Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The theory of inbreeding and outbreeding suggests that there is a hump-shaped relationship between the genetic similarity of sexually reproducing parents and the performance of their offspring. Inbreeding depression occurs when genetic similarity is high, whereas hybrid breakdown is expected when genetic similarity is low. Between these extremes, the effect of genetic similarity on fitness is unclear. We studied the shape of this relationship by crossing 65 target genotypes of the clonal, self-incompatible Ranunculus reptans with partner genotypes spanning a broad scale of genetic similarity, ranging from crosses within populations to between-population crosses and hybridisation with a closely related species. Offspring were raised in outdoor tubs. Results revealed a quadratic relationship between parental genetic distance and offspring performance, with the clonal component of fitness more strongly hump-shaped than the sexual component. Optimal genetic similarity encompassed a broad range of within-population and between-population crosses. This pattern of genomic compatibility has important implications for the evolution of mating systems and mate choice.
 ...
PMID:Genomic compatibility occurs over a wide range of parental genetic similarity in an outcrossing plant. 1600 27

Lymphedema is a chronic and incurable disease, deeply disturbing physical and psychical health of affected individuals. Lymphedema is a progressive, if left untreated. Affected patients are looking for help between physicians and therapists of different specialities. Chronic lymphedema leads to emotional disorders, depression, even to suicidal attempts--especially in young patients. In rare cases it may lead to lymphangiosarcoma--ominous neoplasm with poor prognosis. Complex interdisciplinary approach of the lymphedema team is the key to the success of lymphedema therapy. Optimal treatment of lymphedema requires close cooperation of all people involved in the therapeutic process including physicians, nurses, physiotherapists and psychologists. International Society of Lymphology (ISL) published its recommendations for lymphedema therapy, which are accepted in many countries around the world. Recommended by ISL physiotherapy consists of a manual lymphatic drainage, compressive bandaging, decongestive exercises and meticulous skin care. It is called a manual lymphedema treatment--complex physical therapy (MLT-CPT).
 ...
PMID:The integrated and interdisciplinary treatment of chronic lymphedema. 1611 49

Obstructive sleep apnea syndrome (OSAS) is a common disorder in adults and children, which is characterized by repetitive transient reversible upper airway obstructions during sleep. Due to disrupted sleep architecture and intermittent hypoxemia, OSAS leads to impaired daytime functioning in various neuropsychological and affective domains. The most common abnormalities are executive dysfunction, impaired vigilance, depression, and possibly anxiety and, in children, hyperactivity. Optimal treatment of OSAS with continuous positive airway pressure may reverse the cognitive and affective dysfunction, however, in some patients a residual impairment persists. This persistent deficit, despite effective treatment, raises the possibility of a remaining subtle structural brain damage; such damage has been demonstrated through the use of sensitive functional and other neuroimaging techniques. Prefrontal cortical damage may underlie the cognitive dysfunction in OSAS. Early recognition and treatment may prevent this untoward effect of OSAS.
 ...
PMID:Effect of sleep apnea on cognition and mood. 1619

Two recently completed large, randomised, double-blind, placebo-controlled trials supporting the efficacy of carbamazepine (CBZ) extended-release capsules (ERC) for the treatment of acute manic and mixed episodes have resulted in US FDA approval of CBZ-ERC, and have reinvigorated the importance of understanding the role of CBZ in bipolar disorder (BD) pharmacotherapy. Additional data suggest that CBZ may have a use in BD maintenance treatment and possibly in acute BD depression. Optimal use of CBZ requires sound knowledge of adverse effects and pharmacokinetic interactions with this agent. Adverse effects commonly involve benign side effects but can rarely include serious haematological, dermatological and hepatic manifestations. On the other hand, metabolic adverse effects (thyroid, glucose, lipid disturbances and significant weight gain) can be less problematic with CBZ, compared with lithium, valproate and atypical antipsychotics. Pharmacokinetic considerations (cytochrome P450 3A3/4 metabolism, active epoxide metabolite and catabolic enzyme induction) can influence the clinical use of CBZ. Managing adverse effects and pharmacokinetic complexities is important for optimising pharmacotherapy with CBZ in patients with BD. This paper reviews the chemistry, pharmacodynamics and pharmacokinetics of CBZ, as well as reviews of the controlled trials of CBZ in acute bipolar mania, acute bipolar depression and bipolar maintenance treatment.
 ...
PMID:Clinical use of carbamazepine for bipolar disorders. 1631 39

