Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Patients receiving anticonvulsants such as phenytoin or carbamazepine may be resistant to neuromuscular blocking agents. The authors report the response to rapacuronium bromide (1.5 mg/kg) in two adult patients; one receiving phenytoin and the other receiving carbamazepine. In both patients, there was a delay in achieving maximum blockade; 100% depression of the first twitch was never achieved in the patient receiving phenytoin. Recovery of neuromuscular function was rapid. In the patient receiving phenytoin and carbamazepine respectively, the clinical duration (time to return of T1% to 25% of baseline) was 5 and 9 minutes, the recovery index (T1 25%-75%) was 4 minutes and 3 minutes, and the time to return of T4/T1 to greater than 0.7 was 15 minutes and 18 minutes 40 seconds. As has been reported with other neuromuscular blocking agents of the aminosteroid class, the clinical duration and the recovery index of rapacuronium are shortened in patients receiving either phenytoin or carbamazepine.
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PMID:Rapacuronium administration to patients receiving phenytoin or carbamazepine. 1142

Bromate formation during ozonation of bromide-containing natural waters is somewhat inversely connected to the ozone characteristics: an initial fast increase followed by a slower formation rate. During the initial phase mostly OH radical reactions contribute to bromate formation,whereas in the secondary phase both ozone and OH radicals are important. To minimize bromate formation several control options are presented: ammonia addition, pH depression, OH radical scavenging, and scavenging or reduction of hypobromous acid (HOBr) by organic compounds. Only the two first options are applicable in drinking watertreatment. By both methods a similar effect of a bromate reduction of approximately 50% can be achieved. However, bromate formation during the initial phase of the ozonation cannot be influenced by either method. Ammonia (NH3) efficiently scavenges HOBrto NH2Br. However, this reaction is reversible which leads to higher required NH3 concentrations than expected. The rate constant kNH2Br for the hydrolysis of NH2Br by OH- to NH3 and OBr- was found to be 7.5-10(6) M(-1) s(-1). pH depression shifts the HOBr/ OBr- equilibrium to HOBr and also affects the ozone chemistry. The effect on ozone chemistry was found to be more importantfor bromate formation. For a given ozone exposure, the OH radical exposure decreases with decreasing pH. Therefore, for pH depression the overall oxidation capacity for a certain ozone exposure decreases which in turn leads to a smaller bromate formation.
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PMID:Bromate minimization during ozonation: mechanistic considerations. 1143 58

Inactivation of B. subtilis spores with ozone was investigated to assess the effect of pH and temperature, to compare the kinetics to those for the inactivation of C. parvum oocysts, to investigate bromate formation under 2-log inactivation conditions, and to assess the need for bromate control strategies. The rate of B. subtilis inactivation with ozone was independent of pH, decreased with temperature (activation energy of 42,100 Jmol(-1)), and was consistent with the CT concept. B. subtilis was found to be a good indicator for C. parvum at 20-30 degrees C, but at lower temperatures B. subtilis was inactivated more readily than C. parvum. Bromate formation increased as both pH and temperature increased. For water with an initial bromide concentration of 33 microgl(-1), achieving 2-logs of inactivation, without exceeding the 100 microg l(-1) bromate standard, was most difficult at 30 degrees C for B. subtilis and at midrange temperatures (10-20 degrees C) for C. partum. pH depression and ammonia addition were found to reduce bromate formation without affecting B. subtilis inactivation, and may be necessary for waters containing more than 50 microgl(-1) bromide.
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PMID:Inactivation of Bacillus subtilis spores and formation of bromate during ozonation. 1147 95

Nitric oxide (NO) regulates the release of catecholamines from the adrenal medulla but the molecular targets of its action are not yet well identified. Here we show that the NO donor sodium nitroprusside (SNP, 200 microM) causes a marked depression of the single Ca(V)1 L-channel activity in cell-attached patches of bovine chromaffin cells. SNP action was complete within 3-5 min of cell superfusion. In multichannel patches the open probability (NP(o)) decreased by approximately 60 % between 0 and +20 mV. Averaged currents over a number of traces were proportionally reduced and showed no drastic changes to their time course. In single-channel patches the open probability (P(o)) at +10 mV decreased by the same amount as that of multichannel patches (approximately 61 %). Such a reduction was mainly associated with an increased probability of null sweeps and a prolongation of mean shut times, while first latency, mean open time and single-channel conductance were not significantly affected. Addition of the NO scavenger carboxy-PTIO or cell treatment with the guanylate cyclase inhibitor ODQ prevented the SNP-induced inhibition. 8-Bromo-cyclicGMP (8-Br-cGMP; 400 microM) mimicked the action of the NO donor and the protein kinase G blocker KT-5823 prevented this effect. The depressive action of SNP was preserved after blocking the cAMP-dependent up-regulatory pathway with the protein kinase A inhibitor H89. Similarly, the inhibitory action of 8-Br-cGMP proceeded regardless of the elevation of cAMP levels, suggesting that cGMP/PKG and cAMP/PKA act independently on L-channel gating. The inhibitory action of 8-Br-cGMP was also independent of the G protein-induced inhibition of L-channels mediated by purinergic and opiodergic autoreceptors. Since Ca(2+) channels contribute critically to both the local production of NO and catecholamine release, the NO/PKG-mediated inhibition of neuroendocrine L-channels described here may represent an important autocrine signalling mechanism for controlling the rate of neurotransmitter release from adrenal glands.
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PMID:Nitric oxide inhibits neuroendocrine Ca(V)1 L-channel gating via cGMP-dependent protein kinase in cell-attached patches of bovine chromaffin cells. 1204 44

