Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twenty-six men and women, aged 36-65 years, were studied 8-12 weeks after the first myocardial infarction with regard to silent ischemic ST-segment depression and heart rate by using 24-hour ambulatory electrocardiography and bicycle exercise testing. In 22 patients ambulatory ST-segment recordings revealed 81 episodes of ST-segment depression, including 34 (41.9%) painful and 47 (58.1%) painless episodes. Mean maximal ST-segment depression during symptomatic and asymptomatic episodes was 3.6 +/- 1.0 mm and 2.4 +/- 1.1 mm, respectively (p less than 0.02). Painless episodes most frequently occurred between 06.00 a.m. and 12.00 a.m. Ambulatory monitoring revealed a twofold increase in painful episodes at heart rate below 100 beats/min, whereas at heart rate above 125/min painless episodes were more frequent. Exercise testing showed a sevenfold increased incidence of ST-segment depression also at heart rate above 125 beats/min. In conclusion, silent myocardial ischemia is a frequent event in patients shortly after the first myocardial infarction, and painless episodes occur particularly frequently at high heart rates. Episodes of silent ischemia are found more frequently during ambulatory ECG monitoring than exercise testing. Studies on silent myocardial ischemia may be particularly relevant in the detection of the risk of myocardial infarction.
Kardiol Pol 1989
PMID:[Silent myocardial ischemia in patients after myocardial infarction]. 263 49

Semen was examined in 150 men patients of the Andrology Clinic for demonstration of Chlamydia trachomatis and for analysis of the effect of this infection on semen quality depression. A correlation was noted between the degree of infection (large number of organisms per field of vision) and such changes as cryptozoospermia, azoospermia, asthenozoospermia, teratozoospermia, oligoasthenozoospermia, asthenoteratozoospermia. Of interest was a high proportion of infection (56%) with Ch. trachomatis in this group.
Ginekol Pol 1989 Jun
PMID:[Morphological semen changes in Chlamydia trachomatis infection]. 263 98

In the present work the authors have tried to offer a vast and detailed summary of theories and questions concerning the role of the MDF in shock. One of the major problems that surrounds this molecule is the myocardial contractility depression, the solution of which could allow a more rationalistic therapeutic approach to that which remains one of the most complex and delicate clinical framework.
Mater Med Pol
PMID:Current concepts on myocardial depressant factor. 269 45

The study aimed at evaluating an effect of a single dose of isosorbide dinitrate (Sorbonit) on the exercise reaction in the patients with coronary disease of various degree and in healthy individuals. The study involved 20 male patients of mean age 54.0 +/- 4.5 years with history of myocardial infarction and 12 healthy males of mean age 45.6 +/- 5.0 years. Ergometric test has been performed twice: prior to and 15 minutes after sublingual administration of isosorbide dinitrate in the dose of 10-15 mg. The first test has been interrupted when horizontal ST load exceeded 1 mm or contractions rate was 60% of the maximum value. Similar loads have been used after the administration of Sorbonit. The following parameters have been evaluated: heart rate (HR), systolic blood pressure (BPS), HR x BPS, lactate level (LA), and cardiac index. The value of the load has been measured with the aid of oxygen consumption (VO2). Significant depression of ST segment (less than 3 mm) in the exercise ECG has been noted in 8 patients following isosorbide dinitrate. Exercise tolerance has increased in these patients - CI increased during exercise following drug administration (VO2 the same as prior to the drug administration), and VO2/CI has became closer - physiological.
Pol Tyg Lek 1989 Feb 06
PMID:[Effect of isosorbide dinitrate (sorbonit) on the exercise reaction in patients with coronary disease and in healthy individuals]. 281 70

The evaluation of neurophysiological markers during imipramine treatment of 60 patients with endogenous depression was made. These markers were evaluated in 2 groups of patients: with cardio-vascular, and with brain circulation disturbances; both groups equal 30 subjects. During thymoleptic treatment of patients with circulation disturbances, elevated level of anxiety and statistically significant lower simple and complex reactivity of central nervous system were found. Such reactivity did not improve during the treatment in this group of patients. The lack of improvement of above mentioned parameters under imipramine may be the factor that elucidates the pathomechanism of chronic course of depression in old age. The improvement of circulation conditions, along with the thymoleptic therapy, should have the crucial importance for the therapeutic effect.
Psychiatr Pol
PMID:[Evaluation of clinical and neurophysiological markers of depressive disorder with symptoms of peripheral and brain circulation disturbance]. 281 30

