Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aim of this study was to investigate the value of continuous ECG monitoring in early diagnosis of coronary heart disease. 312 patients (59 women, 253 men, aged 20-60 years) with chest pain since 3-6 months were studied. All patients underwent clinical examination, serum lipid determination, exercise ECG test, ambulatory ECG monitoring and coronary angiography. 194 patients had normal or nonsignificant irregularities of coronary arteries, in 118 patients significant atherosclerotic stenoses were found. Sensitivity and specificity of ECG monitoring were: 46 and 54% respectively. Significantly higher frequency of changes and longer duration of depression or elevation of ST segment in patients with significant coronary artery stenosis was found. ST segment changes without angina were observed in 23,7% of patients.
Pol Arch Med Wewn
PMID:[24-hour ECG monitoring by the Holter system in early diagnosis of coronary disease]. 152 54

Multi-infarct dementia (MID) and dementia of the Alzheimer type (DAT) are the main syndromes in the elderly. This study aims at evaluating the possible differentiation of these syndromes on a clinical basis. The patient population consisted of demented patients hospitalized during the period April 1, 1988-September 30, 1990 at the Department of Cerebrovascular Diseases. The study included 40 patients with MID and 25 with DAT. The clinical diagnosis of dementia included medical history, neurological examination, psychiatric interview and laboratory diagnostic investigations. The severity of the dementia symptoms was rated by many rating scales and a battery of neuropsychological tests. This model of clinical procedure permitted for differential diagnosis between vascular and degenerative dementia, according to DSM-III-R criteria. Patients with multi-infarct dementia of the Alzheimer type did not differ significantly with regard to age, mean duration of cognitive impairment and level of education. In the DAT group women outnumbered men, and this was statistically significant. It should be emphasized, that a great majority of patients with cerebrovascular lesions developed early cognitive impairment, that means within the first year after stroke. In the MID group hypertension, heart disease and smoking were statistically more frequent than in the DAT group. For the preliminary evaluation the severity of cognitive impairment was quantified by Mini-Mental State and Dementia Scale. These scales showed that the degree of dementia was significantly greater in DAT patients as compared to MID patients, whereas the severity of depression assessed by Hamilton's Scale was mild and similar in both group.(ABSTRACT TRUNCATED AT 250 WORDS)
Neurol Neurochir Pol
PMID:[Clinical and differential diagnosis of multi-infarct dementia and Alzheimer's disease]. 152 70

The antidepressants have been reported to be effective in the treatment of many pain syndromes, for example headache and neuralgia. The pain of the study was to evaluate the effectiveness on small (75 mg per die) dose of imipramine administered additionally to the routine. Conservative treatment of patients with acute low back pain. The analysis of six different indices of improvement revealed, that the outcome of therapy in the group of 50 patients treated with imipramine was significantly better, than in comparable group treated routinely. The effect of imipramine have not been related to the occurrence of depression or to the other factors from anamnesis and physical examination influencing pain.
Pol Tyg Lek
PMID:[Value of adjuvant treatment with imipramine for lumbosacral pain syndrome]. 166 4

A group of 250 patients with endogenous depression was studied. Amitriptyline proved to be the most effective drug (51% positive responses) followed by noxiptilin (50%), imipramine (42%), dibenzepin (43%). Clomipramine, desipramine, and nomifensine appeared to be the least effective. Demographic or clinical factors such as age, sex, type of affective illness, severity of depressive syndrome or its particular symptoms (depression, fear, anxiety, psychomotor impairment or biological rhythm alteration) did not show any potential for prediction of the treatment outcome. Worse therapeutic results were observed in patients who had already been given antidepressant treatment for the current depressive cycle before the assessment.
Psychiatr Pol
PMID:[Results of using tricyclic antidepressive drugs in the treatment of endogenous depression (comparative analysis of 7 drugs)]. 168 87

Fifteen patients with endogenous unipolar and bipolar depression were treated with imipramine and, if necessary, one of benzodiazepine or neuroleptic. Total serum concentrations of imipramine (IMI) and its active metabolite desipramine (DMI) were measured in steady-state by FPIA method . Severity of depression was assessed using the Hamilton Depression Rating Scale. IMI + DMI serum concentration monitoring appeared to be useful in every case. It helped to arrive more quickly at the optimal dosage, confirmed the suspicion of overdosage or noncompliance. In nonresponders group, it helped with the earlier decision of changing brands of tricyclic antidepressant or it contributed to intensify the diagnostic process which detected the additional pathology.
Psychiatr Pol
PMID:[Clinical usefulness of monitoring serum levels of imipramine and desipramine in patients treated for endogenous depression]. 178 Mar 75

