Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Plasma zinc levels were measured in 95 elderly patients hospitalized in a long stay unit and in 100 healthy controls under 65 years of age. Plasma zinc concentrations were significantly lower in the elderly patients, as compared to the younger subjects (p 0.001). The correlations with serum prealbumin (p 0.05) and serum albumin (p 0.05) concentrations and the frequent association with protein-calorie malnutrition suggest that the low serum zinc levels mirror a low dietary zinc intake. Immunological tests in the elderly show moderate lymphopenia, high serum IgA and frequent depression of delayed cutaneous hypersensitivity to DNCB and PHA. We find a significant correlation between plasma zinc concentration and peripheral blood lymphocyte counts, but not the other immunological parameters. Linear discriminant analysis shows that the association of low plasma zinc values, low serum protein concentration and high serum IgG concentration implies poor prognosis.
 ...
PMID:[Plasma zinc levels in elderly hospitalized subjects. Correlation with other nutritional and immunological markers and survival]. 632 Mar 99

A reproducible experimental disease model in horses using Streptococcus zooepidemicus was developed. An intravenous challenge dose of 1 X 10(10) colony-forming units (CFU), followed 24 h later with another challenge of 1 X 10(8) CFU of Strep. zooepidemicus produced the desired disease model. The disease was characterized by depression, pyrexia, anorexia, abnormal lung sounds, inflammation of joints, moderate to severe lameness, gradual loss of condition and emaciation. The effects of the disease on hematology, serum chemical profile and different protein fractions were studied. The disease state had no effect on serum glucose, sodium, potassium, chloride, urea nitrogen, creatinine, uric acid, calcium, phosphorus and enzymes SGOT or SGPT. However, the alkaline phosphatase showed a gradual decline. The serum iron levels dropped markedly and remained low to the last day of observations (post-infection day, PID 13). On serum protein electrophoresis, the albumin showed a gradual decrease; whereas, alpha II, beta and gamma globulin levels rose suggesting an immune response. The elevation of rectal temperatures and white blood cell counts related well with clinical observations. The serum iron levels proved very helpful in predicting the severity of clinical signs and often dropped before the onset of clinical signs and pyrexia.
 ...
PMID:Standardization of an experimental disease model of Streptococcus zooepidemicus in the equine. 649 45

Local cerebral glucose utilization (LCGU) was studied using the carbon 14-deoxyglucose method in rats with local freezing lesion in the left parietal cortex. A depression of LCGU developed with time after the lesion, being most prominent throughout the cortical areas of the lesioned hemisphere 3 days after lesion. Corresponding results in other regions were contralateral cortical areas, ipsilateral and contralateral subcortical structures. Brain stem structures were not affected. In white matter bilateral depression of LCGU reached its peak 24 hours after the lesion. LCGU returned to normal within 5 days in all affected areas. The areas affected and the time-course of the observed changes did not correlate with the location and known time-course of development of cerebral edema. Local cerebral blood flow (LCBF) was measured 1 and 3 days after a freezing lesion using the carbon 14-iodoantipyrine method. Twenty-four hours after a freezing lesion normal LCBF were seen throughout the traumatized brain. Three days after the lesion an increased LCBF involved all cortical areas, with the hyperemia being more pronounced in the hemisphere contralateral to the lesion. No corresponding changes in LCBF were observed. Evans blue dye was injected intravenously before the start of the barrier (BBB) at each time period following the lesion could be determined. Blue staining was seen in the area of the lesion in all animals killed 4 or 24 hrs after the lesion was made, indicating a BBB permeable to the Evans blue-serum protein complex.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:[Glucose metabolism in trauma-induced brain edema, with special reference to local blood circulation and blood-brain barrier]. 663 9

