(s) for the development of this tumor, that is, excess body weight, high endogenous estrogen levels, or a history of prior estrogen usage. These data support the concept that conditions which lead to continued, unopposed estrogen stimulation may be associated with malignant transformation of the endometrium.
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PMID:Serum androgens and estrogens in postmenopausal women with and without endometrial cancer. 736 34

340 autopsy cases of pancreatic carcinoma from hospitals of St. Petersburg (1990-1991) and Petrozavodsk (1981-1990) have been studied (male/female proportion 1.1:1). The pancreatic head was involved in 75% of cases, including the head only in 61.3%, head and body in 12%, total organ involvement in 2.7%. Pancreatic carcinoma was combined with other tumors in 7 cases, including 4 cases of simultaneous combination. Histological types of carcinoma were represented by: adenocarcinoma (75.2%), undifferentiated carcinoma (10.9%), solid cancer (5.8%), mucosal (4.1%), squamous cell carcinoma (1.7%), glandular-squamous cell carcinoma (0.6%). Metastases occurred most frequently in the liver (52.6%) and lymph nodes (44.7%). Jaundice was registered in 39.1% of cases, primarily in cases of carcinomatous head involvement, and in 12.8% without such involvement (most frequently with metastases to the portal lymph nodes of the liver). Diabetes mellitus was diagnosed in 18 (5.3%) patients, but only in 4 of them as a consequence of pancreatic carcinoma. The diagnosis was found missed in 48% of patients.
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PMID:[Clinico-anatomic characteristics of pancreatic cancer]. 767 87

We report a family of 4 siblings from a non-consanguineous marriage, presenting with an early onset recessive cerebellar ataxia and progressive distal limb wasting. Ocular or other telangiectasias were absent. There were neither frequent infections nor immunodeficiencies. The two youngest patients exhibited an incapacitating myoclonus which abated markedly after 20 years. Late onset diabetes was demonstrated in 3 patients. Hypogonadism was not a feature and there was a prolonged survival in the 4 patients. The oldest sibling died of a pancreatic adenocarcinoma. alpha-Fetoprotein was elevated with normal carcinoembryonic antigen values in three patients. Cytogenetic analysis and radioresistant DNA synthesis was compatible with the diagnosis of ataxia-telagiectasia. This family probably represents a rare variant of ataxia-telangiectasia.
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PMID:An early-onset recessive cerebellar disorder with distal amyotrophy and, in two patients, gross myoclonia: a probable ataxia telangiectasia variant. 778 63

A new method of intraoperative cytodiagnosis was performed for one patient with occult neoplasms of the pancreas in order to locate the original site of cancer cells, using a balloon catheter. Cancer cells were detected in the pancreatic juice obtained from the pancreatic body only. The pancreatic body was removed, and the tail of the pancreas was anastomosed to the stomach. The post operative course was good without diabetes, and it was confirmed histologically that minimally invasive adenocarcinoma existed in the pancreatic body. Thus this procedure is beneficial because it can preserve as much pancreatic function as possible without losing the chance of cure by surgery.
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PMID:[A case of occult cancer of pancreas which was appropriately resected by intra operative cytodiagnosis using a balloon catheter]. 789 31

107 patients, aged 40 to 87, after surgical intervention with diagnosis of uterine corpus cancer were clinically examined. 68.1 percent of them were 51 to 70 year old women. 20.5 percent had been never pregnant, and 22.47 been pregnant for one time. In 93.2 percent, corpus cancer was revealed after menopause. Among risk factors, there was observed: diabetes mellitus in 7.4%, hypertension in 35.5%, and obesity in 78% of cases. It was stated interdependence between the depth of uterine infiltration, parametrium metaplastic focuses, adnexa metaplastic focuses, cervix infiltration and decrease of adenocarcinoma maturity. The concord between biopsy and clinical stage I degree was stated in 86 percent of cases.
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PMID:[Clinical analysis of patients surgically treated for cancer in the body of the uterus]. 798 21

A mass within the head of the pancreas causing obstructive jaundice is frequently adenocarcinoma, or infrequently focal pancreatitis. Groove pancreatitis is an inflammation of the head of the pancreas which fills the anatomic space between the head of the pancreas on 1 side and the second part of the duodenum on the other. Obstruction from either cause may cause vomiting, abdominal pain, and loss of weight. It is sometimes impossible to differentiate between the 2 conditions clinically. We present 2 women, aged 41 and 42 years, respectively, with recent onset of diabetes mellitus, obstructive jaundice, abdominal pain and severe loss of weight in whom diagnosis was difficult. In 1 repeated fine needle biopsy directly from the mass did not show adenocarcinoma, but she died of the disease a few months later. The other, in whom malignancy was also suspected, recovered from what was retrospectively diagnosed as groove pancreatitis.
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PMID:[Groove pancreatitis and adenocarcinoma of the pancreatic head]. 799 83

A case of endometrial ciliated carcinoma mixed with foci of mucinous adenocarcinoma and argyrophil cells is described. The patient suffered from diabetes mellitus, hypertension and obesity, but had no history of estrogen use. Although the tumor presented well differentiated histologic features, it showed complete diffuse, endophytic extension. Approximately half of the cilia had abnormal inner structures, with 8 + 2 microtubular pattern. Some ciliated cells contained intracytoplasmic mucin, while others contained neurosecretory granules. These findings suggest that malignant ciliated cells have the capacity of further transformation into mucinous or endocrine cells.
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PMID:Ciliated carcinoma of the endometrium associated with mucinous and neuroendocrine differentiation: a case report with immunohistochemical and ultrastructural study. 805 16


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