A false hyperchloremia in a patient with a history of depression suspected bromide intoxication. The diagnosis was confirmed by an increased bromide concentration > 20 mmoL.L-1. Rehydration was effective and allowed to decrease bromide concentration. In conclusion, hyperchloremia associated with a negative anion gap is a clue to the diagnosis.
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PMID:[False hyperchloremia in a bromide intoxication]. 1219 97

Cerebral inflammation plays a role in diseases such as multiple sclerosis (MS), Alzheimer's disease (AD), and depression. Iron is involved in infection and inflammation through free radical production. Theoretically transferrin should prohibit iron from participating in oxidative reactions, but transferrin has also been found to promote free radical damage. We reported previously that isolation of transferrin from plasma by ion exchange column chromatography produced a broad pink protein band that subsequently separated on a gel filtration column into three proteins containing many metals. In this study some properties of the three proteins were studied in 20 volunteers. Protein 3 (identified as transferrin by nephelometry) contained the most iron while Protein 1 (called "toxiferrin") contained significantly less iron (p < 0.00001). Plasma from volunteers obtained under conditions of infection/inflammation with fever (n = 5) had a significantly increased toxiferrin to transferrin ratio compared to healthy volunteers (n = 15; p < 0.001). In vitro, Protein 2 and transferrin inhibited lipid peroxidation, while toxiferrin (possibly a protease degradation product of transferrin), enhanced lipid peroxidation. Also, toxiferrin (1 mg/mL) caused a significant increase in viability of monocytes as measured by the 3-(4,5-dimethyl-thiazol-2-yl) 2,5-diphenyl tetrazolium bromide (MTT) reduction test, as well as the morphological transformation of monocytes to macrophages.
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PMID:Biochemical model for inflammation of the brain: the effect of iron and transferrin on monocytes and lipid peroxidation. 1521 10

Shiga toxins (Stxs, also referred to as verotoxins) were first described as a novel cytotoxic activity against Vero cells. In this study, we report the characterization of an Stx1-resistant (R-) stock of Vero cells. (1) When the susceptibility of R-Vero cells to Stx1 cytotoxicity was compared to that of Stx1-sensitive (S-) Vero cells by methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay, cell viability after 48-hr exposure to 10 pg/ml of Stx1 was greater than 80% and less than 15%, respectively. (2) Although both a binding assay of fluorescence-labeled Stx1 and lipid analysis indicated considerable expression of Gb3Cer, a functional receptor for Stxs, in both Vero cells, anti-Gb3Cer monoclonal antibodies capable of binding to S-Vero cells failed to effectively label R-Vero cells, suggesting a conformational difference in the Gb3Cer expressed on R-Vero cells. (3) The lipid analysis also showed that the R-Vero cells contained significant amounts of Gb4Cer. In addition, introduction of exogenous Gb4Cer into S-Vero cells slightly inhibited Stx1 cytotoxicity, suggesting some correlation between glycosphingolipid composition and Stx1 resistance. (4) Both butyrate treatment and serum depression eliminated the Stx1 resistance of R-Vero cells. (5) The results of the analysis by confocal microscopy suggest a difference in intracellular transport of Stx1 between R-Vero and S-Vero cells. Further study of R-Vero cells may provide a model of Stx1 resistance via distinct intracellular transport of Stx1.
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PMID:Characterization of a shiga-toxin 1-resistant stock of vero cells. 1521 25

