Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011849 (diabetes)
 277,896 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The pattern of HLA distribution was studied in 70 Nigerian diabetics. There was no association at all between HLA-B8 and insulin-dependent diabetes mellitus (IDDM). There was an increased frequency of HLA-B15 in all categories of patients: those with onset before 40 yr, those with onset after 40 yr (P less than 0.05), those with IDDM (P less than 0.05), and those with non-insulin-dependent diabetes mellitus (NIDDM). HLA-B7 was slightly increased in frequency contrary to the findings in Caucasian IDDM. HLA-A10 and HLA-Aw32 were increased in all the groups of patients, while HLA-B17 was higher in those with onset after 40 yr (P less than 0.02) and NIDDM (P less than 0.02). HLA-Bw35 was decreased in all categories of patients. However, all the observed deviations fell short of statistical significance when correction was made for the number of antigens tested for. Comparison of the data with those in other black populations revealed that the over-all pattern of HLA distribution in black diabetics is rather disparate and still relatively ill defined. It is concluded that the pattern of HLA and diabetes association in Nigerian diabetics would appear to be different from that in most other racial groups including North American and South African blacks. There is, however, a need to further study larger numbers of Nigerian diabetics and other black population groups so that a clearer picture may emerge.
Diabetes 1982 Dec
PMID:Pattern of histocompatibility (HLA) antigen distribution among Nigerian (West African black) diabetics. 675 24

The HLA antigens of 44 Asian Indians with juvenile-onset, insulin-dependent diabetes were determined. The frequency of HLA-B8 was increased but that of HLA-B15 was not. There was a significant increase in the frequency of some of the subdivisions of B5.
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PMID:HLA and insulin dependent diabetes in South African Indians. 700 48

The incidence of post-transplant diabetes mellitus (PTDM) was evaluated in 250 patients who underwent live-related renal transplantation at our hospital between 1978 and 1992. Twelve (4.8%) patients developed PTDM requiring drug therapy. PTDM occurred in 4 of 197 (2%) patients on conventional prednisolone-azathioprine immunosuppression as compared to 8 of 53 (15.1%) patients receiving cyclosporine in addition (triple-therapy). Three patients (25%) developed PTDM during or immediately following anti-rejection therapy with intravenous methylprednisolone. Eight patients (66.6%) developed PTDM within six months of transplantation. Majority of our patients (66.6%) could be managed successfully with oral hypoglycemic agents. Two patients (16.6%) showed spontaneous resolution of hyperglycemia within six months of onset of PTDM. Eleven patients (91.6%) were symptomatic for their hyperglycemia with two patients presenting as 'pseudorejection' and one with diabetic ketoacidosis. Females were more predisposed to develop PTDM in our study (10% vs. 4.1%). HLA-B15 and DR 3 were the commonest phenotypes in our PTDM patients. No other known predisposing or triggering factors associated with PTDM were found in our patients. The current study suggests, that addition of cyclosporine to the conventional immunosuppression in live-related renal allograft recipients has contributed to an increased incidence of post-transplant diabetes mellitus. Close and regular blood sugar monitoring is thus recommended in post-transplant patients especially those on triple drug immunosuppression.
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PMID:Post transplant diabetes mellitus in live related renal allograft recipients: a single centre experience. 928 9

Subtypes of HLA-DR4 are associated with susceptibility or protection against type 1 diabetes (T1DM). We addressed whether this reflects linkage disequilibrium with the true susceptibility locus by studying broader MHC haplotypes marked by alleles of HLA-B, IKBL (adjacent to TNFA) and complement C4. The study used a largely Caucasian cohort from Western Australia. HLA-DRB1*0401 and HLA-DRB1*0405 marked susceptibility to T1DM. In Caucasians, DRB1*0401 occurs predominantly in the 44.1 ancestral haplotype (AH; HLA-A2,B44, DRB1*0401,DQB1*0301) and the 62.1AH (HLA-A2,B15(62),DRB1*0401,DQB1*0302). HLA-B15 marked susceptibility and HLA-B44 marked with resistance to T1DM in patients and controls preselected for HLA-DRB1*0401. A gene between TNFA and HLA-B on the 8.1AH (HLA-A1,B8,;DR3,DQ2) modifies the effects of the class II alleles. Here, alleles characteristic of the 62.1AH (C4B3, IKBL+446*T and HLA-A2,B15) were screened in donors preselected for HLA-DRB1*0401. C4B3 was associated with diabetes, consistent with a diabetes gene telomeric of MHC class II. However, increases in carriage of IKBL+446*T and HLA-A2,B15 were marginal, as too few control subjects were available with the diabetogenic alleles. However, with these tools, selection of HLA-DRB1*0401, DQB1*0302 donors who are positive and negative for C4B3 will allow bidirectional mapping of diabetes genes in the central MHC.
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PMID:Does a central MHC gene in linkage disequilibrium with HLA-DRB1*0401 affect susceptibility to type 1 diabetes? 1585 1


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