Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0011570 (depression)
 172,036 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The number of changes in some maternal serum biochemical parameters for some congenital malformations are presented. In all pregnancies we observed low levels of LAT, AST, CPK, HBD, AP and high levels of GGTP, THY, amylase. These data demonstrate total depression in metabolism of women with an affected fetus. The biological basis of altered levels of enzymes in pregnancies with affected fetus is unclear.
 ...
PMID:[Various biochemical parameters in serum of pregnant women carrying fetuses with various congenital defects of development]. 830 59

Three calves received 10 g Riedeliella graciflora dry leaves/kg body weight by gavage. Blood samples were taken immediately before plant administration and at 2, 4, 6, 12 and 24 hours later; serum ALT, AST, AP, TB, urea and creatinine were determined. After R graciflora administration, the calves had anorexia, profound depression and recumbency prior to death. Creatinine levels increased markedly until death. Severe tubular nephrosis was consistently observed.
 ...
PMID:The acute toxicity of Riedeliella graciflora in calves. 859 33

The extract from Sarcocystis cruzi cysts in bovine muscle was subcutaneously injected to mice, guinea pigs, chickens, and rabbits to detect its toxicity. Only rabbits showed reactions after administration of the extract at a dose of 25 micrograms. The main clinical signs of the rabbits were depression, reduction in body temperature and intermittent diarrhea and the hematological findings observed were elevation in WBC, RBC, PCV, TP, BUN, AST, AUT and creatinine values and reduction in glucose, K+ and pH of blood. The extract, crude toxin, was a water soluble, acid-alkali stable and thermolabile protein and estimated to be a molecular mass of 15-16 kd.
 ...
PMID:Toxicity and properties of the extract from Sarcocystis cruzi cysts. 872 45

Wedelia glauca was administered experimentally to 11 sheep and 4 cattle. The minimum toxic dose for both species was of 4 to 5 g of fresh plant/kg bw. Clinical signs were depression, muscle fasciculations, increased respiratory and cardiac frequencies, opisthotonous, sternal or lateral recumbency and terminal paddling movements. Time of onset of signs ranged from 12 to 40 h after dosing. Serum AST, LDH and GGT were increased. Three cattle and 5 sheep died after clinical manifestation periods of 2 to 18 h, and 2 sheep survived after being affected for 14 and 46 h. Macroscopic and histologic lesions were similar in cattle and sheep; the liver was swollen and dark reddish, and the wall of the gall bladder was edematous. The cavities had yellowish fluid. Petechiae and echymoses were seen on serous membranes. Microscopically the liver had periacinar hemorrhagic necrosis. Two sheep dosed with 1 g/kg bw daily for 20 d and 1 dosed with 1 g/kg bw for 10 d were not affected. Six sheep were transferred from an area free of W glauca to an area where this plant was present. These animals ate small amounts of the plant and lost weight rapidly, but clinical intoxication did not occur. Two sheep were fed with lucerne hay containing 9% W glauca. They ingested 2.5 g/kg of the dry plant (corresponding to 10 g/kg bw of fresh plant) in 24 h, but did not show intoxication. Because the intoxication occurred in sheep and cattle administered 4 to 10 g/kg bw of the plant in a period of 1 to 2 h, the intoxication may only occur when animals ingest a single toxic dose in a short time.
 ...
PMID:Experimental intoxication of sheep and cattle with Wedelia glauca. 872 20

The toxicity of Rhazya stricta leaves for Najdi sheep is described in 9 sheep assigned as untreated controls, Rhazya-treated at 0.25 g/kg/d and Rhazya-treated at 1 g/kg/d. The oral use of 1 g/kg/d caused body weight depression, ruminal bloat, diarrhea, dyspnea and weakness of the hind limbs. Enterohepatonephropathy, pulmonary congestion, hemorrhage and emphysema, lymphocytes in vital organs, and congestion of the blood vessels of the heart were associated with increases in serum AST and LDH, in elevated bilirubin and urea concentrations, and decreased total protein, albumin and calcium concentrations, and leucopenia and anemia.
 ...
PMID:Toxicity of Rhazya stricta to sheep. 955 56

