Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In a double-blind, controlled experiment, 62 outpatients with symptoms of depression with anxiety were selected for treatment with phenelzine sulfate, 60 mg daily, phenelzine sulfate, 30 mg daily, or placebo for six weeks. Forty-nine patients (79%) completed the experiment. Phenelzine sulfate, 60 mg daily, was significantly more effective than placebo in relieving symptoms of both depression and anxiety. Phenelzine sulfate, 30 mg daily, did not differ from the placebo. Only phenelzine sulfate, 60 mg daily, resulted in a median inhibition of platelet monoamine oxidase that exceded 80%. The results confirm a previous study that found phenelzine to be effective in the treatment of outpatients with depressive-anxiety states. Drug dosage is an important variable influencing clinical outcome in this patient group.
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PMID:A multiple-dose, controlled study of phenelzine in depression-anxiety states. 76 25

We present the case of a 28-year-old man being treated with Nardil for chronic depression who developed a hypertensive crisis and a severe occipital headache one hour after ingesting an over-the-counter appetite suppressant. The adverse reactions between MAO inhibitors and phenylpropanolamine and discussed, as are the dangers of using Demerol to treat the headache and Aldomet to treat the hypertension.
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PMID:Hypertensive crisis resulting from an MAO inhibitor and an over-the-counter appetite suppressant. 711 95

However currently less used, MAOI (monoamine-oxidase inhibitor) antidepressants have specific indications like refractory or atypical depressions. The main difficulties related to MAOI therapy consist in their potentially very dangerous interactions with certain foods on the one side, many medications on the other side. For example, we report the case of a patient treated for a resistant depression by phenelzine (Nardelzine) who presented a severe delirium after the administration of tramadol (Contramal, Dolzam). This case shows the importance of particular attention before the association of any drug in a patient treated by MAOI.
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PMID:[Clinical case of the month. Mental confusion due to the administration of tramadol in a patient treated with MOAI]. 1068 95