Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Treatment of chronic uremia by hemodiafiltration requires replacement of the filtrate. Using Ringer's solution alone, there is a depression of pH because of bicarbonate loss. To bring the acid base status back to normal, sodium lactate in increasing concentrations (283 mg% = 32 mM/1, 361 mg% = 40 mM/1; 462 mg% = 51 mM/1; 508 mg% = 57 mM/1) was added to the replacement fluid. The optimal concentration is 450 mg% (=50 mM/1) sodium lactate, provided the following conditions are fulfilled: (a) substitution after the filter; (b) mixing ratio of blood and substitution fluid 1:2. Using 12-15 liters of substitution fluid during a 5 hr treatment, the added lactate amounts to 60 g (=0.54 M). With continuous addition of lactate, the serum concentration of lactate is 3.5 times normal and the concentration of serum pyruvate 4 times normal. An excess lactate concentration, according to Huckabee [1,2], was thus not observed. The sieving coefficients were the following: sodium, potassium, urea, lactate, pyruvate, and phosphate 1; chloride greater then 1; calcium and protein less than 1. Serum osmolality fell, on the average, 9 mOsmol/1 during diafiltration.
J Dial 1977
PMID:Acid base status during treatment of chronic uremia with diafiltration. 2 47

The responsiveness of phasically active brainstem respiratory neurons to several amino acids was investigated in cats under Dial anesthesia. Four-barreled microelectrodes were used to extrude iontophoretically the putative neurotransmitters L-glutamate, L-asparatate, glycine, and gamma-aminobutyric acid (GABA), L-glutamate and L-aspartate caused increased activity when applied to either inspiratory or expiratory neurons and appeared to be equal in efficacy. Likewise, GABA and glycine depressed ongoing phasic neural activity of both inspiratory and expiratory units. In this case, however, the dosage of GABA required to produce a given depression was significantly less than the required dosage of glycine. These findings support the hypothesis that L-glutamate and/or L-aspartate may act as excitatory neurotransmitter agents at the synapses of brainstem respiratory neurons and conversely, GABA may act as the natural inhibitory neurotransmitter.
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PMID:Effects of excitatory and inhibitory amino acids on phasic respiratory neurons. 3 45

This study confirms that medullary sponge kidney (MSK) has a good prognosis, but there is a considerable morbidity in patients with renal calcification; they suffer renal colic, ureteric obstruction, and frequently need operation. There is a high incidence of urinary infection in women. On follow-up, glomerular function is well maintained, although careful testing shows a mild depression of glomerular filtration rate in at least 40%. Proximal tubular function is normal, but abnormalities of distal tubular function are often seen: acidification defects occur in 24% and are associated with nephrocalcinosis, poor urine concentrating ability, and diminished glomerular function. Urine concentration defects occur in 73% and are probably secondary to nephrocalcinosis. Hypercalciuria was present in 19% and was not related to other defects.
Proc Eur Dial Transplant Assoc 1977
PMID:Medullary sponge kidney: abnormalities of renal tubular and glomerular function, and their relationship to clinical features. 60 Sep 68

To determine the action of acetate in man, 1.7mEq/ml of sodium acetate was infused in 10 patients on chronic hemodialysis. It was administered intravenously in 1.5mEq/min for 5 min followed by 3.8mEq/min for another 5 min. As control, 1.71mEq/ml of sodium chloride was infused in a similar manner. Following the infusion of sodium acetate, heart rate increased slightly but significantly (p less than 0.01). Limb blood flow measured in an upper limb by the venous occlusion method, showed an increase in all of them and it was significant( p less than 0.001). The peripheral vascular resistance (=mean arterial blood pressure/limb blood flow) showed a significant fall (p less than 0.001). The analysis of systolic time interval showed a change suggestive of depression of heart function at the end of sodium acetate infusion (p less than 0.05). Such a vasodilating effect or a change in heart function was not observed following sodium chloride infusion. A depressant action of acetate upon the cardiovascular system may be, therefore, concluded.
J Dial 1978
PMID:Hemodynamic effects of acetate in man. 72 84

