Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0011570 (
depression
)
172,036
document(s) hit in 31,850,051 MEDLINE articles (0.07 seconds)
.
Concepts found in the documents ranked by [
Frequency
|
Pointwise Mutual Information
|
Symmetric Conditional Probability
] .
Human Gene/Protein
Sep
10427
Mol
2553
CA1
1979
brain-derived neurotrophic factor
1735
GABA
1617
insulin
1409
Gen
1216
cytokine
1179
NMDA receptor
1095
ATP
935
MRI
888
5-hydroxytryptamine
845
serotonin transporter
784
olfactory
761
gut
754
beta-endorphin
752
IL-6
735
lipopolysaccharide
682
ICD
680
CA3
665
tumor necrosis factor
647
CO2
635
She
632
TNF
630
Pol
602
prolactin
561
interferon
538
reserved
530
5-HT1A
526
metabotropic glutamate receptor
519
hemoglobin
511
glucocorticoid receptor
486
SCL
486
5-HTTLPR
464
ATPase
456
opioid receptor
456
Men
455
APA
440
ACTH
435
ANOVA
433
REM
432
C-reactive protein
425
glutamate receptor
419
CD4
410
superoxide dismutase
393
interleukin-6
389
growth hormone
372
corticotropin-releasing factor
369
albumin
367
AMP
354
ADHD
352
San
352
nitric oxide synthase
351
axonal
348
calcium channel
345
substance P
344
HPA
344
vasopressin
338
cage
336
catalase
332
oxytocin
331
MDD
320
CSF
311
acetylcholinesterase
306
short form
302
IFN
296
CBT
282
5-HT2A
277
IL-10
276
ionotropic
264
lymphoid
261
thymus
253
CGI
251
GSH
251
neurotrophic factor
250
amyloid precursor protein
244
tyrosine hydroxylase
244
LPS
244
leptin
241
thyroid hormone
240
calmodulin
238
CB1
237
GDS
236
neurotrophin
233
phosphodiesterase
233
MAO-A
232
CRH
228
Mot
222
collagen
221
renin
219
somatostatin
219
GAD
215
cytochrome P450
214
microsomal
214
anonymous
209
CREB
206
endoplasmic reticulum
206
ADP
205
ACS
204
serotonin receptor
199
mTOR
199
neuropeptide Y
198
creatine kinase
195
GABA(A) receptor
193
NR2B
192
NMR
184
alkaline phosphatase
181
Brain-derived neurotrophic factor
181
glucagon
181
adenylate cyclase
179
caspase-3
178
ERK1
177
adrenocorticotropic hormone
177
ASA
176
PHA
176
ERK
176
glial fibrillary acidic protein
176
MAC
173
B12
173
HDL
168
MAPK
168
inducible nitric oxide synthase
167
IL-1
167
glutathione peroxidase
167
Mem
166
TNF-alpha
165
Met
165
PSD-95
163
dopamine transporter
163
phosphatase
162
IL-2
161
angiotensin II
160
serum albumin
160
histone
158
TRH
158
RDC
154
cannabinoid receptor
153
IgA
152
cytochrome P-450
151
tryptophan hydroxylase
149
nodal
149
muscarinic receptor
148
adenylyl cyclase
147
Mal
147
p38
146
nerve growth factor
143
MAO-B
143
CD8
143
parvalbumin
142
calcitonin
141
c-fos
141
orexin
139
Mil
139
mGluR5
138
lactate dehydrogenase
138
thyrotropin-releasing hormone
138
calcineurin
137
interleukin-2
137
galanin
137
Aplysia
137
more...