The effects of ochratoxin A (OA) and tannic acid (TA) on growing chicks were determined. One-day-old male broiler chicks were fed a diet containing the following additives for 26 days: A) none; B) 3.0 ppm OA; C) 1.5% TA; D) 3.0 ppm OA plus 1.5% TA. When compared to the controls, body weights and feed efficiencies were significantly depressed in the OA and TA groups. There was a further depression in body weights and a dramatic depression of feed efficiency in the OA-TA combination group. Pigmentation, as measured by visual shank scores, was reduced in chicks fed OA singly or in combination with TA but was not affected by feeding TA singly. There were no consistent treatment differences in the relative weights of the kidney, gizzard, proventriculus, liver, bursa, or pancreas, although there was a trend toward an elevated relative kidney weight in the groups receiving OA. Serum uric acid levels were significantly elevated in the OA and the OA-TA combination group indicating impaired renal excretory function attributable to OA. Total serum protein levels were significantly depressed in the groups receiving OA, and serum calcium levels were depressed in all treatment groups. Serum phosphorus levels were decreased in the OA and OA-TA groups but were only decreased significantly in the OA group. There were no consistent treatment differences in the hematology and other blood chemistry and mineral values.
 ...
PMID:Toxicity of ochratoxin A and tannic acid to growing chicks. 663 8

The individual merit of the use of 43 variables to assess the prognosis of equine colic cases was examined. The following variables revealed highly significant (P less than 0.001) differences between cases which survived and those which died: blood pressure; heart rate; oral mucosal capillary refill time; degree of mental depression; venous haemoglobin concentration, haematocrit, erythrocyte count, urea concentration and lactate concentration; peritoneal fluid lactate concentration; and haematocrit/plasma protein and serum protein concentration ratios. Thus, in general, variables which assessed cardiovascular function were good prognostic guides.
 ...
PMID:Prognosis in equine colic: a study of individual variables used in case assessment. 664 80

To investigate the effect of stress on the dynamics of serum protein response during starvation, serum albumin, prealbumin, and transferrin changes were studied in six chair-adapted macaques during two separate 7-day test periods: (1) Starvation--NPO + IV D5/W (100 cc/kg/day), and (2) Surgery/starvation--laparotomy and gastrostomy + NPO + IV D5/W (100 cc/kg/day). During the starvation period, transferrin was the only protein that decreased from baseline values and did so at day 7 of the study period. In contrast, during the period of starvation following surgery, both prealbumin and transferrin were significantly decreased at both day 4 and day 7 of the study period, whereas albumin was only decreased at day 7 of this period. These findings indicate that the addition of a surgical stress to starvation results in a depression of serum protein levels that is not only of greater magnitude, but also more rapid in onset than observed with starvation alone. In addition, the differential response of prealbumin and transferrin to starvation and stress may provide a useful indicator of the presence and/or degree of stress in certain situations. The clinical utility of this finding remains to be ascertained.
 ...
PMID:Serum protein response to surgery and starvation. 689 11

Fibronectin (Fn), a normal serum protein which appears to have important roles in wound healing and in reticuloendothelial system function, is depressed by most types of trauma. Fn is released into the tissue at the site of an injury which suggests the depression is the result of Fn sequestration at the wound site. A competitive inhibition assay for Fn was used to measure the concentration of Fn in fluid draining the site of a radical mastectomy and the level in concurrently obtained plasma. Plasma levels of Fn were significantly depressed following surgery but were returning toward normal by 24 hours postsurgery. The concentration of Fn in drainage fluid collected two hours postop was slightly but significantly lower than the plasma collected simultaneously. By 8 hours after surgery, drainage fluid levels were significantly higher than that in concurrently obtained plasma, and the difference was even more pronounced at 24 hours postop. Fn in the drainage fluid retained opsonic activity but at a lower level than the opsonic activity in plasma. The higher concentration of Fn in drainage fluid than in plasma appears to be due to binding of the Fn to tissue debris in the exudate, which prevents the reentry of Fn into the vascular compartment.
 ...
PMID:Sequestration of fibronectin at the site of an injury. 713 38

