Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Shyness occurs in over 48% of the population, becoming disabling in 13% or more. Clinical observation suggests that individuals seeking treatment for shyness are in significantly greater distress than the general population, showing greater depression, generalized anxiety, social avoidance, interpersonal sensitivity, and shame, than is indicated by earlier studies. We gave the MMPI to 25 men and 20 women referred for problems with shyness to assess our observations. Analysis confirmed the hypotheses. Men scored higher than women in a slightly different profile configuration.
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PMID:Mean MMPI profile of referrals to a shyness clinic. 912 87

A sample of 244 persons in northern California who provided care for individuals with possible or probable Alzheimer's disease was studied to examine the effect of association with companion animals on three indices of psychological health. 124 caregivers had regular contact with pets; 120 caregivers did not. Men who were attached to dogs scored better on some measures of psychological health than did men who had no pets. Women less than 40 years old who were attached to cats scored better on some measures of psychological health than did the same-age women who had no pets. Women aged 40 to 59 years who were attached to dogs scored worse on measures of life satisfaction and depression than did the same-age women who had no pets. The data suggested a positive indirect effect on caregivers' mental health through interaction between the pet and the patient, but small strata numbers precluded definitive conclusions. Association with pets appeared to temper some of the psychological stress associated with caring for a cognitively impaired adult among young female and male caregivers but not among middle-aged female caregivers.
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PMID:Companion animals and the psychological health of Alzheimer patients' caregivers. 914 3

Well-being was examined as a function of the balance of provided and received levels of four types of social support shared by 165 college students and their support networks over 1 semester. Prospective hierarchical regressions of balance of support exchange, after controlling for Time 1 level of the dependent variable, showed some interactions between hassles level and balance of support receipt and provision for symptomatology, but not for depression. These effects were stronger for low than for high hassle levels at Time 1 for men, whereas the opposite held for women. Men who provided more informational support than they received reported more symptoms at Time 2 than did net recipients, if Time 1 hassles were low. In contrast, women who received more tangible or more informational support than they provided at Time 1 reported more symptoms at Time 2 than did net providers, but only at high hassle levels. Results are interpreted in terms of both the costs and the benefits of receiving and providing support.
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PMID:Balance and source of social support in relation to well-being. 919 50

The purpose of this study was to explore the hypothesis that assisting men with prostate cancer to obtain information would enable them to assume a more active role in treatment decision making and decrease their levels of anxiety and depression. Respondents were recruited from one community urology clinic in Winnipeg, Manitoba. Sixty newly diagnosed men were randomly assigned to receive either a self-efficacy information intervention that consisted of a written information package with discussion, a list of questions they could ask their physician, and an audiotape of the medical consultation (n = 30), or a written information package alone (n = 30). Men completed measures of preferred decisional role as the pretest; anxiety and depression before the intervention, and at 6 weeks post-intervention; and assumed decisional role at 6 weeks post-intervention. Results demonstrated that men in the intervention group assumed a significantly more active role in treatment decision making, and had lower state anxiety levels at 6 weeks. Levels of depression were similar for both groups at 6 weeks. This group of older men do want to be informed and participate in medical decisions. Further efforts are required to evaluate the efficacy of such an intervention in other community urology clinics.
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PMID:Empowerment of men newly diagnosed with prostate cancer. 919 93

We compared the specificity of exercise electrocardiography in 1880 men and 1818 women with women grouped by menopausal and estrogen replacement status. Specificity for > or = 1 mm horizontal or downsloping ST-segment depression was determined using angiography in 781 patients and using two other nonangiography-based methods (a pretest probability-based method and a predictive accuracy-based method) in all patients. Using angiography, the specificities+/-SE were 84 +/- 2 for men, 79 +/- 3 for women, 81 +/- 5 for premenopausal women, 81 +/- 4 for postmenopausal women without estrogen replacement, and 77 +/- 5 for women on estrogen replacement. None of these were significantly different. For all patients, the respective specificities using the probability and predictive accuracy-based methods were 97 +/- 1 and 94 +/- 1 for men, 90 +/- 1 and 88 +/- 1 for women, 97 +/- 1 and 92 +/- 2 for premenopausal women, 92 +/- 4 and 88 +/- 3 for postmenopausal women without estrogen replacement, and 85 +/- 4 and 81 +/- 3 for women on estrogen replacement. (Men vs. all women groups except premenopausal women-P < 0.05). Therefore, the premenopausal women had significantly greater specificity than women on estrogen replacement (P < 0.001) and no difference in specificity with men. Women on estrogen replacement had a significantly lower specificity than postmenopausal women not on estrogen replacement (P < 0.05). These results suggest that estrogen replacement therapy and not naturally occurring estrogen has a role in producing false positive exercise electrocardiograms in women.
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PMID:The specificity of exercise electrocardiography in women grouped by estrogen status. 920 40