Disease
depression
172036
major depressive disorder
11171
schizophrenia
5441
cancer
5009
mental illness
4679
suicide
4492
posttraumatic stress disorder
4321
anxiety disorders
4276
dementia
4256
psychosis
3715
diabetes
3586
Alzheimer's disease
3460
cognitive impairment
3289
stroke
3192
Parkinson's disease
3187
bipolar disorder
2864
hypertension
2633
HIV
2541
obesity
2352
epilepsy
2332
chronic pain
2254
ischemia
2069
mania
2043
psychological distress
1997
aggression
1861
violence
1856
AIDS
1856
affective disorder
1831
coronary artery disease
1726
myocardial infarction
1701
addiction
1608
substance abuse
1593
migraine
1580
obsessive-compulsive disorder
1529
substance use
1481
alcoholism
1454
myocardial ischemia
1438
suicide attempts
1424
cardiovascular disease
1406
anhedonia
1337
tumor
1309
autism
1265
postpartum depression
1262
neuroticism
1249
clinical depression
1223
multiple sclerosis
1172
sleep disturbances
1138
heart failure
1115
emotional distress
1102
panic disorder
1069
breast cancer
1014
CES
950
sleep disorders
946
confusion
923
delusions
903
hallucinations
830
rumination
830
asthma
826
ADHD
800
fibromyalgia
792
alcohol abuse
782
dysthymia
761
coronary heart disease
735
sexual abuse
727
cold
702
chronic disease
686
type 2 diabetes
684
chronic obstructive pulmonary disease
684
ICD
681
unipolar depression
678
heart disease
669
major depressive episode
659
anemia
643
HAM
637
delirium
636
drug abuse
622
acute myocardial infarction
619
sexual dysfunction
618
psychological stress
614
rheumatoid arthritis
605
eating disorder
604
malnutrition
594
arthritis
566
fits
564
sepsis
559
social phobia
553
osteoporosis
550
dysphoria
549
anorexia nervosa
536
parkinsonism
521
bipolar depression
516
sepsis
515
personality disorder
498
memory impairment
497
drug addiction
495
pruritus
494
borderline personality disorder
492
binge eating
488
irritable bowel syndrome
476
GAD
464
Syndrome
460
substance use disorders
446
panic attacks
440
West
435
Huntington's disease
431
coma
429
psychiatric diagnosis
428
metabolic syndrome
426
LTD
423
atherosclerosis
423
melancholia
416
immunodeficiency
408
SAD
407
hypothyroidism
400
Brown
400
hypomania
398
disinhibition
396
bulimia nervosa
392
renal disease
379
congestive heart failure
379
hypochondriasis
367
incontinence
366
systemic lupus erythematosus
365
sleep apnea
364
ECT
357
SEM
354
Abuse
349
HPA
344
chronic fatigue syndrome
344
infectious diseases
344
osteoarthritis
343
agoraphobia
335
abortion
332
conduct disorder
330
erectile dysfunction
325
psoriasis
325
obstructive sleep apnea
325
Depressive disorders
324
child abuse
323
xerostomia
322
emotionality
320
carcinoma
315
social stress
312
Autism
311
cerebral ischemia
309
hepatitis C
304
tetanus
303
infertility
299
encephalopathy
298
hyperglycemia
296
phobia
288
renal failure
288
adjustment disorder
280
hypoglycemia
279
paranoia
279
psychopathy
277
cardiomyopathy
276
Disorder
271
dehydration
267
chronic renal failure
265
more...
