Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This study was carried out to confirm or refute the theory that IUDs need to be replaced every few years due to their breaking. Fracture and chemical composition of the deposit formed on 26 Lippes Loops after prolonged use (up to 7 years) were analyzed. The sediment consisted of calcium carbonate (77.2-83.1%), magnesium (.32-.41%), sodium (1.7-2%), and zinc (.14-.21%). The amount of sediment increased the longer the IUD was in the uterus without a change in chemical composition. The length of time in use also caused an increase in rigidity, a decrease in flexibility, and a decrease in the structural thickness of the IUD. After 1 year of use a pressure of 75 kg would only cause a depression while an IUD which had been in use for 5.5 years would break under a pressure of 25 kg. It is concluded that the current medical opinion stating that IUDs should be replaced every few years is a valid theory.
 ...
PMID:Fracture and chemical composition of the deposit formed on the Lippes loop after prolonged use. 69 52

Changes in the plasma levels and urinary excretion of zinc have been studied in a series of adult patients receiving intravenous alimentation. Urinary zinc loss may be very high in this group, but serious plasma depletion does not occur unless there is a concomitant phase of sustained anabolism in the absence of significant exogenous intake. A syndrome of acute zinc deficiency is described consisting of diarrhea, mental apathy and depression, a moist eczematoid dermatitis, most severe in the perioral area and alopecia. The response to intravenous zinc therapy is very striking although alopecia is slower to develop and complete hair regrowth is correspondingly delayed.
 ...
PMID:Acute zinc deficency in man during intravenous alimentation. 81 23

Changes in the plasma and urine levels of the trace metal zinc have been followed in a series of 37 adult patients totally supported by intravenous alimentation. Copper has also been determined in more recent cases. In such a seriously ill group, although urinary zinc loss may be very high at the height of catabolism, severe plasma depletion does not occur unless there is a subsequent phase of sustained anabolism and weight gain. In four patients plasma zinc fell to very low levels during this phase and three of this group developed a syndrome characterized by diarrhea, mental depression, para-nasal, oral and peri-oral dermatitis, and alopecia. The response to oral or intravenous zinc therapy is striking, except for hair regrowth which is delayed but eventually complete. The syndrome we have recognized in adult man has not been previously described. It resembles however the parakeratosis of zinc deficient swine and it is also very similar to Acrodermatitis enteropathica, a genetically determined disorder of infants very recently linked to zinc deficiency. Zinc is clearly essential to human metabolism and it should be included in all parenteral alimentation regimes particularly during the period of rapid, sustained, weight gain.
 ...
PMID:A syndrome of acute zinc deficiency during total parenteral alimentation in man. 81 77

Toxicity of cadmium in the young Japanese quail rapidly produced moderate growth depression, hypogonadism in the male, decreased bone ash, severe anemia, alterations of "indicator" tissue levels of several essential inorganic elements, and marked histological abnormalities of the duodenum, bone marrow, adrenal medulla, and esophageal mucus glands. Cadmium appeared to have direct effects on zinc and iron, particularly iron (III), by decreasing intestinal absorption of these elements. Small amounts of dietary ascorbic acid were protective against many of the adverse effects of cadmium. The young quail proved to be a useful species for these studies. The experience with cadmium may have some facets that would prove useful in further studies of the effects of ascorbic acid on the toxicity of other metals.
 ...
PMID:Protective effects of ascorbic acid against toxicity of heavy metals. 106 Mar 97

The effect of heat exposure and bacterial endotoxins on plasma zinc levels and mean rectal temperature of 8 week old broilers and investigated. Broilers exposed for 2 hours to 35-35 degrees C. had higher (P less than 0.01) mean rectal temperatures (42.8 vs 41.7 degrees C.) than sham treated broilers maintained at 22-24 degrees C. Likewise, endotoxin (E. coli, 500 mug./kg) treated broilers also had mean rectal temperatures significantly higher (P less than 0.01, 42.4 vs 41.7 degrees C.) than sham treated broilers. Plasma zinc levels in the bacterial endotoxin treated broilers were lower (P less than 0.05) than in the sham treated (173 vs 220, and 219 mug/kg./100 ml. plasma, respectively). In contrast, the plasma zinc concentration was not significantly depressed in the broilers exposed to heat for 2 hours. In summary, either endotoxin or heat exposure resulted in increased body temperature, however only the response to endotoxin resulted in a significant depression of plasma zinc concentration.
 ...
PMID:The effect of heat exposure and bacterial endotoxin on plasma zinc concentration and the body temperature in the broiler. 109 33

