Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In the initial months of the Korean War, very high numbers of psychological casualties occurred among American troops, 250 per 1,000 per annum. Initially, these men were evacuated to Japan or the United States, and very few of them were returned to duty. Then the principles of early and far-forward treatment, learned in the previous world wars, were reinstituted. Up to 80% of neuropsychiatric casualties were returned to duty. During and after the war, the prisoners of war were believed to have been "brainwashed," have "give-it-upitis," and exhibit apathy and depression. Mistakenly believed to be signs of moral decay, the psychiatric symptoms during and after release were probably a result of extended inhumane treatment and vitamin deficiencies.
Mil Med 2002 Nov
PMID:Psychiatry in the Korean War: perils, PIES, and prisoners of war. 1244 14

The prevalence of traumatic event exposure and post-traumatic stress disorder (PTSD) were surveyed in a cohort of 198 full-time operational members of the South African National Defence Force stationed in their "home" unit between deployments. Approximately 90% of members reported having experienced or witnessed trauma in their lifetime (mean number of traumatic events = 4.3 +/- 3.2), whereas 51% reported having inflicted trauma. Twenty-six percent met diagnostic criteria for PTSD on self-report with approximately 29% with PTSD also meeting diagnostic criteria for depression. Few members, however, sought help. PTSD symptom severity was best predicted by trauma type (exposure to physical assault and infliction of life-threatening injury). These findings highlight the high rates of exposure to multiple, noncombat-related trauma in military personnel, the potentially high rates of PTSD, and the role of inflicted trauma as an additional risk factor for PTSD.
Mil Med 2003 Jan
PMID:Prevalence and characteristics of trauma and post-traumatic stress symptoms in operational members of the South African National Defence Force. 1254 50

This study aimed at comparing the prevalence of depression among traumatic and surgical amputees and examining the relationship between depression and sociodemographic/clinical characteristics of amputees. Participants were 49 patients with traumatic lower part amputation and 35 patients with surgical lower part amputation. The diagnosis of depression in each participating patient was confirmed by means of the Structured Clinical Interview for DSM-IV, Turkish version. The level of depression was assessed by using the Hamilton Depression Rating Scale. The prevalence of depression was 34.7% in the traumatic amputee group and 51.4% in the surgical amputee group (p > 0.05). In the traumatic group, depression was associated with time since amputation but not with other variables. However, in the surgical group, depression was associated with age, education level, marital status, economic status, time since amputation, and whether the patient was treated with prosthesis. Our data indicated that depression is a common clinical condition among amputees. Clinicians may be advised to schedule periodic contacts with amputees over long periods to identify those in need of psychiatric intervention.
Mil Med 2003 Feb
PMID:Depression in men with traumatic lower part amputation: a comparison to men with surgical lower part amputation. 1263 36

Using the Minnesota Multiphasic Personality Inventory and the Millon Clinical Multiaxial Inventory, we assessed the psychological functioning of U.S. Air Force veterans exposed to Agent Orange and its contaminant, 2,3,7,8-tetrachlodibenzo-p-dioxin (dioxin), during the Vietnam War. Index subjects were veterans of Operation Ranch Hand (N = 1,109). Comparisons (N = 1,493) were U.S. Air Force veterans not involved with spraying herbicides. We found few consistent psychological abnormalities associated with serum dioxin levels. Ranch Hand veterans with higher dioxin levels showed some difficulties in anxiety, somatization, depression, and a denial of psychological factors. However, those with background levels also showed indications of emotional distress, primarily in emotional numbing and lability; a guarded, suspicious, and withdrawn style of relating to others; and unusual thoughts or behaviors.
Mil Med 2003 Feb
PMID:Serum dioxin and psychological functioning in U.S. Air Force veterans of the Vietnam War. 1263 46

The incidence of episodes of harassment and rape among military populations has only recently been examined. In the present study, a sample of 336 female veterans in a primary care setting was assessed. The incidences of lifetime sexual victimization, anxiety, depression, and impact of trauma for victims of specific trauma contexts are presented. Results of the study indicated that female veterans with a history of cumulative rape experiences and civilian rape experiences are more at risk for anxiety and depression than those with only a military experience of rape. No significant differences were found for impact of event scores for different contexts of rape, however. Reporting of trauma was not associated with psychological well-being for women veterans. The results highlight the role of the socioenvironmental context of abuse as an important variable to examine, especially in military populations.
Mil Med 2003 May
PMID:Socioenvironmental context of sexual trauma and well-being of women veterans. 1277 77

