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Query: UMLS:C0011633 (dermatomyositis)
 4,181 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Childhood polymyositis is generally believed to exhibit specific characteristics including involvement of multiple systems, absence of malignancies, severe outcome, cortico-resistance, perforations of the bowel, and inflammatory vasculitis. On the basis of our experience with 23 cases and a review of the literature, we divide childhood polymyositis into five groups: 1) Severe acute dermatomyositis (11 cases) that fits the description above; 2) subacute or chronic polymyositis (4 cases) that resembles the chronic forms seen in adults; 3) infantile polymyositis (3 cases) whose inflammatory origin has not been proved and whose cause may be dystrophic; 4) inclusion polymyositis (2 cases) that are identical with adulthood inclusion myositis; 5) segmentary polymyositis (3 cases). Thus, in children as in adults, polymyositis remains an obscure disease and is a syndrome rather than an entity.
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PMID:[Anatomoclinical expressions of polymyositis in the child. 23 cases]. 274 7

Cases of polymyositis or dermatomyositis in which levels of all the serum muscle enzymes are within the normal range throughout the entire clinical course are very rare. It has recently been suggested that when there is no increase in creatine kinase the prognosis in dermatomyositis is poor and there is a higher incidence of malignancy and interstitial lung disease associated with the condition. We describe a rare case of dermatomyositis without increase in serum muscle enzymes, including creatine kinase. No evidence of malignancy or interstitial lung disease was found after a followup of 18 months. In accordance with the report of a similar case, we suggest that the absence of an increase in creatine kinase in dermatomyositis is not necessarily a poor prognostic sign.
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PMID:[Dermatomyositis associated with normal serum muscle enzyme levels]. 274 49

The aim of dermatologic check-up is the early diagnosis of asymptomatic potentially dangerous skin changes. An early melanoma may be cured by simple excision. Dermatologic signs in general medicine are very important. Paraneoplastic symptoms in patients with glucagonoma consist of the typical necrolytic migratory erythema. Acrokeratosis Bazex is seen in patients with larynx carcinoma and dermatomyositis or acanthosis nigricans may occur in patients with internal malignancy. Spider angioma, jaundice, changes in hair pattern and white nails may be cutaneous signs of liver disease or necrobiosis lipoidica may be found in diabetic patients. Renal transplants and patients with HIV infection should be submitted for a dermatological check-up every six months. In these people several malignant tumors are seen more often than in control people.
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PMID:[The dermatologic check-up]. 275 9

A retrospective study, paying particular attention to the clinical and evolutive aspects of the disease, was performed on 44 subjects affected by polymyositis/dermatomyositis (PM/DM) and hospitalized at the Institute of Medical Clinics of the 1st School of Medicine of Naples University. On the basis of the different clinical pictures, the cases were classified into the following groups: primary PM (4); primary DM (19); DM/PM associated with malignancy (6); childhood DM/PM (3); PM/DM associated with connective tissue disorders (12). Diagnosis was established in terms of the following criteria: a) symmetrical and mostly proximal bilateral muscle weakness (100%); b) elevation of serum enzymes (86.3%); c) electromyographic findings of myopathy sometimes with fibrillation potentials, increased insertional irritability and pseudo-myotonic discharges (93.1%); d) muscle biopsy changes compatible with a clinical form of polymyositis (83.3% out of 30 cases); e) dermatological manifestations including particularly pink or lilac edema-erythema over the periorbital areas, wine-red maculae, Gottron's sign, "poikiloderma vasculare atrophicans", telangiectasias and skin vasculitis (86.3%). An involvement of the extraneural apparatus and organs was present in 40 patients; the most damaged was the osteoarticular apparatus, followed by esophagus, lung, heart and kidney; such pathology was rarely present in the childhood form. A follow-up of the disease has been performed in 36 cases and the therapy consisted fundamentally of high dose corticosteroids (mostly prednisone), associated, in a minority of cases, with methotrexate. A clinical improvement was observed in most cases and a remission of the disease in part of the latter. However, a worsening of the illness was noticed only in the patients suffering from PM/DM associated with malignancy, and mortality rate was 11.1% in all.
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PMID:[Clinico-developmental aspects in 44 cases of polymyositis/dermatomyositis]. 278 12

