Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Because diazepam binding inhibitor (DBI) and its processing products coexist with gamma-aminobutyric acid (GABA) in several axon terminals, DBI immunoreactivity was measured in the cerebrospinal fluid (CSF) of individuals suffering from various neuropsychiatric disorders, that are believe to be associated with abnormalities of GABAergic transmission. Increased amounts of DBI-like immunoreactivity were found in the CSF of patients suffering from severe depression with a severe anxiety component (Barbaccia, Costa, Ferrero, Guidotti, Roy, Sunderland, Pickar, Paul and Goodwin, 1986). Moreover, the amount of DBI and its processing products was found to be increased in the CSF of patients with hepatic encephalopathy (HE) (Rothstein, McKhann, Guarneri, Barbaccia, Guidotti and Costa, 1989; Guarneri, Berkovich, Guidotti and Costa, 1990). The clinical rating of HE correlated with the extent of the increase in DBI in CSF. Other lines of research suggest that DBI and DBI processing products may be important factors in behavioral adaptation to stress, acting via benzodiazepine (BZD) binding sites, located on mitochondria. DBI and its processing products, ODN and TTN, are present in high concentrations in the hypothalamus and in the amygdala, two areas of the brain that are important in regulating behavioral patterns associated with conflict situations, anxiety and stress. In CSF, the content of DBI changes in association with corticotropin releasing factor (CRF) (Roy, Pickar, Gold, Barbaccia, Guidotti, Costa and Linnoila, 1989). Finally DBI is preferentially concentrated in steroidogenic tissues and cells (adrenal cortical cells, Leydig cells of the testes and glial cells of the brain).(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Role of DBI in brain and its posttranslational processing products in normal and abnormal behavior. 166 69

Recent studies have shown that mothers of developmentally delayed children are at risk for depression. During weekly psychoeducational group meetings, Roy's adaptation model was used to identify the focal, contextual, and residual stimuli that contributed to the mothers' depression. Nursing interventions that encouraged adaptation in the four modes were implemented by group facilitators providing parent education and emotional support. Implications for nurses in a variety of settings are given.
 ...
PMID:Enhancing the coping skills of mothers with developmentally delayed children. 170 30

A study was conducted with 103 community-based, low-income, well elderly persons who resided in high-rise apartments and were functionally independent. The nursing framework was Roy and Roberts' (1981) adaptation model and techniques from Beck's (1976) theory on cognitive therapy. This study had the dual purpose of determining nurses' ability to identify normal adaptive reactive depression and use techniques from cognitive therapy for depressed subjects. These nurses were able to identify depression using the Diagnostic and Statistical Manual of Mental Disorders (third edition, revised) guidelines with 92% accuracy. Participants were divided into three groups: control group, crafts group, and experimental group. Over 8 weeks, the experimental group received nursing intervention aimed at reinforcing positive input thought patterns. Daily diaries were used for discussion. The experimental group demonstrated a significant reduction in depressive symptoms. The group receiving craft classes decreased their depression scores, suggesting attention-effects depression. The control group demonstrated no significant change in depression scores.
 ...
PMID:Treating depression in well older adults: use of diaries in cognitive therapy. 173

The paper draws attention to the increased incidence of clinical depression reported during the climacteric period of the female life continuum. It seeks to identify factors which may be responsible for this phenomenon, drawing upon research and anecdotal evidence from both the biological and social sciences. With this aim, changes during the climacteric period for women are examined within a bio-psycho-social framework. Nursing care and treatment of those suffering depression within this stage of the middle years are discussed briefly and the influence of personal beliefs, held by both the patient and clinician, emphasized. The relevance and importance of these factors when employing the Roy Adaptation model in the care of such clients is also considered. In conclusion, the author stresses the need for a holistic approach and highlights the value of Roy's model in care provision for this patient group.
 ...
PMID:Depression during the female climacteric period. 826 43