Monitored treatment of a depressed phase of unipolar affective disorder was conducted in 11 female patients receiving imipramine and in 12 females taking amitriptyline. Patients were randomly assigned to one of the drug and in 6 patients the drugs were switched because of the lack of response to the first used compound. In the imipramine treated group a satisfactory response after 4 weeks of management (less than 6 points on Hamilton's depression scale) was observed in 6 patients and in amitriptyline treated group in 5 patients. Patients displaying a satisfactory response to amitryptyline had significantly higher--as compared to remaining patients in the group--plasma levels of the drug after two and four weeks of treatment. Such an association was not observed in patients treated wtih imipramine. Severity of depression and motor retardation before the treatment was similar both in patients with satisfactory and with poor response to imipramine as well as to amitriptyline. However the intensity of anxiety symptoms was higher in patients exhibiting poor response to treatment with amitriptyline and imipramine as well.
Psychiatr Pol
PMID:[Monitoring of the treatment of endogenous depression with imipramine and amitriptyline (preliminary report)]. 182 70

The analysis of GABA levels in plasma of 28 normal persons and 25 patients with endogenous depression did not show any significant differences between both groups. Neither did we observe any differences in GABA levels in patients treated with antidepressant drugs before and after treatment, during a remission or a depression, in responders or nonresponders to treatment. The study did not indicate any results pointing to a role of gabaergic mechanisms in the pathophysiology of endogenous depression or in the action of tricyclic antidepressant drugs.
Psychiatr Pol
PMID:[GABA levels in the plasma of patients with endogenous depression and during the treatment with thymoleptics]. 182 76

Evaluation of a group of 250 patients with endogenous depression in the course of affective illness suggest that reactions of patients to tricyclic antidepressants in an early phase of the treatment may supply interesting prognostic data. Improvement of mental state (reduction of the Hamilton Depression Scale score) on the seventh day and especially on the 14th day of treatment points to a high probability of positive response to the treatment. Lack of such a reaction or worsening of the mental state in the early phase of pharmacotherapy (on the seventh day) frequently is an early sign of lack of positive response to the treatment. The survey considered following antidepressant drugs: amitriptyline, noxiptilin, clomipramine, dibenzepin and desipramine.
Psychiatr Pol
PMID:[Early results of the treatment of endogenous depression with tricyclic antidepressive drugs and prognosis of their effectiveness]. 182 73

Studies performed on a group of 27 patients with endogenous depression demonstrated that changes of cognitive functions following sleep deprivation may reveal a prognostic potential for results of pharmacological treatment of depression. Worsening of memory following sleep deprivation was more frequently observed in a subgroup of nonresponders. Greater improvement of concentration and increased task mobilization were noticed in a subgroup which positively responded to the antidepressant treatment. Patient's age, sex, self-rating of depression intensity or baseline level of ability to memorize, to concentrate attention, to perform tasks did not exhibit any predictive value.
Psychiatr Pol
PMID:[Changes in cognitive functions after sleep deprivation as a prognostic indicator of drug therapy of endogenous depression]. 182 85

The study aimed to establish prognostic considerations for the course of bipolar affective disorder from its onset till first manic phase in persons in whom depression was that first clinical phase of the disorder. Studied group comprised of 80 patients (34 males and 46 females) with the disorder lasting for 11 to 50 years. Within the evaluated period as positive prognostic factors were identified an early onset of the disorder (before 30 years of age), a short (lasting less than 3 months) first depressed phase and a long (above 5 years) first remission. In women and in persons who had lost their parents before 14 years of age the course of disorder was more severe as indicated by duration and frequency of depressed phases. The time of duration of the disorder until the first manic phase was not influenced by pharmacotherapy. Both, treated and untreated depressions more frequently ended with remission (77% of episodes) than switch to mania (23% of episodes). Perris' criterion for diagnosis of unipolar affective disorder has rather limited value since in almost half of the studied individuals a risk of occurrence of a manic phase following three successive depressed phases still existed and diagnosis was still an open question.
Psychiatr Pol
PMID:[The course of bipolar disorder before the manifestation of the first manic stage]. 182 81


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