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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A total of 117 patients with depression of a various genesis were studied. The patients with endogenous (circular) depression displayed a correlation between the EEG, vascular and vegetative tonus, catecholamine excretion (especially noradrenaline) and peculiarities of the clinical picture. In patients with somatogenic depression a correlation between the studied indices of a functional state of an organism is not present. Psychogenic depression is characterized by a domination of desynchronized activity of low volts in the EEG and the existence of expressed sympathicotony of the peripheral vegetative system, while statistically significant shifts of the vascular tonus and catecholamine excreation are absent.
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PMID:[Pathophysiologic mechanisms of depressive states of endogenous or exogenous origin]. 69 11

1. Adenosine and its nucleotides adenosine-5'-monophosphate (AMP) and adenosine triphosphate (ATP) have been applied by microiontophoresis to neurones in the cerebral cortex of rats anesthetized with urethane. The firing rate of most neurones was depressed, though two cells were encountered which showed biphasic responses to ATP consisting of an initial excitation succeeded by depression. 2. The application of clonidine with iontophoretic currents of less than 25 nA resulted in blockade of the depressant responses to the purines, without affecting responses to noradrenaline, 5-hydroxytryptamine or gamma-aminobutyric acid (GABA). At much higher doses of clonidine, direct depression of cell firing occurred and occasional interaction with noradrenaline was noted. 3. In the case of the biphasic responses to ATP, clonidine seemed to block only the depressant phase. Reduction of the excitatory component paralleled changes of background firing. 4. It is concluded that, in common with some other 2-substituted imidazoline derivatives, clonidine possesses the ability to block responses to purine compounds.
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PMID:Antagonism by clonidine of neuronal depressant responses to adenosine, adenosine-5'-monophosphate and adenosine triphosphate. 71 33

Central panalgesia is a syndrome which includes systemic pains of a central nature, usually classified as hysteria, fibrositis and masked depression. Exploration of the peripheral neuromuscular junctions (in the iris by pupillometry, and in veins by computerized venotest) indicates an increased monoamine receptor sensitivity. 5-HT vein sensitivity is particularly impressive (up to 1,000 times). In the vein there appears to be a decentralization supersensitivity, as it is extended to different monoamines (5-HT, dopamine, noradrenaline, tyramine). This type of supersensitivity is compatible with the theory of a deficiency of neurotransmitters at the level of the anti-nociceptive and integrated systems, with subsequent central and peripheral supersensitivity. A similar condition limited to the rostral section of the anti-nociceptive system is valid for the mechanism of idiopathic headache including migraine: central and peripheral supersensitivity to monoamines and opiates is also episodically observed in headache sufferers.
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PMID:Decentralization supersensitivity in headache and central panalgesia. 72 53

The psychological effects of an injection of methylamphetamine have been measured in 22 drug-free patients with endogenous depressive illness and in 9 patients with other psychiatric illness. A new distinction between the time course of the euphoric and anti-depressant effects is described. The euphoric effects were seen in the first hour after the injection, but the anti-depressant effects were delayed for 1--3 hours and then lasted for as long as 36 hours. These findings are at variance with the noradrenaline depletion hypothesis of depressive illness which (in its simplest form) predicts an immediate alleviation of depression as a result of an immediate rise in the concentration of noradrenaline at central receptor sites.
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PMID:A new distinction between the euphoric and the anti-depressant effects of methylamphetamine. 72 90

In anesthetized and spinal cats the influence of microionophoretic local injections of acetylcholine and noradrenaline into different layers of grey substance of lumbar segments of the spinal cord were studied with aid of monosynaptic EPSPs of motoneurons. Injections of ACH and NA in the surface layers of the grey substance of dorsal horn induced depression of monosynaptic reactions. In the area of 6--7 layers ACH induced a weak depression, while NA significantly increased the reflex responses. In the given arrangement of motoneurons NA depressed and ACH facilitated extensor and flexor monosynaptic reactions of motoneurons.
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PMID:[Microiontophoretic study of the effect of acetylcholine and noradrenaline on the monosynaptic reflex activity of the spinal cord]. 72 40

The effects of catecholamines on the circular muscle of myometria in pregnant rats at term (21st and 22nd days) were investigated by recording electrical and mechanical responses. Slow potentials were found to be the dominant activity in the morning on the 21st day of pregnancy, and spike potentials were manifested on the 22nd day. The alpha-excitation of catecholamines in the circular muscle was represented by mechanical potentiation, prolongation of the slow potential and depolarization of the membrane. In contrast, the beta-inhibition was mechanical inhibition, depression of the slow potential and hyperpolarization. Noradrenaline at a concentration of 6 X 10(-6M caused excitatory action in the circular muscle on the 21st day of pregnancy, while the effect became inhibitory on the 22nd day of pregnancy. Results obtained by the use of adrenergic agonists and antagonists led to the conclusion that the reversal of the effect of noradrenaline could be ascribed largely to the enhancement of the beta-action, the mechanism of which was brought about probably through the endogenous change in the steroid hormone secretion at the very end of pregnancy.
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PMID:Effects of catecholamines on the circular muscle of rat myometria at term during pregnancy. 73 88

