Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0011570 (
depression
)
172,036
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Rat liver
sterol carrier protein
(
SCP
) is a major intracellular protein regulating lipid metabolism and transport. During a dark-light cycle,
SCP
undergoes a dramatic diurnal variation in synthesis and level, reflecting translational events. Several hormones participate in the control of
SCP
synthesis. Insulin was implicated when the circadian rhythm of
SCP
was lost in both diabetes and fasting, states where insulin is low. After a 12-h fast the amplitude of the diurnal rhythm is diminished; after a 48-h fast it disappears, although
SCP
synthesis and level remain high. When endogenous insulin secretion is increased in fasted rats by glucose administration,
SCP
increases 2-fold in less than 30 min. When food intake is manipulated, but the dark-light cycle is unchanged, the circadian rhythm of
SCP
corresponds to feeding patterns and not light cycling. During feeding, increases in
SCP
are triggered following the expected increase in serum insulin. However,
SCP
is rapidly and significantly elevated in response to insulin only when glucocorticoids are normally high or increased by injection of the synthetic glucocorticoid, dexamethasone. Hepatocyte
SCP
levels are also induced by a combination of insulin and dexamethasone (2.3-fold) or insulin alone (1.3-fold). Dexamethasone alone causes a striking
depression
of
SCP
(2.4-fold). Thus, insulin is a major regulator of the diurnal variation of
SCP
synthesis. Glucocorticoids and other hormones (e.g. triiodothyronine) are also essential for maximum induction of
SCP
but play permissive roles.
...
PMID:Hormonal triggering of the diurnal variation of sterol carrier protein. 351 Oct 56
