Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The value of an abnormal ratio of recovery systolic blood pressure to peak exercise SBP for detecting coronary artery diseases (CAD) is controversial. We evaluated the ratio in 39 patients with angiographically documented CAD and 52 patients with normal coronary artery undergoing treadmill exercise. If a response with the ratio higher than 1.0 and 0.8 at 1 and 3 min. of recovery was considered as abnormal, the sensitivity for detecting CAD was 66.7%, the specificity 73.1% and the accuracy 70.3%. If ST segment depression is combined into the criteria, the specificity and accuracy reach 94.2% and 76.9%. In CAD, the ratio at 3 min. of recovery showed significant negative correlation with resting left ventricular ejection fraction (LVEF) (r = -0.461, P < 0.01). It is suggested that low resting LVEF may be one of the mechanism of this abnormal ratio in CAD.
Zhonghua Nei Ke Za Zhi 1992 Jul
PMID:[Value and mechanism of abnormal postexercise systolic blood pressure response for detection of coronary artery disease]. 129 94

81 patients with an average of 61 who had a hemispheric stroke for the first time and survived more than 12 months were followed in order to study the factors related with recovery. The results are: (1). The severity of the initial attack and the presence of depression and other complications in recovery period are the main relating factors with both the quality of life and recovery of neurological deficits. (2). The size of the lesion shown in CT is the main relating factor with the recovery of neurological deficits. (3). function of affected hand is a main relating factor with the quality of life. According to these results, it is essential to have a preliminary consideration to facilitate recovery at the initial stage of stroke and to organize the rehabilitation programs for the patients.
Zhonghua Nei Ke Za Zhi 1992 Oct
PMID:[Factors related with stroke recovery]. 130 58

Chronic renal failure was induced in male Wistar rats with 5/6 nephrectomy (group I) and sham-operation was carried in the controls (group II). The results showed that in group I, plasma ANP levels increased progressively as Scr elevated. The plasma levels of renin and angiotensin raised simultaneously as compared with the controls (P < 0.001). At the 20th week after operation, urine volume and Na decreased significantly (P < 0.05) and the number of glomerular ANP receptors decreased significantly at the 12th week (P < 0.05) and 20th week (P < 0.01). Our data suggest that in 5/6 nephrectomized rats: 1. The elevation of plasma ANP level might be partly caused by damage of glomerular receptors. 2. The elevated plasma ANP could not cause its diuretic, natriuretic, blood pressure depression and R-A inhibition effect due to the damage of kidney ANP receptors.
Zhonghua Nei Ke Za Zhi 1992 Nov
PMID:[The relationship between plasma atrial natriuretic peptide (ANP) and glomerular ANP receptors in 5/6 nephrectomized rats]. 130 71

ST segment change in procordial leads was analysed in 58 patients with acute inferior myocardial infarction (IMI). ST segment depression in V2 lead was negatively correlated with ST segment elevation in a VF lead in patients with IMI. ST segment depression in V2 lead was not observed when IMI was accompanied by right ventricular infarction. It indicates that ST segment depression in procordial leads was the reciprocal change of ST segment elevation in inferior leads. The direction and amplitude of ST segment shift in procordial leads may be affected by the presence of right ventricular infarction (RVI). The ratio of ST V2/ST aVF less than 0.5 may suggest a diagnosis of IMI with accompanying RVI.
Zhonghua Nei Ke Za Zhi 1991 Jul
PMID:[An analysis of ST segment shift in procordial leads in patients with acute inferior myocardiac infarction with and without right ventricular infarction]. 175 55

572 cases have been examined with ambulatory electrocardiogram monitoring (AEM). They are divided clinically into three groups, (1) cases after myocardial infarction (2) cases with angina (3) cases without coronary artery disease (CAD). The incidences of silent myocardial ischemia (SMI) in the three groups were 80%, 24% and 3% respectively. The ratios of silent myocardial ischemia to symptomatic myocardial ischemia in groups (1) and (2) were 88.8% and 70.4%. It is shown that silent myocardial ischemia is very frequent in CAD. The article also reviewed and discussed the criteria for diagnosis of SMI, the mechanism of its presence, and its relation to degree of ST segment depression and daily activities.
Zhonghua Nei Ke Za Zhi 1989 Jul
PMID:[A preliminary report on silent myocardial ischemia detected using ambulatory electrocardiogram monitoring]. 259 Dec 56

Early ECG exercise tests (EET) and ambulatory ECG monitoring (AEM) were performed in 42 patients surviving AMI in order to determine the sensitivity of the two methods for detecting ST-segment deviation and arrhythmias. 23 patients had ST changes during EET and AEM. Of them, 21 patients had ST changes induced by EET and 10 were recorded by AEM. The more the ECG leads used for monitoring during and after EET, the higher the percentage of patients with ST changes will be. There were 2 cases with ST changes found in AEM only. All the 6 patients who had ST elevations during EET had an anterior infarction and echocardiograms did show that they had left ventricular aneurysms or abnormal ventricular wall movement. AEM recorded ventricular premature beats (VPBs) in 37 cases (88.0%), while EET induced VPBs in 8 patients. The 42 patients were followed up for an average time of 6 +/- 1.7 m. (3.4 to 9.3 m.) Cardiac death occurred in 2 cases. One of them had horizontal ST depression of 3 mm during EET, the other had a negative EET but multifocal VPBs during AEM. It is concluded that for detecting ST changes EET is more sensitive than AEM, while VPBs are more frequently found in AEM than in EET. The authors are of the opinion that for better, prediction of the prognosis of patients after AMI, it is preferable to have early EET in combination with AEM.
Zhonghua Nei Ke Za Zhi 1989 Mar
PMID:[Comparative study of the ECG exercise test and ambulatory ECG monitoring after recovery from acute myocardial infarction]. 280 52

