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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Where necessary, women should be counselled so as to understand that a slim, elegant figure is not the prerogative of all. An inherited large frame requires a corresponding body contour, and dieting to change this situation will be in vain. All weight reducing diets must provide an adequate amount of vitamins and minerals. Women on the contraceptive pill often have diminished serum levels of folic acid and vitamin B6, and there have been suggestions that vitamin supplementation may help overcome depression and diminished libido in some women. This has been partially successful. A well-balanced diet should be recommended prior to trial of supplements. During pregnancy and lactation there is an increased need for protein, calcium, iron, iodide and fluoride. Vitamin and iron supplementation may be required where deficiencies exist due to dietary neglect. Excessive alcohol and smoking should be discouraged--especially during pregnancy. The elderly are particularly vulnerable to diseases of nutritional deficiency for various reasons. The importance of foods providing protein, calcium and vitamins should be stressed, as these are the main nutrients lacking. The consumption of meat, milk, cheese, eggs, fish, fresh fruit and vegetables should be encouraged.
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PMID:Nutrition and family practice. 86 Sep 67

Data on prenatal, labor and delivery, and postnatal medication exposure to neonates were collected. During an 11-week period, 100 neonates consecutively admitted to a hospital were studied. The pharmacist obtained a social and medication history from the mothers and reviewed maternal anesthesia records and the charts of the neonates. Fifteen definite and possible adverse medication reactions were detected in 13 neonates. The median number of different medications ingested prenatally was 4.7. The four most commonly ingested prenatal medications were vitamins (97%), iron preparations (90%), headache/pain/arthritis medications (68%) and antinausea/vomiting medications (40%). The most commonly used medications during labor and delivery were oxytocin (73%), meperidine (33%) and promazine (25%). The use of strong narcotics during this period produced neonatal respiratory depression in some cases. The four most commonly prescribed postnatal medications were vitamin K1 (100%), gentamicin (10%), ampicillin (8%) and Poly-Vi-Sol (6%). The maternal interview indicated that most mothers were unaware of the influence that many medications can play upon the fetus. It is recommended that the pharmacist conduct a maternal medication interview prior to labor and delivery.
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PMID:Neonatal medication surveillance by the pharmacist. 87 83

Records of 11 postmenopausal parkinsonism patients were evaluated in comparison with those of 11 postmenopausal depression patients. None had a history of encephalitis, stroke, drug-induced or toxic extrapyramidal disorders, or active bleeding within six months before admission. There was no significant differences between the two groups with regard to time interval from menopause to onset of symptoms, height, weight, or age at first admission. Both groups showed normal height, hemoglobin, hematocrit, and erythrocyte counts. Parkinsonism patients were underweight and had a shorter interval from menopause to onset of symptoms (12.4 +/- 1.9 vs. 16.8 +/- 2.5 yr.). These findings are compatible with the hypothesis that in parkinsonism, hereditary predisposition to positive body iron balance may be associated with alteration of the blood-brain barrier in parkinsonism.
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PMID:Postmenopausal Parkinsonism: brain iron overload? 93 Jul 48

The effect of 10 days of total fasting (energy deprivation) on blood polymorphonuclear granulocyte functions, leukocyte numbers, iron and transferrin levels was evaluated in 14 healthy, normal-weight males. Granulocytes from 7 of the subjects were tested in vitro. A statistically significant depression was noted in their bactericidal capacity against Staph. aureus. The 14 subjects showed a marked decrease in the stainable activity of granulocyte alkaline phosphatase and decreases were noted in plasma iron and serum transferrin levels. The iron saturation of serum transferrin was unchanged. Thus, impairment of granulocyte bactericidal functions may occur secondarily to short-term total energy deprivation, in the absence of iron deficiency.
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PMID:Fasting (acute energy deprivation) in man: effect on polymorphonuclear granulocyte functions, plasma iron and serum transferrin. 96 52

Similar depressions in growth were observed when rats consumed a 10% casein basal diet containing equal quantities of either methionine or S-methyl-L-cysteine. Supplemental glycine or serine partially alleviated the growth depression caused by the high levels of methionine but were ineffective in alleviating the growth depression caused by high levels of S-methylcysteine. Histological examination of five organs of rats fed the basal, high methionine or high S-methylcysteine diet for 6, 13 or 20 days revealed that only the spleens were affected in that there was erythrocyte engorgement and an accumulation of hemosiderin. The intensity of iron staining in spleens decreased from the second to the third week. The similarity in the depression of growth and splenic damage observed in rats consuming high levels of methionine or S-methylcysteine is consistent with an earlier suggestion that metabolism of the methionine or S-methylcysteine is consistent with an earlier suggestion that metabolism of the methyl group is in some way involved in the toxicity of methionine.
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PMID:Growth depression and tissue reaction to the consumption of excess dietary methionine and S-methyl-L-cysteine. 99 52

