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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case report is described wherein the monoamine oxidase inhibitor phenelzine was administered for 10 months at different doses. Drug treatment in the initial part of the study was double blind. Weekly psychotherapy was instituted at the point of symptomatic recovery. At a reduced dose, in month 3, the patient experienced a relapse in depression. While platelet monoamine oxidase inhibition was greater than 80 per cent the patient was well, but at the point of relapse, inhibition was 14 per cent. Clinical ratings at relapse (Beck and SCL-90 scales) revealed greater readiness by the patient to report psychological discomfort compared with the original interview. The combined effects of psychotherapy and pharmacotherapy were felt to be responsible for this change. However, psychotherapy in this form and duration did not prevent relapse, which depended upon maintaining an adequate dose of phenelzine.
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PMID:Single case study. Complementary effects of phenelzine and psychotherapy in long term treatment of depression. 11 5

The authors treated 19 depressive inpatients double-blind with a mean dose of 78 mg/day of phenelzine for 3 weeks to determine the possible relationship between monoamine oxidase (MAO) inhibition and the effectiveness of phenelzine. Clinical ratings made on the Hamilton Depression Rating Scale, the Beck Depression Inventory, and the SCL-90 indicated a minimum of 60% MAO inhibition had to be achieved for the drug to be consistently beneficial.
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PMID:Inhibition of platelet monoamine oxidase in depressed subjects treated with phenelzine. 34 26

In 1973, the Family Planning Services of the University of Pennsylvania developed a pilot project which encouraged high school students to manage their reproductive behavior over a period of time by providing them with educational and emotional incentives. Educational incentive was provided by a series of classroom discussions which emphasized attitudes, personal relationship, and family planning information. Emotional support was provided by encouraging students to request, for free, contraceptives and gynecological services at the hospital. Regular clinic visits were encouraged and dropouts were followed up. The study consisted of 161 never-pregnant high school black girls, 14-18 years old; the majority belonged to low-income families (62%). On clinic visits, students filled out emotional assessment forms. Results of the project showed that of the 161 students, only 10% had unintended pregnancies, and this was attributed to misunderstanding or misuse of the contraceptives. Also noted was the concern for regular clinic visits and support during the initial phase of contraceptive use. Older girls were also found to be more likely to have unintended pregnancies than younger girls. Results of the emotional assessment, using the SCL-90 and the Hopkins Symptoms Checklist, showed that the girls who got pregnant had the highest scores in depression and somatic dimensions than the rest of the study. The findings indicate that given the proper incentives, adolescents who become sexually active are capable of using contraceptives effectively. It is implied that although society does not sanction adolescent use of contraceptives, teenagers who are on the throes of sexual activity should at least be given the opportunity to protect themselves.
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PMID:Adolescent health services and contraceptive use. 67 83

In Dutch samples of treated heroin addicts, high prevalences of a heterogeneous psychiatric co-morbidity can be found with regard to Diagnostic and Statistical Manual (third edition) (DSM-III) classifications, Zung Depression Inventory, and sum scores of a 90-item Symptom Checklist (SCL-90). A high-threshold (N = 87) and a low-threshold (N = 116) program are compared with regard to psychopathology and severity of psychopathology. A consecutive admissions design was used. More than 50% of the respondents suffered from a lifetime DSM-III Axis I disorder (70% with antisocial personality disorder included), and 40% were still suffering from one of the disorders in the year preceding the interview. Schizophrenia was diagnosed five times as much as in normal population samples (5%). The most frequently diagnosed disorders were recurrent major depression, phobic disorders, alcohol abuse and dependence, dysthymic disorder, and antisocial personality disorder. The prevalences of DSM-III disorders, the total number of symptoms, and the score on the Zung Depression Inventory and 90-item Symptom Checklist were all significantly higher in treatment-seeking drug addicts entering the high-threshold program. Within each program, three clinically meaningful subgroups can be distinguished: one group with DSM-III Axis I lifetime or current psychopathology and/or antisocial personality disorder, one with antisocial personality disorder only, and one with neither DSM-III psychopathology nor antisocial personality disorder. Possibly, self-selection results in patients with more serious conditions entering more treatment-oriented facilities. Odds ratios show that schizophrenia and mood disorders and especially associated on a lifetime and current basis.
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PMID:Prevalence of psychopathology in drug-addicted Dutch. 131 65

One hundred and seven consecutive patients attending the outpatient epilepsy clinic at a teaching general hospital were assessed by clinical interview for a history of sexual abuse. Questionnaires dealing with overall psychiatric symptomatology i.e., (SCL-90), (TSC-40) and depression (ZSRDS) were also used. The majority of subjects were single (60%), living at home (76.6%) and had an average age of 29 years. The mean duration of epilepsy was 18.8 years and the seizures were controlled with medication in 65.2% of patients. Ten (9.3%) of the subjects had been sexually abused. This frequency of sexual abuse is lower than in the general population and among psychiatric patients. The specific form of sexual abuse consisted of sexual intercourse (n = 4), fondling (n = 4) and oral sex (n = 2). The sexually abused subjects had significantly higher scores on the anxiety subscale of the SCL-90 and depression score on the ZSRDS than non-abused subjects.
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PMID:Sexual abuse and psychiatric symptoms in an epileptic population. 134 75

