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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Forty endogenously depressed patients given standard antidepressants and/or electroconvulsive therapy in a general hospital psychiatric ward were assessed using the short form of the Beck Depression Inventory and the Hamilton Depression Rating Scale. The patients were then randomly assigned to two groups: Under double-blind conditions, one group received in addition 20 mg diazepam per day and the other, identical placebos. No additional benzodiazepines were prescribed during the study. Standard therapy with tricyclic antidepressants or electric shock was determined by the patients' own psychiatrists. The assessments were repeated after ten days of diazepam or placebo treatment. Fourteen patients (seven in each group) also completed the Buss-Durkee Hostility Inventory. Results of the Beck Depression Inventory indicated that the addition of diazepam retarded the improvement of the patients receiving only tricyclic antidepressants but had no effect on the recovery of patients receiving electroconvulsive therapy.
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PMID:The effect of diazepam on the recovery of endogenously depressed patients. 34 17

1. The effect of [D-Phe6] bombesin (6-13) methylester (OMe), a newly developed potent antagonist of bombesin receptors, has been investigated against bombesin-induced contractions of the guinea-pig and rat isolated urinary bladder. 2. Bombesin (0.1 nM-10 microM) produced a concentration-dependent contraction of the guinea-pig isolated bladder which approached the same maximum response as KCl (80 mM). The response to bombesin was antagonized in a competitive manner (rightward shift of the concentration-response curve without depression of the maximal response) by [D-Phe6] bombesin (6-13) OMe (0.3-10 microM). Degree of antagonism was concentration-dependent between 0.3 and 3 microM (dose ratios = 2.4, 9 and 39 in the presence of 0.3, 1, 3 microM of the antagonist). However, a larger concentration (10 microM) of the antagonist was not more effective (dose ratio = 36) than 3 microM. 3. Neither the action of bombesin nor the activity of the antagonist was influenced by peptidase inhibitors (bestatin, captopril and thiorphan 3 microM each) or by atropine, indomethacin, chlorpheniramine and desensitization of P2x purinoceptors by alpha, beta methylene ATP. 4. The bombesin antagonist was ineffective against contraction of the guinea-pig urinary bladder produced by the NK-1 tachykinin receptor-selective agonist, [Sar9] substance P sulphone. The action of the NK-1 receptor agonist was antagonized by L 668, 169 (3 microM), a cyclic peptide tachykinin antagonist. L 668, 169 had no effect toward bombesin-induced contraction. 5. The bombesin antagonist (1-10 microM) had no effect against the non-adrenergic non-cholinergic response of the guinea-pig isolated urinary bladder to electrical field stimulation.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Effect of [D-Phe6] bombesin (6-13) methylester, a bombesin receptor antagonist, towards bombesin-induced contractions in the guinea-pig and rat isolated urinary bladder. 132 41

Depressed mood is a salient feature of Premenstrual Syndrome (PMS). Fourteen women with prospectively documented PMS and ten without PMS completed the short form of the Beck Depression Inventory (BDI) and the Zung Self-Rating Scale for Depression (Zung-D) during the follicular and late luteal phases of two consecutive menstrual cycles. The short form of the BDI assesses the more cognitive symptoms of depression, while the Zung-D identifies primarily vegetative symptoms. The short form of the BDI was sensitive to cyclic changes in the PMS women, while the Zung-D was not. The BDI items uniquely endorsed by the PMS women during the late luteal phase were pessimism, sense of failure, dissatisfaction, guilt, self-dislike, and indecision. The premenstrual dysphoria experienced by PMS women thus appears to be more cognitive than vegetative in nature. Finally, differential utility of standardized mood measures to detect premenstrual depression is suggested. The BDI proved to be the more sensitive measure.
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PMID:Psychological aspects of premenstrual syndrome. II: Utility of standardized measures. 143 44

131 subjects from a small north central Kansas high school participated and completed the Beck Depression Scale, Coopersmith Self-esteem Inventory short form with the Lie scale included, the Death Anxiety Scale, and the first 11 questions of the Beck Scale of Suicide Ideation. Background information collected from each subject included age, grade, marital status of parents, and sex. Grade point averages (on a 4-point scale) were taken from the students' files. On death anxiety girls had a significantly higher mean than boys while freshmen's and sophomores' scores were significantly higher than those of juniors and seniors but there was no difference between means of students of divorced and nondivorced parents. On self-esteem and GPA children of divorced parents scored significantly lower than children of nondivorced parents, but there was no difference between the sexes on self-esteem. On GPA girls scored significantly higher than boys. On depression the children of divorced parents scored higher than children of nondivorced parents but there was no sex difference.
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PMID:Depression, self-esteem, suicide ideation, death anxiety, and GPA in high school students of divorced and nondivorced parents. 145 20

