Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011633 (dermatomyositis)
 4,181 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Utilizing case-control methods, we surveyed 322 persons who experienced the onset of polymyositis-dermatomyositis (PM-DM) during calendar years 1985 and 1986, in an effort both to test specific hypotheses, and to generate new hypotheses regarding antecedent risk associations for the disease. Data obtained by recall of events during the 12 months before disease onset in cases, and an identical time period in sex matched sibling controls, suggest that important questions for further study include the roles of antecedent heavy muscular exertion and emotional stress as risk factors for PM-DM. Furthermore, it appears that vaccinations, toxic exposures and symptoms of allergic phenomena, throat infection, and upper respiratory infection are either neutral or are negatively associated with risk of PM-DM, findings which also raise important new etiologic questions, or perhaps lay old ones to rest. Malignancy was infrequently noted.
J Rheumatol 1989 Sep
PMID:Predisposing factors in polymyositis-dermatomyositis: results of a nationwide survey. 281 Feb 79

A recent case of childhood dermatomyositis with striking retinopathy is reported. The patient's vision was initially at the 20/80 to 20/100 level with associated macular edema and extensive cotton-wool infarction of the retina. Visual recovery to the level of 20/20 in both eyes was achieved following treatment with high-dose corticosteroids.
J Clin Neuroophthalmol 1985 Sep
PMID:Retinopathy of dermatomyositis. 293 19

Pleuropulmonary disease is a common feature of the following connective tissue diseases: systemic lupus erythematosis (SLE), rheumatoid arthritis (RA), progressive systemic sclerosis (PSS), mixed connective tissue disease (MCTD), polymyositis/dermatomyositis (PM/DM), and Sjogren's syndrome (SS). Features common to most of these disorders include pleurisy with effusion and interstitial lung disease. Pleural effusions caused by SLE and RA have certain characteristics on pleural fluid analysis that aid in diagnosis, but infection and other causes of effusion must be excluded. Interstitial lung involvement is usually indolent in onset, but a more rapidly progressive course over weeks to a few months may mimic infection. Several drugs used to treat connective tissue diseases may cause interstitial disease, increase susceptibility to infection, or both. This complicates differential diagnosis. Acute lupus pneumonitis and SLE-related alveolar hemorrhage are usually fulminant processes, often associated with fever. Diagnosis of these conditions always requires exclusion of infection. Rheumatoid nodules may mimic infectious and neoplastic lung diseases. Needle biopsy helps reduce the likelihood of infection or malignancy, but open lung biopsy is needed if a firm diagnosis of rheumatoid nodules is required.
Semin Respir Infect 1988 Sep
PMID:Respiratory manifestations of connective tissue disease. 305 17

Five patients with dermatomyositis and 2 with polymyositis between 3 and 12 years old are reviewed. All of them fulfil the Bohan and Peter diagnostic criteria. Five presented misery before weakness. Two presented acute renal failure. The pathologic muscular study was not always specific of inflammatory myopathy and without correlation with the degree of symptoms. Treatment which prednisone and in one patient also azathioprine resulted with complete remission in 4 patients.
An Esp Pediatr 1988 Sep
PMID:[Idiopathic inflammatory myopathies in childhood. A study of 7 patients]. 319 70

We examined the relationships between the clinical features and outcome of 43 patients with polymyositis-dermatomyositis (PM-DM) and muscle biopsy findings, with specific reference to the pattern of distribution of inflammatory cells. Perifascicular inflammation was associated with the presence of the rash of DM. No relationships were found between the other patterns of distribution of inflammatory cells in muscle and various clinical findings in patients with PM-DM, or the clinical course of the disease. Vasculitis of large vessels (greater than or equal to 20 micron) was seen in only 5 cases (11%) and was not present in childhood PM-DM.
J Rheumatol 1988 Sep
PMID:Relationships between clinical features and distribution of mononuclear cells in muscle of patients with polymyositis. 319

A review of 96 patients with the established diagnosis of childhood dermatomyositis revealed that 15 patients required surgical therapy in addition to diagnostic biopsy. Four of the patients had perforation of the esophagointestinal tract, and 11 required surgical therapy for abscesses, calcific deposits, or treatment of pneumothorax. The life-threatening lesions were perforations of the esophagus and intestine. The best surgical therapy is closure, resection, and adequate drainage. Prognosis depends on treatment of the underlying medical disease.
Arch Surg 1988 Sep
PMID:Required surgical therapy in the pediatric patient with dermatomyositis. 341 63

Vitamin K-dependent carboxylase is demonstrated in skin microsomes from humans, rats, rabbits, and mice. This enzyme converts a number of distinct protein-bound glutamic acid residues into gamma-carboxyglutamic acid residues, which strongly interact with Ca++ ions. The enzymatic activity (expressed per mg protein) in skin is about 20% of that in liver. Vitamin K-dependent carboxylase is present in both epidermal and dermal tissue. It is demonstrated that warfarin treatment in mice results in an accumulation of noncarboxylated precursor proteins in both dermal and epidermal microsomes. Most probably this effect of warfarin is not restricted to mice, but occurs also in the skin of patients under oral anticoagulant therapy. A possible relation between vitamin K-dependent skin carboxylase and the gamma-carboxyglutamic acid-containing protein in calcified nodules from patients with scleroderma and dermatomyositis is discussed.
J Invest Dermatol 1986 Sep
PMID:Vitamin K-dependent carboxylase in skin. 348 54

An unusual case of nail involvement in dermatomyositis in which complete loss of several toenails was the only cutaneous sign of the disease is reported for its clinical interest.
Cutis 1987 Sep
PMID:Unusual severe nail involvement in dermatomyositis. 365 33

In this study, 82 photomacrographs of nailfold capillary beds from 60 patients with scleroderma spectrum disorders (scleroderma, undifferentiated connective tissue disease, and dermatomyositis) and from 16 normal controls were analyzed blindly, using both semiquantitative and quantitative methods, to estimate the capillary size and the extent of "avascularity." A good correlation was found between results obtained by the two methods. Defining these semiquantitative classifications in quantitative terms should facilitate comparison of results from different investigators.
Microvasc Res 1986 Sep
PMID:Comparison of quantitative and semiquantitative estimates of nailfold capillary abnormalities in scleroderma spectrum disorders. 376 32

Spontaneous pneumomediastinum has not been reported in adult polymyositis or dermatomyositis, either in conjunction with spontaneous pneumothorax or in isolation. Spontaneous pneumothorax has been rarely reported as a complication of rheumatoid arthritis, systemic lupus erythematosus, scleroderma, and childhood dermatomyositis. It is associated with active, progressive pulmonary involvement and a poor prognosis. We describe an adult with dermatomyositis and spontaneous pneumomediastinum with a favourable outcome.
Ann Rheum Dis 1986 Sep
PMID:Spontaneous pneumomediastinum in adult dermatomyositis. 376 67


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>