Numerous difficulties arise during in vivo measurements of transepithelial nasal potential difference (PD) in mice, such as inadequate duration and depth of anaesthesia, bronchoaspiration of solutions perfused in the nose, and respiratory and/or cardiovascular depression. Anaesthesia was induced in adult C57 mice with intraperitoneal injection of a combination of fentanyl, droperidol and medetomidine, each of these at either a small dose (0.20, 10 and 0.33 mg/kg, respectively) or at a large dose (0.40, 20 and 0.40 mg/kg, respectively), combined with a fixed dose of 0.375 microg clonidine. In order to establish a pharmacokinetic-pharmacodynamic relationship, blood concentrations of the first three drugs were measured in 24 animals by liquid-chromatography tandem mass spectrometry. At the end of the experiment, naloxone, a competitive morphinic antagonist, and atipamezole, an alpha-2 adrenergic antagonist, were administered. Bronchoaspiration was prevented by tilting the animal head downwards and by absorbing the excess fluid from the opposite nostril and from the oral cavity. Optimal assessment of anaesthesia associated with regular respiration, loss of blink, pupillary and pedal withdrawal reflexes was obtained with doses of fentanyl, droperidol and medetomidine corresponding to 0.20, 20 and 0.40 mg/kg, respectively. Blood concentrations of fentanyl around 17 ng/mL induced loss of respiratory efforts and were followed by death during the experiment. Integrity of ion transport was demonstrated under continuous perfusion by successive depolarization after amiloride and repolarization after chloride-free solution. The combination investigated in this study lead to adequate surgical anaesthesia (stage III, plane 2) for prolonged nasal PD measurements in spontaneously breathing mice.
 ...
PMID:Successful protocol of anaesthesia for measuring transepithelial nasal potential difference in spontaneously breathing mice. 1646 May 87

Optimal management of depression remains a long-term challenge. Long-term maintenance treatment with antidepressants has been shown to be effective for preventing or delaying recurrence for many patients with a history of previous multiple episodes. However, aside from a history of multiple recurrences, it remains difficult to identify patients who are most likely to experience recurrence and when. Thus we do not really know who might particularly benefit from maintenance therapy and what type may be efficacious. In patients with depression, research has shown there are structural and functional alterations in the brain, particularly in patients with recurrent or chronic depression. These changes have been generally viewed to be consequences of the disease, which are seen to worsen with a longer duration of untreated illness and with a greater number of depressive episodes. However, these neurobiological characteristics may also represent risk factors or vulnerabilities that predispose some patients to chronic or recurrent depression. Additional research has demonstrated that antidepressant treatment may reduce or modulate these functional and structural changes, suggesting that long-term treatment may, in fact, benefit patients not only by controlling symptoms but also by managing these underlying vulnerabilities. A new treatment paradigm, which focuses on identifying patients with risk factors and managing the disease process rather than suppression of symptoms, is needed for recurrent depression.
 ...
PMID:New paradigm for treating recurrent depression: from symptom control to managing enduring vulnerabilities. 1714 15

Pain control following total joint arthroplasty is critical for optimizing patient outcome. Both the real and perceived success of joint arthroplasty surgery depends on the patient's level of pain in the postoperative period. Patients who experience less pain will be more satisfied with their surgery and will be able to more fully participate in postoperative mobilization and rehabilitation. Optimal pain control must be balanced against the adverse effects of narcotics, including alteration of sensorium (especially in older patients) as well as respiratory depression. Modern strategies to control postoperative pain involve a multimodal approach that includes the use of intravenous patient-controlled analgesia.
 ...
PMID:Patient-controlled analgesia for total joint arthroplasty. 1747 98

