Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0011570 (
depression
)
172,036
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The effect of developmental growth on the kidney content of phosphoribosyl pyrophosphate
PPRibP
was studied in rats at ages between the foetal animal and up to 100 days of age. In addition, the effect of short-term diabetes (up to 14 days) on the renal content of
PPRibP
was studied in immature rats and in adults aged approx. 60 days. The developmental pattern of
PPRibP
is such that the
PPRibP
content is lowest in the young rat and increases as the rate of kidney growth slows. In the adult rat, the early kidney hypertrophy of diabetes is accompanied by a fall in
PPRibP
content and, again, the
PPRibP
content returns to normal as the rate of kidney hypertrophy diminishes. Induction of diabetes in the immature rat causes a lesser degree of kidney hypertrophy and also a smaller
depression
of renal
PPRibP
content. The activity of PPRibP synthetase (EC 2.7.6.1) is not significantly affected by age or diabetes. The changes in
PPRibP
content are discussed in relation to the generation of ribose 5-phosphate by the pentose phosphate pathway and the utilization of
PPRibP
for nucleotide synthesis via the 'de novo' and salvage pathways.
...
PMID:Concentration of phosphoribosyl pyrophosphate in the kidney during development and in experimental diabetic hypertrophy. 242 32
