Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0011570 (
depression
)
172,036
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
There is a growing body of research investigating the gene expression signature of
depression
at the genome-wide level, with potential for the discovery of novel pathophysiological mechanisms of
depression
. However, heterogeneity of
depression
, dynamic nature of gene expression patterns and various sources of noise have resulted in inconsistent findings. We systematically review the current state of transcriptome profiling of
depression
in the brain and peripheral tissues with a particular focus on replicated findings at the single gene level. By examining 16 brain regions and 5 cell types from the periphery, we identified 57 replicated differentially expressed genes in the brain and 21 in peripheral tissues. Functional overlap between brain and periphery strongly implicates shared pathways in a comorbid phenotype of
depression
and cardiovascular disease. The findings highlight dermal fibroblasts as a promising experimental model for
depression
biomarker research, provide partial support for all major theories of
depression
and suggest a novel candidate gene,
PXMP2
, which plays a critical role in lipid and reactive oxygen species metabolism.
...
PMID:Differential gene expression in brain and peripheral tissues in depression across the life span: A review of replicated findings. 2756 17
