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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sediment ingestion has been identified as an important exposure route for toxicants in waterfowl. The toxicity of lead-contaminated sediment from the Coeur d'Alene River Basin (CDARB) in Idaho was examined on posthatching development of mallard (Anas platyrhynchos) ducklings for 6 weeks. Day-old ducklings received either untreated control diet, clean sediment (24%) supplemented control diet, CDARB sediment (3,449 microg/g lead) supplemented diets at 12% or 24%, or a positive control diet containing lead acetate equivalent to that found in 24% CDARB. The 12% CDARB diet resulted in a geometric mean blood lead concentration of 1.41 ppm (WW) with over 90% depression of red blood cell ALAD activity and over threefold elevation of free erythrocyte protoporphyrin concentration. The 24% CDARB diet resulted in blood lead of 2.56 ppm with over sixfold elevation of protoporphyrin and lower brain weight. In this group the liver lead concentration was 7.92 ppm (WW), and there was a 40% increase in hepatic reduced glutathione concentration. The kidney lead concentration in this group was 7.97 ppm, and acid-fast inclusion bodies were present in the kidneys of four of nine ducklings. The lead acetate positive control group was more adversely affected in most respects than the 24% CDARB group. With a less optimal diet (mixture of two thirds corn and one third standard diet), CDARB sediment was more toxic; blood lead levels were higher, body growth and liver biochemistry (TBARS) were more affected, and prevalence of acid-fast inclusion bodies increased. Lead from CDARB sediment accumulated more readily in duckling blood and liver than reported in goslings, but at given concentrations was generally less toxic to ducklings. Many of these effects are similar to ones reported in wild mallards and geese within the CDARB.
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PMID:Developmental toxicity of lead-contaminated sediment to mallard ducklings. 1087 25

The present study was conducted to test the effects of exercise stress on the ECG of the congenitally deaf children from school for deaf, in view of the occurrence of the Jervell-Lange Neilsen (Surdo Cardiac) variant of the Long QT Syndrome (LQTS) in them. An ECG Lead II was recorded at rest and after two minutes of static jogging. For comparison, the same protocol was repeated in normal healthy children from another school. ECG were analysed for the calculation of corrected QT interval (QTc) by Bazett's equation QTc = QT/square root of R-R and also for the evidence for other abnormalities. Both in the normal and deaf children, exercise did not produce significant (P > 0.05) change in QTc from their resting values. However, when pre and post exercise QTc values of deaf children were compared with normal children, the female deaf had significantly longer QTc (P < 0.01) both at rest and after exercise than normal female children. Normal children did not show significant ECG abnormality either at rest or on exercise. On the contrary many of their counter part (deaf) exhibited occasional ECG abnormality at rest but plethora of abnormalities after exercise viz., sinus arrhythmias, sinus pauses, ST depression, T-inversion, biphasic-T, notched-T, T-alternans, nodal ectopics and junctional rhythm. These results lend credence to the hypothesis of sympathetic imbalance and repolarisation defects in deaf children's heart, which in more severe form could pass into frank Jervell-Lange Neilsen variant of the Long: QT Syndrome.
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PMID:Electrocardiographic changes following exercise in the congenitally deaf school children: relationship with Jervell Lange Neilsen syndrome (the Long QT syndrome). 1087 53

The present study assessed the relationship between numbing and three associated conditions of alexithymia, apathy, and depression, utilizing data collected on 353 Vietnam combat veterans diagnosed with Posttraumatic Stress Disorder from in- and out-patient settings and an outreach center at various Department of Veterans Affairs Medical centers. All subjects completed four self-report measures: the Glover Numbing Scale, the Beck Depression Inventory, the Apathy Evaluation Scale, and the Toronto Alexithymia Scale-20. The correlation matrix indicated that scores on the four measures were moderately to highly correlated. Principal components analysis with a varimax rotation indicated a five-factor solution that provided evidence for the factorial validity of each of the constructs assessed. Results of the factor analysis of items from the four measures were consistent with numbing being a separate and distinct construct from alexithymia, apathy, and depression. In general, results indicated that all constructs measured were separate and distinct from one another.
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PMID:Relationship of numbing to alexithymia, apathy, and depression. 1129 28