One, as yet unemployed, approach to investigating immunology in depression is the assessment of the cytokine production by leucocytes, which would allow the determination of immune response under standardized conditions. Thus we measured the production of mitogen-induced cytokines (IL-1 beta, IL-2, IL-6, IL-10, interferon-gamma) and sIL-2R in a whole blood assay, and serum protein levels such as C-reactive protein (CRP), haptoglobin (Hp) and alpha 2-macroglobulin (alpha 2 M) in a longitudinal 6-week study in an attempt to assess leucocyte function during and after acute clinical stage of depression in 39 patients. Shortly after admission to hospital we found higher levels of all measured cytokines in the patients. Serum protein levels were significantly higher in the patients than in controls, and decreased over the study period. Whereas slightly elevated monokine levels in patients tended to reach control values, lymphokines showed a significant decrease over the 6 weeks as compared to baseline. These results suggest that the increase in immune activity seen at the beginning of the study may be followed by a suppressed cell-mediated immune function.
 ...
PMID:Cytokine production and serum proteins in depression. 753 45

Recently, it has been reported that major depression is accompanied by changes in plasma protein concentrations indicative of an acute-phase protein (APP) response. The purpose of the present study was to examine total serum protein (TSP) and the electrophoretically separated major fractions of serum proteins (SP), i.e., albumin (Alb), alpha 1, alpha 2, beta and gamma globulin, in depression. Highly significant differences were found in TSP and the separated SP fractions between major depressed patients and normal controls and between melancholic and minor depressed patients. Major depressed subjects showed significantly lower TSP and Alb concentrations and a higher percentage of the alpha 1 globulin fraction than normal controls and minor depressed subjects. Major depressed subjects had significantly higher and lower percentages, respectively, of alpha 2 and gamma globulin fractions than normal controls. In depressed subjects, there were significant negative correlations between TSP or Alb concentrations and severity of illness. Psychomotor retardation and anorexia were psychopathological correlates of lower TSP and Alb concentrations while middle insomnia and psychomotor retardation were related to changes in the alpha 2 globulin fractions. Basal plasma cortisol values were significantly and positively related to serum alpha 2 globulin. The results support the view that major depression is accompanied by an APP response.
 ...
PMID:Total serum protein and serum protein fractions in depression: relationships to depressive symptoms and glucocorticoid activity. 754 74

The influence of altered protein binding on the neuromuscular effect of atracurium has been studied in rats with experimental inflammation induced by subcutaneous injection of turpentine oil. Doses of atracurium ranging from 0.45 to 1.5 mg.kg-1 were administered to control (n = 30) and to experimental inflammation induced rats (n = 30). Neuromuscular transmission was monitored by recording the twitch tension of the tibialis-anterior muscle elicited by stimulation of the sciatic nerve. Three effect parameters were recorded: (i) intensity of the effect, measured as percentage depression of baseline twitch tension, (ii) duration of drug action (min) and (iii) recovery time (min). The dose-intensity of the effect relationship was modelled using a sigmoid Emax model. The ED50 (effective dose eliciting 50% of the maximum effect) was significantly increased (P < 0.01) in the inflammation group as compared to the control group (0.94 vs. 0.68 mg.kg-1). This change was reflected in a shift of the dose-response curve to the right in the pretreated rats. For equipotent doses ED95 (defined as the effective dose eliciting 95% of maximum effect), no differences were found in recovery time and duration of action between the two groups of rats. Mucoproteins levels (index of alpha 1-acid glycoprotein (AAG) and protein binding were significantly increased in rats with experimental inflammation as compared to control rats. Based on these results, altered serum protein binding of atracurium appears to be responsible, at least in part, for the resistance to atracurium.
 ...
PMID:Resistance to atracurium in rats with experimental inflammation: role of protein binding. 860 1


<< Previous 1 2 3 4 5 6 Next >>