Symptom
pain
9782
fatigue
4534
anesthesia
2924
seizures
2525
insomnia
2436
headache
2124
angina
2079
analgesia
1651
Depressive symptoms
1424
sleepiness
1296
nausea
1264
stigma
1220
agitation
1130
anorexia
1125
hopelessness
1118
discomfort
995
vomiting
958
apathy
943
chest pain
879
diarrhea
768
weakness
710
dyspnea
692
tremor
668
discomfort
628
dizziness
616
constipation
586
despair
577
overweight
558
hypothermia
486
ataxia
453
alexithymia
443
exhaustion
417
acute stress
404
low back pain
380
nausea and vomiting
377
lethargy
352
hypercapnia
350
abdominal pain
340
back pain
333
tinnitus
327
cough
322
dystonia
285
memory loss
250
collapse
243
functional recovery
241
spasm
210
spasticity
206
hypersomnia
195
distraction
189
vertigo
187
myalgia
180
acute pain
173
cancer pain
167
arthralgia
166
bradykinesia
166
respiratory distress
163
starvation
160
hunger
155
Ill
150
asthenia
149
exertional angina
140
cachexia
131
hot flushes
129
syncope
117
menopausal symptoms
111
shortness of breath
108
hyperoxia
107
hot flashes
105
numbness
105
thinning
104
myoclonus
103
decreased appetite
103
Sedation
102
catatonia
102
Psychiatric symptoms
99
paresthesia
98
snoring
95
dysarthria
88
personality change
88
pelvic pain
87
facial pain
86
chronic back pain
84
tachypnea
81
forgetfulness
81
polyuria
76
paresis
76
colic
76
bloating
75
chorea
73
erythema
73
neck pain
72
hypotonia
71
incoordination
71
Neuropathic pain
69
flushing
64
twitching
64
motor symptom
64
Poor sleep
63
polydipsia
63
enuresis
62
physical appearance
61
splenomegaly
61
blurred vision
56
mental fatigue
53
muscle rigidity
53
cerebellar ataxia
53
hemiplegia
52
physical symptom
51
tense
51
cyanosis
51
nasal discharge
49
emaciation
48
anosmia
48
chills
47
hypocapnia
46
bewilderment
46
tingling
45
torticollis
45
lassitude
45
Postoperative pain
44
eds
44
tonic-clonic seizure
43
acidity
42
pallor
42
night sweats
41
bone pain
41
neuralgia
40
orofacial pain
40
photophobia
39
shoulder pain
39
hepatomegaly
39
regurgitation
38
asynergy
38
atypical chest pain
33
feeling depressed
33
heartburn
33
body pain
33
ENT
32
lightheadedness
32
Anoxia
32
elevated mood
31
wheezing
29
exertional dyspnea
29
blepharospasm
29
clonus
28
leg pain
27
excessive sweating
27
dysuria
27
knee pain
26
hypertonia
25
Extrapyramidal symptoms
25
stomach pain
24
limb pain
24
dry eye
24
abnormal gait
24
auditory hallucination
24
muscle stiffness
24
Excitability
24
Involuntary Movement
23
hyperacusis
23
more...
Drug
Spectrum
1289
Cardiovasc
748
Dermatol
456
Portal
442
caffeine
422
nitroglycerin
383
CSF
333
Check
279
Monit
202
Nephron
184
Ethanol
170
IL-2
162
lysine
161
Fentanyl
140
Asthma
135
Frontal
135
MAP
128
vitamin E
121
Escitalopram
119
Propofol
118
Leaf
118
ROC
112
Domperidone
111
Clonidine
104
NADH
104
Duloxetine
95
ascorbate
95
Mirtazapine
91
Spectrum
89
Atropine
86
ENT
85
IFN-gamma
84
Dial
84
lactose
78
Alliance
76
Agomelatine
75
PCP
74
CTX
73
EE2
73
TMS
72
DMI
62
CaCl2
62
ICI
61
Moclobemide
61
Prozac
60
Indomethacin
58
Histamine
56
CaCl2
55
CaCl2
55
Ringer's solution
53
CAM
52
niacin
51
Reboxetine
51
DBS
51
EPA
50
Diurnal
50
ROS
50
Retinoic acid
49
Reserpine
49
9-THC
48
Tianeptine
47
Bupivacaine
45
DEX
44
OIF
42
Isotretinoin
42
Phenytoin
40
p75
40
Modafinil
39
CFS
38
Bifidobacterium
38
DHT
35
DHT
35
Gabapentin
34
Ouabain
34
MDS
34
Nephron
32
Mutagen
32
Adriamycin
31
citric acid
31
Growth hormone
30
Growth hormone
30
Pramipexole
29
TAT
29
ABC
28
Angiotensin II
27
Apomorphine
27
BH4
27
Anafranil
27
Forskolin
26
Hyperforin
26
Sulpiride
26
Monensin
26
Scopolamine
26
Rimonabant
26
CDP
26
Vitamin B12
25
Fraction
25
Horizon
25
MRC
25
Pramipexole
25
PTH
25
Vitamin A
25
EPI
24
ADM
24
ALA
24
Theophylline
24
Atenolol
24
HCH
24
Ginseng
24
Norplant
24
Glucagon
23
Glutathione
23
Triad
23
MgSO4
23
Kenyan
23
DFP
23
Phentolamine
23
Vitamin E
22
pyridoxal phosphate
22
Triad
22
Estrogens
21
Gel
21
THF
20
Award
20
Anafranil
20
ACT
20
NVP
19
APD
19
Hypaque
19
NH3
19
Thiopentone
18
Zoloft
18
ampicillin
18
Pregabalin
18
Narcan
18
Butorphanol
17
Tubocurarine
17
FAD
17
Hypaque
17
IL-1ra
17
Norplant
17
Asn
16
DPA
16
Cimetidine
16
Ludiomil
15
Cimetidine
15
Captopril
15
G-CSF
15
IFN-beta
15
HCG
15
Ranitidine
15
Doxapram
15
CTX
14
Ritalin
14
Vitamin B
14
Parkin
14
CPR
14
Donepezil
14
Flunitrazepam
14
Ludiomil
14
more...