In 10 chronic uraemic patients free oxygen species metabolism was evaluated during the early period of haemodialysis with cuprophane, polyacrylonitrile and polysulphone membranes. Cuprophane haemodialysis was found to induce an increased generation of superoxide anion by both unstimulated and opsonised-zymosan-stimulated peripheral blood phagocytes, which was accompanied by a significant depression of erythrocyte superoxide dismutase activity and augmented erythrocyte membrane lipid peroxidation. Haemodialysis with polyacrylonitrile membrane did not induce significant changes in superoxide anion generation, erythrocyte superoxide dismutase activity, and erythrocyte and plasma malonyldialdehyde concentrations. The same was found with polysulphone membrane, except for plasma malonyldialdehyde, the concentration of which was significantly decreased. Our results suggest that use of polyacrylonitrile or polysulphone membranes for haemodialysis seems to be beneficial with regard to free oxygen radical metabolism.
Nephrol Dial Transplant 1991
PMID:Free oxygen species metabolism during haemodialysis with different membranes. 166 2

Functional activity of peritoneal macrophages of 50 patients with end-stage renal failure on intermittent peritoneal dialysis (IPD) and of 30 control subjects with normal renal function was determined. Phagocytosis of latex particles by macrophages of dialyzed patients was significantly lower as compared with the controls. Further depression of the phagocytic activity was observed during bacterial peritonitis. Macrophages from the dialyzed patients also showed nonsignificantly decreased functional expression of Fc receptors (FcR) and increased spontaneous nitro blue tetrazolium (NBT) reduction.
Perit Dial Int 1991
PMID:Functional characteristics of peritoneal macrophages of renal failure patients on peritoneal dialysis. 191 21

Antibody responses against pneumococcal capsular antigens and tetanus toxoid were measured in 14 patients with chronic renal failure who were managed by continuous ambulatory peritoneal dialysis (CAPD) or haemodialysis (HD) and in eight healthy controls. IgG antipneumococcal responses were predominantly of the IgG2 and to a lesser extent IgG1 subclasses, while the IgG response against tetanus toxoid was largely IgG1 with smaller amounts of IgG4 and IgG3. The post-immunisation serum levels of IgG1 and IgM antibody against both antigens were significantly reduced in the uraemic patients compared with controls (P less than 0.05). All the uraemic patients had normal levels of IgG, IgA and IgM in the serum, but elevated levels of IgG3 prior to immunisation. The mechanisms responsible for the asymmetric depression of antibody responses in uraemia are unclear and may account in part for the increased susceptibility to infection in these patients.
Nephrol Dial Transplant 1989
PMID:T-cell-independent and T-cell-dependent antibody responses in patients with chronic renal failure. 249 80

The effects of intravenous acetylsalicylic acid (1.0 g bolus) on renal function and prostaglandin synthesis were evaluated in a prospective, controlled study in eight patients in an intensive care unit. Four of these patients had congestive heart failure. Administration of acetylsalicylic acid caused significant antidiuresis (-56%), antinatriuresis (-82%), renin suppression (-26%) and decreased GFR (-41%). All of these changes were completely reversible within 1-2 hours and tended to be more pronounced in the patients with congestive heart failure. Urinary excretion of prostaglandin E2 was depressed profoundly (-93%) and did not return to more than 45% of control 6 h after the administration of acetylsalicylic acid. We conclude that intravenous acetylsalicylic acid affects kidney function in a manner similar to other prostaglandin synthesis inhibitors. Its effects are, however, short-lived. The inhibition of urinary PGE2 excretion outlasts GFR depression, antidiuresis, antinatriuresis and renin suppression by several hours.
Nephrol Dial Transplant 1986
PMID:Effects of intravenous aspirin on prostaglandin synthesis and kidney function in intensive care patients. 311 Jun 70

A retrospective study in 20 seronegative and 61 seropositive (complement fixation) first cadaver donor graft recipients brought evidence that in cytomegaly, not the infection alone, but curtailment of azathioprine shortly after transplantation (or summation of both) may result in rejection and impaired graft survival. Preliminary data (accumulation of 125I-labelled fibrinogen in two and morphology of the graft in two other patients) showed that depression of graft function in cytomegaly is not necessarily due to rejection.
Proc Eur Dial Transplant Assoc 1980
PMID:Renal allograft function and cytomegaly. 626 21

In this paper, the author emphasizes the practical importance for the internist of determining the underlying content of the patient's fantasies about his illness and its treatment. These fantasies are often the cause of the anxiety and depression that accompanies physical illness and may be quite divorced from the reality of the situation. When the particular fantasies are elicited, the physician will be in a position often to directly reassure the patient about unrealistic concerns. By communicating his understanding, the physician increases the power of the patient's bond to him and is in a position to substantially alleviate emotional distress that stems from physical illness.
Clin Exp Dial Apheresis 1983
PMID:Meaning as an intervening variable. 637 73


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