Potentially carcinogenic bromate forms during the ozonation of bromide-containing waters. Some water treatment facilities have had to use ammonia addition and pH depression to minimize bromate formation, but these processes may prove to be insufficient to comply with upcoming regulations. The chlorine-ammonia process (Cl2-NH3), consisting of prechlorination followed by ammonia addition priorto ozonation is shown to cause a 4-fold decrease in bromate formed when compared to the ammonia-only process. Experiments revealed three key mechanisms: (i) oxidation by HOCl of Br- to HOBr and its subsequent masking by NH3 as NH2Br; (ii) decrease of HO- exposure through halogenation of Dissolved Natural Organic Matter (DNOM) by HOCI and scavenging of HO by NH2Cl; and (iii) DNOM acting as a bromine sink after oxidation of Br- to HOBr. At an ozone exposure of 6 mg/L x min and pH 8, conventional ozonation of Lake Zurich water spiked with 560 microg/L Br- formed 35 microg/L BrO3-, whereas the application of the Cl2-NH3 process resulted in 5 microg/L BrO3-. Additional pH depression to pH 6 further decreased bromate formation by a factor of 4. Trihalomethanes (THM) and cyanogen chloride (CNCl), that mayform during prechlorination and monochloramination, respectively, were well below regulatory limits. The chlorine-ammonia process holds strong promise for water treatment facilities struggling with a bromate formation problem during ozonation.
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PMID:Enhanced bromate control during ozonation: the chlorine-ammonia process. 1550 16

Anion affinities, gammaX-, for the aerial interface of aqueous (Br- + NO3- + I- + SCN- + BF4- + ClO4-) solutions are determined by electrospray ionization mass spectrometry. The composition of the ions ejected from the surface of fissioning nanodroplets shows that gammaX- increase (decrease) exponentially with anionic radii, aX-(dehydration free energies, dGX-), and selectively respond to the presence of surfactants. BF4-, the least hydrated and polarizable anion of the set, has one of the largest gammaX- values. Non-ionic surfactants decrease gammaI- and gammaSCN- but increase gammaBF4-. Cetyltrimethyl ammonium markedly enhances the gammaX- of smaller anions. A similar but weaker effect is observed upon lowering the pH of the bulk solutions from 8.2 to 3.0. Dodecyl sulfate has a negligible effect on gammaX-. Considering that (i) universal many-body electrodynamic interactions will progressively stabilize the interfacial layer as its dielectric permittivity falls relative to that of the bulk solution and (ii) water permittivity is uniformly depressed by increasing concentrations of these anions, we infer that the observed Hofmeister correlation, ln gammaX- infinity - dGX-, is consistent with the optimal depression of the permittivity of the drier interfacial layer by the least hydrated ions. Interfacial ion-ion interactions can significantly influence gammaX- in environmental aqueous media.
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PMID:Experimental anion affinities for the air/water interface. 1718 Nov 93

Serotonin receptors are present in lymphocytes and might be related to the functionality of these cells in health and in pathology. The serotonergic system is affected in the brain and in peripheral immune cells of depressed patients. The objectives of this work were to evaluate the basal proliferation of lymphocytes, the response to the mitogen concanavalin A, and the role of serotonin 5-HT(1A) receptors. Twenty-nine patients, 19-52 years old, were diagnosed for a major depression episode with the Statistical and Diagnostic Manual-IV of the American Psychiatric Association, approved by ethic committees and gave written consent. The Hamilton depression score was 30.60 +/- 2.65. An apparently healthy group without a family history of psychiatric illness was included. Blood peripheral lymphocytes were isolated by density gradients with Ficoll/Hypaque and differential adhesion to plastic, cultured in 96-well plaques with RPMI-1640 medium with or without 4 mug/ml of concanavalin A. 8-Hydroxy-2-(di-n-propylamino)tetralin (5-40 nM) and WAY-100,478 (0.1-100 microM), agonist and antagonist of 5-HT(1A) receptors, serotonin (12.5-100 nM) or imipramine (0.1-100 microM) were also added. Proliferation was evaluated at 72 h with 3-[4,5-dimethythiazol-2-yl]-2,5-diphenyltetrazolium bromide, and the optical density was 570 nm. Basal proliferation was three times higher in depressed patients than in controls, whereas no response to mitogen was obtained, and 5-HT(1A) receptors significantly reacted to the agonist, with increases of about 31-54% at 10, 20 and 40 nM of the specific agonist, indicating initial activation probably in relation to autoimmunity and overreactivity of these receptors in depression. The antagonist reduced proliferation in mitogen-stimulated lymphocytes, 50% in controls and 70% in depressed patients, with a differential concentration dependency; probably, these receptors are more sensitive in depression due to increased 5-HT(1A) receptor transduction. The antagonist also reduced the stimulation produced by the 5-HT(1A) agonist. Imipramine caused biphasic effects according to concentrations, showing a possible dual role for serotonin, although all values were significantly higher in depressed subjects. The described alterations might be of relevance in the pathophysiology of depression.
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PMID:Serotonin, 5-HT1A serotonin receptors and proliferation of lymphocytes in major depression patients. 1770 35


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