Between December 1989 and March 1996, more than 6000 patients were treated with patient-controlled analgesia (PCA) at Auckland Hospital. The overall incidence of potentially life-threatening complications was low (0.28%). A small number (276) received PCA with a background opioid infusion. This technique was associated with a higher incidence of such complications (1.08%, P < 0.05). To further characterize the safety and utilization of PCA, a subgroup of 300 patients was analyzed. The average duration of PCA was 76.4 +/- 39.2 hr. The peak morphine consumption was highest on the day of operation (45.4 +/- 37.0 mg) and rapidly declined over the next 3 postoperative days (40.6 +/- 39.0, 33.3 +/- 26.2, and 27.8 +/- 36.6 mg, respectively). The ratio of drug demands to deliveries decreased from 1.76 on the morning of the first postoperative day to 1.17 on the evening of the third. The percentage of patients with inadequate analgesia (pain score > or = 3/10) and an inability to comply with physiotherapy (Bruggemann comfort score < or = 2/10) was high on the first postoperative day (42% and 18%, respectively). Men used significantly more morphine than women (141.7 +/- 123.6 versus 102.7 +/- 111.2 mg, P < 0.0001) and general surgical patients used more morphine than urology and orthopedic patients (152.6 +/- 136.9 versus 96.0 +/- 84.2 and 83.7 +/- 97.9 mg, P < 0.0001). There was no association between morphine consumption and age (r = -0.216). Of the 6% of patients who experienced hypoxemia and 2% who experienced respiratory depression, virtually all had one of three risk factors: bolus dose greater than 1 mg morphine, age greater than 65 years, or intra-abdominal surgery. The most common side effects were nausea and sedation. The incidence of nausea was highest on day 1 (28%) and decreased over the next 2 days (14.3% and 4.7%, respectively). A similar pattern was observed with sedation (incidence over the first 3 days: 28%, 9.3%, and 3.3%, respectively). Overall patient satisfaction scores were high (8.3/10 +/- 1.9). We conclude that the risk of serious complications with PCA is very low, but worrying degrees of hypoxemia and bradypnea do occur. We suggest prescribing regimens that may reduce complications and identify patients at high risk.
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PMID:The safety and utilization of patient-controlled analgesia. 937 67

Psychotic symptoms occur commonly in Alzheimer's disease (AD), predict a more rapid rate of cognitive decline and increase the risk of aggressive behaviour. Seventy patients with probable AD, recruited from an old age psychiatry service, were assessed to determine the prevalence and clinical correlates of delusions and hallucinations. Psychiatric symptoms were measured using the Behavioural Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD), Hamilton Rating Scale for depression (HRSD) and the Depressive Signs Scale (DSS). Thirty-four per cent of the sample experienced delusions and 11% hallucinations in the previous month. Men were more likely than women to have experienced psychotic symptoms. Psychotic and non-psychotic groups did not differ in age, age at illness onset, dementia severity, HRSD or DSS scores. This study confirms the high prevalence of psychotic symptoms in AD patients encountered in clinical practice, and suggests that psychosis and depression represent independent behavioural disturbances in AD.
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PMID:Prevalence and clinical correlates of psychotic symptoms in Alzheimer's disease. 965 77

The authors investigated the relationships among factors of age, age at onset, and sex in depressed older adults. A group of 96 outpatients (mean age, 60) diagnosed with late-(LOD) and early-onset (EOD) major depression were assessed for severity of depression and underwent magnetic resonance imaging (MRI). The MRI scans were rated for severity of white-matter hyperintensities (WMH) and ventricle-to-brain ratio (VBR). LOD was associated with increased amounts of WMH, larger VBR, and history of hypertension. Men were more severely depressed than women, with higher rates of neurovegetative signs and history of smoking. Age correlated with increased VBR and WMH, history of hypertension, history of percipitants for the current episode, and lack of social support. Results suggest that a subgroup of men may be more at risk for LOD associated with WMH and that sex and age at onset need to be considered in future studies.
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PMID:Relationship of age, age at onset, and sex to depression in older adults. 965 57

This study modeled physical symptom trajectories from ages 30 to 75 in 1079 older male military veterans who were assessed every 3 to 5 years since the 1960s. Combat exposure and noncombat trauma were used to define four groups: no trauma (N = 249), noncombat trauma only (N = 333), combat only (N = 152), and both combat and noncombat trauma (N = 345). Number of symptoms on the Cornell Medical Index physical symptom scale increased 29% per decade. Men who had experienced either combat or noncombat trauma did not differ from nonexposed men, but those who had experienced both combat and noncombat trauma had 16% more symptoms across all ages. There were no differences in age-related trajectories as a function of trauma history. In cross-sectional analysis, men with combat and noncombat trauma had more posttraumatic stress disorder symptoms, but not more depression symptoms, than men with either no trauma or noncombat trauma only. Discussion focuses on the importance of considering physical as well as psychological outcomes of exposure to traumatic events.
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PMID:Physical symptom trajectories following trauma exposure: longitudinal findings from the normative aging study. 974 57

Men and women value different characteristics in potential partners. It was hypothesized that women feel they have less control over traits relevant to their desirability than men feel they have over traits related to male desirability. In Study 1, undergraduates (N = 150) completed questionnaires measuring (a) the importance they attributed to 64 characteristics when choosing a mate and (b) their perceived control over these traits. Men selected partners on the basis of traits that are relatively uncontrollable (e.g., youth, attractiveness), whereas women selected partners on the basis of traits that are more controllable (e.g., status, industriousness; d = 1.75). In Study 2, these findings were replicated in an older, representative community sample (N = 301; d = 1.03). Greater uncontrollability of traits relevant to female mate value may place women at elevated risk for negative affect, depression, low self-esteem, and body dissatisfaction.
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PMID:Sex differences in perceived controllability of mate value: an evolutionary perspective. 982 29


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