Myoporum laetum was collected in the counties of Rio Grande and Capao do Leao in winter and in Santa Vitoria in summer, autumn, winter and spring, in the state of Rio Grande do Sul and in the Department of Rocha, Uruguay, in winter and spring. The fresh green leaves were fed to 16 calves. Two calves that ingested the plant from Capao do Leao at 40 and 44 g/kg bw did not develop clinical signs. The other 14 calves had depression, abdominal pain, ruminal atony, ocular and nasal serous discharge, and dry feces with blood and mucus. Four calves developed icterus. First signs appeared 24-72 h after ingestion, and clinical period varied from 2 to 7 d. One animal had mild photosensitization. Calves dosed with 20 g/kg of plant from Santa Vitoria and 40 g/kg of plant from Uruguay had less severe clinical signs. All cattle recovered except 1 dosed with 40 g/kg of plant collected in winter in Santa Vitoria; it died 70 h after ingestion. Histologic lesions in the liver of this animal and in biopsies obtained 48 h after dosing other calves had centrilobular necrosis, sometimes extending to the midzonal region. Clinical signs and hepatic lesions were also observed in a calf dosed with 5 daily doses at 8 g/kg. Serum AST, GGT and bilirubin were increased. M laetum from Santa Vitoria was the most toxic for cattle, and the plant from Uruguay was the least toxic, suggesting variations in toxicity among plants from different regions.
 ...
PMID:Experimental intoxication by Myoporum laetum in cattle. 977 63

Zygomycosis was produced experimentally in 20 New Zealand white rabbits (Oryctolagus cuniculus) by intra-nasal administration of spores of Absidia corymbifera. Infected animals showed dullness, depression, coughing and mucopurulent nasal discharge, but no mortality. Haematology revealed no significant change in Hb and PCV, but leukocytosis due to neutrophilia in the initial stages of the experiment. There was a significant increase in serum total proteins, creatinine, AST, ALT, total Igs and CICs. A. corymbifera specific IgM and IgG antibodies were detected in the sera of the infected animals. Gross lesions consisted of pneumonic consolidations of the anteroventral lobes of the lungs. Microscopically, histology showed formation of pyogranulommas in the lungs. Fungal elements typical of A. corymbifera were demonstrated in the tissues upto 15 days after infection by special stains and confirmed by indirect immunoperoxidase. Re-isolation of the fungus from lungs was also achieved consistently upto 15 days only. It was concluded that intra-nasal instillation of A. corymbifera in rabbits produced significant clinico-pathological alterations with the lesions confined mainly to the lungs. In the present study, neither systemic dissemination of the disease occurred nor were kidneys site of predilection as reported earlier.
 ...
PMID:Experimental zygomycosis in rabbits: clinicopathological studies. 1042 71

A toxicity study was made on Lepidium sativum L. seeds used in Saudi traditional medicine for the treatment of various ailments. Lepidium sativum L. seed fed to Wistar albino rats at 2% (w/w) was non-toxic, Ten percent (w/w) was toxic but not fatal and 50% (w/w) of the diet for 6 weeks was lethal and caused depression in growth rate and entero-hepato-nephrotoxicity. Organ lesions accompanied by anemia and leukopenia were correlated with alterations in serum AST and ALT activities and concentrations of total protein, cholesterol, urea, and other serum constituents.
 ...
PMID:Effects of various levels of dietary Lepidium sativum L. seeds in rats. 1059 49

Three-mo-old male Wistar rats were sprayed with 250, 500, 1000 and 2000 ppm amitraz 2 w apart or given single doses of 50, 100, or 250 mg/kg p.o, i.m. or i.p. No effects were observed in the amitraz-sprayed rats. Single doses of amitraz p.o, i.m. or i.p. was non-toxic at 50 mg/kg, toxic at 100 mg/kg and lethal at 250 mg/kg within 24 h of dosing. Survivors were killed 48 h post-dosing. Features of toxicity were depression, incoordination of movement, paresis of the limbs, hepatonephrotoxicity, muscular hemorrhage at site of injection and peritonitis following i.p. injection. These changes, accompanied by leucopenia, were correlated with alterations in serum AST and concentrations of serum constituents. Amitraz did not inhibit serum ChE activity.
 ...
PMID:Effects of amitraz given by different routes on rats. 1059 39

Astragalus lusitanicus is a toxic legume grown in Morocco and in some other Mediterranean countries. In small ruminants, poisoning by this plant is dominated by nervous signs characterized by many cycles of excitement-depression. Macroscopic examination of poisoned animals showed congestive lesions and oedema in the brain and lungs. Microscopic lesions consisted mainly of vacuolar degeneration in neurons, hepatocytes and in spleen and kidney cells. Serum activity of AST and CK as well as blood glucose and urea were increased as a result of poisoning. However, serum activity of alpha-mannosidase was not modified as is the case in locoism. Chemical investigations showed that A. lusitanicus does not contain swainsonine or miserotoxin and its selenium concentration is very low. However, this legume contains indolizidin alkaloids and a first compound was purified and identified.
 ...
PMID:Toxicology of Astragalus lusitanicus Lam. 1070 44


<< Previous 1 2 3 4 5 6 Next >>