Enzyme
monoamine oxidase
917
protein kinase
775
mitogen-activated protein kinase
577
acetylcholinesterase
552
ATPase
496
superoxide dismutase
459
ERK
456
protein kinase C
446
catalase
379
cholinesterase
329
creatine kinase
272
tyrosine hydroxylase
237
phosphodiesterase
233
calcineurin
225
renin
219
ACS
206
alanine aminotransferase
204
adenylate cyclase
198
aspartate aminotransferase
193
alkaline phosphatase
181
focal adhesion kinase
173
NO synthase
171
glutathione peroxidase
168
lactate dehydrogenase
164
tryptophan hydroxylase
149
caspase-3
147
phospholipase C
141
peroxidase
139
ACE
130
CaMKII
125
GSK
118
AOR
115
indoleamine 2,3-dioxygenase
111
NOS
104
AMPK
99
guanylate cyclase
85
cytochrome oxidase
81
phospholipase A2
80
xanthine oxidase
78
CFI
76
luciferase
75
lysozyme
75
PCP
74
thrombin
74
proteasome
74
glutathione reductase
74
P-glycoprotein
71
reverse transcriptase
71
gamma-glutamyl transpeptidase
70
demethylase
66
CPT
65
glutathione S-transferase
65
AMP-activated protein kinase
65
trypsin
65
CAD
65
CAD
64
CAD
64
MAP
62
MEK
61
DAT
60
BIS
60
AST
59
CPT
58
CPT
57
succinate dehydrogenase
57
complex I
54
lipase
53
lipoprotein lipase
53
adenosine deaminase
48
adenosine deaminase
48
acid phosphatase
47
choline acetyltransferase
47
caspase-1
47
CYP3A4
47
MCS
45
alcohol dehydrogenase
44
PKG
44
ceruloplasmin
43
tissue plasminogen activator
43
glucose-6-phosphate dehydrogenase
43
monoacylglycerol lipase
42
thromboplastin
40
heme oxygenase
40
NADPH oxidase
38
NADPH oxidase
37
lipoxygenase
37
neuraminidase
36
CPR
36
diaphorase
36
glutamine synthetase
35
pyruvate dehydrogenase
34
plasmin
34
carbonic anhydrase
34
collagenase
33
pyruvate kinase
32
ornithine decarboxylase
31
APC
31
aldehyde dehydrogenase
31
phosphatidylinositol 3-kinase
30
TMT
29
TAT
29
aryl hydrocarbon hydroxylase
28
RNA polymerase
27
pyruvate dehydrogenase
27
pyruvate dehydrogenase
27
alpha-glucosidase
27
PDE
26
phosphoinositide 3-kinase
26
invertase
26
thyroid peroxidase
26
RNase
26
hexokinase
26
urokinase-type plasminogen activator
26
phosphorylase
25
beta-glucuronidase
25
chymotrypsin
24
AMPK
24
phosphofructokinase
24
GAS
24
alpha-amylase
24
citrate synthase
23
SPT
23
glyceraldehyde-3-phosphate dehydrogenase
23
arginase
23
RNase
23
lactase
22
glutamate dehydrogenase
22
DNA polymerase
22
ATP synthase
22
glutamate dehydrogenase
22
SPT
22
prostaglandin synthetase
22
CD10
22
acetyl-CoA carboxylase
21
glutamate dehydrogenase
21
PST
21
pepsin
21
HSD
21
glyceraldehyde-3-phosphate dehydrogenase
21
protein phosphatase 2A
21
BMT
21
aldehyde dehydrogenase
21
N-acetyltransferase
20
malate dehydrogenase
20
dopamine beta-hydroxylase
20
myosin ATPase
20
prolyl endopeptidase
19
glucose-6-phosphatase
19
aldehyde dehydrogenase
19
aldehyde dehydrogenase
19
botulinum neurotoxin
19
aldehyde dehydrogenase
19
elastase
18
GABA transaminase
18
5'-nucleotidase
18
5alpha-reductase
18
5alpha-reductase
18
NQO1
18
glyceraldehyde-3-phosphate dehydrogenase
18
MDP
18
more...
