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Query: UMLS:C0011633 (dermatomyositis)
 4,181 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Rheumatoid arthritis is a multisystem disease, with many clinical forms bearing close resemblance to systemic lupus erythematosus, dermatomyositis or polyarteritis nodosa. Although the involvement of the integument is not as disabiling as the joint disease, the extent of disability may be of sufficient magnitude to necessitate therapeutic intervention. Two patients are presented whose skin involvement was suggestive of cutaneous angiitis and who responded dramatically to treatment using sulfasalazine.
Int J Dermatol 1979 Jun
PMID:Cutaneous rheumatoid vasculitis. 3 16

Intraendothelial tubular aggregates were found in small dermal blood vessels in three healing superficial wounds in patients receiving systemic corticosteroids. Similar inclusions were also demonstrated in two wounds in healthy subjects, but were not found in normal (unwounded) skin of either healthy subjects or steroid-treated patients. Tubular aggregates of similar structure have previously been described as occurring in 'connective tissue' or 'auto-immune' diseases, including lupus erythematosus and dermatomyositis, both in the skin and in internal organs. Although it has been suggested that such aggregates are of viral origin, their morphogenesis and significance remain undertermined. Our findings do not support a viral cause, but suggest that these structures are probably a product of regenerating endothelium.
Br J Dermatol 1975 Aug
PMID:Intraendothelial tubular aggregates in experimental wounds. 16 73

Multicentric reticulohistiocytosis developed in a 45-year-old woman, who had a 3 year history of untreated breast carcinoma. A review of the literature revealed that malignant disease has been associated with 27% of reported cases. It is considered that, like adult dermatomyositis, the onset of multicentric reticulohistiocytosis should stimulate detailed investigation for an underlying neoplasm.
Br J Dermatol 1978 Feb
PMID:Multicentric reticulohistiocytosis and malignant disease. 20 25

Rare intracytoplasmic membranous inclusions derived from the endoplasmic reticulum were observed in the histiocytes of one case of Dego' syndrome and one case of dermatomyositis. Cross-section and longitudinal sections made it possible to establish a three-dimensional model in which both microcylinders and layers of rolled-up double membranes appear.
Br J Dermatol 1979 Feb
PMID:Microcylinders of endoplasmic reticulum in histiocytes in patients suffering from Degos' syndrome and dermatomyositis. 21 3

Clinical and laboratory findings were correlated from 46 patients with IgG localization in epidermal nuclei in a speckled (particulate) pattern on direct immunofluorescence of normal skin. Cutaneous manifestations included lupus erythematosus (LE), swollen hands or sclerodactyly, alopecia, vasculitis, and dyspigmentation. Systemic manifestations included arthritis or arthralgia, Raynaud's phenomenon, serositis, vascular headaches, mild renal disease, myositis, and sicca syndrome. High titer (mean = 1:142, 800) serum antibody to extractable nuclear antigen (ENA) was found in 81%. Eighty-six percent had antibody to an RNase-sensitive antigenic component of ENA (ribonucleoprotein or RNP); 14% had antibody to an RNase-resistant ENA termed Sm. Deposition of IgG in a speckled pattern in epidermal nuclei is an immunopathologic marker for a subset of connective tissue disease characterized by antibody to ENA. Those with Sm specificity had systemic LE (SLE); Those with RNP specificity had Raynaud's phenomenon usually associated with overlapping features of SLE, scleroderma, and/or dermatomyositis.
Arch Dermatol 1978 May
PMID:Speckled (particulate) epidermal nuclear IgG deposition in normal skin. Correlation of clinical features and laboratory findings in 46 patients with a subset of connective tissue disease characterized by antibody to extractable nuclear antigen. 34 15

Acanthosis nigricans of the groin, axillae, and neck developed in a patient on long-term steroid therapy for dermatomyositis after eight years. The dermatosis resolved spontaneously ten years after the steroid use had been discontinued. Review of three personal cases and the literature suggests that acanthosis nigricans may have a hormonal basis.
Arch Dermatol 1979 May
PMID:Steroid-induced acanthosis nigricans in dermatomyositis. 44 33

A case of toxoplasmosis occurred simultaneously with dermatomyositis in a 12-year-old boy. The patient was treated with sulfadiazine and pyrimethamine; within two weeks after initiating therapy, dramatic clinical improvement was noted. Several previous cases of toxoplasmosis occurring in association with polymyositis have been described in the literature. A serologic investigation for Toxoplasma infection might prove to be of value in establishing the cause of dermatomyositis and polymyositis. Moreover, in selected cases of dermatomyositis or polymyositis, treatment with sulfadiazine, pyrimethamine, and folinic acid may be a valuable alternative to the use of steroids and immunosuppressive agents.
Arch Dermatol 1979 Jun
PMID:Toxoplasmosis appearing to be dermatomyositis. 45 79

Dermatomyositis and polymyositis are diseases which must be carefully defined in each patient. Criteria such as those suggested by Bohan and Peter will help define the disease and exclude other possible causes of myositis. Immunological factors are probably involved in the pathogenesis of the disease, although varied types of injury may manifest in clinically similar disease. Dermatomyositis, not polymyositis, is related to internal malignancy in adults; however, an extensive malignancy evaluation is not indicated. Therapy with corticosteroids will improve the quality of life, will prevent contractures and calcinosis and may improve the chance of survival. In cases where steroids are ineffective, immunosuppressives may be helpful.
Int J Dermatol
PMID:Dermatomyositis. 48 7

A woman had the typical clinical, cutaneous, and muscular picture of dermatomyositis but without some of the biochemical alterations of that disease. The positive serological investigations for toxoplasmosis, the pressure in muscles of very numerous toxoplasms and their culture in mice, and the improvement after treatment with pyrimethamine and sulphametoxypyridine demonstrated that the signs of dermatomyositis had been caused by infection with toxoplasmosis.
Br J Dermatol 1979 Nov
PMID:Dermatomyositis-like syndrome due to toxoplasma. 51 29

Lymphocyte cytotoxicity for target cells is a method for evaluating specific lymphocyte stimulation. In vitro lymphocytotoxicity has been demonstrated in chronic ulcerative colitis and granulomatous colitis, polymyositis and dermatomyositis, systemic scleroderma, recurrent aphthous stomatitis, and periodontal disease. We have investigated lymphocytotoxicity in 36 patients with various oral inflammatory diseases using an automated cell-counting system. This investigation demonstrated in vitro lymphocytotoxicity for gingival epithelial target cells by aggressor lymphocytes harvested from patients with recurrent aphthous stomatitis and periodontal disease. This effect was not seen when the lymphocytes were harvested from normal subjects or from patients with other oral mucosal inflammatory diseases. The automated cell-counting system corresponded very well with the assay technique of exclusion of supravital dye.
J Invest Dermatol 1976 Nov
PMID:Lymphocyte-epithelial cell interactions in oral mucosal inflammatory diseases. 97 90


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