Recent studies have shown that younger women are more likely to die during and after hospitalization for acute myocardial infarction (MI) than older women and men of all ages. This may be partly due to incorrect diagnosis or late detection of acute MI in younger women. At high specificity levels (>98%), the sensitivity of the initial ECG to detect acute MI may be as low as 30% when using traditional criteria by both physicians and computerized interpretation programs. This study examines if women of different age groups have a similar ECG presentation to men during acute inferior MI and if the diagnostic accuracies of the initial ECG are comparable. We analyzed chest pain ECGs from Mayo Clinic and Medical College of Wisconsin, which included 1,339 patients with acute inferior MI and 1,169 age-matched controls with noncardiac chest pain. We subdivided all groups by age (below and above 60 years) and compared ECG parameters (ST elevation, ST depression, QRS duration, R-wave amplitude, Q-wave duration and amplitude, QT interval) between genders. For inferior MI patients under age 60, women had lower ST elevations at the J point in lead II than men (57 +/- 91 microV vs. 86 +/- 117 microV, P < .02). This trend was reversed for patients over age 60 (lead a VF: 102 +/- 126 microV vs. 84+/-117 microV, P < .04; Lead III: 130+/-146 microV vs. 103+/-131 microV, P < .007). A neural network method was used to identify the most significant group of ECG parameters for detecting acute MI. An adaptive fuzzy logic method was developed for adapting to the threshold differences among the different gender and age groups. The new algorithm improved the sensitivity of acute inferior MI detection by more than 25% relative to old algorithm, while maintaining the high specificity around 98% for noncardiac chest pain patients.
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PMID:A new method to incorporate age and gender into the criteria for the detection of acute inferior myocardial infarction. 1178 61

O-Isobutyl S-[2-(diethylamino)ethyl]methylphosphonothioate (VR) is a structural isomer of a more widely known chemical warfare agent O-ethyl S-[2(diisopropylamino)ethyl]methylphosphonothioate (VX). VR has the potential of being used as military threat/sabotage/terrorist agent. The development of a sound medical countermeasure will undoubtedly enhance not only our medical readiness and ability in VR casualty management, but also our defense posture against the deployment of VR in both combat and politically volatile environments. Acute exposure to a lethal dose of VR has been shown to cause cholinergic hyperfunction, incapacitation, seizures, convulsions, cardiorespiratory depression and death. In this study, pharmacological antagonism of VR-induced cardiorespiratory failure and lethality was investigated in guinea pigs chronically instrumented for concurrent recordings of electrocorticogram, diaphragmatic EMG, Lead II ECG, heart rate and neck skeletal muscle EMG. Thirty (30) min prior to intoxication with a 2 x LD50 dose of VR (22.6 micrograms/kg, s.c.), animals were pretreated with pyridostigmine (0.026 mg/kg, i.m.). Immediately after VR intoxication, animals were given pralidoxime chloride (2-PAM; 25 mg/kg, i.m.) and atropine sulfate (2, 8 or 16 mg/kg, i.m.). In animals that displayed seizures and convulsions, diazepam (5 mg/kg, i.m.) was administered 10 min following the onset of epileptiform activities. Responses to pretreatment/therapy modality were evaluated at 24 h post-VR. All animals survived the 2 x LD50 VR challenge. With the exception of an increased heart rate in response to atropine, the myocardial and diaphragmatic (respiratory) activity profiles appeared normal throughout the course of intoxication and recovery. Animals receiving 2 mg/kg atropine all developed fasciculations, seizures, signs of excessive mucoid/salivary secretion, and needed diazepam adjunct therapy. One-half (50%) of the animals receiving 8 mg/kg atropine developed seizure activities and were given diazepam, whereas the other half only showed a brief period of increase in CNS excitability. No fasciculations, seizures or convulsions were noted in animals receiving 16 mg/kg atropine. In summary, although lethality can be prevented with the pretreatment/therapy modality containing 2 mg/kg atropine and diazepam adjunct, a complete CNS and cardiorespiratory recovery from 2 x LD50 of VR requires a minimum of 8 mg/kg atropine.
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PMID:Pharmacological antagonism of lethal effects induced by O-isobutyl S-[2-(diethylamino)ethyl]methylphosphonothioate. 1217 52

"This article examines the major economic pros and cons of illegal immigration and answers the question: what, if any, are the public and private costs of illegal immigration in the United States? In brief, the article finds that between four and 5.4 million illegal immigrants reside here.... The article also finds that illegal immigrants and their own citizen children cost taxpayers an additional $12 to $16.2 billion annually for education, public services, and incarceration after deducting all local, state, and federal taxes paid in by them. In the private sector, illegal aliens are found to save their employers and owners of capital about $1.5 billion more than U.S. workers lose due to wage depression. The article also considers what legal and enforcement reforms would be necessary to dramatically slow the current flow of 300,000 illegals yearly and concludes that, although improvements in the system are now being proposed, the actual reforms will be insufficient to more than stem the currently rising tide of illegals due to economic instability in Mexico and the Third World."
Curr World Lead 1995 Apr
PMID:The net national costs of illegal immigration into the United States. 1229 91