The effects of a chemically-modified tapioca starch hydroxypropyl distarch phosphate (HDP), and unmodified tapioca starch (UMS) on 59Fe retention by rats were compared. Three experimental variables were evaluated: 1) the type of starch in the diet, 2) cooking of either the starch alone or the entire diet, and 3) the iron status of the rats. There were no significant differences in 59Re retention between iron-adequate rats fed either UMS or HDP. 59Fe retention by iron-deficient rats was not affected by the type of starch in the diet when uncooked starch was used. However, if the starch was cooked, substitution of HDP for UMS resulted in a significant depression in iron retention by iron-deficient rats. Cooking the entire diet produced a similar but less marked effect. The results of these experiments suggest that the inclusion of one particular type of modified tapioca starch in the diet may affect iron utilization.
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PMID:Effect of modified and unmodified tapioca starches on 59Fe retention in rats. 99 56

Extravasated maternal blood, which escapes from capillaries and larger blood vessels within the tips of the maternal septa, is responsible for the characteristic pigmentation of the central depression of the ovine cotyledon in the last third of pregnancy. The chorionic epithelium of this region is actively engaged in the uptake and subsequent breakdown of maternal erythrocytes, which may represent an important source of iron for the foetus during the period of maximum intra-uterine growth.
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PMID:Ultrastructural studies of the placenta of the ewe: phagocytosis of erythrocytes by the chorionic epithelium at the central depression of the cotyledon. 105 16

Toxicity of cadmium in the young Japanese quail rapidly produced moderate growth depression, hypogonadism in the male, decreased bone ash, severe anemia, alterations of "indicator" tissue levels of several essential inorganic elements, and marked histological abnormalities of the duodenum, bone marrow, adrenal medulla, and esophageal mucus glands. Cadmium appeared to have direct effects on zinc and iron, particularly iron (III), by decreasing intestinal absorption of these elements. Small amounts of dietary ascorbic acid were protective against many of the adverse effects of cadmium. The young quail proved to be a useful species for these studies. The experience with cadmium may have some facets that would prove useful in further studies of the effects of ascorbic acid on the toxicity of other metals.
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PMID:Protective effects of ascorbic acid against toxicity of heavy metals. 106 Mar 97

Cell-mediated immunity has been studied in patients with 1) megaloblastic anemia of folic acid deficiency, 2)megaloblastic anemia of pregnancy, or 3) iron-deficiency anemia. Using dinitrochlorobenzene skin tests, phytohemagglutinin-stimulated lymphocyte transformation, and rosette inhibition by antilymphocyte globulin, we have shown that cell-mediated immunity is depressed in megaloblastic anemia due to folate deficiency; this depression was reversed by folate treatment. Cell-mediated immunity was not impaired by iron-deficiency anemia. Suggested interactions between iron deficiency and folate metabolism were not clarified by these studies.
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PMID:Depressed cell-mediated immunity in megaloblastic anemia due to folic acid deficiency. 111 20

Male Sprague-Dawley rats maintained for a period of 6 or 12 weeks on a basal vitamin E-dificient diet consisting of 70% sucrose, 20% vitamin-free casein, 4% tocopherol stripped lard, 4% salt mixture, and 2% tocopherol-free vitamin fortification mixture were used to compare two sets of commonly used salt mixtures (salt mixtures USP XIV versus Briggs' salt mixture) and two sets of vitamin fortification mixtures (NBC vitamin fortification mixture versus that of Weglicki). Among the rats maintained on the deficient diets for 6 weeks, only those that received the combination of salt mixture USP XIV and vitamin fortification mixture of Weglicki showed a significantly lower level of hepatic catalase activity compared to the corresponding control animals. While there were no significant changes in microsomal cytochromes at this time period, after 12 weeks on the deficient diet, a significant depression in these cytochromes was noted in all experimental groups except the one on salt mixture USP XIV and NBC vitamin fortification mixture. A similar decrease in hepatic catalase was observed in deficient animals at 12 weeks. Since the most striking differences in these diets are in their content of iron and menaquinone, it appears that these two dietary constituents may interact in modulating the effect of vitamin E on hepatic hemeproteins.
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PMID:Effects of different vitamin E-deficient basal diets on hepatic catalase and microsomal cytochromes P-450 and b5 in rats. 118 Feb 43


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