The exploratory and basal locomotor activities were tested in four groups of Albino-Swiss mice twice, at a 4-5 day interval, to investigate the variability of responses and correlation between the exploratory and basal locomotor activity, and their stability in individual animals. We have found that there exists only a weak correlation between the exploratory and basal locomotor activities. The repetition of tests results in a slight but significant depression of the exploratory, but not of the basal locomotor activity. The correlation between individual performances in two subsequent tests is generally low, regarding both the exploratory and the basal locomotor activity. There are no differences in the density of cerebral alpha 1-adrenoceptors between mice exhibiting extremely different exploratory or basal locomotor activities. The results suggest that preselection of mice for the tests involving locomotor activity in attempt to reduce the variability of results is pointless.
Pol J Pharmacol Pharm
PMID:Stability and variability of locomotor responses of laboratory rodents. I. Native exploratory and basal locomotor activity of Albino-Swiss mice. 283 Jun 6

The effects of the kappa-opioid receptor agonists tifluadom, bremazocine and U-50,488 on locomotor activity (test: toggle-floor box) and memory (test: passive avoidance) were assessed in C57BL/6 (C57) and DB/2 (DBA) mice. The drugs administration resulted in activity depression in both strains, the effect was higher in DBA mice and was enhanced by pretreatment with haloperidol and with muscimol. Memory impairment was observed in DBA mice following posttraining administration of all drugs. This effect was enhanced by immobilization stress and decreased by familiarization with the apparatus. Memory improvement was evident in C57 mice (U-50,488 experiments). In a research carried out with CD1 mice, amygdaloid lesions decreased the memory impairing effect of U-50,488. The results are compared with those previously obtained with mu agonists and, as concerns memory, are discussed in terms of the involvement of emotional factors in mice responses to kappa agonists administration.
Pol J Pharmacol Pharm
PMID:Effects of kappa-opioid receptor agonists on locomotor activity and memory processes in mice. 285 67

The N-cyclopropylmethyl derivative of azidomorphine (CAM) was found to have strong opiate agonist and antagonist activity, in various in vitro and in vivo animal tests. The derivatives of azidomorphine were not only more potent analgesics than the corresponding members of the morphine family but their lipid solubility was also markedly improved: the ratios of the median effective subcutaneous/intracerebroventricular doses are between 6.2-22.0 in the azido-group, while that of morphine is 381. The antagonist potencies of N-cyclopropyl-N-allyl azidomorphine derivatives were also quantitatively estimated in oxymorphone righting test, and were found to possess antagonists activity as potent as naloxone and more potent than other opiate antagonists (nalorphine, pentazocine Mr-1452 etc.). CAM also has been shown to produce depression of acetylcholine release from the cat lateral cerebral ventricle similarly to morphine, in a naloxone reversible manner, regardless the applied stimulus (electrical stimulation of sciatic nerve, or ouabain perfusion). CAM, similarly to bremazocine, the reported kappa opioid agonist drug, markedly increased the urinary output in normally hydrated rats. This effect was reversed by high dose of naloxone, suggesting the kappa agonist action of CAM.
Pol J Pharmacol Pharm
PMID:Azidomorphines and heterogenous opiate receptors. 285 84

Alprazolam, a new benzodiazepine from triazolobenzodiazepine group, produced anxiolytic action in the conflict test with potency similar to that of diazepam. The myorelaxant activity of the drug was relatively weak. Unlike desipramine, alprazolam failed to reduce the immobility of rats in the forced swim test and was unable to prevent clonidine-induced hypothermia. Alprazolam, unlike desipramine, failed also to potentiate behavioral effect of noradrenaline injected into the hippocampus. Alprazolam after acute but not chronic administration antagonized the synchronizing effect of clonidine on EEG pattern. On the other hand, alprazolam similarly to tricyclic antidepressants, prevented the suppression of dominance behavior by clonidine in rats competing for food. The results indicate that alprazolam acts only weakly upon noradrenergic mechanisms related to depression and to antidepressant action of drugs.
Pol J Pharmacol Pharm
PMID:Comparative studies on antidepressant action of alprazolam in different animal models. 288 37

The effects of beta-, and alpha 1-antagonists on the clenbuterol- and clonidine-induced depression of the exploratory activity was measured in rats in the open field test. The ability of clenbuterol (0.5 mg/kg) to reduce exploration was antagonized by 1-propranolol, significantly reduced by rauwolscine and unchanged by corynanthine and prazosin. Clonidine (0.2 mg/kg)-induced hypoactivity was significantly reduced by all the used adrenergic antagonists. A combined treatment with non-sedative doses of clenbuterol and clonidine significantly reduced exploration. Results suggest that both beta- and alpha 2-adrenoceptors are involved in clenbuterol- and clonidine-induced sedation. Moreover, they may indicate the existence of beta- and alpha 2-adrenoceptor interaction.
Pol J Pharmacol Pharm
PMID:Are beta- and alpha 2-adrenoceptors co-regulated during their stimulation? Behavioral studies. 288 38


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