Research about the dominating hypoactivity in electrodermal system in affective disorders led to the assumption that electrodermal activity (EDA) could be an important biopsychological trait in the etiology of depression. However, experimental results are contradictory. Some studies find nosological validity, other studies an influence of psychomotor status on EDA or correlations to clinical improvement, etc. Most of these results are based on laboratory conditions (habituation experiment with tones). The person-situation-environment interaction and their dynamic process regulation on electrodermal activity are neglected. Also lacking is a comparable description of nosology, psychomotor status and experimental design. After discussing the neuropsychological background of the habituation paradigm which led to the "traditional" assumptions of the correlation between electrodermal activity and depression, results of different samples are shown tested over years using always the same classification and experimental methods. None of our assumptions could be verified. Although low levels in SCL dominate, we could not find results of high sensitivity and specificity in contrast to controls. However we found differences in other, more complex experiments containing personality traits and reactions to emotional words. In a multi-level process-oriented stress paradigm of the success/failure type we found a delay in regeneration of psychological and electrodermal measures after failure. This results demonstrate that investigation in electrodermal activity needs more complex and process-oriented experimental designs. EDA probably has not the quality of a biological marker, but seen in the context of person and situation factors it differentiates depressed states.
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PMID:[Electrodermal hypoactivity in depression: psychobiological marker or differential psychophysiologic disposition?]. 137 48

Atypical facial pain is generally an unclearly defined pain syndrome. We tested in 35 patients (31 women, 4 men) with a mean age of 53.2 +/- 14.9 years and a chronic facial pain syndrome the quality of the new diagnostic criteria of the International Headache Society (IHS), at the same time using the SCL-90-R (Self-Report Symptom Inventory), to identify any associated psychopathology. In accordance with the literature there is a marked female preponderance, an altogether vague description of symptoms and a long history of incorrect diagnoses. Of note is the high number of invasive procedures (3.5 +/- 3.0). In agreement with the IHS commentary, an operation or injury to the face was a suspected cause in 43%. In contrast to the IHS criteria, we found in our patient sample dysaesthesia (63%), bilateral occurrence (37%), remission periods (57%), pain attacks (23%) and presence of superficial as well as deep pain. Depression is by no means the only psychopathological abnormality in atypical facial pain; a broad spectrum of complaints is seen. The IHS classification appears insufficient to separate atypical facial pain from other primary headache and facial pain syndromes. We therefore suggest a modified version of the IHS criteria for atypical facial pain.
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PMID:[Atypical facial pain--quality of IHS (International Headache Society) criteria and psychometric data]. 143 49

The Symptom Checklist-90-Revised (SCL-90-R) has often been used in studies of alcoholic populations. Based on findings reported in the literature and data gathered on 712 alcoholics in treatment, this paper investigates the general trends in the responses of alcoholics to the SCL-90-R. On global measures as well as on each of the symptom scales, the scores of alcoholic groups reveal a symptomatology two to five times as severe as that observed in the general population. The Psychoticism dimension shows the most marked divergence with the general population. In almost each of the study groups, the Depression Scale registers the highest scores, followed by Obsessive-Compulsive, Interpersonal Sensitivity, and Anxiety.
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PMID:Profiles of alcoholics according to the SCL-90-R: a confirmative study. 144 61

This study investigated the relationship between medical severity, stress appraisals, and psychological symptoms in a representative sample of mothers of children with myelomeningocele. Although these mothers may be at risk for the development of depression and anxiety problems, substantial variability in their psychological adjustment exists, perhaps due to differences in illness severity and stress appraisals. A sample of 66 mothers answered several questionnaires, including the Stress Questionnaire and SCL-90-R. Medical indexes reflecting severity were obtained from medical charts. Correlational analyses indicated no relationship between medical indexes and maternal adjustment. Appraised illness stress was not related to medical indexes but was significantly related to adjustment. Regression analyses including demographic, medical, and appraised stress variables accounted for 32% of the variance in adjustment. The findings suggest the importance of cognitive appraisal of stress as opposed to objective medical severity in the explanation of maternal psychological adjustment to myelomeningocele.
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PMID:Medical stress, appraised stress, and the psychological adjustment of mothers of children with myelomeningocele. 146 8

The purpose of this study was to investigate antecedents of first incidence of major depressive disorder and recurrent brief depression with the help of a cohort of 20 year-old Swiss, who was interviewed four times up to age 30. Cases diagnosed as depressed at the third or fourth interview (age 28 or 30) were compared with never diagnosed controls for antecedents at the first and second interview (age 21 and 23). Besides retrospectively assessed childhood precursors, later depressives showed slight differences in their relationship to parents and friends and early symptoms of subclinical depression, persistent helplessness and a surplus of life events. These antecedents were mainly found in females. The most persistent antecedent of later depression for both sexes was a higher score than controls' on the SCL-90R ("negative affectivity"). Whether this finding signifies that proneness to the milder depressions in young adults is rooted in personality is subject to discussion.
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PMID:The Zurich Study. XVI. Early antecedents of depression. A longitudinal prospective study on incidence in young adults. 148 4


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