Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0011570 (
depression
)
172,036
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The regulation of
dihydrodipicolinate synthase
(
EC 4.2.1.52
) and aspartate kinase (EC 2.7.2.4) was studied in Bacillus subtilis 168. Starvation for lysine gave
depression
of one aspartate kinase isoenzyme but not of
dihydrodipicolinate synthase
. Strains resistant to growth inhibition by the lysine analogue thiosine exhibited constitutively derepressed synthesis of one aspartate kinase isoenzyme but had normal levels of
dihydrodipicolinate synthase
. The data provide strong evidence that lysine is not the signal for derepression of
dihydrodipicolinate synthase
. Nevertheless,
dihydrodipicolinate synthase
specific activity increased during sporulation, and it is suggested that this increase may result, in part, from resistance to proteolysis of that enzyme.
...
PMID:Regulation of dihydrodipicolinate synthase and aspartate kinase in Bacillus subtilis. 16 19