A deficiency of dietary zinc during the suckling period of the rat results in a depression in normal growth, which is, in part, due to the inanition experienced by the dam. The pups from such zinc-deficient dams have smaller forebrains at all of the time intervals investigated in comparison with pups from both zinc-adequate controls. The cell number of the forebrain of the zinc-deficient pup was also reduced in comparison with the zinc-adequate pups. RNA concentration did not appear to be affected, although the total RNA content was reduced because of the smaller brain size. The amount of protein per cell was reduced at 6 and 15 days in the zinc-deficient forebrain and polysomal profiles displayed abnormal distribution of material between monosomes and polysomes in the zinc-deficient brain. Zinc deficiency during the suckling period thus appears to disadvantage the animal in terms of body, brain growth, accretion of cells into the forebrain, and normal protein metabolism.
 ...
PMID:Some effects of postnatal zinc deficiency on developing rat brain. 111 96

The effects of adding tetrodotoxin, zinc, tetraethylammonium and manganese ions and the effects of the changes in calcium concentration in the bathing solution were studied upon the initiation and propagation of spreading depression waves elicited in the isolated chicken retina. The spreading depression (SD) was unaffected by tetrodotoxin in the concentrations used to block action potentials on axons. Tetraethylammonium and zinc ions had only a slight effect slowing the rate of propagation, an effect which was relieved by increasing the potassium or the calcium concentration. Zero calcium gave rise to the appearance of spontaneous waves of SD and a late loss of the excitability of the preparation. Low calcium concentrations slowed, and high concentrations increased, the rate of propagation. The late and prolonged increase in light reflectance was diminished under high calcium. Manganese blocked the responses. This blocking effect was antagonized by calcium simply by elevating its concentration above that of manganese.
 ...
PMID:Ionic movements in the isolated chicken retina during spreading depression. 122 40

Zinc nutritional status was examined in 10 adult patients with biopsy-proven celiac disease; five of these patients were clinically well on gluten-free diets at the time of study. Plasma zinc and taste acuity were used as indices of zinc nutrition. Depression of plasma zinc and lowered taste discrimination were observed among the untreated patients, and some patients who were otherwise in clinical remission also had impaired zinc nutrition. With confirmation of plasma copper depression in patients with celiac sprue, these observations indicate that trace metal deficiency is another common nutritional complication of adult celiac disease.
 ...
PMID:Zinc nutrition in celiac sprue. 126 87

Tissue and organ deposition and blood parameters were evaluated as indices of mineral and trace element absorption in rats. The absorption of elements was quantified in relation to nitrogen retention, i.e., considering the weight gain and new tissue synthesis. A rapeseed meal diet was supplied with three levels of calcium, two levels of zinc, and two levels of copper in a factorial design. In general, an increase in dietary mineral content increased the relative absorption, which in turn, increased the tissue deposition progressively. Striated muscle, however, did not respond to either an increased calcium or zinc supply. Furthermore, an increased calcium absorption caused a depression of the fractional phosphorus and magnesium content of femur bones. The copper content of the kidneys and the heart muscle was directly proportional to the amount of absorbed zinc and iron, respectively. The iron content of tissue was, in general, inversely proportional to zinc absorption and showed a tendency to be directly proportional to copper absorption. The zinc level in tissues was, in a similar way, inversely correlated to measured calcium absorption. In conclusion, interactions between elements do not only affect the intestinal element absorption, but also the distribution of already absorbed elements in tissues and organs.
 ...
PMID:Tissues and organs as indicators of intestinal absorption of minerals and trace elements, evaluated in rats. 128 Sep 83

A study of 35 (5 x 7) male, individually housed, albino rats (initial average weight = 50 g) was undertaken to examine the effect of an addition of microbial phytase to a diet containing phytate on the availability of zinc. The rats were fed a semisynthetic diet based of egg white and cornstarch over a 3-week period. All diets were supplemented with 20 mg Zn/kg. Group I (control) was fed the basal diet free of phytic acid (PA) and phytase. By replacing cornstarch by Na-phytate (0.5% in group II and 1.0% group III), molar phytate: Zn ratios of 25 and 50:1 were obtained, respectively. In groups IV (0.5% PA) and V (1.0% PA) 1000 U of microbial phytase were added. A molar phytate:Zn ratio of 25 (group II) and 50:1 (group III) resulted in a dose-dependent depression of growth and feed efficiency ratio. These negative effects of the addition of PA could be completely counteracted by the supplementation of 1,000 U of phytase in group IV and partially so in group V. Similarly, the apparent absorption and retention of Zn, Zn-concentration in femur and testes and different Zn-status-parameters in plasma (Zn-concentration, percent unsaturated plasma-Zn binding capacity, activity of alkaline phosphatase) were improved by adding 1,000 U microbial phytase/kg diet. The present study shows that an addition of microbial phytase to phytate-rich diets considerably improves the availability of Zn in growing rats.
 ...
PMID:[The effect of a supplement of microbial phytase on zinc availability]. 133 30


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>