Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011633 (dermatomyositis)
 4,181 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Transcobalamin II (TC II) is a serum protein responsible for transporting vitamin B12 to the cells. A previous observation of a child with congenital TC II deficiency and agammaglobulinemia suggested that this protein plays an important role in the immune response. Accordingly, TC II levels ere determined in 32 patients with autoimmune disease (AID) (i.e. 26 with lupus erythematosus, 4 with dermatomyositis, and 2 with autoimmune hemolytic anemia) and in 40 patients with acquired immunodeficiency due to chemotherapy. It was found that elevated TC II levels corresponded to active phases of AID. Changes in TC II levels correlated better with the clinical course of AID than complement, antinuclear antibody or native DNA binding capacity. This suggests that TC II could be a valuable parameter in following up activity of AID.
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PMID:[Increase of unsaturated transcobalamine II in autoimmune diseases; effect of immunosuppressive therapy (proceedings)]. 69 99

An unusual type of prostatic carcinoma associated with crossed renal ectopia and dermatomyositis is reported in a young man. Infiltration by an epithelial tumor filled the enlarged prostate with soft papillary masses. Cystoprostatectomy and removal of a single large pelvic lymph node metastasis were done. Histologically, the tumor resembled endometrial carcinoma and may have arisen from paramesonephric tissue in the prostate. Large amounts of immunoglobulins were found in the tumor tissue. The patient has survived for more than 5 years, although a slow growing urethral recurrence has been noted.
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PMID:Probable endometrial carcinoma of the prostate, crossed renal ectopia and dermatomyositis in a 32-year-old man. 70 78

Seven young adults, six of whom were male, all suffering from dermatomyositis unassociated with malignancy are described. These patients were not adequately controlled with high doses of corticosteroids but all responded when immunosuppressive therapy was also given.
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PMID:Dermatomyositis: observations on the use of immunosuppressive therapy and review of literature. Cairo--Glasgow study group. 73 82

Familial frequency of malignant neoplasms from 20 children with dermatomyositis was investigated and compared with 225 controls. Eight patients with dermatomyositis (40 per cent) had nine family members with a malignant tumour; this frequency is significantly higher than those found in the controls with juvenile rheumatoid arthritis (P less than 0.01), neoplasms (P less than 0.01), and a variety of diseases (P less than 0.05). This finding and the known association of neoplasm-dermatomyositis might suggest an hereditary predisposing factor, possibly a subtle inmune deficiency, common for tumours and dermatomyositis.
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PMID:[Familial neoplasms and childhood dermatomyositis]. 74 11

Determination in peripheral blood T and B lymphocytes performed in progressive systemic scleroderma (8 patients); dermatomyositis (5 patients); and inflammatory or mesenchymal scleroderma ('mixed' connective tissue disease) (5 patients) demonstrated a marked increase in peripheral B cells with T cell depression in patients with mesenchymal scleroderma. Patients with progressive systemic scleroderma and dermatomyositis demonstrated also a peripheral T depression, but no consistent changes in B cell population were found. The clear relationship between a B lymphocyte increase and elevated immunoglobulins, antinuclear and antiribonucleoprotein antibody and positive direct immunofluorescence of skin (basal membrane and blood vessels) defines inflammatory or mesenchymal scleroderma in which a disturbance in humoral immunity is involved. B lymphocyte determination can help to measure these changes in immunoreactivity.
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PMID:Peripheral blood lymphocyte distribution in scleroderma. 77 15

The biosynthesis of collagen was studied in skin of healthy subjects and patients with progressive sclerodermia and dermatomyositis. The incorporatione of radioactive precursors (14C-proline), the rate of so-called collage-like-protein in sera, and the excretion of hydroxyprolin in urine depended on the severity of the dermatomyositis in progressive sclerodermia.
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PMID:[Metabolism of collagen in progressive scleroderma and dermatomyositis]. 78 83

Eight cases of dermatomyositis in children admitted to Scottish hospitals between 1962 and 1972 have been reviewed. 6 of the 8 were currently in complete remission. In the other 2 cases the disease remained active in 1 and 1 had died of cardiac failure 6 years after the onset of disease. 5 had developed extensive soft tissue calcification for which 2 were treated with ethanehydroxydiphosphonate, one showing definite improvement and the other no change. All had been treated with corticosteroids and two in addition had had cytotoxic agents (methotrexate or cyclophosphamide). The overal prognosis had probably been improved by the use of corticosteroids but not by the cytotoxic drugs. Only one of the patients was incapacitated by residual contractures or calcinosis.
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PMID:Dermatomyositis in childhood. Review of eight cases. 82 85

The mitochondrial anomalies observed in the skeletal muscle of a patient with dermatomyositis included paracrystalline inclusions, dense bodies and stacks of lamellae. Virions were not found. These anomalies are similar to those noted in other myopathies.
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PMID:Dermatomyositis: ultrastructure of abnormal mitochondria in the skeletal muscle. 83 1

Dermatomyositis is a disease of unknown etiology characterized by muscle weakness and associated with a variety of cutaneous lesions. There appears to be an increased incidence of malignancy among patients with dermatomyositis. The association is estimated at about 20 percent.
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PMID:Dermatomyositis and Malignancy. 83 25

The electron microscopic changes in a muscle biopsy from a child with the clinical picture of acute dermatomyositis are described. Skin and muscle tissue examined by light microscopy did not revealed vascular alterations. Degeneration of isolated muscle fibers was detected with complete loss of myofilaments and disintegration of the Z-band material. Muscle arteries and veins were free of thrombi, but striking ultrastructural changes were seen in the smallest blood vessels in the muscle. These consisted mainly of vascular occlusion due to necrotic cells mixed with degenerated platelets. Dissoluted endothelial cells and denuded basement membrane were usually seen in the wall of the occluded capillaries. Cytoplasmic tubular particles were present in otherwise unaltered endothelial cells. The possibility that the capillary lesions are related to an acute immunological injury is mentioned.
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PMID:Small blood vessel involvement in childhood dermatomyositis. An ultrastructural study of a case. 83 68


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