Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Mice ingesting 30 to 50% D2O (heavy water, deuterium oxide) developed a dose-dependent depression of formed peripheral blood elements in 4 to 9 days. The principal mechanism of anemia and thrombocytopenia is impaired hematopoiesis. Despite pancytopenia in the peripheral blood, bone marrow cellularity and morphology remained normal. Upon replacement of D2O with tap water, platelet and neutrophil concentrations returned to normal within 48 to 72 hr. In contrast, blood lymphocyte concentrations remained low for several weeks. B-lymphocytes may be more affected by deuteration than other lymphocyte subsets. In vivo reticuloendothelial cell function, as assessed by 51Cr-labeled sheep erythrocyte clearance, was unaffected by D2O. Although a dose-dependent decrease in fluid intake occurred during deuteration, hematocytopenia was not a consequence of dehydration. In view of the known kinetics of D2O in biological systems, the rapid response of myeloid elements to deuteration must be due primarily to the solvent (nonmetabolic) isotope effect. Prolonged deuteration has proven toxic when included in regimens for treatment of neoplasia, including leukemia, in animal models. The present study shows that modulation of hematopoiesis by D2O is possible without invoking the toxicities associated with prolonged deuteration.
 ...
PMID:Effects of deuteration on hematopoiesis in the mouse. 283 49

Further knowledge of the nature and significance of the relationships of elderly persons to their adult children requires the application of social support scales tapping the quality and content of their interactions. Scaling efforts must further address conceptual and operational specification, the differentiation of sources and dimensions of support, the objectification of self-report scales, and construct validity. Respondents to this survey are a community, stratified probability sample of adults aged 50 and older (N = 1,174). Measures employed include 2 items reflecting instrumental support and 17 items designed to tap Cobb's (1976) definition of expressive support as consisting of information that one is loved, esteemed, and embedded in a social relationship characterized by mutual caring and obligation. Factor analyses consistently discern one instrumental and three expressive dimensions of support: Caring and Concern, Social Integration, and Love and Affection. These subscales are differentially correlated with sociodemographic characteristics of the parents and adult children, as well as with depression and disability. Implications of these and other findings are discussed.
 ...
PMID:Measuring the communication of social support from adult children. 292 81

Progressive central nervous system depression developed in a Celebes black macaque (Macaca nigra) acquired from a zoo in Texas. A spinal tap revealed motile trypanosomes in the spinal fluid. Histological examination of the heart and brain revealed focal myocarditis and intracellular amastigotes, respectively.
 ...
PMID:Encephalitis associated with Trypanosoma cruzi in a Celebes black macaque. 310 52

The association between the presence of depressive symptoms and cancer incidence and mortality and mortality from noncancer causes was studied in a population-based cohort of 6848 persons free of cancer who were followed from 1965 to 1982 as part of the Alameda County study. Age-adjusted and multivariate analyses involving over 111,000 person-years of follow-up demonstrated an association between high levels of depressive symptoms at baseline and deaths from noncancer causes but no association with either cancer incidence or cancer mortality. Our analyses suggest the possibility that the presence of previously diagnosed cases of cancer and the inclusion of items which tap somatic problems in depression scales may contribute to differences between these results and others in which depression has been linked to cancer mortality.
 ...
PMID:Depression and cancer mortality and morbidity: prospective evidence from the Alameda County study. 336 68

Tendon reflex characteristics were examined in endurance-trained, sprint-trained, and control subjects (10 SS/group) using a conditioned patellar tendon reflex (PTR) paradigm. Paired PTRs were administered using inter-tap intervals of 0, 25, 50, 75, 150, and 300 ms, with the left leg reflex elicited first, followed by a right leg PTR. A force transducer secured at the ankle was used to measure peak force, time to peak force, and reflex latency. In the unilateral condition, significant differences (P less than 0.05) existed between athletic groups, with the sprint-trained athletes exhibiting greater peak force, faster time to peak force, and faster reflex latency than the endurance athletes. Significant differences (P less than 0.05) also existed for the conditioned reflex. There was a slight depression in reflex parameters in the untrained and sprint-trained groups up to an interval of 50 ms. At later intervals (greater than 50 ms), a marked enhancement occurred in all groups for all dependent measures studied. This longer latency excitatory effect persisted until the 150 ms interval. These differences in both simple and conditioned reflexes in individuals trained for endurance and sprint activities may reflect inherent differences in muscle-tendon stiffness or neural organization.
 ...
PMID:Conditioned patellar tendon reflexes in sprint- and endurance-trained athletes. 336 53