This prospective study assessed the caregiving responsibilities and reactions of family members who provide home care to a relative who is dependent on total parenteral nutrition (TPN). A short, semistructured interview based on the Roy adaptation model was used to gather data about the caregiving experiences of 20 relatives of adult TPN-dependent patients. Data were content analyzed, and frequently occurring themes identified. Results indicated that altered family responsibilities as well as negative and positive psychologic reactions to caregiving do occur. The interviews suggested that caregivers master TPN technology but make little use of assistance from extended family or professionals. Although depression and fatigue were reported as common, these family members felt capable and successful in their caregiving roles. Further longitudinal research with larger samples should allow for comparison of caregivers on demographic differences, stress, and other variables pertinent to managing complex home care.
 ...
PMID:Responsibilities and reactions of family caregivers of patients dependent on total parenteral nutrition at home. 837 32

This study examined the relationships between and among the variables of loneliness, social support, depression, and cognitive functioning in adults over 60, living in senior housing in a metropolitan area. Other variables, namely, life-satisfaction and ability to perform activities of daily living, were also measured. Although the research hypotheses were not supported, relationships between subjects' health status, life satisfaction, and self-assessment of health were significant. Assessment of these variables by community and advanced practice nurses who work with community elderly, to effect positive client outcomes, is presented within the context of Roy's adaptation model.
 ...
PMID:Loneliness, social support and depression as interactive variables with cognitive status: testing Roy's model. 885 Sep 83

Although self-esteem is an important concept, nursing has only begun to focus on the significance of self-esteem as a mechanism for achieving wellness among adolescents, and as a variable for targeted intervention. Nursing studies identifying self-esteem as the primary focus of their research in an adolescent population seeking treatment in mental health settings are scarce. The Roy Adaptation Model's Theory of a Person as an Adaptive System was used to guide this descriptive, correlational study. Research examined the self-report of self-esteem on age, gender, smoking, exercise, depression, anger, and parental alcohol use in a sample of adolescents ages 12-19 years who were being treated in an outpatient mental health setting.
 ...
PMID:Self-esteem in adolescents treated in an outpatient mental health setting. 1053 92

Over the past decade, nursing has identified the significance of self-esteem in maintaining wellness among adolescents. Low self-esteem has been linked to numerous adolescent risk behaviors such as smoking, drug use, and sexual activity. Adolescents engaging in these risk behaviors may have subsequent health problems, such as alcohol and drug addiction, as well as teen pregnancy. Present treatment modalities for low self-esteem have not been optimally effective. Nursing needs to examine adolescent self-esteem within the discipline of nursing and develop its own prevention and intervention strategies. Guided by the Roy Adaptation Model, our study used a descriptive, correlational design and examined the self-report of self-esteem on age group, gender, exercise participation, smoking, parental alcohol usage, depression, and anger in a nonclinical, community sample of adolescents aged 12-19.
 ...
PMID:A study of self-esteem among well adolescents: seeking a new direction. 1053 89

Depression is a common condition among long-term care residents with limited treatment options available. There are few nonpharmacological interventions available to this population. This study examined the use of a prescribed, therapeutic recreation-nursing intervention, wheelchair biking, for treatment of symptoms of depression in older adults in a long-term care setting. A classical experimental design was used and was guided by the Roy Adaptation Model. Forty residents were pretested for depression and randomly assigned to two groups. A 2-week trial of biking therapy was provided to the treatment group. All participants were posttested. Findings indicated there was a statistically significant improvement in depression scores for the treatment group and no significant change for the control group. This study contributes to the body of knowledge of nursing regarding options for the treatment of depression in older adults, and is an encouraging indicator that psychosocial interventions may be effective in reducing depression.
 ...
PMID:Easy rider wheelchair biking. A nursing-recreation therapy clinical trial for the treatment of depression. 1191 69

Roy was advised that a new drug which had just come on the market would assist his chronic depression. He was not given any further information, but after taking it for a few days found that it had a strong effect on his personality and he became aggressive and violent. As a consequence of a fight at work he lost his job and now claims that had he known of these effects he would not have taken the new drug.
 ...
PMID:Giving medicinal information to mentally capacitated patients. 1459 63


1 2 Next >>