The present investigation was carried out to study the ameliorative effects of L-Met (L-methionine) on Pb-exposed mice by the measurement of the weight gain, the weight of organs, the Hb content, the level of lipid peroxidation (LPO), and the Pb and Fe contents of selected organs and serum. Thirty mice were randomly divided into the healthy control group (A), the Pb control group (B), and the Pb+L-Met-treated group (C). Lead-induced depression of growth and Hb content was reversed when L-Met was added to the daily drinking water. The level of LPO of all the samples from group B was significantly higher than group A (p<0.05); however, in group C, it was lowered, especially that in the brain, kidney, and serum, which were not significantly different than normal (p>0.05). Significant enhancement of Pb content (p<0.05) and significant decrease of Fe content of all the samples in group B (p<0.05) were observed. However, dietary Met significantly lowered Pb concentration of all the samples (p<0.05) compared to that of the liver and kidney, reaching no significance in comparison to group A (p>0.05). The Fe concentration changed little (p>0.05). The result suggests that L-Met has an ameliorative effect on Pb-exposed mice.
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PMID:Ameliorative effect of L-methionine on Pb-exposed mice. 1283 4

This paper describes the results of non-destructive investigations by indirect neutron radiography methods obtained at the facility NEUTRA [Nondestruct. Testing Eval. 16 (2000b) 203], spallation neutron source SINQ [Operating experience and development projects at SINQ, PSI Report 98-04, ISSN 1019-0643]. Target rods from the second SINQ metal target were removed after 6 Ah of proton beam exposure and studied under well-shielded conditions. No real damage was found at one of the 11 observed rods and one tube. However, hydrogen accumulation could be identified inside the zircaloy rods and the steel rods as well. Whereas the hydrogen has a homogenous distribution in Zr (with the peak value near the centre of the applied beam), the steel samples show clusters of hydrogen near the edge of the Zr cladding. Lead (in steel cladding) was found modified by accumulations of spallation products, mainly mercury. In the radiography images, a depression of the neutron field was observed due to the absorption by mercury. The applied method with Dy and In as neutron converters and imaging plates [Nucl. Instrum. Methods 377 (1996) 119] as secondary detectors seems to be optimal for such kind of investigations, especially when quantitative considerations have to be made.
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PMID:Study of material changes of SINQ target rods after long-term exposure by neutron radiography methods. 1524 6

The bioaccumulations of lead in the liver and hepatic microsomes of fish after 1, 3, 7, 14, 28, and 45 days exposure were studied. In addition, the relationship between the bioaccumulated lead in both hepatic microsomes and the liver and their haem biosynthetic enzymes were studied. Lead toxicity was shown to result in a depression of the microsomal mixed function oxidase system, as assessed by a decrease in hepatic microsomal cytochrome P-450 and b5 content and by a decrease in the activity of the enzymes aniline hydroxylase and aminopyrine demethylase. Lead had a more marked effect on cytochrome P-450 than b5. The activity of the rate-limiting enzyme of haem biosynthesis, delta-aminolevulinic acid synthase, was inversely correlated with the microsomal cytochrome P-450 content. The activity of the heam biosynthetic enzymes delta-aminolevulinic acid dehydratase, coproporphyrinogen oxidase and ferrochelatase were decreased by increasing lead pretreatment. The activity of the haem catabolic enzyme, haem oxygenase, was increased by concentration and length of time to lead exposure.
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PMID:The effect of lead bioaccumulation on haem biosynthetic enzymes in fish. 1525 3

Six weak whooper swans (Cygnus cygnus) and two weak tundra swans (Cygnus columbianus) were found at Swamp Miyajima (Hokkaido, Japan) in May 1998. Anorexia, depression, green watery feces, pale conjunctiva, and anemia were observed. Radiographs showed from six to 38 suspected lead pellets in the gizzard. Blood lead concentrations were 2.5-6.7 microg/g (mean+/-SD=4.6+/-1.14 microg/g) on day 1. After blood collection, the birds were treated with calcium disodium ethylenediaminetetraacetate (CaEDTA) given intravenously and force fed. Despite treatment, seven birds died the next day. Green, bile-stained livers and pale or green kidneys were observed on necropsy. Microscopically, bile pigment was widespread in the liver and acid-fast intranuclear inclusion bodies were observed in renal tubular epithelium. Lead concentrations in livers and kidneys were 14.0-30.4 microg/g and 30.2-122 microg/g wet weight, respectively. Only one bird survived and this whooper swan continued to be treated with CaEDTA and activated charcoal. No lead shot was observed in the proventriculus and gizzard by radiography on day 64 and the blood lead concentration decreased from 2.9 microg/g to 0.09 microg/g during that same period. After 4 mo of rehabilitation, the whooper swan was returned to the wild. Lead intoxication continues to be a problem at Swamp Miyajima.
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PMID:Lead poisoning in whooper and tundra swans. 1582 33


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