Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Hepatic cysteine sulfinic acid decarboxylase (EC 4.1.1.29) activity has been reported to decrease in response to both L-methionine (Met) feeding and adrenalectomy in rats. A series of experiments was conducted to (a) determine if CSAD depression was evident in female rats fed a methionine-supplemented diet; and (b) determine if adrenal hormones mediated the response of CSAD to dietary methionine. Cysteine sulfinic acid decarboxylase (CSAD) activity was measured in livers of male and female rats fed a methionine-supplemented diet. In female rat liver, CSAD activity was only 25% of the activity measured in livers of male rats. Hepatic enzyme activity in male rats fed a casein-based basal diet containing 0.6% L-methionine was 2.5-fold higher than activity in male rats fed a methionine-supplemented diet containing 1.35% L-methionine (+Met). Similarly, enzyme activity in livers of female rats fed the basal diet was 1.7-fold higher than in female rats fed a methionine-supplemented diet. CSAD activity in adrenalectomized (ADX) male rats fed the basal diet was depressed (990 +/- 120 nmol/min.g liver) compared to activity in intact controls (2347 +/- 89) and sham controls (2040 +/- 143) fed the basal diet. CSAD activity was further depressed in ADX, intact controls, and sham controls fed +Met. Immunochemical detection and quantification of CSAD protein in rat liver demonstrated that changes in CSAD protein were consistent with the observed decreased enzyme activity in female rats, ADX rats, and rats fed +Met. S-Adenosylmethionine and S-adenosylhomocysteine concentrations tended to increase in livers of rats fed +Met. ADX rats fed +Met had the greatest increase in S-adenosylmethionine and S-adenosylhomocysteine concentrations. The depression in hepatic CSAD observed after feeding +Met to rats does not appear to involve adrenal function.
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PMID:Quantification of cysteine sulfinic acid decarboxylase in male and female rats: effect of adrenalectomy and methionine. 156 10

In order to determine the effect of taurine depletion in primates, two species were selected which differed in their taurine conjugtion of bile acids. Consequently, eight cebus (taurine conjugators) and nine cynomolgus monkeys (glycine conjugators) were raised from birth with soybean infant milk formula lacking taurine. Half the monkeys received a 500 ppm taurine supplement. After 5 months the taurine concentration of plasma, urine and several tissues was greatly reduced in the unsupplemented monkeys. The least depletion occurred in retinal tissue of both species and in bile acids of cebus, whereas cynomolgus monkeys increased the glycine conjugation of their bile acids 125%. Taurine depletion was associated with a significant growth depression (16.8%) in the unsupplemented monkeys, but retinal degeneration was not observed. Neither species demonstrated an appreciable capacity to synthesize taurine as measured by cysteinesulfinic acid decarboxylase activity in liver and brain. The data suggest that dietary taurine is essential for maximum growth, as measured by weight gain, of infant nonhuman primates fed a soy protein milk formula.
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PMID:Growth depression in taurine-depleted infant monkeys. 742 Feb 9