Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011633 (dermatomyositis)
 4,181 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Described here is a 59 year old man with dermatomyositis and hypogammaglobulinemia. His muscle power improved after corticosteroid therapy, but extensive amyloidosis and repeated infections appeared. Bone marrow morphology suggested multiple myeloma, but treatment with cytotoxic drugs had no beneficial effect on the amyloidosis. Because of rapid progression of the amyloidosis and further infections, cytotoxic drug therapy was stopped, corticosteroid dosage was decreased, and supplementary immunoglobulin therapy was instituted. The infections occurred less frequently and the amyloidosis appeared to regress. This case suggests that immunosuppressive therapy may exacerbate amyloidosis. The literature is reviewed, and the possible role of humoral immunodeficiency in the pathogenesis of amyloidosis is discussed. It is suggested that supplementary immunoglobulin may be beneficial in amyloidosis.
Am J Med 1975 Sep
PMID:Amyloidosis associated with dermatomyositis and features of multiple myeloma. The progression of amyloidosis associated with corticosteroid and cytotoxic drug therapy. 5 87

Hemopexin, a serum glycoprotein that binds free heme and transports it to hepatic parenchymal cells, has been measured by radial immunodiffusion. We have confirmed elevation of serum hemopexin concentration in Duchenne's muscular dystrophy patients and carries, and demonstrated elevations in dermatomyositis/polymyositis and myasthenia gravis, but not in amyotrophic lateral sclerosis. In monkeys, elevations of hemopexin levels were specifically induced by hematin injections, muscle-crush, or myoglobin injections. Myoglobin leakage is the likely explanation of hemopexin level elevation in Duchenne's dystrophy patients and carriers and in dermatomyositis/polymyositis. In myasthenia gravis there might be a slight myoglobin leakage not heretofore suspected; or, the elevation of hemopexin levels might be a new reflection of a dysimmune state in myasthenia gravis, and perhaps as such is a further incrementing factor in dermatomyositis/polymyositis. Hemopexin, presumably as a longer-phase reactant, is sometimes an index of neuromuscular disease when other data are negative or equivocal.
Arch Neurol 1978 Sep
PMID:Elevations of hemopexin levels in neuromuscular disease. 9 25

A Caucasian male developed florid dermatomyositis documented by serum enzyme elevation, electromyography, and histology of skin and muscle. Serum enzymes, including creatine phosphokinase (CPK), aldolase, glutamic oxaloacetic transaminase (SGOT), and lactic dehydrogenase (LDH), decreased initially during high dose systemic corticosteroid therapy, although profound muscle weakness persisted. Subsequent elevation of serum LDH and SGOT levels during treatment provided a clue to underlying neoplasia. Primary hepatoma with widespread metastases was found at necropsy.
J Rheumatol 1976 Sep
PMID:Aberrant serum enzyme patterns in dermatomyositis associated with hepatoma. 18 84

Two cases are presented which have been treated anticonvulsively for many years - especially with Phenytoin and Mephenytoin. The clinical syndrom as well as the changes of the connective tissue show transitions of Progressive systemic sklerosis (PSS) to systemic Lupus Erythematodes (SLE) and Dermatomyositis. The correlation with the therapy is reflected in consideration of immunological phenomenons.
Fortschr Neurol Psychiatr Grenzgeb 1977 Sep
PMID:[A progressive systemic sclerosis like disease due to anticonvulsive therapy? (author's transl)]. 24 60

In this case of dermatomyositis, the patient's clinical course was complicated by the development of acute granulocytic leukemia. Various malignancies complicating dermatomyositis have been reported in the literature. Rarely have these been of the hematopoietic system.
South Med J 1978 Sep
PMID:Dermatomyositis complicated by acute granulocytic leukeumia. 27 27

Baby hamster kidney cells fixed in acetone on glass slides were used as antigen for demonstration of antinuclear antibodies. Where certain storage conditions were observed (drying agent, 4 degrees C) they have kept for 12 months up to now. As regards specificity, sensitivity, reproducibility, and differentiation of fluorescent types the baby hamster kidney cell test appears superior to other immunofluorescence methods used (chicken erythrocytes, rat liver sections, and crithidiae). These results were obtained in 73 sera from patients with disseminated lupus erythematodes, drug-induced lupus erythematodes, discoid erythematodes, allergic vasculitis, progressive scleroderma, dermatomyositis, and 36 control sera.
Dtsch Med Wochenschr 1978 Sep 15
PMID:[Baby hamster kidney cells as antigen for demonstration of antinuclear antibodies (author's transl)]. 30 47

Sera of children with juvenile rheumatoid arthritis and other connective tissue diseases were tested for antibodies to native DNA by a radiolabeled-binding assay. Normal values were obtained in 130 children with JRA, including 28 with uveitis and 14 with selective IgA deficiency. Normal values were also found in sera from children with dermatomyositis, scleroderma, polyarteritis, ankylosing spondylitis, and a variety of other nonconnective tissue diseases. The only sera with elevated DNA-binding assays were from children with systemic lupus erythematosus. On the basis of these data, increased levels of antibodies to native DNA distinguished patients with active SLE from children with JRA.
J Pediatr 1978 Sep
PMID:Diagnostic significance of antibody to native deoxyribonucleic acid in children with juvenile rheumatoid arthritis and other connective tissue diseases. 69 Jul 54

Necrotic lesions of the scrotum usually result from infectious processes, vascular occlusion or trauma. The first case of necrotic non-purulent skin changes associated with dermatomyositis is reported.
J Urol 1977 Sep
PMID:Case report: dermatomyositis of the scrotum. 90 71

The Leucocyte-Migration-Inhibition-Test was performed to examine 10 patients with Systemic Lupus Erythematosus (SLE), 10 patients with Discoid Lupus Erythematosus (DLE) and 4 patients with Dermatomyositis for evidence of cell-mediated immunity to RNA, DNA, human muscle antigen and collagen human type I. Our results support, that cell-mediated immunity plays a pathogenic role in both diseases. Patients with SLE show a correlation between activity of disease, Leucocyte-Migration-Inhibition to DNA and DNA-binding-activity of serum. Muscle-antigen is an obvious relevant partner of reaction of cellular immunity in patients with Dermatomyositis.
Z Hautkr 1977 Sep 01
PMID:[Leukocyte migration inhibition test in lupus erythematosus and dermatomyositis]. 91 May 38

A case is presented, in which classic dermatomyositis occurred six weeks after documented rhabdomyolysis. The literature concerning the immunopathogenesis of dermatomyositis is briefly reviewed.
J Rheumatol 1976 Sep
PMID:Dermatomyositis following rhabdomyolysis. 97 61


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