Rats treated chronically with caffeine become tolerant to caffeine-induced stimulation of locomotor activity and cross-tolerant to theophylline. This study was performed to determine if the cross-tolerance between these two methylxanthine drugs is symmetrical. Symmetrical cross-tolerance produced by two different drugs implies a common underlying mechanism of action. Separate groups of rats were given scheduled access to drinking bottles containing either drug-free tap water or 1.0 mg/ml theophylline solution. Daily theophylline intake averaged 59 mg/kg. Dose-effect curves were determined in both control and theophylline-treated groups for 5 drugs: the methylxanthines theophylline and caffeine, a nonxanthine psychomotor stimulant, d-amphetamine, and the adenosine analogs R(-)-N6-2-(phenylisopropyl)adenosine and 5'-(N-ethyl)carboxamidoadenosine. All drugs were injected i.p. and locomotor activity was measured for 30 min beginning 35 min later. Rats that were maintained chronically on theophylline were completely tolerant to the locomotor activity stimulant effects of acutely administered theophylline and cross-tolerant to caffeine-induced stimulation of locomotor activity. In contrast, both control and treated groups were fully responsive to the stimulant effects of d-amphetamine. Low doses of the adenosine analogs produced stimulation of locomotor activity in both groups of rats. Higher doses produced a dose-dependent depression of locomotor activity in control rats; curves for the theophylline-treated rats were shifted to the right of the control curves. Thus, adenosine antagonist activity of theophylline remained evident at a time of complete tolerance to the stimulant effect of the drug on locomotor activity.
 ...
PMID:Tolerance and cross-tolerance to theophylline-induced stimulation of locomotor activity in rats. 337 67

The many conceptual and methodological difficulties involved in evaluating depression rating scales for children are discussed. A clinical validation of the Depression Self-Rating Scale for Children (DSRSC) is described. The instrument is easy to use and has a predictive value comparable with that of a psychiatric global rating of depressed appearance and history of depression obtained at interview. There was confirmation that the DSRSC can tap an internal dimension of depression and that children are able to evaluate their feeling states. An examination of misclassified children pointed to diagnostic overlap and some unreliability of diagnosis by clinicians.
 ...
PMID:Clinical evaluation of a self-rating scale for depressive disorder in childhood (Depression Self-Rating Scale). 355 38

As a result of temperature differential dipping of turkey eggs in 715 p.p.m. of tylosin or 1000 p.p.m. spiramycin in tap water, air sac lesions caused by M. meleagridis were reduced 87% and 72%, and the M. meleagridis isolations were reduced 85% and 84% respectively. Mean weights at six weeks of age showed that poults hatched from eggs dipped in tylosin and spiramycin were 128 and 130 grams heavier than control birds. This difference in mean weights was apparent at two weeks of age. DIPPING OF EGGS IN SPIROMYCIN APPARENTLY PRODUCED A DETRIMENTAL EFFECT ON THE POULTS ONE TO SEVEN DAYS OF AGE, RESULTING IN: increased mortality of 62.4% vs. 12.5% for control and 14.7% for those dipped in tylosin, and a mean weight depression of -3.6 grams and -4.4 grams below those dipped in control or tylosin solutions, although no detrimental effect of the antibiotic introduction was apparent at hatching time.
 ...
PMID:Experimental control of Mycoplasma meleagridis in turkeys by the dipping of eggs in tylosin and spiramycin. 424

The effects on the Hoffmann reflex and tendon tap responses in the human soleus and medial gastrocnemius muscles of a brief conditioning volitional contraction have been compared with the objective of distinguishing contributions from the central nervous system and the periphery. The H-wave on successive trials over a 50 sec period following contraction for the most part demonstrated a depression, especially upon the initial trial. The T-wave responses in the first few trials were greater than those in the control period. Using the assumption that responses to tendon taps had been reduced by the amounts reflected in the excitability curve for H-response, it was deducted that a marked enhancement in T-wave excitability had been present at the initial tendon tap and more moderate facilitation thereafter. This is consistent with the post-contraction discharge and increase in stretch sensitivity of spindle receptors seen after contraction of a muscle in experimental animals. It is concluded that such effects on spindles may occur in man, maybe of such force as to detectably influence dynamic movements.
 ...
PMID:Changes in excitability of tendon tap and Hoffmann reflexes following voluntary contractions. 615 55

Moderate body deuteration combined with a cytostatic drug [methotrexate (MTX)] significantly increases the survival time of young adult DBA/2 mice bearing transplantable P815. L5178Y, or L1210 tumors. Neoplastic cells were grown in vitro from tumor stock and injected i.p. into mice from two groups, one drinking tap water, and other drinking 30% heavy water in tap water. One-half of the animals in each of these two groups was given a single injection of MTX (4 mg/kg body weight) on 3 consecutive days per week. At death, extension of primary and metastatic tumors was examined and was found to be macro- and microscopically comparable in the corresponding groups. The mean survival time of untreated mice drinking tap water was about 2 weeks following injection of the fast-growing P815, L5178Y, or L1210 (V) tumors and approximately 5 weeks after injection of cells from a slower-growing L1210 subline. Body deuteration alone roughly doubled the survival time solely of mice bearing this L1210 subline. Treatment with MTX approximately doubled the mean survival time of hosts bearing one of the fast-growing tumors. Combined treatment with heavy water and MTX increased the mean survival time of the mice in all groups by 15 to 125% as compared to control values. The reasons for this effect are unknown. However, heavy water has been shown to exert antimitotic activity and to depress the incorporation of radioactive precursors into DNA of proliferating mammalian cells. The depression of antibody formation following antigenic stimulation and the reduction in numbers of nonneoplastic lymphoid cells of mice following moderate body deuteration may have contributed to the enhancement of MTX activity in addition to other effects of deuterium.
 ...
PMID:Survival of tumor-bearing mice exposed to heavy water or heavy water plus methotrexate. 680 Jun 46


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>