U.S. soldiers' appraisal and experience of the Kosovo peacekeeping mission is described. Using a prospective design, we evaluated the prevalence, severity, and predictors of several mental health outcomes at redeployment. We found that peacekeepers frequently were exposed to potentially traumatizing and other stressful events while in Kosovo, but on average, their appraisal of those events was moderate. Postdeployment psychopathology was also low--soldiers endorsed more severe mental health difficulties at predeployment, which suggests anticipatory negative affect. After controlling for the impact of predeployment stressors, we examined the contribution of potentially traumatizing events, general overseas military duty stressors, negative aspects of peacekeeping roles, and generic positive military experiences, including morale, to explain variance in four outcomes: post-traumatic stress disorder, depression, hostility and aggression problems, and problems with alcohol abuse. Findings indicate that hostility and drinking may be more chronic problems that emerge during stressful times, whereas depression and post-traumatic stress disorder symptoms may be more apt to fluctuate and are associated with potentially traumatizing experiences during peacekeeping. The implications and limitations of the study are discussed.
Mil Med 2004 Mar
PMID:The stressors and demands of peacekeeping in Kosovo: predictors of mental health response. 1508 Feb 39

The purpose of this prospective study was to investigate the effects of the Boot Camp Survival Training for Navy Re cruits--A Prescription (BOOT STRAP) intervention on stress depression, situational events, interpersonal factors, and recruit training performance. Divisions of Navy recruits were randomly selected and 801 recruits participated for the 9 weeks of their training. Recruits "at risk" for depression were randomly assigned to the intervention or nonintervention groups, and the remaining recruits served as the comparison group. The at-risk recruits who received the BOOT STRAP intervention significantly increased their sense of belonging, experienced less loneliness, used more problem-solving coping skills, and decreased insecure attachment by the end of recruit training. Percentages of recruits in the study success fully completing basic training were 84% of the comparison group, 86% of the intervention group, and only 74% of the nonintervention group. Results suggest that the BOOT STRAP intervention improves recruit functioning, strengthens train ing performance, helps reduce attrition, and may have impor tant implications for stress and depression interventions.
Mil Med 2004 Oct
PMID:Psychosocial effects of the BOOT STRAP intervention in Navy recruits. 1553 47

O-ethyl S-(2-diisopropylaminoethyl) methylphosphonothioate (VX) is an extremely toxic organophosphate nerve agent that has been weaponized and stockpiled in a number of different countries, and it has been used in recent terrorist events. It differs from other well-known organophosphate nerve agents in that its primary use is as a contact poison rather than as an inhalation hazard. For this reason, we examined the effects of application site and skin decontamination on VX toxicity in anesthetized domestic swine after topical application. VX applied to the surface of the ear rapidly resulted in signs of toxicity consistent with the development of cholinergic crisis, including apnea and death. VX on the epigastrium resulted in a marked delayed development of toxic signs, reduced toxicity, and reduction in the rate of cholinesterase depression compared with animals exposed on the ear. Skin decontamination (15 minutes post-VX on the ear) arrested the development of clinical signs and prevented further cholinesterase inhibition and death. These results confirm earlier work that demonstrates the importance of exposure site on the resultant toxicity of this agent and they also show that decontamination postexposure has the potential to be an integral and extremely important component of medical countermeasures against this agent.
Mil Med 2004 Nov
PMID:Clinical aspects of percutaneous poisoning by the chemical warfare agent VX: effects of application site and decontamination. 1560 29

Measures of post-traumatic stress disorder (PTSD) and depression were used to predict Veterans Affairs outpatient treatment costs among Persian Gulf War veterans with medically unexplained physical symptoms. Patients (N = 206) enrolled in a Veterans Affairs primary care clinic for Persian Gulf War veterans completed study assessments at the initial appointment or at a proximal follow-up visit. Costs of care for mental health, medical, and pharmacy services for these veterans were computed for the subsequent 6-month period. Depression and PTSD symptoms explained a significant share of variance in costs of mental health care and pharmacy services, after adjustment for covariates. None of the mental status measures was significantly related to costs of medical care. Models using global measures of mental health status were as robust as models using disorder-specific measures of PTSD and depression in predicting mental health care and pharmacy costs. The implications of these findings for anticipating costs of care for Persian Gulf War veterans are discussed.
Mil Med 2005 Jan
PMID:Predicting costs of Veterans Affairs health care in Gulf War veterans with medically unexplained physical symptoms. 1572 58

This study provides descriptive information and preliminary first-year outcome data on the only overseas military gambling treatment option currently available. Implemented in January 2003 within the Substance Abuse Rehabilitation Program, U.S. Naval Hospital, Okinawa, Japan, gambling treatment was developed as a specific track within the overall substance abuse program. The present study explores the various considerations and requirements for setting up such a program, as well as a description of individuals seeking gambling treatment and preliminary outcome data. Participants consisted of all gambling referrals (N = 35, 26 males; mean age, 33.2 years; SD = 8.93) obtained over the first year that gambling services were offered. A significant degree of depression, suicidality, and substance abuse problems were observed in the sample. Results revealed that the gambling program was easily implemented within an established substance abuse program. The program was effective in preventing suicides in both military members and eligible beneficiaries and was effective in facilitating the retention of military members with gambling problems.
Mil Med 2005 Aug
PMID:Review of the first year of an overseas military gambling treatment program. 1617 9


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