Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In vitro tests of cellular immune responses, using lymphocyte transformation tests and rosette tests for T and B lymphocytes, were studied in a cross-section analysis of a total of fifty-five patients in six groups (non-pregnant, 2--3 months pregnant, 4--5 months pregnant, 6--7 months pregnant, at parturition and 3 months after parturition). No pregnancy-related changes were found in the numbers of T, B or null cells, nor changes in PHA, PWM or MLC responses, but a significant reversible depression of the PPD response was found in the second half of pregnancy.
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PMID:Cellular immunity in pregnancy: blast transformation and rosette formation of maternal T and B lymphocytes: A cross-section analysis. 14 81

The influence of irradiation upon human lymphocytes was studied using lymphocyte transformation tests and formation of E and HEAC rosettes. Irradiation was given in vitro using doses between 0 and 50,000 rad. It was shown that blast transformation after stimulation with T-cell stimulating agents (as PHA, PWM, Con.A and PPD) was suppressed by irradiation. The effect of irradiation upon T lymphocytes was also shown in different kinds of MLC experiments. Both the effect of irradiation upon rosetts formation and the influence of irradiation upon already formed rosettes were analyzed. The ability of lymphocytes to form E rosettes was affected after irradiation with 500 rad: there were fewer E rosettes with 3 SRBCs, decrease in total number of E rosettes and more null cells, with no depression of the number of HEAC rosettes formed. Already formed E and HEAC rosettes were totally unaffected of irradiation, and this radioresistance was also observed for 18-hour-old rosettes. The ability to form spontaneous E rosettes was decreased after irradiation of the lymphocytes with 100 rad; increasing doses did not cause further depression, and already formed spontaneous E rosettes were radioresistant. The mechanisms involved in E-rosette formation thus seem to be radiosensitive.
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PMID:In vitro radiosensitivity of human T and B lymphocytes evaluated using lymphocyte transformation tests and rosette formation tests. 14 70

The immune responses of 60 patients undergoing therapeutic irradiation were evaluated according to four anatomical sites irradiated. In vitro lymphocyte transformation tests with PHA, Con-A, and PWM and quantitative assays of IgG, IgA, and IgM were performed on blood obtained from each patient before and during therapy, and two weeks, two months, and six months after therapy. At these same testing intervals, skin tests with PPD, mumps antigen, Candida antigen, and SD-SK were performed. During irradiation, the mean values of all lymphocyte transformation tests were depressed, varying from 48% to 64% of pretreatment baseline. This depression persisted until about two months after completion of treatment. By six months, response rose to pretreatment values. When response was evaluated according to sites irradiated with all mitogens, the pelvic and pelvic plus abdominal groups showed consistently greater depression than the chest or head and neck groups. Radiation effected no significant changes in the mean values of IgG, IgA or IgM. A decrease in skin sensitivity was noted during radiation; 73% of the subjects responded positively before therapy while only 53% had at least one positive test during therapy. By two months postirradiation, 73% of the group clinically free of disease had positive skin tests. A comparison of clinical condition with test results is significant when one considers the 17 patients who developed metastatic disease or died from disease. The depression for all three mitogens during radiation therapy was greater for this group. Of the 17, only four had IgG levels in the normal range, and consistently fewer positive skin tests were demonstrated.
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PMID:Effect of therapeutic irradiation on the immune responses. 17

Sera from unselected and untreated patients with Hodgkin's disease (HD) were examined for antibodies to Epstein-Barr viral (EBV) capsid antigens (VCA). Delayed cutaneous hypersensitivity reactions were carried out with purified tuberculoprotein (PPD). Highly purified blood lymphocytes of the same patients were studied morphologically and classified for cell surface markers. Incorporation of 14C-thymidine was used as a measure of spontaneous DNA synthesis and DNA synthesis after exposure to different concentrations of three mitogens (PHA, Conconavalin A and pokeweed mitogen) and PPD. The distribution of EBV titres was in good agreement with previous reports. Most patients were lymphopenic, due to subnormal levels of T lymphocytes. The lymphocyte stimulation and skin tests showed different degrees of impairment in a considerable number of the patients. The results in 43 patients indicated that a relation exists between the immune defect and the anti-VCA titres. High serological anti-VCA reactivity was related to a poor cutaneous response to PPD, a decreased level of T lymphocytes in the blood and a depression of mitogen-induced DNA synthesis.
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PMID:Epstein-Barr virus (EBV)-associated antibody patterns in relation to the deficiency of cell-mediated immunity in patients with Hodgkin's disease. 19 67

In vitro tests of cellular immune response using lymphocyte transformation tests and rosette tests for T and B lymphocytes were studied in a cross-section analysis of a total of 55 patients in six groups (non-pregnant, 2-3 month pregnant, 4-5 month pregnant, 6-7 month pregnant, at parturition and 3 months after parturition). No pregnancy-related changes were found in the numbers of T, B or nil cells, nor changes in PHA, PWM or MLC responses. However, a significant reversible depression of the PPD response was found in the second half of pregnancy.
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PMID:Cell-mediated immunity in pregnancy evaluated using lymphocyte transformation tests and rosette tests for T and B lymphocytes. A cross-section analysis. 30 44