In order to investigate the mode of action of biogenic amines in rat cerebral cortex, the unitary activity of spontaneously firing neurons and their excitatory response to acetylcholine (ACh) were examined using microiontophoretic administration of dopamine (DA), noradrenaline (NA) and serotonin (5-HT). The predominant effect of these biogenic amines on the spontaneous activity was a profound and prolonged inhibition of firing (2-4 min), which attained its maximum within 15-120 sec. This response was generally more abrupt in onset and of greater magnitude with NA and 5-HT than with DA. Most units inhibited by DA, NA and 5-HT also showed marked depression of their excitatory response to ACh when pretreated with these biogenic amines. With repetitive administration of ACh, it could be shown that the total duration of inhibition of ACh responses by DA and NA was not as prolonged as the inhibition of the spontaneous firing of the same cells. With 5-HT, the initial ACh responses of many neurons could be completely blocked, and this inhibitory effect lasted as long as the inhibition of spontaneous firing. In view of the anatomical data demonstrating a relative sparsity of monoamine nerve terminals in cerebral cortex, the strong inhibition induced by DA, NA or 5-HT may have reflected slow inactivation of the biogenic amines. However, it could also be indicative of underlying mechanisms of action dependent on metabolic changes. Indeed, the interaction between biogenic amines and ACh might imply a balance between the intracellular pools of cAMP and cGMP is directly or indirectly influenced by the biogenic amines and ACh, respectively. This hypothesis would not exclude other modes of local interaction between DA, NA, 5-HT and ACh, and appears compatible with the modulatory role of biogenic amines in cerebral cortex.
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PMID:Modulatory role for biogenic amines in the cerebral cortex. Microiontophoretic studies. 76 Oct 65

1. The acute cardiovascular effects of neomycin and gentamicin, representative aminoglycoside antibiotics, were examined in surgically-prepared anaesthetized rhesus monkeys. 2. Intravenous administration of 14, 28, and 56 mg/kg of neomycin consistently induced a dose-dependent depression of systemic blood pressure, cardiac output, left ventricular contractile force, maximum dF/dt of left ventricular contraction, and heart rate. Neomycin produced similar cardiovascular depressant effects when heart rate was maintained constant by electrical pacing. 3. Maximum depression of haemodynamic values usually occurred within 2 to 5 min after injection of neomycin; values then gradually returned to control levels within 20 to 30 (14 mg/kg) or 60 to 80 (56 mg/kg) minutes. 4. Injection of CaCl2 (1.35 mEq Ca2+/kg, i.v.) during the peak depressant effect of neomycin produced a rapid and maintained restoration of cardiovascular function to control levels; conversely, noradrenaline (2 mug, i.v.) of isoprenaline (0.5 mug, i.v.) produced only transient reversal of the neomycin effects. 5. Similar evidence of cardiovascular dysfunction was observed with gentamicin. 6. These findings demonstrate the direct cardiovascular depressant effects of aminoglycoside natibiotics in a higher primate species, and suggest that this adverse response is related to an alteration of calcium ion function.
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PMID:Cardiovascular depressant effects of neomycin and gentamicin in rhesus monkeys. 80 79

Sensitivity of neurones in the rostral hypothalamus of methoxyflurane anesthetized cats to the prostaglandin synthetase inhibitors (PGSIs), salicylate and fenoprofen, has been examined using the technique of microiontophoresis. Results were compared with sensitivity to prostaglandin (PG) E1 and no noradrenaline (NA) and 5-hydroxytryptamine (5HT). Simultaneous applications of PGSIs and NA or 5HT were made to investigate the role of PG in monoamine induced changes in neuronal excitability. PGSIs did not excite these cells, but depression were common, particularly with fenoprofen. PGE1 did not reverse the depressions. NA and 5HT responses were generally unaffected by simultaneous PGSI application and responsiveness to PGSIs was found to be unrelated to amine sensitivity. The results support the conclusion that PGSIs have a depressant action on neurones in this region, which may not be related to inhibition of prostagladin synthesis, and that the actions of microiontophoretically applied NA and 5HT are not dependent upon PG.
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PMID:Action of prostaglandin synthetase inhibitors on rostral hypothalamic neurones: thermoregulation and biogenic amines. 81 16

Rats in which central noradrenergic terminals have been damaged by injecting 6-hydroxydopamine (6-OHDA) into the cerebral ventricular system have been used to study the possible role of noradrenaline (NA) in the effect of trauma on thermoregulation. In non-injured rats the 6-OHDA treatment did not affect the threshold environmental temperature (Ta) for the onset of shivering or the slope of the regression lines relating intensity of shivering to Ta. It raised the core temperature (Tc) threshold for the opening of the A-V anastomoses in the tail. Whereas in normal rats ischaemic limb injury depresses the threshold Ta for the onset of shivering without altering the slope of the regression line, in 6-OHDA-treated rats no depression of the threshold Ta was observed during limb ischaemia but the slope of the regression line was lower. The Tc threshold for the opening of the A-V anastomoses in the tail was the same as in the 6-OHDA-treated controls. The injection of NA into a lateral cerebral ventricle of a normal rat in a 5 degrees environment inhibited shivering and lowered Tc. The 6-OHDA treatment did not induce hypersensitivity to the injection of NA by this route. It is thought that NA is concerned in the central inhibition of shivering during limb ischaemia.
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PMID:The role of catecholamine in the effects of trauma on thermoregulation, studied in rats treated with 6-hydroxydopamine. 83 66


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