Depression is a common but underrecognized disorder in family practice. The purpose of this study was to determine the relationship between physician attitudes toward psychosocial aspects of care and psychiatric knowledge and recognition of depression in a family practice residency clinic. Adult patients (n = 582) presenting to 16 family practice residents were screened for depression using the short form of the Beck Depression Inventory. A regression model was created with the rate of recognition of depression for each physician as the dependent variable. Independent variables included in the model were resident scores on the Physician Belief Scale and the psychiatric subsection of the in-training exam scores, patient familiarity, and whether the attending physician was consulted. Orientation toward psychosocial aspects of medical care was found to be significantly related to recognition of patients at risk for depression. In-training examination psychiatric subsection scores were unrelated to a resident's clinical recognition of depression risk. This study suggests that physician attitude is a significant factor in successful recognition of depression by family practice residents.
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PMID:Physicians' recognition of depression. 148 12

We studied the ability of internal medicine residents to recognize depressive symptoms in a population of lower socio-economic primary care patients. Four hundred twenty patients completed the short form of the Beck Depression Inventory (BDI). Simultaneously, the resident caring for the patient estimated the degree of depression for each patient. One-fourth of the patients scored at or above the moderately depressed level on the BDI and the residents rated 23 percent of their patients as at least moderately depressed. However, the accuracy of the residents' assessment of his or her individual patient was poor (correlation = 0.42, sensitivity = 0.46, specificity = 0.84). Patients with a prior history of psychiatric disorder scored higher on the BDI and were given higher ratings of depression. No other pre-existing medical condition was significantly associated with a higher or lower BDI score. The amount of alcohol consumed and the amount smoked, were both associated with higher BDI scores. Residents varied in their sensitivity to their patients' BDI scores. Some showed high agreement with BDI scores, others low. There were no specific resident characteristics (e.g. year of training, resident gender) that could explain this variability. Patients with a history of depression were given lower resident ratings compared to other patients and patients with a history of depression were given lower resident ratings than predicted by their BDI scores. Residents' ability to accurately diagnose and treat depression in the underprivileged primary care patient can be facilitated by the institution of depression screening in the ambulatory clinic.
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PMID:Recognition of depression by internal medicine residents. 151 5

This paper describes a prospective, double blind, randomised and dummy-controlled trial in 28 patients with chronic mechanical low back pain presenting to the York Pain Clinic. The therapeutic effects of epidural methyl prednisolone (80 mg) were compared with intrathecal midazolam (2 mg). All the patients had pain for a considerable length of time (range: 1-35 years) and all had received previous treatments which had failed. The two groups of patients were comparable in terms of pain duration, demography, extent of disability, anxiety and depression and pain locus of control. The pain was assessed before and for 2 months after treatment using the short form McGill Pain Questionnaire as well as visual analogue and verbal rating scales for sensory and affective components of their pain experience; patients also completed a pain diary. Both treatments caused a similar improvement in one-half to three-quarters of the patients for 2 months in patterns of activity and sleep as well as in the sensory and affective components of the pain. However, although the improvement in the two groups was similar, all the patients treated with steroid were either taking more or the same amount of self-administered analgesic medication after their treatment, whereas between one-third and one-half of the midazolam-treated patients took less medication during the 2 month follow-up period. We conclude that intrathecal midazolam is an effective treatment for chronic mechanical low back pain. The mechanism responsible for this effect is discussed.
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PMID:Intrathecal midazolam for the treatment of chronic mechanical low back pain: a controlled comparison with epidural steroid in a pilot study. 153 83

This paper describes the derivation of a 22-item Situational Confidence Questionnaire for heroin users [SCQ (Heroin)]. Results revealed the SCQ (Heroin) to be an internally consistent scale with an acceptable level of test-retest reliability. Construct and discriminant validation were demonstrated through moderately significant correlations of all subscales with the short form of the Beck Depression Inventory. Factor analysis revealed a three-factor structure which could be labeled: coping with or enhancing arousal states, casual or occasional usage, and coping with negative emotions.
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PMID:The Situational Confidence Questionnaire (Heroin). 193 9

The Geriatric Depression Scale (GDS) exists in both short and long forms. The original 30-item form of the GDS has been shown to be an effective screening test for depression in a variety of settings. However, its utility in patients with dementia of the Alzheimer type (DAT) is questionable. The short, 15-item version of the GDS was developed primarily for brevity and, in particular, for use in populations such as the medically ill or those with dementia, where the longer form might be burdensome. How well this short form works in these populations, however, is largely undetermined. In this paper, the sensitivity and specificity of the 15- and 30-item GDS are compared in a group of patients who were either cognitively intact or had mild DAT. The findings suggest that the short version of the GDS, like its longer predecessor, is an effective screening tool in the cognitively intact. However, in a population of subjects with mild DAT, it does not appear to retain its validity.
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PMID:The short form of the Geriatric Depression Scale: a comparison with the 30-item form. 195 71

Indices of self-reported depression and psychological adjustment after stroke were evaluated using a short form of the MMPI. Patients with poststroke periods of 2 to 6 and 7 to 24 months were selected, and indices of general intellectual functioning and lesion size/location were obtained. Despite similar levels of intellectual functioning and lesion parameters, the longer duration group showed significantly higher depression scores and significant (T greater than 70) elevations on several other clinical scales of the MMPI. In contrast, the mean overall profile of the short-duration group was roughly within normal limits. These findings have implications for the clinical assessment and treatment of stroke patients and long-term psychological adjustment after stroke.
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PMID:Short- and long-term psychological status following stroke. Short form MMPI results. 202 55


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