Ten patients with multiple myeloma (two refractory and eight relapsing) received vincristine and adriamycin infusion therapy with oral high-dose dexamethasone (VAD regimen). Reduction in monoclonal immunoglobulin in serum exceeding 75 per cent was noted in three patients and reduction from 50 per cent to 75 per cent in four patients. Total response rate was 70 per cent. It was as high as the results reported in other countries. The responses to VAD regimen occurred rapidly. Most of them needed only one course. The side effects of VAD were not severe and were mainly reversible depression of leukocyte and infection of various kinds. All patients tolerated well. The probable mechanisms for increased response to VAD regimen are as follows. 1. Instead of administration as a bolus, vincristine and adriamycin were infused continuously and were given several times; therefore there was a prolonged unchanged concentration of the drugs in blood and exerting a possibly superior antitumor effect. 2. high-dose dexamethasone.
Zhonghua Nei Ke Za Zhi 1989 May
PMID:[Treatment of refractory multiple myeloma with vincristine, adriamycin, and dexamethasone]. 280 63

We compared electrocardiographic abnormalities and plasma norepinephrine concentration in 40 patients with subarachnoid hemorrhage within the first 24 hours, at 72 hours, and after 1 week. In the 20 patients with high plasma norepinephrine concentrations within the first 24 hours, sinus tachycardia and negative T waves were more frequently seen than in the 20 patients with normal plasma norepinephrine concentrations. After 72 hours, only sinus tachycardia was found with increased frequency in the 26 patients with high plasma norepinephrine concentrations. Although 24 patients had high plasma norepinephrine concentrations after 1 week, we found no difference in the frequency of electrocardiographic abnormalities as compared with patients with normal plasma norepinephrine. QT prolongation, U waves, ST depression, and arrhythmias were found with similar frequency in patients with high and normal plasma norepinephrine concentrations. We conclude that, with the exception of sinus tachycardia and negative T waves, other electrocardiographic changes in patients with subarachnoid hemorrhage do not depend on elevated plasma norepinephrine concentrations.
Zhonghua Nei Ke Za Zhi 1993 Jun
PMID:[Effect of elevated plasma norepinephrine on electrocardiographic changes in subarachnoid hemorrhage]. 826 66

Heart rate power spectral analysis in 44 patients with coronary artery disease was obtained from 24-hour dynamic electrocardiogram. 195 episodes of transient myocardial ischemia that was defined as horizontal or down sloping depression of the ST segment of > or = 0.1 mV and lasted for > or = 2 minutes were studied. The area of low frequency components (LF, 0.02-0.10 Hz) representing predominontly sympathetic tone with some contribution from the parasympathetic tone and that of high frequency components (HF, 0.15-0.40 Hz) representing mainly parasympathetic tone and the value of LF/HF on 4 minute heart rate power spectral graph at the deepest depression of ST segment were compared with that before the episode of myocardial ischemia. The area of HF of fast rate myocardial ischemia occurring in night reduces significantly (P < 0.001), the value of LF/HF increases markedly (P < 0.05) and the area of LF increases slightly. The results suggest that there is a change of autonomic nervous activity during the episode of fast rate myocardial ischemia in night, parasympathetic nervous tone decreases markedly, there may be secondary increase of sympathetic nervous activity.
Zhonghua Nei Ke Za Zhi 1995 May
PMID:[Autonomic nervous activity at episodes of myocardial ischemia in patients with coronary artery disease by heart rate power spectral analysis]. 856 9

Bisoprolol was administered orally at doses of 1.25-5 (mean 3.2 +/- 1.1)mg/day for 3-10 (mean 4.1 +/- 1.6) months in 19 patients with congestive heart failure secondary to dilated cardiomyopathy. All patients heart rate and blood pressure were sensitive to the first dose 1.25 mg bisoprolol and when the dose was titrated to 2.5 mg, it was effective and led to a smooth course during a 10-hour period of observation. After treatment, the patients heart function, including fractional shortening, ejection fraction and exercise ability increased significantly and both the severity and the incidence of ventricular arrhythmias decreased significantly. The response of heart rate to exercise and isoproterenol infusion tended to be normal lymphocyte beta-adrenergic receptor density was increased. It is shown that bisoprolol is a promising beta-blocking agent in treating congestive heart failure. The mechanisms of its effects may be related to depression of excessive sympathetic activity, decrease of heart rate and up-regulation of beta-adrenergic receptor.
Zhonghua Nei Ke Za Zhi 1995 Oct
PMID:[Clinical effects of bisoprolol in congestive heart failure due to dilated cardiomyopathy]. 873 31


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