The authors report the first results concerning the systematic use of "immunological monitoring" in patients suffering from well-developed laryngeal cancer. The authors have also studied, in 50 cases in different stages of development, the activity of T-cells using the cutaneous tests (BCG, PPD, PHA and SK-SD), the E-rosette test and the PHA-induced lymphocytic blastization test (it is well known that the T-cells are responsible for a cytotoxic effect against neoplastic cells). The authors have also studied the activity of B-lymphocytes by means of the EA and EAC rosette test and of IgG, IgA, IgM and complement serum titles. They have observed a progressive depression of the T-cell activity after surgical intervention, whereas the B-cell activity in several cases tends to increase. The authors discuss these immunological results and the possibility that these findings may represent the basis for a complementary immunotherapy following the surgical treatment and/or radiotherapy or chemotherapy. Finally, the authors discuss the possibilities and the limitations of these immunological methods from the point of view of clinical application.
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PMID:Prospects and limitations of systematic monitoring in patients with laryngeal cancer. 31 88

In 52 patients undergoing tests of cell-mediated immunity before surgical resection of bronchial carcinoma a positive tuberculin test result was found in 71% compared with 68% of age- and sex-matched controls. Sensitisation to DNCB occurred in 52% of 37 patients but in 78% of controls. There was depression of lymphocyte transformation by PPD in 19 patients compared with controls (P=0.001), but there was no difference in lymphocyte transformation by PHA or pokeweed mitogen between 34 patients and controls. In a pilot study patients were randomly allocated to autograft (eight) or non-autograft (seven) groups. The autograft group were given an intradermal injection of a suspension of irradiated autologous tumour-cells mixed with intradermal BCG on the day of operation. Tests of cell-mediated immunity were repeated two weeks after operation. Five patients in each group received a course of radiotherapy to the mediastinum three weeks after operation. There was a rise in cutaneous tuberculin reactivity (P=0.08) and total leucocyte count (P=0.09) in the autograft group postoperatively with a fall in total lymphocyte and T lymphocyte counts in the non-autograft group (P less 0.05). These differences, however, were not followed by any difference in the frequency of tumour recurrence or the survival rate two years after operation. The results show that the immunological surveillance mechanism is impaired even in patients with early bronchial carcinoma and that it is possible to overcome postoperative immunological depression with specific immunotherapy combined with BCG. This treatment did not produce any clinical advantage in this small number of patients and the skin lesions caused the patients considerable discomfort.
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PMID:Cell-mediated immunity in operable bronchial carcinoma: the effect of injecting irradiated autologous tumour cells and BCG. 44 2

Humoral and cell-mediated immunity were studied in a group of patients with Wilson's disease not previously treated with D-penicillamine, and in a group of patients treated with the drug for more than two years. The previously untreated patients showed an exaggerated humoral immune response, i. e. increased levels of IgG and, IgM, higher titer of antibodies to Kunin's antigen, and depression of cell-mediated immunity, namely a decreased response to DNCB, decreased lymphocyte transformation after stimulation with Con A, PPD, Candida and streptokinase and a reduced response to streptokinase in the MIF test. After treatment the humoral response returned to normal, and in the case of IgA and antibodies to S. typhi O antigen, it even dropped below normal values. The cell-mediated immune response returned to normal with the exception of lymphocyte transformation by PHA and Candida albicans. In in vitro studies it was found that D-penicillamine had no influence on lymphocyte transformation when PHA and Con A were used as mitogens. With PPD as antigen, lymphocyte stimulation and migration inhibition were inhibited by concentrations of penicillamine ranging from 6 to 1000 microgram/ml.
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PMID:The influence of prolonged treatment with D-penicillamine on the immune response in Wilson's disease. 59 Mar 12

Untreated patients with bronchogenic carcinoma of the epidermoid type showed a marked depression of cutaneous delayed hypersensitivity reactions to DNCB, PPD and Varidase. As compared to a control group of healthy individuals and to a control group of patients with non-malignant chest diseases, 46% of cases responded to the DNCB skin test, 56% to the PPD skin test and 39% to the Varidase skin test. The patients were subsequently divided according to the TNM classification in stage I, II and III groups. Correlation of the skin test positivity to the stage of the disease and to the survival of patients was followed.
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PMID:Prognostic significance of skin reactivity in patients with bronchogenic carcinoma grouped according to the TNM classification. 59 68

The immune functions in patients with mammary, pulmonary, or head and neck tumors were investigated after irradiation. The treatment caused an initial lymphopenia and longlasting depression in the lymphocyte proliferative responses to PHA, Con A and PPD. The percentages and the ratio of E and EAC rosette forming cells remained unchanged.
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PMID:Effects of irradiation on the immune function in patients with mammary, pulmonary or head and neck carcinoma. 69 99


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