Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0011570 (
depression
)
172,036
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
More than 300 million people are suffering from
depression
, one of the civilization diseases in the 21st century. Serotonin 5-HT
1A
R and dopamine D
2
R play an important role in the treatment and pathogenesis of
depression
. Moreover, in recent years, the efficacy of dual 5-HT
1A
/D
2
receptors ligands has been demonstrated in the fight against
depression
. In this work the new bulky arylpiperazine derivatives (
LCAP
) were synthesized in microwave radiation field. The affinities for the selected serotonin (5-HT
1A
,5-HT
2A
,5-HT
6
,5-HT
7
) and dopamine (D
2
) receptors have been evaluated in vitro. Compounds 5.3a, 5.4, 5.1c, 5.3d, 5.2a are promising dual 5-HT
1A
R/D
2
R ligands. The SAR analysis were additionally supported with molecular docking studies.
...
PMID:New dual ligands for the D
2
and 5-HT
1A
receptors from the group of 1,8-naphthyl derivatives of LCAP. 3125 32
