Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A series of experiments was conducted using White Leghorn male chicks to study the arginine-lysine relationship in rapeseed meal (RSM). Semi-purified diets containing 15% protein either from RSM or soybean meal (SBM) were fed. Arginine supplementation completely reversed the growth depression caused by the addition of lysine to RSM diets. Potassium acetate was only partially effective in alleviating the growth depression caused by supplemental lysine, while polyvinyl pyrrolidone significantly reduced chick performance. Tannic acid addition (1.5%) to SBM diets resulted in a severe growth depression which was partially corrected by the supplementation of arginine in the presence of methionine. Supplementation of these amino acids to RSM had a less drastic effect. It is suggested that a portion of the arginine in rapeseed meal may be required for metabolic processes involved in tannic acid excretion.
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PMID:Arginine-lysine relationship in rapeseed meal. 94 70

Spreading depression in the olfactory bulb of rats is an elusive phenomenon, the demonstration of which requires specific conditioning procedures. The present paper describes a simple technique for reliable initiation of bulbar spreading depression with microinjections of potassium acetate. Adult hooded rats were anesthetized with pentobarbital (50 mg/kg) and slow potential changes accompanying spreading depression were recorded with capillary microelectrodes stereotaxically inserted into the olfactory bulb and adjacent forebrain structures. KCl microinjection (0.5-1.0 microliter, 0.134-0.670 mol/l) into the olfactory bulb elicited local depolarization which only exceptionally developed into a propagating spreading depression. Potassium acetate (0.5-1.0 microliter, 0.15 mol/l) injected into the rostral olfactory bulb evoked a negative slow potential wave (amplitude of around 25 mV and duration 30-50 s) propagating at a rate of 3-4 mm/min through all the olfactory bulb layers. Low positive (5 mV) instead of negative waves were recorded in the superficial olfactory nerve layer with reversal in the glomerular layer (200-300 micron). The slow potential decreased in the rostrocaudal direction and expired at the caudal boundary of the olfactory bulb. Bulbar spreading depression never spread to neocortex, and cortical spreading depression never entered into the olfactory bulb but stopped in the anterior olfactory nucleus 7 mm rostral to bregma. Repeated potassium acetate injections into the olfactory bulb occasionally elicited a series of spreading depression waves recurring at regular intervals, probably reflecting reverberation of scroll-shaped waves around the rostrocaudal axis of the olfactory bulb.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Spreading depression in the olfactory bulb of rats: reliable initiation and boundaries of propagation. 244 64