Conventional clinical dosages of local anesthetics may not be sufficient to block conduction of all afferent impulses, which is important for an effective epidural sensory blockade. Further depression of the transmission of information can be accomplished by central modulating mechanisms, preventing sensory perception. Since there are interindividual differences in the quality of modulating mechanisms, standardized depression of impulse propagation by the local anesthetic is associated with a wide variation in the total depression of afferent impulses. For that reason, the results of a particular dosage of a local anesthetic will be variable regarding the amount of epidural sensory blockade perceived. A continuous epidural technique using a catheter permits the dosage to be individualized by means of additional injections. Patients with a low pain threshold require a more highly concentrated local anesthetic. The addition of opioids to the local anesthetic will permit the use of lower concentrations of the local anesthetic itself. Optimal use of diagnostic, prognostic, and therapeutic epidural blockades is possible only if the influence of modulating mechanisms is taken into account.
 ...
PMID:[The effect of central nervous modulation on the quality of epidural blockade.]. 1841 92

The aim of this work was to develop two logistic regression models capable of predicting physical and mental health related quality of life (HRQOL) among rheumatoid arthritis (RA) patients. In this cross-sectional study which was conducted during 2006 in the outpatient rheumatology clinic of our university hospital, Short Form 36 (SF-36) was used for HRQOL measurements in 411 RA patients. A cutoff point to define poor versus good HRQOL was calculated using the first quartiles of SF-36 physical and mental component scores (33.4 and 36.8, respectively). Two distinct logistic regression models were used to derive predictive variables including demographic, clinical, and psychological factors. The sensitivity, specificity, and accuracy of each model were calculated. Poor physical HRQOL was positively associated with pain score, disease duration, monthly family income below 300 US$, comorbidity, patient global assessment of disease activity or PGA, and depression (odds ratios: 1.1; 1.004; 15.5; 1.1; 1.02; 2.08, respectively). The variables that entered into the poor mental HRQOL prediction model were monthly family income below 300 US$, comorbidity, PGA, and bodily pain (odds ratios: 6.7; 1.1; 1.01; 1.01, respectively). Optimal sensitivity and specificity were achieved at a cutoff point of 0.39 for the estimated probability of poor physical HRQOL and 0.18 for mental HRQOL. Sensitivity, specificity, and accuracy of the physical and mental models were 73.8, 87, 83.7% and 90.38, 70.36, 75.43%, respectively. The results show that the suggested models can be used to predict poor physical and mental HRQOL separately among RA patients using simple variables with acceptable accuracy. These models can be of use in the clinical decision-making of RA patients and to recognize patients with poor physical or mental HRQOL in advance, for better management.
 ...
PMID:Logistic regression models for predicting physical and mental health-related quality of life in rheumatoid arthritis patients. 1856 85

The present study aims to determine the use of Preparatory Grief in Advanced Cancer Patients (PGAC) Scale for screening preparatory grief according to independent criterion standards (ie, the Hospital Anxiety and Depression [HAD] Total scale and the HAD Depression and Anxiety subscales) and to establish an optimal cutoff point for discriminating between subjects with and without preparatory grief. One hundred advanced cancer patients treated in a Pain Relief and Palliative Care Unit completed the PGAC and HAD Scales, while researchers recorded data on demographic characteristics, disease status, and treatment regimen. Optimal balance between sensitivity and specificity for the PGAC Scale as a screening instrument was achieved at a cutoff score of 40+ for all the criterion standards (ie, HAD Total, HAD Anxiety, and HAD Depression), giving a sensitivity range between 84% and 92%, and specificity between 70% and 86%. The area under the receiver operating characteristic curve ranged between 0.867 and 0.968. The PGAC Scale had a favorable sensitivity and specificity in identifying cases of preparatory grief. The receiver operating characteristic analyses demonstrated that the scale is a useful screening instrument in advanced cancer patients.
 ...
PMID:Screening for preparatory grief in advanced cancer patients. 1860 Jan 21


<< Previous 1 2 3 4 5 6 7 8 9 10 Next >>