We present the case of a 56-year-old woman with proven dermatomyositis associated with an adenocarcinoma of the gallbladder. The association of dermatomyositis-polymyositis and cancer has been known for many years but is still controverted. The search for a malignancy in a patient with DM-PM should not be systematic but guided by abnormal history, physical examination and laboratory results.
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PMID:[The association of dermatomyositis with cancer: myth or reality?]. 279 32

Utilizing case-control methods, we surveyed 322 persons who experienced the onset of polymyositis-dermatomyositis (PM-DM) during calendar years 1985 and 1986, in an effort both to test specific hypotheses, and to generate new hypotheses regarding antecedent risk associations for the disease. Data obtained by recall of events during the 12 months before disease onset in cases, and an identical time period in sex matched sibling controls, suggest that important questions for further study include the roles of antecedent heavy muscular exertion and emotional stress as risk factors for PM-DM. Furthermore, it appears that vaccinations, toxic exposures and symptoms of allergic phenomena, throat infection, and upper respiratory infection are either neutral or are negatively associated with risk of PM-DM, findings which also raise important new etiologic questions, or perhaps lay old ones to rest. Malignancy was infrequently noted.
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PMID:Predisposing factors in polymyositis-dermatomyositis: results of a nationwide survey. 281 Feb 79

A case of gastric carcinoma associated with dermatomyositis is reported. Total gastrectomy was performed and subsequently excision of hepatic metastasis. Although the cause-effect relationship between dermatomyositis and internal malignancy remains controversial, the obvious dependence of the clinical course of dermatomyositis on that of the gastric carcinoma in this case suggests a causal involvement.
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PMID:Gastric carcinoma associated with dermatomyositis. Case report. 281 24

The paraneoplastic disorders of the nervous system are clinicopathologic syndromes that occur in association with systemic cancer. Dysfunction of any part of the nervous system or its effector organs may be produced by a paraneoplastic process. The temporal relationship between the onset of a paraneoplastic syndrome and the diagnosis of the associate cancer varies. Most of the paraneoplastic syndromes of the nervous system may appear months to years before the cancer is discovered. The pathogenesis of most of the paraneoplastic syndromes of the nervous system is unknown and specific, effective therapy is lacking. With rare exceptions, treatment of the associated cancer seldom alters the course of patients with these syndromes. However, in other paraneoplastic syndromes such as myasthenia gravis, myasthenic syndrome of Eaton-Lambert and polymyositis-dermatomyositis an autoimmune pathogenesis is established or strongly suspected.
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PMID:Paraneoplastic syndromes of the nervous system. 299 71

Serum muscle enzyme levels are usually elevated in patients with untreated polymyositis and dermatomyositis. Creatine kinase is the muscle enzyme most often used to diagnose inflammatory myopathies. Seven patients with dermatomyositis and normal creatine kinase levels are described. Five of the seven patients had either an associated malignancy or severe interstitial lung disease. The one-year survival of the six patients followed for that length of time was 33 percent. A lack of creatine kinase elevation in patients with dermatomyositis is a poor prognostic sign.
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PMID:Dermatomyositis without creatine kinase elevation. A poor prognostic sign. 300 9

In the early stage of internal malignancies, it is important to detect the relation between the malignancy and accompanying skin lesions. Skin lesions are commonly classified according to their origin as follows; skin lesions induced by internal malignancies, skin lesions as a part of a syndrome, nonspecific lesions and complications of internal malignancies, but with an unknown relationship so-called Bowen's disease, and Paget's disease. These skin lesions consist of various kinds and are multiple. Commonly, the disease which is detected seems to be an immunological reaction to internal malignancy; malignant acathosis nigricans, and dermatomyositis are examples in point. A description of internal malignancies and skin lesions is presented, including those which are most commonly encountered together with a description of such cases experienced at the National Cancer Center Hospital.
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PMID:[Internal malignancies and skin lesions]. 301 97


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