Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A group of 78 women with sudden flushes and associated disorders (pruritus vulvae, headache, anxiety, instability, depression, libido disturbances) related to the menopause were treated with one or two capsules of veralipride daily for 20 days. Excellent or good results were obtained in 54 of the 69 patients (78 p. cent) with sudden flushes, and 29 of the 57 cases (51 p. cent) with associated disorders. The difference in scores before and after treatment is very highly significant (p < 0.001). Clinical tolerance was good as only 2 cases of minimal galactorrhea. 2 cases of mastodynia, 3 cases with mild drowsiness, 2 patients with nervous tension or insomnia, 3 with digestive disorders, 1 with vertigo, and 1 with mild visual disturbances were observed. No modifications in the biological parameters studied were noted. Blood prolactin levels increased during treatment but returned to normal levels 4 days after discontinuation of therapy. No significant modifications in FSH, LH, E2, or E3 plasma levels were noted at the end of the study. Veralipride appears, therefore, to be the prototype for non-hormonal therapy of menopausal disorders.
Sem Hop 1980 Oct 15
PMID:[A new therapeutic approach to menopausal sudden flushes and psychofunctional disorders (author's transl)]. 625 60

Mitral valve prolapse is usually a benign affection, and yet but rather seldom, severe rhythmic troubles and even a sudden death may happen. The authors relate an observation about a seventeen years old young man presenting syncopes caused by ventricular fibrillation fit. The existence of a mitral valve prolapse is demonstrated by phonomecanogram and specially by echocardiogram which shows a telesystolic depression of the small valve. The observation is followed by commentaries about the frequency and clinic of Barlow syndrome. The rhythmic troubles liable to accompany this mitral damage are analysed and so is the evaluation of the risk of a sudden death by ventricular fibrillation.
Sem Hop
PMID:[Mitral valve prolapse and severe rhythmic trouble (author's transl)]. 625

The authors are reporting about a two years experiment, following up alcoholics after their withdrawal treatment. Their work estimates the comparative results of two homogeneous groups : two-hundred patients, undergoing the same supporting psycho-therapy but receiving a different drug treatment. Reviewing their experiment, they evaluate the improvements they have achieved concerning anxiety, asthenia and depression on the one hand ; and on the other hand the alcoholics' ability to reintegrate into normal life, from a family, conjugal, sexual, professional and social point of view. The overall results are expressed in terms of abstinence, relapse, hospitalization and normalization of their behavior and character.
Sem Hop
PMID:[Following up alcoholics. Comparative results two years after being treated for their alcoholism (author's transl)]. 626 33

During treatment of an anxiety-depression syndrome, a young woman presented with amenorrhoea probably related to sulpiride administration. Interruption of treatment provoked depression relapse; the addition of bromocriptine prevented recurrence of the amenorrhoea without affecting the therapeutic results of the second course of treatment with sulpiride.
Sem Hop
PMID:[The treatment of an anxiety - depression syndrome in young women. Report of a case (author's transl)]. 626 45

Alterations of brain monoamines in animals produced by antidepressant administration suggest that depression may involve these monoamine systems. In an attempt to examine these possibilities, investigations of central noradrenergic and serotoninergic metabolism in depressed patients were performed but at times these have failed to produce convincing results. The exact mechanism of action of antidepressants remains also unknown. Nevertheless recent findings show that chronic treatment induces changes in the sensitivity of the beta-noradrenergic and serotoninergic receptors closely correlated in time with clinical improvement and common to all types of antidepressant drugs. Tricyclic anti-depressants also act directly as antagonists on alpha-adrenergic, cholinergic and H1, and H2 histaminergic receptors and it has been assumed that these pharmacological properties account for the side-effects of these drugs. Recently, high affinity binding sites for 3H-imipramine were demonstrated, the significance of which is still unresolved.
Sem Hop
PMID:[Biochemical aspects of depression (author's transl)]. 626 84

Depression can be observed in individuals with any type of personality structure especially in situations in which change is involved. The mourning model is not sufficient to account for the type of difficulties, the particular mood and the lowered self-esteem so characteristic of depressive syndromes. The study of the psychological development of children helps us to sort out those situations which are of depressive type. However, not a single past incident during childhood can be clearly singled out as a causal factor of adult depression. Depressed adults as well as neurotics, psychotics, psychopaths or alcoholics have in common the fact that they have experienced early separation more often than control subjects. The attempts to isolate a particular aspect of the premorbid personality of depressed individuals are not at all conclusive. The notion of the typus-melancholicus (Tellenbach) has, however, the value of emphasizing the limiting character of these personalities: the need for a restricted perimeter of activity, limitations as concerns daily goals and painful sensitivity to change. The psychological reconstruction of depression can be done only after the event.
Sem Hop
PMID:[Psychopathology of depression (author's transl)]. 626 88

The author presents the classical nosology of depressive states, with its five main categories (depression belonging to the manic-depressive psychosis, involutional organic-symptomatic, psychogenic, depressive personality disorder). He comments on the two recent modifications: distinction between the unipolar and bipolar forms, suppression of the category of involutional depression. He presents finally the two modern nosological systems, ICD 9, a relatively traditional nosology, and DSM III whose fundamental principles and categories are discussed.
Sem Hop
PMID:[The nosology of depressions (author's transl)]. 626 83

The authors use a number of recent studies to illustrate what can be achieved by exemplary work on depression. One of the studies is concerned with incidence in one community and others with comparisons of clinical and psycho-social aspects of depression in different cultures. They underscore the importance of making the distinction between conspicuous and hidden morbidity when measuring morbidity rates. In clinical practice, psychiatrists see only a narrow range of the depressive spectrum, which is made up of many different clinical entities varying in symptomatology and severity. Attempts to compare the prevalence of these conditions are often frustrated by problems of definition and classification of the clearly morbid states, in addition to the difficulties inherent in differentiation between these states and the normally accepted range of mood variations. These points are probably largely responsible for wide differences in the prevalence rates published by different authors and for different countries. The latter part of the discussion emphasizes the scientific importance of transcultural comparisons of depressive symptoms and points out the need to assess the influence of socio-cultural changes upon the frequency and types of depressive states. Throughout all this discussion, the necessity of standardized instruments of clinical assessment is underlined.
Sem Hop
PMID:[Epidemiology of depression (author's transl)]. 626 89

The different biological treatments of depression are first reviewed from an analytical point of view. The drugs are divided in three groups: the classical tricyclic antidepressants, the MAO inhibitors and the recent antidepressants. Some drugs with potential antidepressant properties are also studied. The other biological treatments of depression include electroconvulsive therapy and sleep deprivation. In a second step, the characteristics of these different treatments are detailed. Finally, the strategy of a drug treatment is considered with regard to the choice of the best drug and the best dosage for a given depressed patient.
Sem Hop
PMID:[Biological treatments of depression (author's transl)]. 626 90

Fifty-six patients with clinically and biologically unequivocal Cushing disease underwent psychological evaluation including at least one interview, a graphological test, a tree test, and a Szondi test. Patients were found to be hyperadapted, with a rigid repressive system, concealing major anxiety. These patients are closely dependent on their familial and professional affective relationships. This probably establishes the intensity of their repressive system. They need approval, appreciation, and recognition. Obsessional features are found (scrupulous conscience, compulsive activity) as well as manic-depressive features (fluctuations between depression and euphoric activity acting as a defense against depression). During the interviews it was established that onset of Cushing disease occurred a few months after prolonged stress; this stress dealt electively with the patients affective relationships.
Sem Hop
PMID:[Psychological profile with Cushing disease (author's transl)]. 627 29


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