Compound
Clin
12553
Dec
11648
calcium
4214
DSM
4182
oxygen
3059
water
3007
glutamate
2860
5-HT
2717
glucose
2269
Cardiol
2057
sodium
2011
DNA
1655
GABA
1654
GABA
1630
ethanol
1612
noradrenaline
1369
potassium
1183
NMDA
1073
CO2
1055
CES
950
ATP
936
tryptophan
901
AMPA
884
tryptophan
882
nitric oxide
882
tryptophan
856
tryptophan
856
acetate
638
TNF
630
phosphate
604
gamma-aminobutyric acid
595
cAMP
543
arginine
528
iron
485
zinc
484
sulfate
481
nitrogen
465
ACTH
451
methionine
450
tyrosine
440
His
435
caffeine
426
LTD
424
AMP
375
salt
351
hydrogen
350
creatinine
344
Ketamine
343
Cereb
338
Malondialdehyde
337
urea
330
Mg2+
305
TSH
295
Phe
278
Morphine
275
leucine
272
vitamin D
270
GSH
265
GSH
265
hydroxyindoleacetic acid
259
copper
257
Dopamine
256
Lithium
253
cGMP
252
Naloxone
251
serine
246
carbonate
244
nitrate
244
ADP
236
Cortisol
229
ASA
228
EPSP
226
lysine
221
alanine
214
glutamine
213
galactose
210
ADP
208
ADP
205
ACS
205
ACS
204
L-DOPA
200
Neuronal
195
ammonia
194
Imipramine
190
N2O
190
Imipramine
189
Glutamate
188
ACh
187
Adenosine
187
TRH
183
HCl
180
Diazepam
180
Nicotine
180
Dexamethasone
180
threonine
178
phosphorus
176
glycerol
169
5-hydroxytryptophan
167
Venlafaxine
167
iodine
167
Insulin
163
cysteine
159
acetic acid
159
Sertraline
154
Paroxetine
152
ammonium
148
Melatonin
148
Norepinephrine
147
Gly
146
cadmium
145
Hearts
144
PEG
144
Thyroid
143
propionic acid
142
propionic acid
142
Adrenal
141
SDS
140
silver
139
homocysteine
139
Estrogen
138
aspartic acid
138
bromide
137
Bupropion
136
DHA
135
6-12
134
aldosterone
133
Halothane
131
DBA
131
manganese
131
Pac
130
5-HIAA
130
Propofol
130
NH2
128
Cocaine
128
Asp
122
Citalopram
119
Propranolol
119
Optimal
119
methanol
118
DBA
117
DBA
117
Propranolol
115
Verapamil
114
NAD
114
Estrogen
113
Amitriptyline
112
pyridine
111
Verapamil
110
PEG
107
selenium
106
prostacyclin
105
NADH
104
nicotinamide
103
Nifedipine
102
cyanide
102
isoxazole
100
proline
99
H2O2
98
dicarboxylic acid
98
cobalt
97
more...